Michael Andre, Ph.D. Research Interests

•  Quan%ta%veUltrasoundBacksca3erTissueCharacteriza%on

•  DiagnosisandGradingofNon-AlcoholicFa3yLiverDisease•  Quan%ta%veCharacteriza%onofBreastMasses•  LiverMasses•  Pre-TermCervix

•  UltrasoundInverse-Sca3erComputedTomography•  BreastUltrasoundComputer-AidedDiagnosis•  ObserverPerformanceStudies(ROC)•  Quan%ta%veX-RayComputedTomography

Non-AlcoholicFa-yLiverDisease(NAFLD)Leadingcauseofchronicliverdisease(USA:21-50%adults,17%children)

Steatosis->Steatohepa%%s->Fibrosis->Cirrhosis->Carcinoma

CUS:Highreadervariability,operatordependent,lowsensi%vityatearlystages

ReferenceStandards:•  Biopsy•  MRI-PDFF•  ClinicalUS

Normal Severesteatosis

Par>cipant’sLiver

ROI

ReferencePhantom

ROI

AveragePowerSpectrumofPar%cipant

AveragePowerSpectrumofReferencePhantom

RawRFsignalfromtransducer

ROI(windowfunc>on)

(a.) (b.)

(c.)

QUS

CompareQUStoMRIPDFFDefineNAFLDasPDFF≥5%BSC,AChighlycorrelated

BothaccuratelydiagnoseNAFLDAUC=0.98(BC),0.89(AC)

Sound Speed

Reflection

Coronal

Sonogram

MG

Ultrasound CT

MIP

Coronal T1

SONOGRAM

MRI

Infiltrating Ductal CA