-
961
INDEX
Volume 239, October-December, 1986
A23187, analysis of airway responses (cats),395
Aarhus, L. L., see Zander, J. F., 760Abdel-Latif, A. A., see Howe, P. H., 574Abel, P. W. and Minneman, K. P.: Alpha-i
adrenergic receptor binding and con-traction of rat caudal artery, 678
Abou-Donia, M. B., see Patton, S. E., 597Acetaminophen
hepatoxicity, pre- or post-treatment withmethoxsalen (mice), 559
pharmacokinetics, prevention of inor-
ganic sulfate depletion (rats), 94Acetylcholine
excitatory amino acid receptors, folates,locomotor activity (rats), 627
releasecholecystokinin receptor mediation,
sphincter of Oddi (guinea pigs), 554muscarinic receptors, urinary bladder
(rats), 522
substance B isolation, presynapticmodulation (guinea pigs), 185
Acetylcholinesterase, inhibitor, clonidineprotection (mice), 43
N-Acetyltransferase, isoenzymes, identifi-
cation and inheritance, peripheralblood (hamsters), 823
a1-Acid glycoprotein, human serum albumin
and, interaction, lidocaine binding,754
Acoustic startle, dose-response analysis,
nicotine tolerance, receptor changes(mice), 358
Adenosine
renal transport, effects, papaverine and
theophylline (rats), 748
spinal, modulated antinociceptive path-ways, morphine stimulation (mice),88
Adenosine triphosphatase, digitalis me-chanical toxicity, protection by slowcalcium channel blockers (guineapigs), 206
Adenylate cyclaseage dependence, ureter homogenate
(guinea pigs), 99-y-aminobutyric acid B receptor-mediated
inhibition, cerebellar granule cells(rats), 568
Adipose tissue, 2,3,7,8-tetrachlorodibenzo-p-dioxin, mechanism of absorptionand distribution (rats), 673
Adler, B., see Yoburn, B. C., 132Adrenal gland, modulated catecholamine re-
lease, -y-aminobutyric acid (dogs),584
Adrenergic nerves, effects of naftidrofuryl,isolated blood vessels (dogs), 760
Adrenergic receptors, see AdrenoceptorsAdrenoceptors
alphaamiloride, myocardial and vascular ac-
tions (rats), 365
AY-28,925, in vitro characterization(rabbits, rats, dogs, guinea pigs), 1
nifedipine, vasoconstriction (dogs,
monkeys), 648
regulation of coronary artery bloodflow, normal and stenotic arteries(dogs), 641
sympathetic purinergic vasoconstric-tion, thermosensitivity in cutaneous
vein (dogs), 784alpha-i
anat.agonist, optical isomers of YM-12617 (rabbits), 512
antagonist effects, optical isomers ofYM-12617 (rabbits), 512
binding and contraction, caudal artery
(rats), 678
caffeine, discriminative stimulus prop-erties (rats), 706
alpha-2antagonist effects, fenoldopam (rab-
bits), 881
regulation ofsympathetic and parasym-pathetic nerves, salivary glands(rats), 488
alpha and betaablation of myenteric plexus, jejunal
longitudinal muscle (rats), 9estrogen modulation (guinea pigs), 270
betaagonists and antagonists, kinetic analy-
sis, 136AY-28,925, in vitro characterization
(rabbits, rats, dogs, guinea pigs), 1blocking agents, potentiation (rats),
797decreased responsiveness, aging (man),
802
dilevalol, cardiac electrophysiologicalactions (dogs), 719
down regulation in S49 lymphoma cells,atypical agonists, 654
effects of agonists and antagonists,ovarian suspensory ligament (rats),
591effects of pindolol and propanolol, lym-
phocytes, 117modulation, cytotoxic T cell generation
(mice), 460
uterine relaxation, cyclic AMP (rats),236
vascular smooth muscle relaxation, age-related decrease (rats), 411
beta-i, homogenous population, bovinecoronary artery, 634
low-affinity, prazosin, norepinephrinecontractions (rabbits), 846
Agbanyo, M., see Khatter, J. C., 206Aging
adenylate cyclase, ureter homogenate
(guinea pigs), 99decreased beta responsiveness (man), 802hypertension and, nitrovasodilators, en-
dothelial modulation of vascular
modulation (rats), 861vascular smooth muscle relaxation, beta
adrenergic receptor (rats), 411Agonists
alpha-i adrenoceptors, binding and con-
traction, caudal artery (rats), 678beta adrenoceptors
antagonists and, kinetic analysis, 136ovarian suspensory ligament (rats), 591
diazepam-agonist effects and, CGS 8216
(rats, mice), 166ethylketazocine and morphine, effects on
schedule-controlled behavior (pi-goons, monkeys), 433
regional characterization, depolarization-induced phosphoinositide hydrolysis,brain (rats), 873
Aguayo, L. G. and Albuquerque, E. X.:Blockade and recovery of the acetyl-choline receptor produced by athienyl analog of phencyclidine: In-fluence of voltage, temperature, fre-quency of stimulation and condition-
ing pulse duration, 25Aguayo, L. G. and Albuquerque, E. X.: Ef-
fects ofphencyclidine and its analogs
on the end-plate current of the neu-romuscular junction, 15
Aguayo, L. G., see Idniss, M. K., 279Airway
analysis of responses, A23187 (cats), 395histamine contraction, role of prostaglan-
dins (humans), 536vasoactive intestinal peptide receptors,
visualization, lung (humans, guineapigs), 249
Akhtar, R A., see Howe, P. H., 574Albumin, human serum, a,-acid glycopro-
tein and, interaction, 754
Albuquerque, E., see Idriss, M. K., 279Albuquerque, E. X., see Aguayo, L. G., 15,
25
Alcohol
dopamine release, preferential stimula-tion, nucleus accumbens (rats), 219
effects on LHRH-stimulated luteinizing
hormone, follicle-stimulating hor-
mone (monkeys), 693ethanol sensitivity and tolerance, WSP
and WSR mouse lines, 327Aiho, H., see Kataoka, Y., 584Aluminum chloride, ferric chloride or, effect
of lead uptake into brain and softtissues (rats), 548
Amiloride, myocardial and vascular actions,
SHR rats, 365-y-Aminobutyric acid
B receptor-mediated inhibition, adenylatecyclase, cerebellar granule cells(rats), 568
receptor modulation, catecholamine re-lease, adrenal gland (dogs), 584
5-Amino-2,4-dihydroxy-a-methylphenyl-ethylamine, neurochemical charac-
-
962 Index Vol. 239
terization, selective neurotoxin, cen-tral noradrenergic neuions (rats), 55
p-Aminohippurat.e, morphine tolerance,renal disposition, xenobiotics (mice),
346
Amino-pyridazine derivatives, evaluation,
conflict test (rats), 542Amiodarone, acute and chronic, cardiac
electrophysiologic effects, alteredthyroid hormone (rabbits), 179
Ammonium chloride, modification of behav-ioral effects, phencyclidine (rats), 48
Analgesiaadenosine-mediated, antinociceptive
pathways, morphine stimulation(mice), 88
intracerebroventricular injection of
TMB-8, antinociception production(mice), 320
Met-enkephalin release, �9-endorphin,stereoselective effect (rats), 160
opioid receptor upregulation, pharmaco-dynamic supersensitivity (mice), 132
Anaphylaxis, thromboxane and prostacyclinbiosynthesis, leukotriene D4, lung
(guinea pigs), 63Andresen, M. C., see Kunze, D. L., 303Angiotensin analogs, decapeptide, cardiac
and vascular actions (rabbits), 790Angiotensin II
atrial natnuretic peptide, interactions,sympathetic and endocrine systems
(rats), 480cyclic AMP concentrations, vascular
smooth muscle cells, endogenousprostaglandins (rats), 334
monoiodinated, full agonist analog ofangiotensin II, 71
Antagonists
beta adrenoceptorsagonists and, kinetic analysis, 136dilevalol, cardiac electrophysiological
actions (dogs), 719ovarian suspensory ligament (rats), 591
platelet activating factor receptor, L-652,731, profile (rats), 841
vasopressin receptor, analysis (humans),737
Anti-cholinesterase agents, glutamatergicsynapse, pre- and postjunctional ef-fects (locusts), 279
Anticonvulsant drugsbaclofen and phenobarbital, efficacy
against kainic acid limbic seizure-brain damage syndrome (rats), 612
effects on substantia nigra pars reticulataneurons, 606
temporal lobe epilepsy, quinoline acid(rats), 256
Anticonvulsant sensitivity, genetic differ-ences, selective breeding, ethanolwithdrawal severity (mice), 154
Antihypertensive agents, dilevalol, cardiac
electrophysiological actions (dogs),719
Antisuppressant drugs, histamine H1 antag-onists, behavioral effects (monkeys),104
Antiulcer agents, enprostil (rats), 382Anxiolytic drugs, amino-pyridazine deriva-
tives, evaluation, conflict test (rats),542
Aoki, K., see Asano, M., 198Aorta
extraneuronal serotonin uptake, mecha-nisms (rats), 264
norepinephrine contraction potentiation,
verapamil, diltiazem and nifedipine
(rabbits, swine), 808optical isomers of YM-12617, alpha-i ad-
renoceptor antagonist effects (rab-bits), 512
phorbol butyrate contractions, calcium
dependence, 8-Br-cyclic GMP, 78
role of vascular endothelium, contractileresponse, prostacyclin (rats), 390
Appel, N. M., see Kiritsy-Roy, J. A., 814Arachidonic acid
increased glomerular prostaglandin syn-
thesis, dexamethasone treatment(rats), 296
metabolites, leukotriene D4, lung (guineapigs), 63
AR-LiOO, cardiotonics, mechanism of ac-tion (cats), 375
Armstrong, D. R., see Ault, B., 612Aronstam, R. S., see Buccafusco, J. J., 43Asano, M., Aoki, K. and Matsuda, T.: Con-
tractile effects of bay k 8644, a dihy-dropyridine calcium agonist, on iso-lated femoral arteries from sponta-neously hypertensive rats, 198
Atrial natriuretic peptide, interactions,
sympathetic and endocrine systems(rats), 480
Atriopeptin, turnover, changes in plasmalevels and atrial content (rats), 474
Ault, B., Gruenthal, M., Armstrong, D. R.
and Nadler, J. V.: Efficacy of baclo-fen and phenobarbital against thekainic acid limbic seizure-brain dam-age syndrome, 612
Autonomic nerves, geographutoxin II, so-chum channel inhibitor (mice, bull-
frogs, guinea pigs, rabbits), 243Autoradiography, electron microscopic, cal-
cium redistribution, renal artery(rabbits), 286
AY-28,925, adrenoceptor activity, in vitrocharacterization (rabbits, rats, dogs,
guinea pigs), 1Ayad, M. J., see Hondeghem, L. M., 808
Baclofen, phenobarbital and, efficacyagainst kainic acid limbic seizure-brain damage syndrome (rats), 612
Baer, P. G., see Erman, A., 296Bains, R., see Khatter, J. C., 206Baker, K. M. and Khosla, M. C.: Cardiac
and vascular actions of decapeptideangiotensin analogs, 790
Baker, S., see Roszkowski, A. P., 382Balkovetz, D. F., see Ganapathy, V., 192Balster, R. L., see Beardsley, P. M., 311Banks, W. A. and Kastin, A. J.: Modulation
of the carrier-mediated transport ofthe Tyr-MIF-i across the blood-brain barrier by essential amino
acids, 668
Barbiturates, genetic differences, anticon-
vulsant sensitivity, ethanol with-drawal severity (mice), 154
Barnes, P. J., see Carstairs, J. R., 249Barrett, R. J. and Kau, S. T.: Myocardial
and vascular actions of amiloride inspontaneously hypertensive rats, 365
Bass, P., see Fox, D. A., 9Bay k 8644
contractile effects, femoral arteries, spon-
taneously hypertensive rats, 198
depolarization-induced phosphoinositide
hydrolysis, regional characterizationof agonist (rats), 873
Bayol, A., see Haye-Legrand, I., 536Beardsley, P. M., Balster, R. L. and Harris,
L. S.: Dependence on tetrahydrocan-nabinol in rhesus monkeys, 311
Behavioroperant, dependence of tetrahydrocanna-
binol (monkeys), 311schedule-controlled, effects of ethylketa-
zocine and morphine (pigeons, mon-keys), 433
tetrahydrocannabinol, sensory-evoked
potentials (rats), 936Belknap, J. K., see Crabbe, J. C., 154Benigni, A., see Perico, N., 229Benishin, C. G., Pearce, L. B. and Cooper,
J. R.: Isolation of a factor (substanceB) that antagonizes presynapticmodulation: Pharmaclogical proper-
ties, 185
Benveniste, J., see Haye-Legrand, I., 536Benzodiazepine
acute chlordiazepoxide dependence, phar-macologic characterization (rats),775
agonist and diazepam-agonist effects,CGS 8216 (rats, mice), 166
genetic differences, anticonvulsant sensi-
tivity, ethanol withdrawal severity(mice), 154
Benzodiazepine antagonists, amino-pyida-
zine derivatives, evaluation, conflict
test (rats), 542Bepridil, calcium entry blockade, vulnera-
bility toward ventricular fibrillation(dogs), 340
Bergman, J. and Spealman, R. D.: Somebehavioral effects of histamine H1antagonists in squirrel monkeys, 104
Berkowitz, B. A., see Ohlstein, E. H., 737Bevan, J. A., see Laher, I., 846Biftu,T.,seeWu,841
Bigelow, G. E., see Griffiths, R. R., 416Biliary excretion, organic anions, diabetes
(rats), 467Biziere, K., see Perio, A., 542Blair, D., see Matthews, R. T., 124Blaschke, T. F., see Pan, H. Y.-M., 802Blei, A., see Fung, H.-L., 701Blood, peripheral, N-acetyltransferase is-
oenzymes, identification and inher-itance (hamsters), 823
Blood-brain barrier, carrier-mediated trans-port of Tyr-MIF-i, essential aminoacids (mice), 668
Blood flownormal and stenotic coronary arteries, al-
pha adrenoceptor regulation (dogs),641
splanchnic, oral hydralazine and propran-
olol, interaction (dogs), 517Blood vessels
aging and hypertension, nitrovasodila-tom, endothelial modulation of vas-cular modulation (rats), 861
cutaneous, sympathetic purinergic vase-constriction, thermosensitivity
(dogs), 784low-affinity adrenoceptors, norepineph-
rime contractions (rabbits), 846vascular effects of naftidrofuryl (dogs),
760
BMY 14802, effects, brain dopaminergicfunction (rats), 124
Bobbitt, F. G., see Kiritsy-Roy, J. A., 814
-
1986 Index 963W
Bodd, E., Gadeholt, G., Christensson, P. I.and M#{248}rland,J.: Mechanisms behindthe inhibitory effect ofethanol on theconjugation of morphine in rat hep-atocytes, 887
Boisse, N. R., Periana, R. M., Guarino, J.
J., Kruger, H. S. and Samoriski, G.M.: Pharmacologic characterizationof acute chiordiazepoxide depend-ence in the rat, 775
Boldry, R., see Stephens, R. L., Jr., 627Boullet, C., see Haye-Legrand, I., 536Bowman, K. F., see Frazier, D. L., 946Bradbury, M W. B., see Deane, R., 548Bradycardia, amiloride, SHR rats, 365Brain
depolarization-induced phosphoinositidehydrolysis, regional characterizationof agonist (rats), 873
dopaminergic function, effects of BMY
14802 (rats), 124effect ofchronic cholinesterase inhibition,
phosphoinositide metabolism, car-bachol- and norepinephrine- stimu-lated (rats), 32
effects of mu-opioid receptor stimulation,
catecholamine secretion (rats), 814forskolin binding, guanylyl-5’-imidodi-
phosphate and sodium fluoride (rats),952
LY 165163, central serotonin agonist ac-tions (rats), 454
membranes, binding of fl-funaltrexamine,opioid receptors (guinea pigs), 351
salivary gland and, bupivacaine transport(rats), 724
soft tissues and, lead uptake, effects ofintravenous ferric or aluminum chlo-ride (rats), 548
soman to�icity, clonidine protection(mice), 43
spinal cord and, tri-O-cresyl-induced de-layed neurotoxicity, enhanced phos-phorylation (hens), 597
substance B isolation, presynaptic modu-lation (guinea pigs), 185
Bree, M. P., see Mello, N. K., 693Brink, C., see Haye-Legrand, I., 536O-4-Bromo-2,5-dichlorophenyl, tri-O.cresyl
phosphate-induced delayed neuro-toxicity, enhanced phosphorylation,brain and spinal cord proteins (hens),
597
a-Bromoisovalerylurea, glutathione conju-
gation, 898, 905Brush-border, placental sodium-hydrogen
exchanger, inhibition by cimetidine,
192
Brussee, J., see te Koppele, J. M., 898Buccafusco, J. J. and Aronstam, R. S.: Clon-
idine protection from the toxicity of
soman, an organophophate acetyl-cholinesterase inhibitor, in themouse, 43
Buja, L. M., see Wheeler-Clark, E. S., 286Bupivacaine, plasma protein binding, trans-
port into brain and salivary gland(rats), 724
Byrne, A. J., see Corbett, H., 517
Caffeinechronically consumed, elimination, preg-
nancy (monkeys), 891discriminative stimulus properties, nor-
adrenergic mediation (rats), 706
human coffee drinking, reinforcing andphysical dependence producing ef-fects, 416
Cahill, C. M., see Corbett, H., 517Calassi, R., see Perio, A., 542Calcium
antagonistscalcium channel action, baroreceptor
function (rats), 303TMB-8 injection, antinociception pro-
duction (mice), 320effect of carbachol, myosin light chain
phosphorylation, contraction of irissphincter muscle (rabbits), 574
entry blockers, vulnerability toward yen-tricular fibrillation (dogs), 340
phorbol butyrate contractions, 8-Br-cyclic GMP, 78
redistribution, electron microscopic au-toradiography, renal artery (rabbits),286
Calcium channel
Bay k 8644 contractile effects, femoralarteries, SHR rats, 198
blockers, digitalis mechanical toxicityprotection (guinea pigs), 206
calcium antagonists, baroreceptor func-tion (rats), 303
1,4-dihydropyridine activator-antagonistpairs, smooth muscle (rats, guinea
pigs), 144dihydropyridine binding to receptors, ef-
fect of diltiazem, magnesium influ-ence (chicks), 768
norepinephrine contraction potentiation,verapamil, diltiazem and nifedipine(rabbits, swine), 808
ouabain and canrenone, macrophages,
vascular smooth muscle cells (mice),
867Calcium disodium ethylenediamine tetraa-
cetate, treatment of lead-poisoned
children, lead, zinc and copper decor-poration, 829
Campbell, B. S., see Lakshmanan, M. R.,673
Campbell, K. A., Foster, T. C., Hampson, R.E. and Deadwyler, S. A.: Effects of�#{176}-tetrahydrocannabinol on sensory-evoked discharges of granule cells in
the dentate gyms of behaving rats,941
Campbell, K. A., Foster, T. C., Hampson, R.E. and Deadwyler, S. A.: �9-Tetra-hydrocannabinol differentially af-fects sensory-evoked potentials in the
rat dentate gyms, 936Canrenone, effect on cation handling, oua-
bain, macrophages and vascular
smooth muscle cells (mice), 867Carbachol
effect on myosin light chain phosphor-ylation, contraction, iris sphinctermuscle (rabbits), 574
phosphoinositide metabolism, effect ofchronic cholinesterase inhibition,brain (rats), 32
Carbamate, organophosphates and, pre- andpostjunctional effects, glutamatergicsynapse (locusts), 279
Cardiac electrophysiology, acute and
chronic amiodarone, effects, alteredthyroid hormone (rabbits), 179
Cardiac output, determinant, nitroglycerinpharmacokinetics (rats), 701
Cardiotonics, AR-L100, mechanism of ac-
tion (cats), 375Cardiovascular system
actions, decapeptide angiotensin analogs(rabbits), 790
desensitization, responses of histamine
(rats),730effects of mu-opioid receptor stimulation,
brain, catecholamine secretion (rats),
814
Carstairs, J. R. and Barnes, P. J.: Visuali-zation of vasoactive intestinal pep-tide receptors in human and guineapig lung, 249
Carter, H., see Roszkowski, A. P., 382Catalepsy, effects of BMY 14802, brain do-
paminergic function (rats), 124Catecholamines, modulated release, ‘y-ami-
nobutyric acid, adrenal gland (dogs),584
Caudal artery, alpha-i adrenoceptors, bind-ing and contraction (rats), 678
Celiprolol, beta adrenoceptors, down regu-lation, 549 lymphoma cells, 654
Central nervous system
carrier-mediated transport of Tyr-MIF-1,blood-brain barrier, essential aminoacids (mice), 668
Met6-enkephalin-Ar�-Phe7 degradation,
inhibition, dipeptidyl carboxypeptid-ase inhibitors (rats), 174
Cerebellar granule cells, inhibited adenylate
cyclase, GABAB, blockade by islet-activating protein (rats), 568
Cerrina, J., see Haye-Legrand, I., 536CGS 8216, agonist and diazepam-agonist
effects (rats, mice), 166Chambon, J.-P., see Perio, A., 542Chang, H., see Hoffman, B. B., 715Chan, W. C., see Glass, J., 742Chan, W. Y., Hruby, V. J., Rockway, T. W.
and Hiavacek, J.: Design of oxytocinantagonists with prolonged action:
Potential tocolytic agents for the
treatment of preterm labor, 84Chen, Y.-F., see Nagahama, S., 426Chiari, M. C., see D’Agostino, G., 522Chirtel, S. J., see Lakshmanan, M. R., 673Chisoim, J. J., Jr., see Thomas, D. J., 829Chiu, P. J. S., see Sybertz, E. J., 78Chlordiazepoxide, acute dependence, phar-
macologic characterization (rats),775
CholecystokininCCK-related peptides and, neurons in in-
ferior mesenteric ganglion (guineapigs), 618
receptor mediation, acetylcholine release,sphincter of Oddi (guinea pigs), 554
Cholinesterase, effect of chronic inhibition,phosphoinositide metabolism, car-bachol- and norepinephrine-stimu-lated (rats), 32
Chong, S., see Fung, H.-L., 701Choroid plexus, cimetidine transport (rats),
927
Cho, Y. H., see Wheeler, M. A., 99Christensen, H., see Christensen, S., 211Christensen, S., Steiness, E. and Christen-
sen, H: Tubular sites of furosemidenatriuresis in volume-replaced andvolume-depleted consious rats, 211
Christensson, P. I., see Bodd, E., 887Cimetidine
inhibition, placental sodium-hydrogen ex-
changer, 192transport, choroid plexus (rats), 927
-
964 Index Vol. 239
Clark, M. A., see Mong, S., 63Cline, W. H., Jr., see Shirasaki, Y., 861Clonidine
ablation of myenteric plexus, alpha adre-nergic response, jejunal longitudinalmuscle (rats), 9
dopamine1 receptor agonist, a4,ha-2 ad-renoceptor antagonist, effects of fen-oldopam (rabbits), 881
protection from soman toxicity (mice), 43Codeine, dextromethorphan effect on ileal
contractility, compared with levome-thorphan and loperamide (guineapigs), 627
Coffee, drinking, reinforcing and physical
dependence producing effects, 416
Collins, A. C., see Marks, M. J., 358Collins, A. C., see Miner, L. L., 853Constantine, J. W., see Woodman, 0. L.,
648Contreras, M. L., Wolfe, B. B. and Molinoff,
P. B.: Kinetic analysis of the inter-actions of agonists and antagonistswith beta adrenergic receptors, 136
Cooper, J. R., see Benishin, C. G., 185Copper, lead and zinc decorporation, treat-
ment of lead-poisoned children, 829Corbett, H., Cahill, C. M., Heinzow, B.,
Harrison, P. M., Byrne, A. J. andMcLean, A. J.: Interaction betweenoral hydralazine and propranolol. II.Assessment of altered splanchnicblood flow as the determinant of al-tered presystemic extraction, 517
Coronary arteryblood flow, alpha adrenoceptor regulation,
normal and stenotic arteries (dogs),641
bovine anterior descending, beta-i adre-noceptors, homogenous population,
634histamine-induced relaxation, mecha-
nisms (monkeys, dogs), 529norepinephrine contraction potentiation,
verapamil, diltiazem and nifedipine
(rabbits, swine), 808phorbol diesters, after contractile re-
sponses (swine), 38
Corticosterone, LY 165163, central sero-tonin agonist actions (rats), 454
Costa, E., see Mellstrom, B., 174Costa, L. G., Kaylor, G. and Murphy, S. D.:
Carbachol- and norepinephrine-stimulated phosphoinositide metab-olism in rat brain: Effect of chroniccholinesterase inhibition, 32
Coulson, R. and Trimble, M. E.: Effects of
papaverine and theophylline on renal
adenosine transport, 748
Crabbe, J. C. and Kosobud, A.: Sensitivityand tolerance to ethanol in mice bredto be genetically prone or resistant to
ethanol withdrawal seizures, 327Crabbe, J. C., Young, E. R., Tam, B., Ko-
sobud, A., Belknap, J. K. and Laur-sen, S. E.: Genetics differences inanticonvulsant sensitivity in mouse
lines selectively bred for ethanolwithdrawal severity, 154
Crews, F. T., see Gonzales, R. A., liiCrooke, S. T., see Mong, S., 63Cyclic AMP
inhibited adenylate cyclase, GABAB, cer-
ebellar granule cells (rats), 568prostaglandin E1 receptor-mediated re-
sponse, effects of chronic ethanol ex-posure, neuroblastoma clone (mice),687
uterine relaxation, isoproterenol and for-skolin, differential effect (rats), 236
vascular smooth muscle relaxationage-related decrease, beta adrenergic re-
ceptors (rats), 411vasoactive peptide hormones, endoge-
nous prostaglandins (rats), 334Cyclic GMP, phorbol dibutyrate contrac-
tions, aorta, calcium dependence, 78
Cycbooxygenase
A23i87, analysis of airway responses
(cats), 395leukotriene D4, arachidonic acid metabo-
lites (guinea pigs), 63
Cyclopentenone, prostaglandins, site andmechanism of growth inhibition, 500
Cyclosporine, effect of short-term adminis-tration, renin-angiotensin and
thromboxane A2, glomerular filtra-tion rate (rats), 229
Cytotoxic T lymphocytes, generation, mod-ulation by beta adrenoceptors (mice),460
D’Agostino, G., Kilbinger, H., Chiari, M. C.and Grana, E.: Presynaptic inhibi-tory muscarinic receptors modulating[3HJ acetylcholine release in the rat
urinary bladder, 522Dall’aglio, E., see Hoffman, B. B., 715Dar, M. S., see Garris, D. R., 270Deadwyler, S. A., see Campbell, K. A., 936,
941Deane, R., Park, S. H. and Bradbury, M. W.
B.: Effect of intravenous ferric or alu-minum chloride on the uptake of�#{176}�Pbinto brain and other soft tissuesof rats, 548
DeGott, C., see Letteron, P., 559DeLander, G. E. and Hopkins, C. J.: Spinal
adenosine modulates descending an-tinociceptive pathways stimulated bymorphine, 88
Denson, D. D., see Terasaki, T., 724Dentate gyros
tetrahydrocannabinolsensory-evoked discharges, granule
cells (rats), 941
sensory-evoked potentials (rats), 936Descatoire, V., see Letteron, P., 559Desiderio, D. M., see Sybertz, E. J., 78Devoe, L. D., see Ganapathy, V., 192Dewey, W. L., see Welch, S. P., 320Dexamethasone, treatment, increased gb-
merubar prostaglandin synthesis(rats), 296
Dextromethorphan, effect on ileal contrac-tility, compared with levomethor-
phan, boperamide and codeine(guinea pigs), 627
Diabetes, biliary excretion, organic anions
(rats), 4671,2-Diacylglycerol, effect of carbachol, con-
traction, iris sphincter muscle (rab-bits), 574
Diastereomers, glutathione conjugation, a-bromoisovalerylurea as model sub-
strate, 898, 905
Diazepam, agonist effects, CGS 8216 (rats,mice), 166
Di Chiara, G., see Imperato, A., 219
8-(N,N-Diethylamino)octyl-3,4,5,-trime-thoxybenzoate, see TMB-8
Digitalis, mechanical toxicity, protection byslow calcium channel blockers(guinea pigs), 206
DihydropyridineBay k 8644 contractile effects, femoral
arteries, SHR rats, 198increased binding, magnesium, effect of
diltiazem (chicks), 768Dilevalol, cardiac electrophysiologic actions
(dogs), 719Diltiazem
action on calcium channels, baroreceptorfunction (rats), 303
calcium entry blockade, vulnerability to-ward ventricular fibrillation (dogs),340
influence of magnesium, increased dihy-dropyridine binding, cardiac and
skeletal muscle membranes (chicks),768
verapamil and nifedipine, norepinephrinecontractions, potentiation (rabbits,swine), 808
DiMicco, J. A., see Hatfield, S. M., 460Dipeptidyl carboxypeptidase, inhibitors, in-
hibition of Met5-enkephalin-Ar�-
Phe7 degradation (rats), 174Dix, L. P., see Frazier, D. L., 946Doebber, T. W., see Wu, 841Dogterom, P., see te Koppele, J. M., 905Dopamine
5-amino-2,4-dihydroxy-a-methylphenyl-ethylamine, neurochemical charac-
terization, central noradrenergic neu-rons (rats), 55
LY 165163, central serotonin agonist ac-tions (rats), 454
LY171555, mechanism of depressor ac-
tion (rats), 426modulated release, D-2 dopamine recep-
tors, striatal slices (rats), 442preferential stimulation, nucleus accum-
bens, ethanol (rats), 219receptor agonist, fenoldopam effects (rab-
bits), 881
Dorsal caudate, dopamine release, prefer-ential stimulation, ethanol (rats), 219
Drug dependence, human coffee drinking,
caffeine, 416Drug interaction, oral hydralazine and pro-
pranobol (dogs), 517Dungan, K. W., see Stanton, H. C., 591Dwoskin, L. P. and Zahniser, N. R.: Robust
modulation of [3Hjdopamine releasefrom rat striatal slices by D-2 dopa-mine receptors, 442
Eckfeldt, J. H., see Krauss, E., 754Eicosatetraynoic acid, endothelial potentia-
tion of relaxation response, beta ad-renoceptor blocking agent (rats), 797
Ekarohita, N., see Lakshmanan, M. R., 673Elverdin, J. C., see Kaniucki, M. D., 488Endocrine system, sympathetic nervous sys-
tem and, interactions, atrial natri-uretic peptide (rats), 480
13-Endorphin, stereoselective effect, analge-sia production, Met-enkephalin re-lease (rats), 160
Endothelium
effects ofnaftidrofuryl, isolated blood yes-
sels (dogs), 760
-
1986 Index 965
modulation of vascular relaxation, nitro-vasodilators, aging and hypertension
(rats), 861potentiation of relaxation response, beta
adrenoceptor blocking agents (rats),
797vascular, contractile response in aorta,
prostacyclin (rats), 390Endothelium-derived relaxing factor, hista-
mine, mechanisms of relaxation, cor-onary arteries (monkeys, dogs), 529
End-plate currentneuromuscular junction, effects of phen-
cycbidine and analogs (frogs), 15thienyl analog of phencyclidine, acetyb-
choline receptor, blockade and recov-ery (frogs), 25
Enboe, L., see Richelson, E., 687Enprostil, gastric antisecretory and antiul-
cer properties (rats), 382Epilepsy
kainic acid limbic seizure-brain damagesyndrome, efficacy of bacbofen and
phenobarbital (rats), 612
temporal lobe, anticonvulsant drugs,
quinoline acid (rats), 256
Epinephrinebeta adrenoceptors, modulation, cytotoxic
T cell generation (mice), 460LY171555, mechanism of depressor ac-
tion (rats), 426EPSP, glutamatergic synapse, pre- and
postjunctional effects, organophos-
phates and carbamate compounds(locusts), 279
Erman, A., Hassid, A., Baer, P. G. andNasjletti, A.: Treatment with dexa-methasone increases gbomerular
prostaglandin synthesis in rats, 296Estrogen, , preferential stimulation, nucleus
accumbens (rats), 219effects of chronic exposure, prostaglandin
E1, neuroblastoma clone (mice), 687mechanisms behind inhibitory effect,
conjugation of morphine, hepato-cytes (rats), 887
membrane actions, inhibited histaminerelease, mast cells (rats), lii
sensitivity and tolerance, WSP and WSR
mouse lines, 327withdrawal severity, genetic differences,
anticonvulsant sensitivity (mice),154
Ethylketazocine, morphine and, effects onschedule-controlled behavior (pi-geons, monkeys), 433
Evans, D. C., see Lin, T.-M., 400, 406Ezekiel, M., see Lakshmanan, M. R., 673
Fatty acids, free, suppression by phenyliso-propyladenosine (rats), 715
Femoral artery, Bay k 8644 contractile ef-fects, SHR rats, 198
Fenoldopam, alpha-2 adrenoceptor antago-nist effects, dopamine1 receptor ago-nist and (rabbits), 881
Fenoterol, bovine anterior descending coro-nary artery, beta-i adrenoceptors, ho-mogenous population, 634
Ferguson, R. J., see Hem, D. W., 823Ferric chloride, aluminum chloride or, effect
of lead uptake into brain and softtissues (rats), 548
Fetus, chronically consumed caffeine, elim-ination, pregnancy (monkeys), 891
Flavahan, N. A. and Vanhoutte, P. M.: Sym-pathetic purinergic vasoconstrictionand thermosensitivity in a canine cu-taneous vein, 784
Folici acid, activation of excitatory amino
acid receptors, locomotor activity,nucleus accumbens (rats), 627
Follicle-stimulating hormone, LHRH-stim-ulated luteinizing hormone, alcoholeffects (monkeys), 693
5-Formyltetrahydrofolic acid, activation ofexcitatory amino acid receptors, bo-
comotor activity, nucleus accumbens(rats), 627
Forray, C., see Richelson, E., 687Forskolin
binding, guanylyl-5’-imidodiphosphate
and sodium fluoride (rats), 952isoproterenol and, uterine relaxation,
cyclic AMP (rats), 236vascular smooth muscle relaxation, age-
related decrease, beta adrenoceptors(rats), 411
Foster, T. C., see Campbell, K. A., 936, 941Fox, D. A. and Bass, P.: Ablation of the
myenteric plexus impairs alpha butnot beta adrenergic receptor-me-diated mechanical responses of ratjejunal longitudinal muscle, 9
Frazier, D. L., Dix, L. P., Bowman, K. F.,Thompson, C. and Riviere, J. E.: In-creased gentamicin nephrotoxicity innormal and diseased dogs adminis-tered identical serum drug concentra-tion profiles: Increased sensitivity insubclinical renal dysfunction, 946
Fujimoto, M., see Kataoka, Y., 584Fujiwara, M., see Narumiya, S., 506Fujiwara, M., see Ueda, N., 494Fukuda, S., Su, C. and Lee, T. J.-F.: Mech-
anisms of extraneuronal serotonin
uptake in the rat aorta, 264Fukushima, M., see Narumiya, S., 500, 506Fuller, R. W., Snoddy, H. D. and Molloy, B.
B.: Central serotonin agonist actionsof LY 165163, 1-(m-trifluoromethyl-phenyl)-4-(p-aminophenylethyl) pi-
perazine, in rats, 454fl-Funaltrexamine, binding to opioid recep-
tors, brain membranes (guinea pigs),
351
Fung, H.-L., Blei, A. and Chong, S.: Cardiac
output is an apparent determinant ofnitroglycerin pharmacokinetics inrats, 701
Furosemide, natriuresis, tubular sites (rats),211
Furukawa, T., see Harad.a, T., 554
Gadeholt, G., see Bodd, E., 887Gaginella, T. S., see Kachur, J. F., 627Ganapathy, M. E., see Ganapathy, V., 192Ganapathy, V., Balkovetz, D. F., Miyamoto,
Y., Ganapathy, M. E., Mahesh, V. B.,Devoe, L. D. and Leibach, F. H.: In-hibition of human placental Na�-H�
exchanger by cimetidine, 192Ganglion, inferior mesenteric, action of cho-
lecystokinin octapeptide and CCK-related peptides (guinea pigs), 618
Garay, G. L., see Roszkowski, A. P., 382Garay, R., see Hannaert, P., 867Garris, D. R., McConnaughey, M. M. and
Dar, M. S.: Estrogen modulation ofuterine adrenergic-cholinergic inter-
action: Effects on vasoactivity andadrenergic receptors in the guineapig, 270
Garty, M. and Hurwitz, A.: Tolerance tomorphine effects on renal dispositionof xenobiotics in mice, 346
Gastric acidnizatidine actions (dogs, rats, frogs), 406nizatidine actions (rats, dogs), 400
Gastric antisecretory action, antiulcer prop-erties and, enprostil (rats), 382
Geffard, M., see Kataoka, Y., 584Gehlert, D. R.: Regional modulation of
[3Hjforskolin binding in the rat brainby guanylyl-5’-imidodiphosphate andsodium fluoride: Comparison withthe distribution of guanine nucleo-tide binding sites, 952
Geneticsanalysis of nicotine-induced seizures,
nicotinic receptors (mice), 853differences, anticonvulsant sensitivity,
ethanol withdrawal (mice), 154nicotine tolerance, dose-response analy-
sis, receptor changes (mice), 358
Geneve, J., see Letteron, P., 559Gentamicin, nephrotoxicity (dogs), 946Geoffroy, S., see Gilbert, S. G., 891Geographutoxin II, sodium channel inhibi-
tor, skeletal muscles, autonomic
nerves (mice, bullfrogs, guinea pigs,rabbits), 243
Gerber, J. G., see Hedberg, A., 117Gertner, S. B., see Poulakos, J. J., 730Ghilardi, F., see Perico, N., 229Gilbert, S. G., So, Y., Klassen, R. D., Goof-
froy, S., Stavric, B. and Rice, D. C.:Elimination of chronically consumedcaffeine in the pregnant monkey (ma-coca fascicularis), 891
Gillespie, M. N., Kojima, S., Kunitomo, M.and Jay, M.: Coronary and myocar-dial effects of activated neutrophilsin perfused rabbit hearts, 836
Gintzler, A. R., see Glass, J., 742Glass, J., Chan, W. C. and Gintzber, A. R.:
Direct analysis of the release of me-thionine-enkephalin from guinea pigmyenteric plexus: Modulation by en-dogenous opioids and exogenousmorphine, 742
Gleason, J. G., see Mong, S., 63Gbomerular filtration rate, short-term cycbo-
sporine administration, renin-angio-tensin and thromboxane A2 (rats),
229Glutamatergic synapse, pre-and postjunc-
tional effects, organophosphates andcarbamate compounds (locusts), 279
Glutathione, conjugation, a-bromoisovaler-
ylurea, 898, 905Goldberg, S. R., see Katz, J. L., 433Gonzales, R. A. and Crews, F. T.: Correla-
tion of ethanol’s membrane actionsand inhibition of receptor-stimulatedhistamine release from rat mast cells,111
Grana, E., see D’Agostino, G., 522Granule cells, dentate gyros, sensory-evoked
discharges, tetrahydrocannabinol(rats), 941
Griffiths, R. R., Bigebow, G. E. and Liebson,
I. A.: Human coffee drinking. Rein-forcing and physical dependence pro-ducing effects of caffeine, 416
-
966 Index
Grimes, D., see Rimele, T. J., 1Gruenthal, M., see Ault, B., 612Gualandris, L., see Perico, N., 229Guanylyl-5’-imidodiphosphate, sodium flu-
oride and, forskolin binding (rats),952
Guarino, J. J., see Boisse, N. R., 775Guidotti, A., see Kataoka, Y., 584Gunnes, P., Reiker#{224}s,0. and Lygren, I.:
Secretion infusion in acute ischemicleft ventricular failure: Effects onmyocardial performance and metab-
olism in a closed-chest dog model, 915
Haass, M., see Zukowska-Grojec, Z., 480Halsall, H. B., see Krauss, E., 754Hampson, R. E., see Campbell, K. A., 936,
941Hanano, M., see Suzuki, H., 927Hanbauer, I., see Kataoka, Y., 584Hannaert, P., Thormann, B. and Garay, R.:
Effect of canrenone on the disturb-ances of cation handling induced byouabain in macrophages and vascularsmooth muscle cells, 867
Harada, T., Katsuragi, T. and Furukawa,T.: Release of acetylcholine mediatedby cholecystokinin receptor from theguinea pig sphincter of Oddi, 554
Harbon, S., see Khac, L. D., 236Harris, L. S., see Beardsley, P. M., 311Harrison, P. M., see Corbett, H., 517Hassid, A.: Increase of cyclic AMP concen-
trations in cultured vascular smoothmuscle cells by vasoactive peptidehormones. Role of endogenous pros-taglandins, 334
Hassid, A., see Erman, A., 296Hatfield, S. M., Petersen, B. H. and Di-
Micco, J. A.: Beta adrenoceptor mod-ulation of the generation of murinecytotoxic T lymphocytes in vitro, 460
Hawkins, D. J., see Miller, J. R., 38Haye-Legrand, I., Cerrina, J., Raffestin, B.,
Labat, C., Boullet, C., Bayol, A., Ben-veniste, J. and Brink, C.: Histaminecontraction of isolated human airwaymuscle preparations: Role of prosta-glandins, 536
Hayes, J. S., Wyss, V. L., Wilson, H. C.,Robertson, D. W. and Kauffman, R.F.: Molecular basis for the in vitroand in vivo cardiotonic activities ofAR-L100, 375
Heart
acute failure, secretin infusion (dogs), 915beta adrenoceptors, effects ofpindobol and
propranobol, lymphocytes, 117
digitalis mechanical toxicity, protectionby slow calcium channel blockers(guinea pigs), 206
effects of activated neutrophils (rabbits),836
electrophysiobogical actions
acute and chronic amiodarone, alteredthyroid hormone (rabbits), 179
SCH 19927 (dogs), 719Heart rate, dose-response analysis, nicotine
tolerance, receptor changes (mice),
358Heaslip, R. J., see Rimele, T. J., 1Heaulme, M., see Perio, A., 542Hedberg, A., Gerber, J. G., Nies, A. S.,
Wolfe, B. B. and Molinoff, P. B.:Effects of pindobol and propranobol
on beta adrenergic receptors on hu-man lymphocytes, 117
Hedler, L., see Szabo, B., 881Hem, D. W., Kirlin, W. G., Ferguson, R. J.,
Thompson, L. K. and Ogolla, F.:Identification and inheritance ofinbred hamster N-acetyltransferaseisozymes in peripheral blood, 823
Heinzow, B., see Corbett, H., 517Hepatic clearance, oral hydralazine and pro-
pranolol (dogs), 517Hepatocytes, conjugation of morphine,
inhibitory effect of ethanol, mecha-nisms (rats), 887
Hepatoxicity, acetaminophen, pre- or post-treatment with methoxsalen (mice),559
Hippocampus
anticonvulsant drugs, temporal lobe epi-lepsy, quinoline acid (rats), 256
efficacy of baclofen and phenobarbital,kainic acid limbic seizure-brain dam-age syndrome (rats), 612
nicotine-induced seizures, nicotinic re-ceptors, genetic analysis (mice), 853
Histamineairway muscle contraction, role of pros-
taglandins (humans), 536central cardiovascular responses, desen-
sitization (rats), 730
H1-receptor antagonist, behavioral effects(monkeys), 104
H2-receptor antagonistnizatidine actions, gastric acid secre-
tion (dogs, rats, frogs), 406nizatidine actions on uterus and stom-
ach (rats, dogs), 400induced relaxation, mechanisms, coro-
nary arteries (monkeys, dogs), 529receptor-stimulated release, ethanol’s
membrane actions, mast cells (rats),111
Hlavacek, J., see Chan, W. Y., 84Hoeschen, R. J., see Khatter, J. C., 206Hoffman, B. B., Dall’aglio, B., Hollenbeck,
C., Chang, H. and Reaven, G. M.:Suppression of free fatty acids andtriglycerides in normal and hypertri-glyceridemic rats by the adenosinereceptor agonist phenylisopropylad-
enosine, 715Hoffman, B. B., see Pan, H. Y.-M., 802Hoffman, B. B., see Tsujimoto, G., 411Hollenbeck, C., see Hoffman, B. B., 715Holtzman, J. L., see Krause, E., 754Holtzman, S. G.: Discriminative stimulus
properties of caffeine in the rat: Nor-adrenergic mediation, 706
Honda, K. and Nakagawa, C.: Alpha-i ad-renoceptor antagonist effects of theoptical isomers of YM-i26i7 in rab-bit lower urinary tract and prostate,512
Hondeghem, L. M., Ayad, M. J. and Rob-
ertson, R. M.: Verapamil, diltiazemand nifedipine block the depolariza-tion-induced potentiation of norepi-nephrine contractions in rabbit aortaand porcine coronary arteries, 808
Hopkins, C. J., see DeLander, G. B., 88Hosey, M. M., see Maan, A. C., 768Housman, A., see Wheeler, M. A., 99Howe, P. H., Akhtar, R A., Naderi, S. and
Abdel-Latif, A. A.: Correlative stud-ies on the effect of carbachol on myo-
Vol. 239
inositol trisphosphate accumulation,myosin bight chain phosphorybationand contraction in sphincter smoothmuscle of rabbit iris, 574
Hruby, V. J., see Chan, W. Y., 84Hurwitz, A., see Garty, M., 346Husain, A., Pajka, S. F., Taylor, S. M. and
Speth, R. C.: Monoiodinated angio-tensin II is a potent, full agonist an-
abog of angiotensin II, 71Hydralazine, oral, propranobol and, inter-
action (dogs), 517Hydrocortisone, plasma, prednisobone con-
centration-effect relations (man),919
5-Hydroxytryptamine, see SerotoninHyman, A. L., see Kriseman, T., 395Hypertension
aging and, nitrovasodilators, endothelialmodulation of vascular modulation(rats), 861
Bay k 8644 contractile effects, femoralarteries, SHR rats, 198
Hypotension, amiboride, myocardial andvascular actions, SHR rats, 365
Hypothalamic nuclei, 5-amino-2,4-dihy-droxy-a-methylphenylethylamine,neurochemical characterization, cen-tral noradrenergic neurons (rats), 55
Hypothermia, ethanol sensitivity and tol-erance, WSP and WSR mouse lines,
327
Iadarola, M. J., see Melbstrom, B., 174Idriss, M. K., Aguayo, L. G., Rickett, D. L.
and Albuquerque, E. X.: Organophos-phate and carbamate compoundshave pre- and postjunctional effectsat the insect glutamatergic synapse,
279
Iga, T., see Suzuki, H., 927Ileum
effect on contractility, dextromethorphan(guinea pigs), 627
release of methionine-enkephalin, endog-enous opioids and exogenous mor-
phine (guinea pigs), 742Immunoregulation, beta adrenoceptors,
modulation, cytotoxic T cell genera-tion (mice), 460
Immunosuppression, prednisobone concen-tration-effect relations, influence ofplasma hydrocortisone (humans),
919Imperato, A. and Di Chiara, G.: Preferential
stimulation of dopamine release in
the nucleus accumbens of freely mov-ing rats by ethanol, 219
Impromidine, central cardiovascular re-sponses, histamine, desensitization(rats), 730
Indocyanine, biliary excretion, organic an-ions, diabetes (rats), 467
Indomethacin, histamine contraction, air-way muscle, role of prostaglandins(humans), 536
Inorganic sulfate, depletion prevention, ac-etaminophen pharmacokinetics
(rats), 94Inositol trisphosphate, effect of carbachol,
contraction, iris sphincter muscle(rabbits), 574
Inotropismamiloride, myocardial and vascular ac-
tions, SHR rats, 365
-
Index 9671986
AR-Li#{174}cardiotonics, mechanism of ac-tion (cats), 375
Inturrisi, C. B., see Yoburn, B. C., 132lothalamate, renal disposition, morphine
tolerance, xenobiotics (mice), 346
Iris sphincter muscle, effect of carbachol,myosin light chain phosphorylation,contraction (rabbits), 574
Isoenzymes, N-acetyltransferase, identifi-cation and inheritance, peripheralblood (hamsters), 823
Isoproterenolablation of myenteric plexus, alpha adre-
nergic response, jejunal longitudinalmuscle (rats), 9
adenylate cyclase, ureter homogenate(guinea pigs), 99
beta adrenoceptorsbovine anterior descending coronary ar-
tery, homogenous population, 634down regulation, 549 lymphoma cells,
654modulation, cytotoxic T cell generation
(mice), 460forskolin and, uterine relaxation, cyclic
AMP (rats), 236
Jarry, H., Lookingland, K. J, Palmer, J. R.
and Moore, K. E.: Neurochemicalcharacterization of the actions of 5-amino-2,4-dihydroxy-a-methylphen-ylethylamine (5-ADMP): A selectiveneurotoxin to central noradrenergicneurons, 55
Jay, M., see Gillespie, M. N., 836Jejunum, longitudinal muscle, impaired a!-
pha adrenergic responses, ablation ofmyenteric plexus (rats), 9
Kachur, J. F., Morgan, D. W. and Gaginella,
T. S.: Effect of dextromethorphan onguinea pig ileal contractility in vitro:Comparison with levomethorphan,loperamide and codeine, 627
Kadowitz, P. J., see Kriseman, T., 395Kainic acid, limbic seizure-brain damage
syndrome, efficacy of bacbofen andphenobarbital (rats), 612
Kajiwara, A., see Ohizumi, Y., 243Kaniucki, M. D., Elverdin, J. C., Luchelli-
Fortis, M. A., Perec, C. J. and Ste-fano, F. J. E.: Sympathetic and par-asympathetic nerves regulate post-synaptic alpha-2 adrenoceptor in sal-ivary glands, 488
Kastin, A. J., see Banks, W. A., 668Kataoka, Y., Fujimoto, M., Alho, H., Gui-
dotti, A., Geffard, M., Kelly, G. D.and Hanbauer, I.: Intrinsic gammaaminobutyric acid receptors modu-late the release of catecholaminefrom canine adrenal gland in situ, 584
Katsube, N., Schwartz, D. and Needleman,P.: Atriopeptin turnover: Quantita-tive relationship between in vivochanges in plasma levels and atrialcontent, 474
Katsuragi, T., see Harada, T., 554Katusic, Z. S., see Zander, J. F., 760Katz, J. L. and Goldberg, S. R.: Effects of
ethylketazocine and morphine onschedule-controlled behavior in pi-geons and squirrel monkeys, 433
Katzman, N. J., see Shannon, H. B., 166
Kauffman, R. F., see Hayes, J. S., 375Kau, S. T., see Barrett, R. J., 365Kaylor, G., see Costa, L. G., 32KB-944, calcium entry blockade, vulnera-
bility toward ventricular fibrillation(dogs), 340
Kelly, G. D., see Kataoka, Y., 584Khac, L. D., Mokhtari, A. and Harbon, S.:
A re-evaluated role for cyclic AMP inuterine relaxation. Differential effectof isoproterenol and forskolin, 236
Khatter, J. C., Agbanyo, M., Hoeschen, R.J., Navaratnam, S. and Bains, R.:Digitalis-induced mechanical toxic-
ity: Protection by slow Ca� channel
blockers, 206Khazaeli, M. B., see Patterson, E., 179Khosla, M. C., see Baker, K. M., 790Kidney
adenosine transport, effects of papaverineand theophylline (rats), 748
gentamicin nephrotoxicity (dogs), 946morphine tolerance, disposition, xeno-
biotics (mice), 346Kilbinger, H., see D’Agostino, G., 522Kiritsy-Roy, J. A., Appel, N. M., Bobbitt, F.
G. and Van Loon, G. R: Effects ofMu-opioid receptor stimulation inthe hypothalamic paraventricularnucleus on basal and stress-inducedcatecholamine secretion and cardio-vascular responses, 814
Kirlin, W. G., see Hem, D. W., 823Klassen, R. D., see Gilbert, S. G., 891Kobayashi, J., see Ohizumi, Y., 243Kojima, S., see Gillespie, M. N., 836Kolm, P., see Shirasaki, Y., 861Koopmans, R. P., see Oosterhuis, B., 919Kopaciewicz, L., see Kopia, G. A., 641Kopia, G. A., Kopaciewicz, L. J. and Ruffobo,
R. R., Jr.: Alpha adrenoceptor regu-lation of coronary artery blood flowin normal and stenotic canine corn-nary arteries, 641
Kopin, I. J., see Zukowska-Grojec, Z., 480Kosobud, A., see Crabbe, J. C., 154, 327Kot, P. A., see Van Dam, J., 390Krauss, E., Polnaszek, C. F., Scheeler, D.
A., Halsall, H. B., Eckfeldt, J. H. andHoltzman, J. L.: Interaction betweenhuman serum albumin and a1-acidglycoprotein in the binding of lido-caine to purified protein fractions
and sera, 754Kreulen, D. L., see Schumann, M. A., 618Kriseman, T., Underwood, D. C., Hyman,
A. L. and Kadowitz, P. J.: Analysisof airway responses to A23187 in thecat, 395
Kruger, H. S., see Boisse, N. R., 775Kunitomo, M., see Gillespie, M. N., 836Kunze, D. L., Andresen, M. C. and Torres,
L. A.: Do calcium antagonists act di-rectly on calcium channels to alterbaroreceptor function?, 303
L-652,73i, platelet activating factor recep-tor antagonist, profile (rats), 841
Labat, C., see Haye-Legrand, I., 536Labetalol
dilevabol, cardiac electrophysiobogical ac-
tions (dogs), 719endothelial potentiation of relaxation re-
sponse, beta adrenoceptor blockingagent (rats), 797
Laher, I., Nishimura, S. and Bevan, J. A.:Prazosin selectively antagonizes nor-
epinephrine contractions at bow-af-finity, non-alpha adrenoceptor sites
(extraceptors) in arterial muscle, 846Lakshmanan, M. R., Campbell, B. S., Chir-
tel, S. J., Ekarohita, N. and Ezekiel,M.: Studies on the mechanism of ab-sorption and distribution of 2,3,7,8-tetrachlorodibenzo-p-dioxin in therat, 673
Lapadula, D. M., see Patton, S. E., 597Larrey, D., see Letteron, P., 559Laursen, S. E., see Crabbe, J. C., 154Lead
poisoning in children, metal excretion inchelation therapy, 829
uptake into brain and soft tissues, effectof intravenous ferric or aluminumchloride (rats), 548
zinc and copper decorporation, treatmentof lead-poisoned children, 829
Lee, C.-H., see Tsujimoto, G., 411Lee, D. K. H., see Rimele, T. J., 1Lee, E. K., see Waszczak, B. L., 606Lee, T. J.-F., see Fukuda, S., 264Lee, T. J.-F., see Shirasaki, Y., 861Lee, T., see Stephens, R. L., Jr., 627Leibach, F. H., see Ganapathy, V., 192Lethality, opioid receptor upregulation,
pharmacodynamic supersensitivity
(mice), 132
Letteron, P., Descatoire, V., Larrey, D.,DeGott, C., Tinel, M., Geneve, J. andPessayre, D.: Pre- or post-treatmentwith methoxsalen prevents the hep-atotoxicity of acetaminophen inmice, 559
Leucine, carrier-mediated transport, blood-brain barrier, Tyr-MIF-i (mice), 668
Leukotriene D4, thromboxane and prosta-cyclin biosynthesis, lung (guineapigs), 63
Levomethorphan, dextromethorphan effecton ileal contracility, compared withboperamide and codeine (guinea pigs),627
Levy, G., see Lin, J. H., 94Lidocaine
binding, interaction, human serum albu-mm and a1-acid glycoprotein, 754
intracerebroventricular injection ofTMB-8, antinociception production
(mice), 320Liebson, I. A., see Griffiths, R. R., 416Lindheimer, M. D., see Nagahama, S., 426Lin, J. H. and Levy, G.: Effect of prevention
of inorganic sulfate depletion on thepharmacokinetics of acetaminophenin rats, 94
Lin, T.-M., Evans, D. C., Warrick, M. W.
and Pioch, R. P.: Actions of nizati-dine, a selective histamine H2-recep-tor antagonist, on gastric acid seers-tion in dogs, rats and frogs, 406
Lin, T.-M., Evans, D. C., Warrick, M. W.
and Ruffolo, R. R., Jr.: Actions ofnizatidine on the rat uterus, dogstomach and experimentally induced
gastric lesions, 400Lipolysis, suppression of free fatty acids and
triglycerides, phenylisopropyladeno-sine (rats), 715
Lithium, furosemide natriuresis, tubularsites (rats), 211
-
968 Index Vol. 239
Liu-Chen, L.-Y., see Tam, S. W., 351Liver
glutathione conjugation, a-bromoisoval-erylurea, 905
2,3,7,8-tetrachlorodibenzo-p-dioxin,mechanism of absorption and distri-bution (rats), 673
Lookingland, K. J., see Jarry, H., 55Loperamide, dextromethorphan effect on
ileal contractility, compared with 1ev-omethorphan and codeine (guineapigs), 627
Lucchesi, B. R., see Lynch, J. J., 340, 719Lucchesi, B. R., see Patterson, E., 179Luchelli-Fortis, M. A., see Kaniucki, M. D.,
488Luchowski, E. M., see Wei, X. Y., 144Lung
beta adrenoceptors, effects ofpindobol andpropranolol, lymphocytes, 117
visualization, vasoactive intestinal pep-tide receptors (humans, guinea pigs),249
Luteinizing hormone, LHRH-stimulated,follicle-stimulating hormone, alcoholeffects (monkeys), 693
LY 165163, central serotonin agonist ac-tions (rats), 454
LY171555, mechanism of depressor action(rats), 426
Lyddane, J. E., see Thomas, B. F., 48Lygren, I., see Gunnes, P., 915Lymphocytes, beta adrenoceptors, effects of
pindolol and propranolol, 117Lymphoma cells, 549, beta adrenoceptors,
down regulation, 654Lynch, J. J., Montgomery, D. G. and Luc-
chesi, B. R.: The effects of calciumentry blockade on the vulnerabilityof infarcted canine myocardium to-ward ventricular fibrillation, 340
Lynch, J. J., Montgomery, D. G. and Luc-chesi, B. R.: Cardiac electrophysio-logic actions of SCH 19927 (dile-valol), the R,R-isomer of labetabol,719
Maan, A. C., Ptasienski, J. and Hosey, M.M.: Influence of Mg� on the effectof diltiazem to increase dihydropyri-dine binding to receptors on Ca�-channels in chick cardiac and skele-tal muscle membranes, 768
Macrophages, vascular smooth muscle cellsand, ouabain and canrenone, cationhandling (mice), 867
Maddox, Y. T., see Mostaghim, R., 797Maddox, Y. T., see Van Dam, J., 390Magnesium, influence on diltiazem effect,
increased dihydropyridine binding,cardiac and skeletal muscle mem-branes (chicks), 768
Mahesh, V. B., see Ganapathy, V., 192Marks, M. J., see Miner, L. L., 853Marks, M. J., Stitzel, J. A. and Collins, A.
C.: Dose-response analysis of nic-otine tolerance and receptor changesin two inbred mouse strains, 358
Martin, B. R, see Thomas, B. F., 48Mast cells, receptor-stimulated histamine
release, ethanol’s membrane actions(rats), 111
Matsuda, T., see Asano, M., 198Matthews, R. T., McMillen, B. A., Sallis, R.
and Blair, D.: Effects of BMY 14802,a potential antipsychotic drug, on ratbrain dopaminergic function, 124
McConnaughey, M. M., see Garris, D. R.,270
McGuffee, L. J., see Wheeler-Clark, E. S.,286
McLean, A. J., see Corbett, H., 517McMillen, B. A., see Matthews, R. T., 124Meijer, D. K. F., see te Koppele, J. M., 905Mello, N. K., Mendelson, J. H., Bree, M. P.
and Skupny, A. S. T.: Alcohol effectson luteinizing hormone-releasinghormone stimulated luteinizing hor-mone and follicle-stimulating hor-mone in ovariectomized female rhe-sus monkeys, 693
Mellstrom, B., ladarola, M. J., Yang, H.-Y.T. and Costa, E.: Inhibition of met6-enkephalin-ar�-phe7 degradation byinhibitors of dipeptidyl carboxypep-tidase, 174
Membranes, correlation of ethanol’s ac-tions, inhibited histamine release,mast cells (rats), 111
Mendelson, J. H., see Mello, N. K., 693Mercapturates, glutathione conjugation, a-
bromoisovalerylurea as model sub-
strate, 898Met6-enkephalin-Arg�-Phe7, degradation in-
hibition, dipeptidyl carboxypeptidaseinhibitors (rats), 174
Methionine-enkephalinrelease from myenteric plexus, endoge-
nous opioids and exogenous mor-
phine (guinea pigs), 742spinal release, analgesia production, ster-
eoselective effect of f�-endorphin(rats), 160
Methoxsalen, pre- or post-treatment with,acetaminophen toxicity prevention(mice), 559
N-Methyl-D-aspartic acid, folates, excita-tory amino acid receptors, locomotoractivity (rats), 627
Miller, J. R., Hawkins, D. J. and Wells, J.N.: Phorbol diesters alter the con-tractile responses of porcine coronaryartery, 38
Miner, L. L., Marks, M. J. and Collins, A.C.: Genetic analysis of nicotine-in-duced seizures and hippocampal ni-cotinic receptors in the mouse, 853
Minneman, K. P., see Abel, P. W., 678Minoshima, S., see Ohizumi, Y., 243Mitochondria, digitalis mechanical toxicity,
protection by slow calcium channelblockers (guinea pigs), 206
Miyamoto, Y., see Ganapathy, V., 192Mokhtari, A., see Khac, L. D., 236Molinoff, P. B., see Contreras, M. L., 136Molinoff, P. B., see Hedberg, A., 117Molinoff, P. B., see Reynolds, E. E., 654Molloy, B. B., see Fuller, R. W., 454Mong, S., Wu, H.-L., Clark, M. A., Gleason,
J. G. and Crooke, S. T.: LeukotrieneD4 receptor-mediated synthesis andrelease of arachidonic acid metabo-bites in guinea pig lung Induction ofthromboxane and prostacyclin bio-
synthesis by leukotriene D4, 63Montgomery, D. G., see Lynch, J. J., 340,
719
Montgomery, D. G., see Patterson, E., 179Moore, K. E., see Jarry, H., 55
Morgan, D. W., see Kachur, J. F., 627M#{248}rland,J., see Bodd, E., 887Morphine
conjugation, inhibitory effect of ethanol
in hepatocytes, mechanisms (rats),887
ethylketazocine and, effects on schedule-controlled behavior (pigeons, mon-keys), 433
exogenous, methionine-enkephalin re-lease, myenteric plexus (guinea pigs),
742intracerebroventricular injection of
TMB-8, antinociception production(mice), 320
tolerance, renal disposition, xenobiotics
(mice), 346Mostaghim, R., Maddox, Y. T. and Ram-
well, P. W.: Endothelial potentiationof relaxation response to beta adre-noceptor blocking agents, 797
Mulder, G. J., see te Koppele, J. M., 898,905
Muramatsu, I., see Ueda, N., 494Murphy, S. D., see Costa, L. G., 32Muscle, heart, dihydropyridine binding to
calcium channel receptors, effect ofdiltiazem, influence of magnesium(chicks), 768
Muscle, longitudinal, substance B isolation,presynaptic modulation (guineapigs), 185
Muscle, skeletaldihydropyridine binding to calcium chan-
nel receptors, effect of diltiazem, in-fluence of magnesium (chicks), 768
geographutoxin II, sodium channel inhib-itor (mice, bullfrogs, guinea pigs, rab-bits), 243
Muscle, smoothafter contractile responses, phorbol dies-
ters, coronary artery (hogs), 38calcium redistribution, renal artery, elec-
tron microscopic autoradiography(rabbits), 286
1,4-dihydropyridine activator-antagonistpairs, radioligand binding analysis(rats, guinea pigs), 144
extraneuronal serotonin uptake, mecha-nisms, aorta (rats), 264
phorbol butyrate contractions in aorta,calcium dependence, 8-Br-cyclicGMP, 78
uterine relaxation, cyclic AMP, iso-proterenol and forskolin (rats), 236
vascularcyclic AMP concentrations, endoge-
nous prostaglandins (rats), 334decreased beta responsiveness (hu-
mans), 802
effects of naftidrofuryl, blood vessels(dogs), 760
ouabain and canrenone, cation han-cUing (mice), 867
relaxation, age-related decrease (rats),411
Muscle cells, dextromethorphan effect onileal contractility, compared with 1ev-
omethorphan, loperamide and co-deine (guinea pigs), 627
Myenteric plexusablation, impaired alpha adrenergic re-
sponses, jejunal longitudinal muscle
(rats), 9methionine-enkephalin release, endoge-
-
1986 Index 969
nous opioids and exogenous mor-
phine (guinea pigs), 742substance B isolation, presynaptic modu-
lation (guinea pigs), 185Myocardium
calcium entry blockade, vulnerability to-ward ventricular fibrillation (dogs),340
effects of activated neutrophils (rabbits),836
infarctionischemia, secretin infusion (dogs), 915
Myo-inositol trisphosphate, effect of car-bachol, contraction, iris sphinctermuscle (rabbits), 574
Myometrium, uterine relaxation, cyclic
AMP, isoproterenol and forskobin(rats), 236
Naderi, S., see Howe, P. H., 574Nadler, J. V., see Ault, B., 612Naftidrofuryl, vascular effects (dogs), 760Nagahama, S., Chen, Y.-F., Lindheimer, M.
D. and Oparil, S.: Mechanism of thedepressor action of LY171555, a se-lective dopamine D2 receptor agonist,in the anesthetized rat, 426
Nahorski, S. R., see Rooney, T. A., 873Nakagawa, C., see Honda, K., 512Nakamura, H., see Ohizumi, Y., 243Nakanishi, S., see Ueda, N., 494Naloxone
acute chlordiazepoxide dependence, phar-macologic characterization (rats),775
effects of ethylketazocine and morphine,schedule-controlled behavior (pi-geons, monkeys), 433
Naltrexone, opioid receptor upregulation,
pharmacodynamic supersensitivity(mice), 132
Narumiya, S. and Fukushima, M.: Site andmechanism of growth inhibition byprostaglandins. I. Active transportand intracellular accumulation of cy-clopentenone, prostaglandins, a re-action leading to growth inhibition,500
Narumiya, S., Ohno, K., Fujiwara, M. andFukushima, M.: Site and mechanismof growth inhibition by prostaglan-dims. II. Temperature-dependenttransfer of a cyclopentenone prosta-glandin to nuclei, 506
Nasjletti, A., see Erman, A., 296Natriuresis, furosemide, tubular sites (rats),
211
Navaratnam, S., see Khatter, J. C., 206Needleman, P., see Katsube, N., 474Nephrotoxicity, gentamicin (dogs), 946Neuroblastoma cells, N1E-115, effects of
chronic ethanol exposure, prosta-glandin E1 receptor-mediated re-sponse (mice), 687
Neurokinin A, substance P and electricalstimulation, effects on iris sphinctermuscle (rabbits), 494
Neuroleptic drugs, effects of BMY 14802,brain dopaminergic function (rats),
124Neuromuscular junction
end-plate current, effects of phencyclidineand analogs (frogs), 15
thienyl analog of phencyclidine, acetyl-
choline receptor, blockade and recov-ery (frogs), 25
Neurons
central noradrenergic, 5-amino-2,4-dihy-
droxy-a-methylphenylethylamine,neurochemical characterization(rats), 55
dopaminergic, effects of BMY 14802,brain (rats), 124
inferior mesenteric ganglion, action ofcholecystokinin octapeptide andCCK-related peptides (guinea pigs),618
Neurotoxicity
anticonvulsant drugs, temporal lobe epi-lepsy, quinoline acid (rats), 256
tri-O-cresyl-induced delay, enhancedphosphorylation, brain and spinalcord proteins (hens), 597
Neurotoxins, 5-amino-2,4-dihydroxy-a-methylphenylethylamine, neuro-
chemical characterization, centralnoradrenergic neurons (rats), 55
Neutrophils, activated, coronary and myo-cardial effects (rabbits), 836
Nickols, G. A., see Shirasaki, Y., 861Nicotine
induced seizures, nicotinic receptors, ge-netic analysis (mice), 853
tolerance, dose-response analysis, recep-tor changes (mice), 358
Nies, A. S., see Hedberg, A., 117Nifedipine
alpha adrenoceptor-mediated vasocon-striction (dogs, monkeys), 648
verapamil and diltiazem, norepinephrine
contractions, potentiation (rabbits,swine), 808
Nishimura, S., see Laher, I., 846Nitrendipine
action on calcium channels, baroreceptorfunction (rats), 303
calcium redistribution, renal artery, elec-
tron microscopic autoradiography(rabbits), 286
Nitroglycerinpharmacokinetics, determinant, cardiac
output (rats), 701vascular relaxation, decreased beta re-
sponsiveness (humans), 802Nitrovasodilators
aging and hypertension, endothelial mod-ulation of vascular relaxation (rats),861
phorbol dibutyrate contractions, aorta, 78Nizatidine
actions on uterus and stomach (rats,dogs), 400
effect on gastric acid secretion (dogs, rats,frogs), 406
NMDA, see N-Methyl-D-aspartic acidNoda, H., see Watkins, J. B., III, 467Nomifensine, modulation of dopamine re-
lease, D-2 dopamine receptors, stria-tal slices (rats), 442
Norepinephrine
5-amino-2,4-dihydroxy-a-methylphenyl-ethylamine, neurochemical charac-terization, central noradrenergic neu-rons (rats), 55
atrial natriuretic peptide, interactions,sympathetic and endocrine systems(rats), 480
beta adrenoceptors, modulation, cytotoxicT cell generation (mice), 460
beta-i adrenoceptors, bovine anterior de-scending coronary artery, homoge-nous population, 634
contraction potentiation, verapamil, dil-
tiazem and nifedipine (rabbits,swine), 808
contractions, prazocin-sensitive adre-noceptors, arterial muscle (rabbits),846
estrogen modulation, adrenergic-cholin-ergic interaction, uterus (guineapigs), 270
phosphoinositide metabolism, effect ofchronic cholinesterase inhibition,
brain (rats), 32Nucleus accumbens
activation of excitatory amino acid recep-tors, folates, locomotor activity(rats), 627
dopamine release, preferential stimula-tion, ethanol (rats), 219
Nunes, F. A., see Yoburn, B. C., 132
Ogolla, F., see Hem, D. W., 823Ohizumi, Y., Minoshima, S., Takahashi, M.,
Kajiwara, A., Nakamura, H. and Ko-
bayashi, J.: Geographutoxin II, anovel peptide inhibitor of Na chan-nels of skeletal muscles and auto-nomic nerves, 243
Ohlstein, E. H. and Berkowitz, B. A.: Hu-man vascular vasopressin receptors:Analysis with selective vasopressinreceptor antagonists, 737
Ohno, K., see Narumiya, S., 506Olde Boerrigter, J. C., see te Koppele, J. M.,
898Oosterhuis, B., ten Berge, I. J. M., Schellek-
ens, P. T. A., Koopmans, R. P. andvan Boxtel, C. J.: Prednisolone con-
centration-effect relations in humansand the influence of plasma hydro-cortisone, 919
Oparil, S., see Nagahama, S., 426Opiates, acute chlordiazepoxide depend-
ence, pharmacologic characterization(rats), 775
Opioid antagonists, receptor binding, a-fun-
altrexamine, brain membranes(guinea pigs), 351
Opioidsendogenous, methionine-enkephalin re-
lease, myenteric plexus (guinea pigs),742
mu receptor stimulation, catecholaminesecretion, brain and cardiovascularresponses (rats), 814
receptor upregulation, pharmacodynamic
supersensitivity (mice), 132spinal adenosine, modulated antinocicep-
tive pathways, morphine stimulation(mice), 88
Organic anions, biliary excretion, diabetes(rats), 467
Organophosphatesacetylcholinesterase inhibitor, clonidine
protection (mice), 43carbamate compounds and, pre- and post-
junctional effects, glutamatergic syn-apse (locusts), 279
effects of chronic cholinesterase inhibi-tion, brain (rats), 32
Ouabaindigitalis mechanical toxicity, protection
-
970 Index Vol. 239
by slow calcium channel blockers(guinea pigs), 206
disturbances ofcation handling, effects of
canrenone, macrophages and vascu-lar smooth muscle cells (mice), 867
Ovarian suspensory ligament, effects of betaadrenoceptors, agonists and antago-nists (rats), 591
Oxytocin antagonists, prolonged action, po-tential tocolytic agents, preterm la-bor (rats), 84
Pajka, S. F., see Husain, A., 71Palmer, J. R., see Jarry, H., 55Pan, H. Y.-M., Hoffman, B. B., Pershe, R.
A. and Blaschke, T. F.: Decline inbeta adrenergic receptor-mediatedvascular relaxation with aging inman, 802
Papaverine, theophylline and, effects on
renal adenosine transport (rats), 748Parasympathetic nerves, sympathetic
nerves and, postsynaptic a4,ha-2 ad-renoceptor regulation, salivaryglands (rats), 488
Pardridge, W. M., see Terasaki, T., 724Park, S. H., see Deane, R., 548Pasternak, G. W., see Yoburn, B. C., 132Patterson, E., Walden, K. M., Khazaeli, M.
B., Montgomery, D. G. and Lucchesi,B. R.: Cardiac electrophysiologic ef-fects of acute and chronic arnioda-rone administration in the isolatedperfused rabbit heart: Altered thyroidhormone metabolism, 179
Patton, S. E., Lapadula, D. M. and Abou-Donia, M. B.: Relationship of tri-o-cresyl phosphate-induced delayed
neurotoxicity to enhancement of invitro phosphorylation of hen brainand spinal cord proteins, 597
Pearce, L. B., see Benishin, C. G., 185Peptides
CCK-related and cholecystokinin octa-peptide, neurons in inferior mesen-
teric ganglion (guinea pigs), 618
Tyr-MIF-1, carrier-mediated transportacross blood-brain barrier, essentialamino acids (mice), 668
vasoactive intestinal, visualization, lung
(humans, guinea pigs), 249
Perec, C. J., see Kaniucki, M. D., 488Pergolide, modulation of dopamine release,
D-2 dopamine receptors, striatalslices (rats), 442
Periana, R. M., see Boisse, N. R., 775Perico, N., Zoja, C., Benigni, A., Ghilardi,
F., Gualandris, L. and Remuzzi, G.:Effect of short-term cyclosporine ad-ministration in rats on renin-angio-tensin and thromboxane A2: Possiblerelevance to the reduction in gbomer-
ular filtration rate, 229Perio, A., Chambon, J.-P., Calassi, R.,
Heaulme, M. and Biziere, K.: Evalu-ation of two anticonvulsant amino-pyridazine derivatives in the conflicttest in rats, 542
Pershe, R A., see Pan, H. Y.-M., 802Pessayre, D., see Letteron, P., 559Petersen, B. H., see Hatfield, S. M., 460Pfenning, M., see Richelson, E., 687Pharmacogenetics, ethanol sensitivity and
tolerance, WSP and WSR mouse
lines, 327
Pharmacokinetics, atriopeptin, changes inplasma levels and atrial content(rats), 474
Phencyclidineeffects on end-plate current, neuromus-
cular junction (frogs), 15modified effects, ammonium chloride
(rats), 48thienyl analog, acetylcholine receptor,
blockade and recovery (frogs), 25Phenobarbital, baclofen and, efficacy
against kainic acid limbic seizure-brain damage syndrome (rats), 612
Phenoxybenzamine, low-affinity adre-noceptors, norepinephrine contrac-tions, arterial muscle (rabbits), 846
Phenylisopropyladenosine, suppression offree fatty acids and triglycerides(rats), 715
Phorbol-12,13-dibutyratecontractile responses, coronary artery
(swine), 38
contractions in aorta, calcium depend-ence, 8-Br-cyclic GMP, 78
Phorbol esters, effect of carbachol, contrac-tion, iris sphincter muscle (rabbits),574
Phorbol myristate acetate, activated neutro-phils, coronary and myocardial ef-fects (rabbits), 836
Phosphatidylinositol 4,5-bisphosphate, ef-feet of carbachol on myosin lightchain phosphorylation, contraction,iris sphincter muscle (rabbits), 574
Phosphodiesterase, AR-Li#{174} cardiotonics,mechanism of action (cats), 375
Phosphoinositide, carbachol- and norepi-nephrine-stimulated, effect ofchronic cholinesterase inhibition(rats), 32
Phosphoinositide hydrolysis, depolariza-tion-induced, regional characteriza-
tion of agonist (rats), 873Phosphoprotein phosphatases, tri-O-cresyl
phosphate-induced delayed neuro-toxicity, brain and spinal cord pro-teins (hens), 597
Phosphorylationmyosin light chain, effect ot carbachol,
contraction of iris sphincter muscle(rabbits), 574
tri-O-cresyl phosphate-induced delayedneurotoxicity, brain and spinal cordproteins (hens), 597
Pindololbeta adrenoceptors
down regulation, S49 lymphoma cells,654
propranolol, lymphocytes, 117Pioch, R P., see Lin, T.-M., 406Placenta, sodium-hydrogen exchanger, in-
hibition by cimetidine, 192
Plasmahydrocortisone, prednisolone concentra-
tion-effect relations (humans), 919protein binding, bupivacaine transport,
brain and salivary gland (rats), 724Plasma membrane, calcium redistribution,
renal artery, electron microscopic au-toradiography (rabbits), 286
Platelet-activating factor, antagonist L-652,731, profile (rats), 841
Polnaszek, C. F., see Krauss, E., 754Polyphosphoinositides, effect of carbachol,
contraction, iris sphin#{233}ter muscle(rabbits), 574
Potassium, depolarization-induced phos-phoinositide hydrolysis, regionalcharacterization ofagonist (rats), 873
Potassium channel, ouabain and canrenone,macrophages, vascular smooth mus-cle cells (mice), 867
Poulakos, J. J. and Gertner, S. B.: Studieson the desensitization of the centralcardiovascular responses of hista-mine, 730
Practololablation of myenteric plexus, alpha adre-
nergic response, jejunal longitudinalmuscle (rats), 9
bovine anterior descending coronary ar-
tery, beta-i adrenoceptors, homoge-nous population, 634
Prazocinablation of myenteric plexus, alpha adre-
nergic response, jejunal longitudinalmuscle (rats), 9
low-affinity adrenoceptors, blood vessels(rabbits), 846
Prednisolone, concentration-effect rela-tions, influence of plasma hydrocor-tisone (man), 919
Pregnancychronically consumed caffeine, elimina-
tion (monkeys), 891preterm labor, oxytocin anatagonists, pro-
longed action (rats), 84Procaine, intracerebroventricular injection
of TMB-8, antinociception produc-tion (mice), 320
Progesterone, estrogen modulation, adre-nergic-cholinergic interaction, uterus(guinea pigs), 270
Prolactin, LY 165163, central serotonin ag-onist actions (rats), 454
Propranololablation of myenteric plexus, alpha adre-
nergic response, jejunal longitudinalmuscle (rats), 9
oral hydralazine and, interaction (dogs),517
pindolol and, beta adrenoceptors, lympho-cytes, 117
Prostacyclincontractile response, role of vascular en-
dothelium, isolated aorta (rats), 390thromboxane and, leukotriene D4, lung
(guinea pigs), 63
Prostaglandin E1, effects of chronic ethanolexposure, neuroblastoma clone(mice), 687
Prostaglandin E�enprostil, gastric antisecretory and an-
tiulcer properties (rats), 382uterine relaxation, cyclic AMP, iso-
proterenol and forskolin (rats), 236Prostaglandins
endogenous, cyclic AMP concentrations,vascular smooth muscle cells (rats),334
increased glomerular synthesis, dexa-methasone treatment (rats), 296
role, airway muscle contraction, hista-mine (humans), 536
site and mechanism of growth inhibition,
500Prostate, alpha-i adrenoceptor antagonist
effects, optical isomers of YM-12617(rabbits), 512
Proteinislet-activating, inhibited adenylate cy-
clase, -y-aminobutyric acid B (rats),
-
1986 Index 971
568
myosin light chain, effect of carbachol,contraction of iris sphincter muscle(rabbits), 574
Protein kinase, tri-O-cresyl-induced delayedneurotoxicity, enhanced phosphory-lation, brain and spinal cord proteins(hens), 597
Protein kinase Cphorbol dibutyrate contractions, aorta, 78phorbol diesters, after contractile re-
sponses, coronary artery (swine), 38Proximal tubules, sites of furosemide natri-
uresis (rats), 211Ptasienski, J., see Maan, A. C., 768Purdy, R. E. and Stupecky, G. L.: Bovine
anterior descending coronary artery
possesses a homogeneous population
of beta-i adrenergic receptors, 634Pyridylethylamine, central cardiovascular
responses, histamine, desensitization(rats), 730
Quinoline acid, anticonvulsant drugs, tem-poral lobe epilepsy (rats), 256
Radioligands
binding analysis, 1,4-dihydropyridine ac-tivator-antagonist pairs, smoothmuscle (rats, guinea pigs), 144
monoiodinated angiotensin II, full agonistanalog of angiotensin II, 71
Raffestin, B., see Haye-Legrand, I., 536Ramwell, P. W., see Mostaghim, R., 797Ramwell, P. W., see Van Dam, J., 390Reaven, G. M., see Hoffman, B. B., 715Receptor agonists
monoiodinated angiotensin II, biologicalactivity, 71
substance B isolation, presynaptic modu-lation (guinea pigs), 185
Receptorsacetylcholine, blockade and recovery,
thienyl analog of phencyclidine(frogs), 25
adenosine, free fatty acids and triglycer-ides, phenylisopropyladenosinesuppression (rats), 715
adrenergic, see Adrenoceptorsadrenoceptors, see Adrenoceptorsbaroreceptors, calcium antagonists, ac-
tion on calcium channels (rat), 303cholecystokinin, acetylcholine release,
spinchter of Oddi (guinea pigs), 554D-2 dopamine, robust modulation, stria-
tal slices (rats), 442epsilon opioid, Met-enkephalin release, �-
endorphin effect (rats), 160excitatory amino acid, folates, locomotor
activity (rats), 627mu-opioid, effects on catecholamine se-
cretion (rats), 814muscarinic
acetylcholine release, urinary bladder(rats), 522
phosphoinositide metabolism, chroniccholinesterase inhibition (rats), 32
soman toxicity, clonidine protection(mice), 43
nicotinicacetylcholine receptor and, thienyl an-
alog of phencyclidine (frogs), 25nicotine-induced seizures, genetic
analysis (mice), 853phencyclidine and its analogs, end-
plate current of neuromuscular junc-
tion (frogs), 15tolerance, dose-response analysis
(mice), 358opioid, �l-funaltrexamine binding, brain
membranes (guinea pigs), 351vasoactive intestinal peptide, visualiza-
tion, lung (humans, guinea pigs), 249vasopressin, analysis with antagonists
(humans), 737
Reflexes, loss of righting, ethanol sensitivityand tolerance, WSP and WSR mouselines, 327
Reiker5s, 0., see Gunnes, P., 915Remuzzi, G., see Perico, N., 229Renal artery, calcium redistribution, elec-
tron microscopic autoradiography(rabbits), 286
Renin-angio�ensin system, short-term cy-closporine administration, glomeru-lar filtration rate (rats), 229
Reynolds, E. E. and Molinoff, P. B.: Downregulation of beta adrenergic recep-tors in S49 lymphoma cells inducedby atypical agonists, 654
Rice, D. C., see Gilbert, S. G., 891Richelson, E., Stenstrom, S., Forray, C., En-
lee, L. and Pfenning M.: Effects ofchronic exposure to ethanol on theprostaglandin E1 receptor-mediatedresponse and binding in a murineneuroblastoma clone (N1E-i15), 687
Rickett, D. L., see Idriss, M. K., 279Rimele, T. J., Heaslip, R. J., Lee, D. K. H.
and Grimes, D.: In vitro characteri-zation of the adrenoceptor activity ofAY-28,925, 1
Riviere, J. E., see Frazier, D. L., 946Ro 15-1788, acute chlordiazepoxide depend-
ence, pharmacologic characterization(rats), 775
Robertson, D. W., see Hayes, J. S., 375Robertson, R M., see Hondeghem, L. M.,
808
Rockway, T. W., see Chan, W. Y., 84Rooney, T. A. and Nahorski, S. R.: Regional
characterization of agonist and de-polarization-induced phosphoinosi-
tide hydrolysis in rat brain, 873Rose bengal, biliary excretion, organic an-
ions, diabetes (rats), 467
Roszkowski, A. P., Garay, G. L., Baker, S.,Schuler, M. and Carter, H.: Gastricantisecretory and antiulcer proper-ties of enprostil, (±)- lla,15a-dihy-droxy- 16-phenoxy-i7,18,19,20-te -
tranor-9-oxoprosta-4,5, 13(t)-tn-enoic acid methyl ester, 382
Rubanyi, G. M., see Zander, J. F., 760Ruffolo, R. R., Jr., see Kopia, G. A., 641Ruffolo, R. R., Jr., see Lin, T.-M., 400Rutledge, A., see Wei, X. Y., 144
Salbutamol, bovine anterior descending con-onary artery, beta-i adrenoceptors,homogenous population, 634
Saligenin, tri-O-cnesyl phosphate-induced
delayed neurotoxicity, enhancedphosphorylation, brain and spinalcord proteins (hens), 597
Salivary glandbrain and, bupivacaine transport (rats),
724sympathetic and parasympathetic nerves,
regulation by postsynaptic a!pha-2
adrenoceptor (rats), 488Sallis, R., see Matthews, R. T., 124Samanin, R., see Vezzani, A., 256Samoriski, G. M., see Boisse, N. R., 775Sarcoplasmic reticulum, calcium redistri-
bution, renal artery, electron micro-scopic autoradiography (rabbits), 286
Sawada, Y., see Suzuki, H., 927SCH 19927, cardiac electrophysiologic ac-
tions (dogs), 719Scheeler, D. A., see Krause, E, 754Sehellekens, P. T. A., see Oosterhuis, B.,
919Schuler, M., see Roszkowski, A. P., 382Schumann, M. A. and Kreulen, D. L.: Action
of cholecystokinin octapeptide andCCK-related peptides on neurons ininferior mesentenic ganglion ofguinea pig, 618
Schwartz, D., see Katsube, N., 474Secretin, infusion, acute isehemic left yen-
tricular failure (dogs), 915Seizures
anticonvulsant drugseffects on substantia nigra pars reticu-
lata neurons, 606temporal lobe epilepsy, quinoline acid
(rats),256nicotine-induced, nicotinic receptors, ge-
netic analysis (mice), 853Serotonin
agonist actions of LY 165163 (rats), 454extraneuronal uptake, mechanisms, aorta
(rats), 264Serum, albumin and a1-acid glycoprotein,
interaction, lidocaine binding, 754Shannon, H. E. and Katzman, N. J.: CGS
8216: Agonist and diazepam-antago-
nist effects in rodents, 166
Shirasaki, Y., Su, C., Lee, T. J.-F., Kolm,P., Cline, W. H., Jr. and Nickols, G.A.: Endothelial modulation of vascu-bar relaxation to nitrovasodilators inaging and hypertension, 861
SK&F 101926, vascular vasopressin recep-tors, analysis (humans), 737
Skupny, A. S. T., see Mello, N. K., 693Snoddy, H. D., see Fuller, R. W., 454Sodium
channel blocker, amiloride, myocardialand vascular actions (rats), 365
digitalis mechanical toxicity, protectionby slow calcium channel blockers(guinea pigs), 206
Sodium channel, geographutoxin II inhibi-tion, skeletal muscles, autonomicnerves (mice, bullfrogs, guinea pigs,rabbits), 243
Sodium fluoride, guanylyl-5’-imidodiphos-phate and, forskolin binding (rats),952
Sodium-hydrogen exchange, placental
brush-border membrane, inhibitionby cimetidine, 192
Sodium-potassium-ATPase, AR-Li#{174} car-diotonics, mechanism of action(cats),375
Sodium-potassium pump, ouabain and can-renone, macrophages, vascularsmooth muscle cells (mice), 867
Soman, toxicity, clonidine protection(mice), 43
So, Y., see Gilbert, S. G., 891Spealman, R. D., see Bergman, J., 104Species differences, histamine-induced re-
laxation, mechanisms, coronary ar-
-
972 Index Vol. 239
tenies (monkeys, dogs), 529Speth, R. C., see Husain, A., 71Sphincter muscle, effects of neurokinin A,
substance P and electrical stimula-tion (rabbits), 494
Spinal cordadenosine, modulated antinociceptive
pathways, morphine stimulation(mice), 88
brain and, tri-O-cresyl-induced delayedneurotoxicity, enhanced phosphory-lation (hens), 597
Met-enkephalin release, analgesia pro-duction, stereoselective effect of �-endorphin (rats), 160
Spincter of Oddi, acetylcholine release, cho-lecystokinin receptor mediation(guinea pigs), 554
SQ 29,548, A23i87, analysis of airway re-
sponses (cats), 395SR 41378, anticonvulsant amino-pyridazine
derivatives, evaluation, conflict test(rats), 542
SRS-A, leukotriene D4, thromboxane andprostacyclin biosynthesis, lung(guinea pigs), 63
Stanton, H. C. and Dungan, K. W.: In vitroeffects of beta adrenoceptor agonistsand antagonists on the rat ovariansuspensory ligament, 591
Starke, K., see Szabo, B., 881Stavnic, B., see Gilbert, S. G., 891Stefano, F. J. E., see Kaniucki, M. D., 488Steiness, E., see Christensen, S., 211Stenstrom, S., see Richelson, E., 687Stephens, R. L., Jr., Lee, T., Boldry, R. and
Unetsky, N. J.: Activation of excita-tory amino acid receptors may me-diate a folate-induced stimulation oflocomotor activity after bilateral in-jection into the rat nucleus accum-bens, 627
Stereoisomers, YM-126i7, alpha-i adreno-ceptor antagonist effects (rabbits),512
Stitzel, J. A., see Marks, M. J., 358Stomach
gastric acid secretion, nizatidine actions
(dogs, rats, frogs), 406nizatidine actions, gastric lesions (rats,
dogs), 400Stress, effects of mu-opioid receptor stimu-
lation, brain, catecholamine secre-
tion and cardiovascular responses
(rats), 814Striatum
effects ofBMY 14802, brain dopaminergicfunction (rats), 124
modulation of dopamine release, D-2 do-pamine receptors (rats), 442
Stupecky, G. L., see Purdy, R. E., 634Substance B, isolation, presynaptic modu-
lation (guinea pigs), 185
Substance P, neurokinin A and electricalstimulation, effects on iris sphinctermuscle (rabbits), 494
Substantia nigra, effects of BMY 14802,brain dopaminergic function (rats),124
Substantia nigra pars reticulata, neurons,
effects of anticonvulsant drugs, 606
Su, C. M., see Wei, X. Y., 144Su, C., see Fukuda, S., 264Su, C., see Shirasaki, Y., 861Sugiyama, Y., see Suzuki, H., 927
Sulfobromophthalein, biliary excretion, or-ganic anions, diabetes (rats), 467
S-Sulpinide, modulation of dopamine re-lease, D-2 dopamine receptors, stria-tal slices (rats), 442
Suzuki, H., Sawada, Y., Sugiyama, Y., Iga,T. and Hanano, M.: Transport of ci-metidine by the rat choroid plexus invitro, 927
Sybertz, E. J., Desidenio, D. M., Tetzboff, G.
and Chiu, P. J. S.: Phorbol dibutyratecontractions in rabbit aorta: Calciumdependence and sensitivity to nitro-vasodilators and 8-BR cyclic GMP,78
Sympathetic nervesparasympathetic nerves and, postsynaptic
alpha-2 adrenoceptor regulation, sal-ivary glands (rats), 488
purinergic vasoconstriction, thermosen-sitivity, cutaneous vein (dogs), 784
Sympathetic nervous systembeta adrenoceptors, modulation, cytotoxic
T cell generation (mice), 460endocrine system and, interactions, atnial
natniuretic peptide (rats), 480Synapse, glutamatergic, pre- and postjunc-
tional effects, organophosphates andcarbamate compounds (locusts), 279
Szabo, B., Hedler, L. and Starke, K.:Dopamine1 receptor agonist and at-pha-2 adrenoceptor antagonist ef-fects of fenoldopam in rabbits, 881
Tachykinins, effects on iris sphincter mus-cle (rabbits), 494
Takahashi, M., see Ohizumi, Y., 243Tam,B.,seeCrabbe,J.C., 154Tam, S. W. and Liu-Chen, L.-Y.: Reversible
and irreversible binding of /3-funal-trexamine to mu, delta and kappaopioid receptors in guinea pig brainmembranes, 351
Taniguchi, T., see Ueda, N., 494Taylor, S. M., see Husain, A., 71te Koppele, J. M., Dogterom, P., Vermeulen,
N. P. E., Meijer, D. K. F., van denGen, A. and Mulder, G. J.: a-Bro-moisovalerylurea as model substratefor studies on pharmacokinetics ofglutathione conjugation in the rat. II.Pharmacokinetics and stereoselectiv-ity of metabolism and excretion invivo and in the perfused liver, 905
te Koppele, J. M., van der Mark, E. J., Olde
Boernigter, J. C., Brussee, J., van denGen, A., van den Greef, J. andMulder, G. J.:a-Bromoisovalerylureaas model substrate for studies onpharmacokinetics of glutathione con-
jugation in the rat. I. (Bio-) synthesis,analysis and identification of diaster-
eomeric glutathione conjugates andmercapturates, 898
Temperature, body, dose-response analysis,nicotine tolerance (mice), 358
ten Berge, I. J. M., see Oosterhuis, B., 919Terasaki, T., Pardridge, W. M. and Denson,
D. D.: Differential effect of plasmaprotein binding of bupivacaine on itsin vivo transfer into the brain andsalivary gland of rats, 724
Terbutaline, beta adrenoceptors, modula-tion, cytotoxic T cell generation
(mice), 4602,3,7,8-Tetrachborodibenzo-p-dioxin, mech-
anism of absorption and distribution(rats), 673
12-O-Tetradecanoylphorbol-13-acetate,contractile responses, coronary ar-tery (swine), 38
Tetrahydrocannabinoldependence (monkeys), 311sensory-evoked discharges, granule cells,
dentate gyrus (rats), 941sensory-evoked potentials, dentate gyrus
(rats), 936Tetzloff, G., see Sybertz, E. J., 78Theophylline, papaverine and, effects on
renal adenosine transport (rats), 748Thermosensitivity, sympathetic purinergic
vasoconstriction, cutaneous vein(dogs), 784
Thomas, B. F., Lyddane, J. E. and Martin,B. R.: Modification of behavioral ef-fects and biodisposition of phencycli-dine in rats by ammonium chloride,48
Thomas, D. J. and Chisolm, J. J., Jr.: Lead,zinc and copper decorporation during
calcium disodium ethylenediaminetetraacetate treatment of lead-poi-soned children, 829
Thompson, C., see Frazier, D. L., 946Thompson, L. K., see Hem, D. W., 823Thormann, B., see Hannaert, P., 867Thromboxane
prostacyclin biosynthesis and, leuko-tniene D4, lung (guinea pigs), 63
short-term cyclosporine administration,glomerular filtration rate (rats), 229
Thromboxane A2, A23187, analysis of air-way responses (cats), 395
Thyroid, hormone alteration, cardiac elec-trophysiologic effects, acute andchronic amiodarone (rabbits), 179