Download - Not Again! Secondary Prevention of Future Cardiovascular Events J. Clay Hays, Jr., MD, FACC
Not Again!
Secondary Prevention of Future Cardiovascular Events
J. Clay Hays, Jr., MD, FACC
56 yr old insurance man
• Presents with chest tightness after playing golf. Trying to walk 18 holes
• Hypertension on diuretics
• Not diabetic
• Unsure of lipids
• Smoker
• 82 year old mother with CHF, father died of stroke at 79 years old
56 year old man
• Heart rate 100 beats/ min
• BP 154/92
• 5’11’’; 230 lbs; BMI 32
• Soft right carotid bruit
• Clear lungs
• Regular rhythm with soft apical systolic murmur; soft s4
56 year old man
• Obese
• Can’t feel aorta, no bruits
• 1+ pedal pulses
• EKG sinus, nonspecific st-t wave changes
• Trop 10
• What next?
Diagnostics
• 80% circumflex lesion with mild disease elsewhere
• Placed 3.0x 12mm Taxus drug eluting stent
• EF 45% with inferior wall hypokinesis
• 30% right carotid lesion by ultrasound
• Tchol 205, HDL 27, Trig 425
What do you do?
ASCVD
• Coronary Artery Disease
• Peripheral Arterial Disease
• Carotid Arterial Disease
• Atherosclerotic Aortic Disease
Benefits of Aggressive Risk Factor Reduction
• Improves survival
• Reduces recurrent events
• Reduces need for further intervention
• Improves quality of life
Smoking
Goal
Complete Cessation
No exposure to environmental tobacco smoke
Recommendations
• Ask about tobacco use at every visit. I(B)
• Advise user to quit. I(B)
• Assist with counseling and a plan. I(B)
• Arrange for followup, referral, or pharmacotherapy. I(B)
• Avoid exposure at home or work. I(B)
Blood Pressure Control
Goal
<140/90
Or
<130/80 if diabetic or chronic kidney disease
Recommendations
For all patients
• Weight control• Increased activity• Alcohol moderation
• Sodium reduction• Increased fruit intake• Increased veggies• Low fat dairy
Recommendations
For hypertensive patients
• Initially treat with B blockers and/or ACEI
• Add other drugs such as thiazides prn to achieve goal
Lipid Management
Goal
LDL-C < 100
If Triglycerides are >200,
non-HDL-C should be < 130
(Total cholesterol – HDL)
For all patients
• Start diet therapy I(B)
• Reduce saturate fat (<7% of total calories)
• Reduce trans-fatty acids
• Reduce to total cholesterol <200 mg/dl
• Add plant sterols (2g/d) and fiber (>10g/d)
• Promote daily activity and weight reduction
• Omega 3 (1g/d), more if trig are up. II(B)
For lipid management
• Assess fasting lipids within 24 hrs for patients with acute events.
• Initiate medication before discharge according to :
• LDL should be <100 (IA) and <70 is reasonable (IIaA)
• See attached table
Physical Activity
Goal
30 minutes, 7 days per week
(Minimum 5 days per week)
Physical Activity
All patients
• Assess risk with physical activity history and/or exercise test to guide prescription
• 30 to 60 mins of moderate intensity I(B)
• 2 days/ week of resistance training. IIb (C)
• Medical supervision for high risk patients I(B)
Weight Management
Goal
BMI: 18.5 to 24.9kg/m2
Waist circumference: Men <40 inches,
Women < 35 inches
Weight management
• Assess BMI on each visit
• Encourage diet and exercise I(B)
• Consider treatment strategies for metabolic syndrome I(B)
• Initial goal to reduce 10% from baseline weight I(B)
Diabetes Management
Goal
HbA1C <7%
Antiplatelet agents
• Aspirin 75 to 162 mg/d in all patients I(A)
• For CABG, start ASA within 48 hrs to reduce chance of graft closure. 162 to 325mg for up to one year
• Clopidogrel 75 mg/d with ASA for up to 1 year after an acute event
Plavix and ASA after PCI
• ASA 325 with Plavix 75 mg/day
• 1 month with bare metal stents
• 3 months with Cypher stents
• 6 months with Taxus stents
Warfarin
• INR 2.0-3.0
• Paroxysmal atrial fib
• Chronic atrial fib or flutter
• Post MI patient with LV thrombus
ACE Inhibitors
• LV dysfunction <40%
• Hypertension
• Diabetes
• Chronic Kidney disease
• Optional for patients with normal LV function and good control of other risk factors
Angiotensin Receptor Blockers
• Intolerant to ACEI and have CHF or MI with EF <40%
• Intolerant to ACEI
• Combined with ACEI in pts with systolic-dysfunction heart failure
Aldosterone Blockade
• Post MI patients, without renal dysfunction or hyperkalemia, who are on ACEI and B blocker, have EF <40% and have diabetes or CHF. I(A)
Beta blockers
• All patients with MI, Acute coronary syndrome, or LV dysfunction
• Continue indefinitely
• Consider in other forms of vascular disease
Influenza Vaccination
• All patients with any form of ASCVD
• Have you had yours?
Questions?