Download - Krebs cycle
Krebs Cycle
How well do you know the Krebs cycle?
Let me explain these steps.
In cellular respiration 2 pyruvate are created but only 1 is needed to go through the Krebs cycle, thus it goes around twice so remember what you end up with it doubled.
Takes place in the mitochondria.
• 1) Acetyl CoA adds two carbon fragment so that it can oxaloacetate to make citrate.
• 2) Citrate is converted to isocitrate by removing one water molecule to add another.
• 3) citrate loses a CO2 molecule, where the resulting compound would than be oxidized making NAD to NADH. Making 1 NADH.
• 4) Another CO2 is lost which than cause NAD to become NADH, than the left over molecule attaches to coenzyme A, but is unstable. Making 1 NADH.
• 5) CoA is than displaced by a phosphate group which is formed into GDP, which makes GTP, than ADP, which formed ATP. Making 1 ATP.
• 6) 2 hydrogen's are transformed into FAD to form FADH2. producing 1 FADH2.
• 7) the addition of water molecules cause the bonds in substrate to rearrange.
• 8) The substrate is than oxidized making NAD to NADH, than regenerating oxaloacetate. Making 1 NADH.
Results
• 3 NADH• 1 ATP• 1 FADH