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Inflammation and repair
Dr Shaesta Naseem 19-09-13
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Inflammation and repair
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Gross and histopathology
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1- Fibrinous pericarditis
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Organ: Pericardium Dx: Fibrinous Inflammation
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ACUTE FIBRINOUS PERICARDITIS
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ACUTE FIBRINOUS PERICARDITIS
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Fibrinous Pericarditis: Section of Heart shows:
The pericardium is distorted by thick irregular layer of pinkish fibrinous exudate with some red cells and inflammatory cells.
The subpericardial layer is thickened by edema and shows dilated blood vessels, chronic inflammatory cells and areas of calcification.
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2- Acute appendicitis
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ACUTE APPENDICITIS
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Acute appendicitis
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ACUTE APPENDICITIS
Accumulation of inflammatory exudate and pus cells in the lumen
The mucosa is ulcerated
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ACUTE APPENDICITIS
Infiltration by many neutrophils.
Edema
Dilated and congested blood vessels
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Acute Suppurative appendicitis:Cross Section of Appendix shows:
On gross, fibrino-purulent exudate is present on the serosal surface.Accumulation of inflammatory exudate and pus cells in the lumen and the mucosa is ulcerated.
All layers of the appendix wall show edema, dilated and congested blood vessels and infiltration by many neutrophils.
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3-Skin pilonidal sinus
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3- FOREIGN BODY REACTION
(PILONIDAL SINUS)
Sinus tract with surrounding inflammation and hairs
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FOREIGN BODY REACTION (PILONIDAL SINUS)
Hair Shaft
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Foreign Body reaction (Pilonidal sinus):Section of Skin Shows:
A sinus tract lined by an inflammatory granulation tissue in the dermis .
The lumen of sinus and wall contain large number of hair shafts with foreign body giant cells, lymphocytes , macrophages & neutrophils .
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4-Chronic cholecystitis with stones
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CHRONIC CHOLECYSTITIS
Rokitansky- Aschoff sinuses
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Chronic cholecystitis:Section of gallbladder wall shows:
Irregular mucosal folds and foci of ulceration in mucosa.
Wall is penetrated by mucosal glands which are present in muscle coat ( Rokitansky- Aschoff sinuses).
All layers show chronic inflammatory cells infiltration and fibrosis.
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5- Brain abscess
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6- Granulation tissue
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GRANULATION TISSUE (Inflammatory vascular granulation tissue)
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GRANULATION TISSUE
Edema
Chronic inflammatory infiltration
Proliferating blood vessels
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Granulation Tissue: Section of fragments of edematous, loose
connective tissue shows:
Many small newly formed capillaries lined by plump endothelial cells.
Proliferation of fibroblasts is seen.
Inflammatory cells including macrophages, lymphocytes, plasma cells and neutrophils in the oedematous stroma.
Pink homogenous collagen fibres may be identified.