National Institute on Aging
Judith A. Salerno, M.D., M.S.
Deputy Director
NIA/NIH/DHHS
ADC MeetingApril 2004
National Institute on AgingTrends in AppropriationsFiscal Years 1994 - 2004
0
200
400
600
800
1,000
Fiscal Year
Mil
lio
ns
$ Millions 420.3 433.3 453.5 484.3 517.1 594.6 685.7 785.4 891.3 993.6 1025
94 95 96 97 98 99 2000 2001 2002 2003 2004
3%increase
5%increase
7%increase
7%increase
15%increase
15%increase
15%increase
14%increase
12%increase
3.2%increase
National Institutes of HealthAlzheimer’s Disease Research
Fiscal Years 1990 – 2003
0100200300400500600700
Fiscal Year
Dol
lars
in M
illio
ns
NIA 94 155 197 203 213 215 225 244 260 300 350 399 447 502
Other NIH 52.2 74.4 81.8 84.5 85.3 81.7 79.6 85.3 96.3 106.3 106.5 126.0 148 157
90 91 92 93 94 95 96 97 98 99 00 01 02 03
National Institute on AgingDistribution of Obligations by
Budget Category: Fiscal Year 2003
Training2.3%
SBIR/STTR2.3%
Centers8.5% Research
Project Grants 64.5%
Intramural9.7%
Contracts6.2%
Other3.3%
RM&S3.3%
Total NIA: $993,598,000 FY 2003 appropriations post rescission NIA Budget Sept. 2003
NIA CentersFiscal Year Obligations
0
10
20
30
40
50
60
70
80
90
FY01 FY02 FY03 FY04 est.
AD Centers
Other Centers
Do
llars
in m
illio
ns
6.9% increase5.5% increase
1.5 - 2.0% increase
Alzheimer’s Disease CentersFY 2004 (est.)
41%
59%
Other CentersAD Centers
Total NIA Centers FY 04: $85.4M
Additional Sources of Supportfor Alzheimer’s Disease Centers
National Alzheimer’s Coordinating Center– $3.222 M in FY03 RPG funds– Re-competing in FY 04
NIA Centers Reserve– Additional $1.2 M in FY 03; little or no reserve in FY 04
NIA Director’s Reserve– RFA on Collaborative Studies on AD and Other
Neurodegenerative Diseases Associated with Aging: $1.5M for FY 03
– RFA on the Alzheimer’s Disease Neuroimaging Initiative: NIA will commit $8M (U01) for FY 04; additional support from non-government sources anticipated.
NIA Funding Policy for RPGsFY 2004
NIA has experienced a 38% increase in the number of new and competing applications received from FY 2003 to FY 2004 and a 40% increase in total funds requested by these applications.
At the same time, the FY 2004 NIA extramural budget has increased by approximately $28 million or 2.9%.
NIA Funding Policy for RPGsFY 2004 – Cont’d
To manage its resources, consider program priority areas and to support a full range of excellent research, NIA announces the following funding policy:
– In FY2003, NIA funded 411 competing Research Project Grants (RPGs) at a total cost of $159 million. In FY2004, NIA plans to support a similar number of grants at a total cost of $165 million.
– NIA expects to fund Research Project Grants (R01, P01, U01, R03, R21, R15) to approximately the 15th percentile at this time.
– To reach this pay line, NIA will reduce competing grants by an average of 18% below levels recommended in peer review.
– Reductions for other non-RPG mechanisms will be negotiated on a case-by-case basis. Further adjustment in the pay line may be made as the fiscal year proceeds.
New Funding Policy for Program Project (PO1) Applications
To continue to fund a diverse research portfolio, new and competing PO1 applications will be limited to no more than $1.5 million in direct costs in first year. Budget increases in non-competing years will be at the standard NIH adjustments.
Policy effective with applications submitted for June 1, 2004 receipt date.
Exceptions to the cap will be rarely allowed and only after approval of NIA-wide Planning Group.
Outlook for FY 2005:
? ? ?
The Roadmap:
Where are we going?
Bench Bedside Practice
Building Blocks PathwaysMolecular LibrariesBioinformatics and Computational BiologyStructural BiologyNanomedicine
TranslationalResearchInitiatives
Clinical ResearchInformatics
Integrated ResearchNetworksClinical outcomes
TrainingNational Clinical Research Associates
Interdisciplinary ResearchPioneer Award Nanomedicine
Public PrivatePartnerships
NIH Roadmap Strategy
Re-engineering the Clinical Research
Enterprise
Public-PrivatePartnerships
High-riskResearch
Interdisciplinary Research Nanomedicine
Bioinformatics and Computational Biology
StructuralBiology
Building Blocks, Biological Pathways
and Networks
Molecular Libraries
and Imaging
ImplementationImplementationGroupsGroups
New Pathways to DiscoveryResearch Teams
ClinicalEnterprise
Key Elements of Roadmap Funding and Management
All Institutes:– Participate with their scientific community in defining all components
of the Roadmap– Contribute equally and proportionately– Participate directly in decision making and have a direct liaison to the
Roadmap
All Roadmap initiatives are offered for competition to researchers from all fields
All research communities can compete for all initiatives
The peer-review process will ensure appropriate expertise
Roadmap Funding (dollars in millions)
New Pathwaysto Discovery
Re-engineering the Clinical Research Enterprise
Research Teamsof the Future
NIH
$64.1
$26.6 $37.6
FY 2004 Funding = $128.3 (dollars in millions)
Roadmap Funding(dollars in millions)
FY04 FY05 FY06 FY07 FY08 FY09 Total
Pathways to
Discovery
64 137 169 182 209 188 948
Research
Teams
27 39 44 92 96 93 390
Clinical
Research
38 61 120 174 214 227 833
Total 128 237 332 448 520 507 2,172
To be competed for in a common pool of initiatives by all researchers from every discipline
0.34% 0.63% ~0.9%
NIH Roadmap Goals
Accelerate basic research discoveries and speed translation of those discoveries into clinical practice
Explicitly address roadblocks that slow the pace of medical research in improving the health of the American people
“How does the NIH Roadmap benefit my research area?”
Speeding removal of major and fundamental roadblocks common to all diseases
No Institute can solve these issues alone
THIS IS A COMMON TRANS-NIH POOL OF TRANSFORMING INVESTMENTS OPEN TO ALL DISEASE AREAS FOR COMPETITION
“Yes, but we’re already doing those things. What’s new?”
THE NIH ROADMAP POOLS RESOURCES FOR SPECIFIC ENABLING INVESTMENTS THAT INDIVIDUAL INSTITUTES COULD NOT UNDERTAKE
Expanding molecular probe libraries publicly available to researchers by a factor of 7
Increasing the number of publicly available molecular probes from less than 100,000 to over 500,000
Developing a common national research informatics platform allowing interoperability for data for all patients whether seen at a research hospital or in their own community (NECTAR)
Improving the implementation of Breakthrough research trials through the creation of INTEGRATED research partnerships
MORE RAPID DIFFUSION OF BEST PRACTICES TO PATIENTS
Keep up-to-date on the Roadmap activities:
www.nihroadmap.nih.gov