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Interpenetrating Networks for Delivery
SystemsClient: Professor John W. Kao
Advisor: Professor Kristyn Masters
Claire FlanaganAshley Huth
Max MichalskiAdam Rieves
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Overview
• Problem Statement
• Background Information
• Design Constraints
• Design Approaches
• Preliminary Data
• Conclusions
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Problem Statement
• Our goal is to create a novel delivery mechanism to reconstitute the components of an interpenetrating network (IPN).
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Interpenetrating Network (IPN) Covalently Linked
Therapeutic(s) and/orCell Adhesion Ligands
Bifunctional PEG Linkers
Soluble Therapeutic(s)
BiodegradableGelatin Backbone
PEG-diacrylate(2-3.4 kDa )
Solution(drugs +matrix component)
in situ UV curing
*Kao, W.J
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Clinical Applications
•Issues •Uneven administration•Reconstitution Method
•Heat•Time
•Shelf life
IPNConventional Dressings
Irregular Wound
•Benefits •Moist healing environment•Conforms to irregular wounds•Covers large surface areas•Delivers drug cocktails•Very biocompatible
*Kao, W.J.
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ingredients w/drug(s) in onecontainer
Mix
Ideal Clinical
Administration
11
Cover55
Shake22
33 Spraywith a controlled distribution over irregular wound surface
44 Curein 30 sec to obtain a rubbery film
66 Sustained Releasewhile the IPN biodegrades
Day
7Day
3Day
1
77 Clean
*Kao, W.J
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Design Constraints • Clinically applicable
• No special equipment required • Simple reconstitution methods
• Administration via spray bottle
• Completely reconstitutes
• Meets viscosity requirements
• Cure time < 60 seconds
• Improves Shelf Life
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Approach 1: Heating Element
•Exothermic Reaction
•Resistive Element
•Pros•Feasibility•Viscosity•Passive Procedure
•Cons•Cost•Client Preference•Safety
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Approach 2: Research•Alter pH•Add Surfactants•Try Buffer Varieties
•Pros•Client Preference•Reconstitution Time•Cost
•Cons•Feasibility•Safety•Active Procedure
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Design MatrixCriteria Weight Heating Element ResearchClient Preference 15 4 15Feasibility 15 12 8Viscosity 15 10 7Reconstitution Time 10 7 9Safety 10 6 6Cure Time 10 9 9Human Factors 10 8 7Sterility 5 5 5Shelf Life 5 5 4Cost 5 1 4TOTAL 100 67 74
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Preliminary Data
Weight % Gelatin (g/mL) Dissolution10 Yes15 Yes20 No25 No
**Water at 60 ºC
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Preliminary DataInitial pH Final pH Dissolved
14 14 +11 10 + / -
9.4 8.3 + / -9.1 8 + / -
7 7.5 -8.2 7.5 + / -
5 6 + / -4 5 + / -
3.1 4.5 + / -2.2 3 +
1 1 +
**All solutions at room temperature
**Final solution 10% gelatin
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Conclusions
• We hope to further the clinical applications of IPNs
• Future Work• Continue literature research
• Gather data
• Test complete IPNs
• Reconsider design approach
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Questions