![Page 1: Neurosonology Role for Patients with Acute Ischemic Stroke Annual Meeting/Handouts... · 2019-02-27 · Neurosonology Role for Patients with Acute Ischemic Stroke Andrei V. Alexandrov,](https://reader036.vdocuments.us/reader036/viewer/2022070814/5f0e682f7e708231d43f1862/html5/thumbnails/1.jpg)
Neurosonology Role for Patients
with Acute Ischemic Stroke
Andrei V. Alexandrov, MD
Semmes-Murphey Professor and Chairman
Department of Neurology
The University of Tennessee Health Science Center
Memphis, TN
![Page 2: Neurosonology Role for Patients with Acute Ischemic Stroke Annual Meeting/Handouts... · 2019-02-27 · Neurosonology Role for Patients with Acute Ischemic Stroke Andrei V. Alexandrov,](https://reader036.vdocuments.us/reader036/viewer/2022070814/5f0e682f7e708231d43f1862/html5/thumbnails/2.jpg)
Disclosures
Funding: Cerevast Therapeutics, Inc.
Speaker’s Bureau: Genentech, Inc
Editorial Board
Cerebrovasc Dis, Intl J Stroke
Director, Neurosonology Examination 1998-2018
American Society of Neuroimaging
Former Board Member
ICAVL, ASN
Inventor, US Patent # 6733450
President-Elect, ASN
![Page 3: Neurosonology Role for Patients with Acute Ischemic Stroke Annual Meeting/Handouts... · 2019-02-27 · Neurosonology Role for Patients with Acute Ischemic Stroke Andrei V. Alexandrov,](https://reader036.vdocuments.us/reader036/viewer/2022070814/5f0e682f7e708231d43f1862/html5/thumbnails/3.jpg)
1998
![Page 4: Neurosonology Role for Patients with Acute Ischemic Stroke Annual Meeting/Handouts... · 2019-02-27 · Neurosonology Role for Patients with Acute Ischemic Stroke Andrei V. Alexandrov,](https://reader036.vdocuments.us/reader036/viewer/2022070814/5f0e682f7e708231d43f1862/html5/thumbnails/4.jpg)
TJC Requirements and Brain Attack Coalition Guidelines for
Comprehensive Centers:
•Key Personnel –•Neurologists
•Neurosurgeons
•Vascular Surgeons
•Intensivists (Neuro-Critical Care Specialists)
•Advanced Practice Nurses (Masters or Doctoral degree)
•Endovascular Specialists
•Ultrasound Technicians
•Physical Medicine/Rehabilitation Physicians & Therapists
•Endovascular Treatment –•Angioplasty/Stents
•Coil embolization
•Intra-arterial lytic and mechanical clot retrieval/disruption
•Expanded Neuroradiology Capabilities –•MRI/MRA/DWI
•CT Angiography
•Digital Angiography
•Echocardiography (TTE/TEE)
•Carotid and Transcranial Doppler
•Stroke Unit & ICU
•Rehabilitation Program
•Formal Patient and Staff Education
•Stroke Registry with Outcomes/Process Tracking
![Page 5: Neurosonology Role for Patients with Acute Ischemic Stroke Annual Meeting/Handouts... · 2019-02-27 · Neurosonology Role for Patients with Acute Ischemic Stroke Andrei V. Alexandrov,](https://reader036.vdocuments.us/reader036/viewer/2022070814/5f0e682f7e708231d43f1862/html5/thumbnails/5.jpg)
TCD, CDUS, CTA, MRA
H&P Head CT ECG, blood work-up
Evaluation of a Stroke Patient
Invasive Angiography
![Page 6: Neurosonology Role for Patients with Acute Ischemic Stroke Annual Meeting/Handouts... · 2019-02-27 · Neurosonology Role for Patients with Acute Ischemic Stroke Andrei V. Alexandrov,](https://reader036.vdocuments.us/reader036/viewer/2022070814/5f0e682f7e708231d43f1862/html5/thumbnails/6.jpg)
NIHSS is sensitive to clot presence (>10 points)
CLOTBUST: Find Thrombus Fast
Portable TCD and duplex
Fast track protocol
Use full power
High PRF, gate > 10 mm
Occlusion(s) location
The worst residual flow
Monitoring set
![Page 7: Neurosonology Role for Patients with Acute Ischemic Stroke Annual Meeting/Handouts... · 2019-02-27 · Neurosonology Role for Patients with Acute Ischemic Stroke Andrei V. Alexandrov,](https://reader036.vdocuments.us/reader036/viewer/2022070814/5f0e682f7e708231d43f1862/html5/thumbnails/7.jpg)
Carotid US + TCD:
Lesions Amenable to Intervention
Chernyshev et al. Stroke 2005:36:32-37.
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%
TIA (n=33)
No Thrombolytic Rx (n=63)
Thrombolytic Rx (n=54)
TANDEM (ICA+MCA) obstructions
ICA obstruction
MCA obstruction
BA or VA obstruction
Normal study
0% 20% 40% 60% 80% 100%
TIA
n=33
No thrombolysis
n=63
IV TPA or IA
n=54
Neurovascular US exam yields excellent
agreement with urgent DSA
![Page 8: Neurosonology Role for Patients with Acute Ischemic Stroke Annual Meeting/Handouts... · 2019-02-27 · Neurosonology Role for Patients with Acute Ischemic Stroke Andrei V. Alexandrov,](https://reader036.vdocuments.us/reader036/viewer/2022070814/5f0e682f7e708231d43f1862/html5/thumbnails/8.jpg)
Acute vs Chronic
![Page 9: Neurosonology Role for Patients with Acute Ischemic Stroke Annual Meeting/Handouts... · 2019-02-27 · Neurosonology Role for Patients with Acute Ischemic Stroke Andrei V. Alexandrov,](https://reader036.vdocuments.us/reader036/viewer/2022070814/5f0e682f7e708231d43f1862/html5/thumbnails/9.jpg)
Carotid Occlusion: Acute or Chronic▪ Acute: normal vessel diameter, preserved intima-media complex, some
distensibility
▪ Chronic: fibrosis, vessel collapse, lack of vessel wall pulsations
Cerbrovascular Ultrasound in Stroke Prevention and Treatment (2nd Ed)
Oxford: Wiley-Blackwell Publishers. 2011. ISBN 9781405195768
Acuson P300
![Page 10: Neurosonology Role for Patients with Acute Ischemic Stroke Annual Meeting/Handouts... · 2019-02-27 · Neurosonology Role for Patients with Acute Ischemic Stroke Andrei V. Alexandrov,](https://reader036.vdocuments.us/reader036/viewer/2022070814/5f0e682f7e708231d43f1862/html5/thumbnails/10.jpg)
Normal MCA and
MCA/ACA Waveforms
![Page 11: Neurosonology Role for Patients with Acute Ischemic Stroke Annual Meeting/Handouts... · 2019-02-27 · Neurosonology Role for Patients with Acute Ischemic Stroke Andrei V. Alexandrov,](https://reader036.vdocuments.us/reader036/viewer/2022070814/5f0e682f7e708231d43f1862/html5/thumbnails/11.jpg)
Normal MCA and ACA
Waveforms with Severe ICA Stenosis
![Page 12: Neurosonology Role for Patients with Acute Ischemic Stroke Annual Meeting/Handouts... · 2019-02-27 · Neurosonology Role for Patients with Acute Ischemic Stroke Andrei V. Alexandrov,](https://reader036.vdocuments.us/reader036/viewer/2022070814/5f0e682f7e708231d43f1862/html5/thumbnails/12.jpg)
TCD and CTA in Acute Ischemia
![Page 13: Neurosonology Role for Patients with Acute Ischemic Stroke Annual Meeting/Handouts... · 2019-02-27 · Neurosonology Role for Patients with Acute Ischemic Stroke Andrei V. Alexandrov,](https://reader036.vdocuments.us/reader036/viewer/2022070814/5f0e682f7e708231d43f1862/html5/thumbnails/13.jpg)
P
A1 ACA
M2 MCAP1 PCA
M1 MCA
PMD-TCD – CTA Depth Ranges
54 – 64mm 36-46mm
40 – 56mm64 – 70mm
34445766
67 59
![Page 14: Neurosonology Role for Patients with Acute Ischemic Stroke Annual Meeting/Handouts... · 2019-02-27 · Neurosonology Role for Patients with Acute Ischemic Stroke Andrei V. Alexandrov,](https://reader036.vdocuments.us/reader036/viewer/2022070814/5f0e682f7e708231d43f1862/html5/thumbnails/14.jpg)
RDVAP
BA
P
RPVA
46mm
78mm
82mm
78 - 102mm
105mm
44mm
PMD-TCD – CTA Depth Ranges
![Page 15: Neurosonology Role for Patients with Acute Ischemic Stroke Annual Meeting/Handouts... · 2019-02-27 · Neurosonology Role for Patients with Acute Ischemic Stroke Andrei V. Alexandrov,](https://reader036.vdocuments.us/reader036/viewer/2022070814/5f0e682f7e708231d43f1862/html5/thumbnails/15.jpg)
TCD and CTA in Acute Ischemia
Tsivgoulis G. et al. Stroke 2007:38:1245-1249.
![Page 16: Neurosonology Role for Patients with Acute Ischemic Stroke Annual Meeting/Handouts... · 2019-02-27 · Neurosonology Role for Patients with Acute Ischemic Stroke Andrei V. Alexandrov,](https://reader036.vdocuments.us/reader036/viewer/2022070814/5f0e682f7e708231d43f1862/html5/thumbnails/16.jpg)
PMD in Acute Posterior Ischemia
![Page 17: Neurosonology Role for Patients with Acute Ischemic Stroke Annual Meeting/Handouts... · 2019-02-27 · Neurosonology Role for Patients with Acute Ischemic Stroke Andrei V. Alexandrov,](https://reader036.vdocuments.us/reader036/viewer/2022070814/5f0e682f7e708231d43f1862/html5/thumbnails/17.jpg)
PMD in Acute Posterior Ischemia
Tsivgoulis G. et al. Stroke 2008:39:1197-1204.
![Page 18: Neurosonology Role for Patients with Acute Ischemic Stroke Annual Meeting/Handouts... · 2019-02-27 · Neurosonology Role for Patients with Acute Ischemic Stroke Andrei V. Alexandrov,](https://reader036.vdocuments.us/reader036/viewer/2022070814/5f0e682f7e708231d43f1862/html5/thumbnails/18.jpg)
Mikulik R, et al. Stroke 2006;37:229-230.
TCD&CDUS via Telemedicine
![Page 19: Neurosonology Role for Patients with Acute Ischemic Stroke Annual Meeting/Handouts... · 2019-02-27 · Neurosonology Role for Patients with Acute Ischemic Stroke Andrei V. Alexandrov,](https://reader036.vdocuments.us/reader036/viewer/2022070814/5f0e682f7e708231d43f1862/html5/thumbnails/19.jpg)
CTA
H&P Head CT ECG, blood work-up
Evaluation of a Stroke Patient
Invasive Angiography
![Page 20: Neurosonology Role for Patients with Acute Ischemic Stroke Annual Meeting/Handouts... · 2019-02-27 · Neurosonology Role for Patients with Acute Ischemic Stroke Andrei V. Alexandrov,](https://reader036.vdocuments.us/reader036/viewer/2022070814/5f0e682f7e708231d43f1862/html5/thumbnails/20.jpg)
Good or Bad Collaterals?
![Page 21: Neurosonology Role for Patients with Acute Ischemic Stroke Annual Meeting/Handouts... · 2019-02-27 · Neurosonology Role for Patients with Acute Ischemic Stroke Andrei V. Alexandrov,](https://reader036.vdocuments.us/reader036/viewer/2022070814/5f0e682f7e708231d43f1862/html5/thumbnails/21.jpg)
• Refine CTA• 3 phases• One injection• Relatively easy to standardize and train• Minimal post processing time
Multiphase CTA
![Page 22: Neurosonology Role for Patients with Acute Ischemic Stroke Annual Meeting/Handouts... · 2019-02-27 · Neurosonology Role for Patients with Acute Ischemic Stroke Andrei V. Alexandrov,](https://reader036.vdocuments.us/reader036/viewer/2022070814/5f0e682f7e708231d43f1862/html5/thumbnails/22.jpg)
Multiphase CTA
![Page 23: Neurosonology Role for Patients with Acute Ischemic Stroke Annual Meeting/Handouts... · 2019-02-27 · Neurosonology Role for Patients with Acute Ischemic Stroke Andrei V. Alexandrov,](https://reader036.vdocuments.us/reader036/viewer/2022070814/5f0e682f7e708231d43f1862/html5/thumbnails/23.jpg)
Collateral Scoring on
mCTA
Figure. Upper panel shows a patient with a left M1 MCA occlusion (arrow) and good collaterals (backfilling arteries) on multi-phase
CTA. Middle Panel shows a patient with a left M1 MCA occlusion (arrow) and intermediate collaterals. Lower panel shows a patient
with a right M1 MCA occlsion (arrow) and poor collaterals (minimal backfilling arteries) on multi-phase CTA.
![Page 24: Neurosonology Role for Patients with Acute Ischemic Stroke Annual Meeting/Handouts... · 2019-02-27 · Neurosonology Role for Patients with Acute Ischemic Stroke Andrei V. Alexandrov,](https://reader036.vdocuments.us/reader036/viewer/2022070814/5f0e682f7e708231d43f1862/html5/thumbnails/24.jpg)
Collaterals in Stroke Research
Fax +41 61 306 12 34
E-Mail [email protected]
www.karger.com
Or ig inal Paper
Cerebrovasc Dis 2006;21:74–78
DOI: 10.1159/000090006
Flow Diversion in Transcranial Doppler
Ul t rasound Is A ssociat ed w i t h Bet t er
Im provem ent in Pat ient s w i t h A cut e M iddle
Cerebral A r t er y Occ lusion
Yo Sik Kim a John Stirling Meyer b Zsolt Garami c Carlos A. Molina e
Aleksandra M. Pavlovic f, g Andrei V. Alexandrov d
a Department of Neurology, Wonkwang University School of Medicine and Wonkwang Medical Science
Research Center, Jeonbuk , Korea; b Department of Neurology, Baylor College of Medicine, and c
Department of
Neurology, University of Texas Medical School at Houston, Houston, Tex. , and d Neurosonology Program and
Stroke Research, Barrow Neurogical Institute, Phoenix, Ariz. , USA; e Neurovascular Unit, Vall d’Hebron Hospital,
Barcelona , Spain; f Department of Neurology, Royal Melbourne Hospital, Melbourne , Australia; g Institute of
Neurology, Department for Cerebrovascular Disorders, Belgrade , Serbia
In 35 patients with a persistent occlusion, the average
NIHSS score reduction was 22% (FD+) and 0.52% (FD–)
during 90 min after t-PA bolus (p = 0.017), and 29 versus
–25% during the fi rst 24 h after the t-PA bolus, respec-
tively (p = 0.01). Conclusions: In patients with persistent
MCA occlusions after thrombolytic treatment, arterial
blood fl ow diversion is associated with earlier and better
neurological improvement. FD has protective effects on
the ischemic brain tissue with persistent MCA occlu-
sion.
Copyright © 2006 S. Karger AG, Basel
In t roduct ion
Clinical outcome after intravenous thrombolysis is in-
fl uenced by several factors including age, severity of ini-
tial neurological defi cit, blood glucose levels, extent of
hypodensity on pretreatment CT, site of the occlusion,
degree of recanalization and adequacy of collateral circu-
lation [1–6] . In patients with acute middle cerebral artery
(MCA) occlusion, leptomeningeal collateral channels
are the only collateral pathways between distal MCA
Key Words
Cerebral infarction Flow diversion Collateral
circulation Transcranial Doppler ultrasound
A bst ract
Backgound: Flow diversion (FD) can occur with an acute
middle cerebral artery (MCA) occlusion. FD is thought to
represent the collateral blood fl ow to the occluded MCA
territory, but it is unclear whether or not FD lessens the
stroke severity or leads to improved outcome. Methods:
Patients with a proximal MCA occlusion were selected
from the CLOTBUST trial data bank. FD to the anterior or
posterior cerebral artery was determined using transcra-
nial Doppler ultrasound. Stroke severity and clinical im-
provement were measured using the National Institutes
of Health Stroke Scale (NIHSS) scores. Results: We eval-
uated 47 patients with an isolated M1 MCA occlusion
who received intravenous tissue-type plasminogen acti-
vator (t-PA) within 3 h of symptom onset. FD was present
in 83% of the patients. Median baseline NIHSS scores
were 15.5 in the FD– group and 18 in the FD+ group (n.s.).
Complete recanalization rates were 25 and 25.6% (n.s.).
Received: June 23, 2005
Accepted: September 2, 2005
Published online: November 28, 2005
Yo Sik Kim, MD
Department of Neurology, Wonkwang University Hospital
344-2 Shinyong-Dong, Iksan
Jeonbuk (Korea)
Tel. +82 63 850 1142, Fax +82 63 842 7379, E-Mail [email protected]
© 2006 S. Karger AG, Basel
1015–9770/06/0212–0074$23.50/0
Accessible online at:
www.karger.com/ced
Cerebrovascular Dis 2006;21:74-78.
![Page 25: Neurosonology Role for Patients with Acute Ischemic Stroke Annual Meeting/Handouts... · 2019-02-27 · Neurosonology Role for Patients with Acute Ischemic Stroke Andrei V. Alexandrov,](https://reader036.vdocuments.us/reader036/viewer/2022070814/5f0e682f7e708231d43f1862/html5/thumbnails/25.jpg)
Cerebrovascular Dis 2006;21:74-78.
![Page 26: Neurosonology Role for Patients with Acute Ischemic Stroke Annual Meeting/Handouts... · 2019-02-27 · Neurosonology Role for Patients with Acute Ischemic Stroke Andrei V. Alexandrov,](https://reader036.vdocuments.us/reader036/viewer/2022070814/5f0e682f7e708231d43f1862/html5/thumbnails/26.jpg)
Upward and
anterior
probe
angulation
Transtemporal
insonation
Transducer
position
Insonation
focus (gate)
TCD Monitors the Residual Flow Signals
50 mm
Stroke 2000;31:610-14. Circulation 2000;100:2282-83.
![Page 27: Neurosonology Role for Patients with Acute Ischemic Stroke Annual Meeting/Handouts... · 2019-02-27 · Neurosonology Role for Patients with Acute Ischemic Stroke Andrei V. Alexandrov,](https://reader036.vdocuments.us/reader036/viewer/2022070814/5f0e682f7e708231d43f1862/html5/thumbnails/27.jpg)
Neurology 2001;56:568-570.
![Page 28: Neurosonology Role for Patients with Acute Ischemic Stroke Annual Meeting/Handouts... · 2019-02-27 · Neurosonology Role for Patients with Acute Ischemic Stroke Andrei V. Alexandrov,](https://reader036.vdocuments.us/reader036/viewer/2022070814/5f0e682f7e708231d43f1862/html5/thumbnails/28.jpg)
-Reocclusion occurs in up to 27% of TPA
treated patients with MCA occlusions
-Reocclusion accounts for 2/3 of early clinical
deterioration following improvement
![Page 29: Neurosonology Role for Patients with Acute Ischemic Stroke Annual Meeting/Handouts... · 2019-02-27 · Neurosonology Role for Patients with Acute Ischemic Stroke Andrei V. Alexandrov,](https://reader036.vdocuments.us/reader036/viewer/2022070814/5f0e682f7e708231d43f1862/html5/thumbnails/29.jpg)
Case illustration
▪60 y.o. AA man
▪NIHSS 17
▪ASPECTS 9
▪iv tPA at 3 hrs
▪CTA persisting
LMCAO after transfer
Images courtesy of Dr Nitin Goyal
![Page 30: Neurosonology Role for Patients with Acute Ischemic Stroke Annual Meeting/Handouts... · 2019-02-27 · Neurosonology Role for Patients with Acute Ischemic Stroke Andrei V. Alexandrov,](https://reader036.vdocuments.us/reader036/viewer/2022070814/5f0e682f7e708231d43f1862/html5/thumbnails/30.jpg)
Case illustration
Images courtesy of Dr Nitin Goyal
▪Symptom onset to TICI 3 246 min
![Page 31: Neurosonology Role for Patients with Acute Ischemic Stroke Annual Meeting/Handouts... · 2019-02-27 · Neurosonology Role for Patients with Acute Ischemic Stroke Andrei V. Alexandrov,](https://reader036.vdocuments.us/reader036/viewer/2022070814/5f0e682f7e708231d43f1862/html5/thumbnails/31.jpg)
Case illustration
Images courtesy of Dr Nitin Goyal
▪ Post MT SBP 170s-180s up to 8 hrs; decreasing LOC
• 3 month mRS 4
![Page 32: Neurosonology Role for Patients with Acute Ischemic Stroke Annual Meeting/Handouts... · 2019-02-27 · Neurosonology Role for Patients with Acute Ischemic Stroke Andrei V. Alexandrov,](https://reader036.vdocuments.us/reader036/viewer/2022070814/5f0e682f7e708231d43f1862/html5/thumbnails/32.jpg)
Knowns from bp mgmt for iv tPa
Tsivgoulis G, et al. Stroke 2009;40:3631-3634. TUCSON Trial. Ann Neurol 2009;66:28-38.
Tsivgoulis G, et al. Stroke 2007;38:961-966.
▪BP goals before bolus below<185/110 mm
Hg and <180/105 for 24 hrs post treatment
were set by NINDS-rt-PA Stroke Study.
Violations increase sICH risk OR 2.59; 95% CI,
1.07 to 6.25; P=0.034
▪Pre-bolus SBP inversely associated with
recanalization: OR per 10-mm Hg increase
0.85; 95% CI: 0.74 to 0.98, P=0.022
![Page 33: Neurosonology Role for Patients with Acute Ischemic Stroke Annual Meeting/Handouts... · 2019-02-27 · Neurosonology Role for Patients with Acute Ischemic Stroke Andrei V. Alexandrov,](https://reader036.vdocuments.us/reader036/viewer/2022070814/5f0e682f7e708231d43f1862/html5/thumbnails/33.jpg)
Mulder M, et al. Stroke 2017;48:1869-1876.
![Page 34: Neurosonology Role for Patients with Acute Ischemic Stroke Annual Meeting/Handouts... · 2019-02-27 · Neurosonology Role for Patients with Acute Ischemic Stroke Andrei V. Alexandrov,](https://reader036.vdocuments.us/reader036/viewer/2022070814/5f0e682f7e708231d43f1862/html5/thumbnails/34.jpg)
Where should bp goals post mt be?
Wartenberg KE, Mayer SA. Neurology 2017;89:528-529.
▪Permissive HTN <220/120 without IVT or
<180/90 after IVT
▪Moderate BP control <160/90
▪Intensive BP control <140/90
![Page 35: Neurosonology Role for Patients with Acute Ischemic Stroke Annual Meeting/Handouts... · 2019-02-27 · Neurosonology Role for Patients with Acute Ischemic Stroke Andrei V. Alexandrov,](https://reader036.vdocuments.us/reader036/viewer/2022070814/5f0e682f7e708231d43f1862/html5/thumbnails/35.jpg)
![Page 36: Neurosonology Role for Patients with Acute Ischemic Stroke Annual Meeting/Handouts... · 2019-02-27 · Neurosonology Role for Patients with Acute Ischemic Stroke Andrei V. Alexandrov,](https://reader036.vdocuments.us/reader036/viewer/2022070814/5f0e682f7e708231d43f1862/html5/thumbnails/36.jpg)
Can one size fit all?
▪TICI 3 + Dramatic neurological recovery
▪TICI 3 and no Neurological improvement
▪TICI 2 + Neurological improvement
▪No recanalization
![Page 37: Neurosonology Role for Patients with Acute Ischemic Stroke Annual Meeting/Handouts... · 2019-02-27 · Neurosonology Role for Patients with Acute Ischemic Stroke Andrei V. Alexandrov,](https://reader036.vdocuments.us/reader036/viewer/2022070814/5f0e682f7e708231d43f1862/html5/thumbnails/37.jpg)
Lessons learned with monitoring
Upward
and
anterior
probe
angulation
Transtemporal
insonation
Transducer
position
Insonation
focus (gate)
50 mm
Demchuk AM, et al. Circulation 2000;100:2282-83.
![Page 38: Neurosonology Role for Patients with Acute Ischemic Stroke Annual Meeting/Handouts... · 2019-02-27 · Neurosonology Role for Patients with Acute Ischemic Stroke Andrei V. Alexandrov,](https://reader036.vdocuments.us/reader036/viewer/2022070814/5f0e682f7e708231d43f1862/html5/thumbnails/38.jpg)
Lessons learned with monitoring
13:02 Time 13:38
TPA bolus
NIHSS 15 NIHSS 15GCS 3 15:25
Demchuk AM, et al. Circulation 2000;100:2282-83.
![Page 39: Neurosonology Role for Patients with Acute Ischemic Stroke Annual Meeting/Handouts... · 2019-02-27 · Neurosonology Role for Patients with Acute Ischemic Stroke Andrei V. Alexandrov,](https://reader036.vdocuments.us/reader036/viewer/2022070814/5f0e682f7e708231d43f1862/html5/thumbnails/39.jpg)
Hyperemic reperfusion after mt
▪Analogous to cerebral hyperperfusion syndrome after carotid endarterectomy leading to headache, seizures and SAH/blood extravasation
▪Contributes to hemorrhagic transformations, sICH, edema, neurological decline and seizures after stroke
▪Directly detectable by TCD during or after MT: normal or elevated MFVs with abnormally low resistance flow pattern (PI decrease >30% vs unaffected side) in the previously occluded vessel1
1Rubiera M, et al. Stroke 2010;41:695-699.
![Page 40: Neurosonology Role for Patients with Acute Ischemic Stroke Annual Meeting/Handouts... · 2019-02-27 · Neurosonology Role for Patients with Acute Ischemic Stroke Andrei V. Alexandrov,](https://reader036.vdocuments.us/reader036/viewer/2022070814/5f0e682f7e708231d43f1862/html5/thumbnails/40.jpg)
Until RCT(s) become available…
▪TICI 3 + Dramatic neurological recovery < 140/80
▪TICI 3, no Neurological improvement <160/90
▪TICI 2 + Neurological improvement <160/90
▪No recanalization <160/90 or permissive hypertension <180/90
▪Strict BP control to avoid variability in all groups
Personal opinion.
![Page 41: Neurosonology Role for Patients with Acute Ischemic Stroke Annual Meeting/Handouts... · 2019-02-27 · Neurosonology Role for Patients with Acute Ischemic Stroke Andrei V. Alexandrov,](https://reader036.vdocuments.us/reader036/viewer/2022070814/5f0e682f7e708231d43f1862/html5/thumbnails/41.jpg)
Stroke Patient Evaluation with US
▪Extension of neurological examination
▪Bedside testing
▪Real time assessment of hemodynamics
▪Ascertaining stroke pathogenesis
▪Continuous monitoring
▪Aid therapies
![Page 42: Neurosonology Role for Patients with Acute Ischemic Stroke Annual Meeting/Handouts... · 2019-02-27 · Neurosonology Role for Patients with Acute Ischemic Stroke Andrei V. Alexandrov,](https://reader036.vdocuments.us/reader036/viewer/2022070814/5f0e682f7e708231d43f1862/html5/thumbnails/42.jpg)
Any questions?