Supplement
Antibiotic search terms: antibiotic OR "Anti-Bacterial Agents"[Mesh] OR "Anti-Bacterial
Agents"[Pharmacological Action] OR 2,4-diacetylphloroglucinol OR 2-deoxystreptamine OR
acedapsone OR actinonin OR actinorhodin OR alamethicin OR albomycin OR amdinocillin OR
amdinocillin pivoxil OR amikacin OR aminosalicylic acid OR amoxicillin OR amphomycin OR
amphotericin b OR ampicillin OR amprenavir OR angustmycin a OR anisomycin OR antibiotic
1233a OR antimycin a OR arsphenamine OR aurodox OR avilamycin OR azithromycin OR
azlocillin OR aztreonam OR bacampicillin OR bacitracin OR bacteriocins OR bambermycins
OR benzathine cloxacillin OR beta-lactams OR bialaphos OR bicozamycin OR blasticidin s OR
bongkrekic acid OR bredinin OR brefeldin a OR broadcillin OR butirosin sulfate OR calcimycin
OR candicidin OR capreomycin OR carbenicillin OR carbenicillin indanyl OR carfecillin OR
cefaclor OR cefadroxil OR cefamandole OR cefamandole nafate OR cefatrizine OR cefazedone
OR cefazolin OR cefdinir OR cefditoren OR cefditoren pivoxil OR cefepime OR cefetamet OR
cefetamet pivoxyl OR cefixime OR cefmenoxime OR cefmetazole OR cefminox OR cefodizime
OR cefonicid OR cefoperazone OR ceforanide OR cefoselis OR cefotaxime OR cefotetan OR
cefotiam OR cefoxitin OR cefpiramide OR cefpirome OR cefpodoxime OR cefpodoxime
proxetil OR cefprozil OR cefsulodin OR ceftazidime OR cefteram pivoxil OR ceftezole OR
ceftibuten OR ceftiofur OR ceftizoxime OR ceftobiprole OR ceftobiprole medocaril OR
ceftriaxone OR cefuroxime OR cefuroxime axetil OR cephacetrile OR cephalexin OR
cephaloglycin OR cephaloridine OR cephalosporins OR cephalothin OR cephamycins OR
cephapirin OR cephradine OR cethromycin OR chelerythrine OR chloramphenicol OR
chloramphenicol succinate OR chlortetracycline OR citrinin OR clarithromycin OR clavulanic
acid OR clavulanic acids OR clindamycin OR clindamycin-2-phosphate OR clofazimine OR
cloxacillin OR colistin OR cyclacillin OR cycloserine OR dactinomycin OR dalbavancin OR
dalfopristin OR dapsone OR daptomycin OR decamethoxine OR demeclocycline OR
desoxyfructo-serotonin OR dibekacin OR dicloxacillin OR dihydrostreptomycin sulfate OR
diketopiperazines OR dirithromycin OR distamycins OR diucifon OR doxycycline OR
dynemicin a OR echinomycin OR edeine OR efrotomycin OR emiglitate OR enviomycin OR
epicillin OR ertapenem OR erythromycin OR erythromycin estolate OR erythromycin
ethylsuccinate OR erythromycin lactobionate OR erythromycin stearate OR essential 303 forte
OR ethambutol OR ethionamide OR filipin OR FK 565 OR florfenicol OR floxacillin OR
fluoroquinolones OR forphenicinol OR fosfomycin OR framycetin OR fumagillin OR fusafungin
OR fusidic acid OR gamithromycin OR GE 2270 A OR gemifloxacin OR gentamicins OR
gramicidin OR grepafloxacin OR hepcidin OR herbimycin OR hygromycin b OR imipenem OR
immunomycin OR isepamicin OR isoniazid OR josamycin OR kanamycin OR kitasamycin OR
KRM 1648 OR KT 5720 OR lactacystin OR lactams OR lacticin 481 OR lactoferricin b OR
lasalocid OR leucomycins OR lincomycin OR lincosamides OR loracarbef OR lucensomycin
OR lydicamycin a OR lymecycline OR maduramicin OR maltotetraose OR manoalide OR
manumycin OR marbofloxacin OR meclocycline OR mepartricin OR meropenem OR
methacycline OR methampicillin OR methicillin OR mevastatin OR mezlocillin OR
micronomicin OR midecamycin OR mikamycin OR minocycline OR miocamycin OR
mocimycin OR moxalactam OR muconomycin a OR mupirocin OR mycobacillin OR n-
methyldeoxynojirimycin OR nafcillin OR narasin OR natamycin OR nebacetin OR nebramycin
OR nebularine OR neomycin OR netilmicin OR netropsin OR nigericin OR nisin OR
nojirimycin OR norfloxacin OR novobiocin OR nystatin OR ofloxacin OR oleandomycin OR
oligomycins OR oxacillin OR oxetanocin OR oxytetracycline OR panipenem-betamipron OR
paromomycin OR pazufloxacin OR pediocin pa-1 OR penicillanic acid OR penicillic acid OR
penicillin g OR penicillin g benzathine OR penicillin g procaine OR penicillin v OR
phenethicillin OR phosphoramidon OR piericidin a OR piperacillin OR piperacillin-tazobactam
OR pivampicillin OR polymyxin b OR polymyxins OR polyoxorim OR PR 39 OR pristinamycin
OR prodigiosin OR propicillin OR prothionamide OR pyrazinamide OR pyrazofurin OR
quinupristin OR quinupristin-dalfopristin OR radezolid OR ramoplanin OR ribostamycin OR
rifabutin OR rifamexil OR rifampin OR rifamycins OR rifapentine OR ristocetin OR
rolitetracycline OR roxarsone OR roxithromycin OR rutamycin OR saframycin a OR
salinomycin OR sangivamycin OR sirolimus OR sisomicin OR SM-4300 OR sodium thiosulfate
OR sparfloxacin OR spectinomycin OR spiramycin OR squalamine OR staphylococcin OR
stigmatellin OR streptogramin a OR streptogramin group a OR streptogramin group b OR
streptogramins OR streptomycin OR streptovaricin OR sulbactam OR sulbenicillin OR
sulfamerazine OR sulfameter OR sulfamethoxypyridazine OR sulfanilamide OR sultamicillin
OR syringomycin OR talampicillin OR teicoplanin OR telithromycin OR temafloxacin OR
temocillin OR tetracenomycin c OR tetracycline OR thalidomide OR thiamphenicol OR
thienamycin OR thienamycins OR thioacetazone OR thiobenzamide OR thiocarlide OR
thiolactomycin OR thiostrepton OR thymopoietin iii OR tiamulin OR ticarcillin OR ticarcillin-
clavulanic acid OR tigecycline OR tilmicosin OR tobramycin OR tomaymycin OR triostin a OR
troleandomycin OR tunicamycin OR tylosin OR tyrocidine OR tyrothricin OR ubenimex OR
undecylprodigiosin OR valinomycin OR vancomycin OR vernamycin b OR viomycin OR
virginiamycin OR aminoglycoside OR carbapenem OR cephalosporin OR macrolide OR
fluoroquinolone OR quinolone OR penicillin OR telavancin OR gentamicin OR rifaximin OR
doripenem OR ceftaroline OR furazolidone OR nitrofurantoin OR linezolid OR flucloxacillin
OR ciprofloxacin OR gatifloxacin OR levofloxacin OR lomefloxacin OR moxifloxacin OR
nalidixic acid OR ofloxacin OR sulfonamide OR sulfadiazine OR sulfamethizole OR
sulfamethoxazole OR ethionamide OR rifampicin OR metronidazole OR trimethoprim OR
tinidazole.
Supplement Naranjo scale:
Are there previous conclusive reports on this reaction?
o Yes (+1) No (0) Do not know/Not measured/Not done (0).
Did the adverse events appear after the suspected drug was given?
o Yes (+2) No (-1) Do not know/Not measured/Not done (0)
Did the adverse reaction improve when the drug was discontinued or a specific antagonist
was given?
o Yes (+1) No (0) Do not know/Not measured/Not done (0)
Did the adverse reaction appear when the drug was readministered?
o Yes (+2) No (-1) Do not know/Not measured/Not done (0)
Are there alternative causes that could have caused the reaction?
o Yes (-1) No (+2) Do not know/Not measured/Not done (0). For alternative causes,
only infections involving the brain (such as meningitis or encephalitis) were
interpreted as “Yes.” Rest were marked as “Do not know/Not measured/Not
done,” as active infection could plausibly considered a potential alternative cause
for altered mental status
Did the reaction reappear when a placebo was given?
o Yes (-1) No (+1) Do not know/Not measured/Not done (0)
Was the drug detected in any body fluid in toxic concentrations?
o Yes (+1) No (0) Do not know/Not measured/Not done (0)
Was the reaction more severe when the dose was increased, or less severe when the dose
was decreased?
o Yes (+1) No (0) Do not know/Not measured/Not done (0)
Did the patient have a similar reaction to the same or similar drugs in any previous
exposure?
o Yes (+1) No (0) Do not know/Not measured/Not done (0)
Was the adverse event confirmed by any objective evidence?
o Yes (+1) No (0) Do not know/Not measured/Not done (0). Abnormalities on EEG
were not counted as objective evidence because of lack of specificity.
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