NSF Workshop on Shared Organizing Principles in the Computing and Biological
Sciences, May 25-26, 2010
Networks and my
other playgroundsother playgrounds
Luis A. Nunes Amaral
Howard Hughes Medical Institute
Dept. of Chemical and Biological Engineering
Dept. of Medicine
Northwestern Institute on Complex Systems
The communication gap
How many biologists do you
need for counting worm eggs?
How many modelers do you
need in order to predict their
counting?counting?
What do you need for them to
believe one another?
1
What don’t we know?
2
Metabolism
3
Protein interaction networks
Giot et al. Science 302, 1727 (2003)
Too much information
5
My solution…
Guimera, Amaral. Nature 433, 895 (2005) 6
Detect hierarchies
Sales-Pardo, Guimera, Moreira, Amaral, PNAS 104, 15224 (2007) 7
Cartographic representation
Amaral, PNAS 105, 6795 (2008) 8
