Innovations in Healthcare
Key Drivers of Change
October 18, 2016US Chamber of Commerce
Washington, DC
1 Contents are proprietary and confidential.
Three Major Drivers of Innovation
SCIENCEBIG DATA AI, MACHINE LEARNING & NEURAL NETWORKS
2 Contents are proprietary and confidential.
The Information Genome
Everything we do, inside or out, can be monitored
Our bodies and all we do are the next frontier for
search
Patterns = Products Personalization becomes mainstream
Our intellectual capital is magnified when we
enable software to learn on its own
Pattern-based learning will lead to more
personalized solutions
The combination of science and technology
opens up new thinking for treatment, services and
solutions
3
And often require previously unrelated areas to merge
Innovation eras take time to develop
The WebFirst plan for WWW in 1989
The genome meets its match with AI
Precision of knowledge powers rare disease innovation
Health data attracts technology entrepreneurs
Tim
e
Artificial Intelligence1952-56 timeframe
Human Genome ProjectLaunched 1990Completed 2003
A look at our future is forming……
4 Contents are proprietary and confidential.
What if we combine high volume semiconductor and pharmaceutical
technology?
5 Contents are proprietary and confidential.
An ingestible sensor the size of a grain of sand, a patch, an app and a provider portal are combined
We can track patients thousands of miles away, see if they took the medicine, what their
pharmacokinetics are and where it was made
This is Proteus Digital Health
6 Contents are proprietary and confidential.
What if we could figure out how to edit disease?
7 Contents are proprietary and confidential.
The CRISPR–Cas9 system
Treat and edit diseaseTarget and study particular DNA sequences
Send proteins to precise DNA targets to turn genes on or off
Bayer & CRISPR Therapeutics form JV
8 Contents are proprietary and confidential.
What new medical disciplines will form as a result of technology and healthcare
converging?
9 Contents are proprietary and confidential.
Bioelectronics medicineA new discipline combining molecular medicine, neurophysiology, biomedical
engineering, deciphering and manipulating the electrical signal produced by the nervous system to communicate information
Neural bypass technology allowed a paralyzed person, for the first time, to regain movement through the use of a brain implant. Therapies can be developed that work
by recording, stimulating, and blocking neural signaling
Chad Bouton and The Feinstein Institute for Medical Research
10 Contents are proprietary and confidential.
What is the promise of virtual reality in health?
11 Contents are proprietary and confidential.
Train physicians anywhere in the world Distract burn victims via VR and decrease their
painHelp veterans learn to deal with PTSD
It is a matter of our applied imagination
12 Contents are proprietary and confidential.
What if we can unlock the power of our immune system to fight disease and replace more toxic therapies?
13 Contents are proprietary and confidential.
The power of Immunotherapy
Anti PD-1 immunotherapy blocks the pathway so our immune system can do its job
14 Contents are proprietary and confidential.
How can technology and machines improve what humans do?
15 Contents are proprietary and confidential.
Robotic-assisted minimally invasive surgery guided by MDs
Intuitive Surgical
16 Contents are proprietary and confidential.
What new minds are tackling health issues?
17 Contents are proprietary and confidential.
Jeff Huber (Google) joins newly formed Grail, a joint venture of Illumina, Jeff Bezos, Bill Gates
& Google Ventures
Goal: develop a proactive cancer-detecting blood test to identify the tiny bits of cancer DNA that are hanging out in our blood but are currently
undetectable.
18 Contents are proprietary and confidential.
What if all or most of our health data could be integrated?
19 Contents are proprietary and confidential.
The equivalent of our data immune systemWill we unlock its power?
20 Contents are proprietary and confidential.
Personalization is being redefined
Your body is an untapped data sourceData, AI and robotics are drivers of innovation
Any disease or disorder is fair game today
21 Contents are proprietary and confidential.
The United States of America has an unprecedented opportunity to drive a new era
of innovation
Technology and Healthcare partnerships will lead to exponential advance for the next few
decades
22 Contents are proprietary and confidential.
Innovation will accelerate at a greater pace in the years ahead
23 Contents are proprietary and confidential.
Organizations will struggle to keep up…..Martec’s Law
24 Contents are proprietary and confidential.
Political and business interests must align around improving the health of all people
25 Contents are proprietary and confidential.
Our role in supporting innovatorsWill we create an environment that can accelerate innovation, transform health outcomes and drive our economy?
Clarity of Rules
How we regulate
Ambiguity stifles investment
Clarity of Payment
Return on investment
If payment is unclear, entrepreneurs find other things to innovate
Ability to Learn Together
The Role of FDA
FDA and innovators should commit to learn together, stay on top of what’s next and evolve thinking at the same pace
Ability to Evolve Together
New regulations
If we evolve together, we save years, even decades of misaligned regulatory standards and innovative advances
Everyone is counting on us to succeed! The journey continues….
27 Contents are proprietary and confidential.