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Introduction to Diffusion Tensor Imaging
Prof Larry Frank
http://csci.ucsd.edu/courses/cogs260w2018/
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Lecture 1 Introduction and Class Outline
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Exploring the Brain
anatomical Diffusion Functional
The Three Pillars of MR Neuroimaging
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Lecture Summary
1. Why are you here? 2. Class Objectives3. Course outline4. Lab Lectures (AFNI & QUEST)5. Term Project6. Grading7. Readings
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The Problem
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The Problem
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The Problem
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Fiber tract mapping and extensions of DTI
The Problem
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The Goal
Understand the basic “standard method” and its limitations
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DTI Derived White Matter Map
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Tractography
Standard DTI
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The Goal
By end of class, have a working knowledge of the state-of-the-art method
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Course Logic
Preliminary Mathematics
Diffusion
MRI
MRI diffusion sensitivity
Diffusion weighted imaging (DWI)
DWI analysis
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Course Logic
Preliminary Mathematics
Basic structuresScalars,Vectors
Matrices, TensorsComplex Numbers
Transformations RotationsFourier Transforms
Linear Algebra Least squaresEigensystems
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Course Logic
Diffusion
Classical DiffusionFlux, concentration,
continuitydiffusion equation
Probability theory Random walkdiffusion equation
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Course Logic
MRI
NMR
Image formation(MRI) Pulse sequencesFourier reconstruction
signal creation and detection
Spatial localization GradientsFourier reconstruction
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Course Logic
MRI diffusion sensitivity
DTI
diffusion in gradients
diffusion weighting,sampling
signal loss
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Course Logic
DWI analysis
Standard DTIdiffusion tensor
anisotropytractography
Heterogeneous voxel DWI(State-of-the-art)
DWI-ESPanisotropy
tractography
DWI pre-processing distortion correctionimage registration
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By the time we get to standardDiffusion Tensor Imaging,
it will seem obvious,
... an assemblage of parts you already know
Course Logic
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Our ultimate goal, however, is to learn
DWI-ESP
Course Logic
A new methodMore complicated, but worth it!
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The Goal
a b
c d
anisotropy tractography
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CFMRI Autism Study
in collaboration with the lab of Dr Axel Mueller
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The two lab lectures will focuson getting practical experience with
the QUEST platform
Requirement
AFNI and the QUEST Plugin must be working onto your computer prior to these lectures.
Thomas will assist people who need help with this.
Lab Lectures
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Lab Lectures
https://afni.nimh.nih.gov
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Lab Lectures
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Lab Lectures
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SWD
Morphology
ab
cdDTI-ESP
Connectivity
FMRI-ESP
Function
The Three Pillars of Neuro-MRI
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Write a review paper on an application of DTI relevant to
your interests
•Importance of your application•Why DTI is useful for your application•Review and critique of 5 (min) related papers•Summary of current status of field
Term Project
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Grading
40% attendance30% homework30% final project
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Office Hours
Wed 12-2La Jolla Village Professional Center
(behind Rock Bottom Brewery)Suite B227
My contact in: [email protected]