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Increasing Kidneys for Transplantation: Decreasing Discards
Matthew Cooper, MD Director, Kidney and Pancreas Transplantation
Medstar Georgetown Transplant Institute Professor of Surgery
Georgetown University School of Medicine Board of Directors, National Kidney Foundation
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I have no conflicts of interest
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I have no conflicts of interest
I am, however, incredibly conflicted with the U.S. Organ Discard Rate……
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Growing Incidence of ESRD
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Epidemic???
Growing Incidence of ESRD
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The Growing Waiting List
Ref: http://optn.transplant.hrsa.gov
**94,915 as of 4/11/19
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Kidney Transplant Totals
Ref: http://optn.transplant.hrsa.gov/
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Transplant is the preferred option All cause mortality among Medicare beneficiaries
0
100
200
300
400
<20 20-44 45-64 65+
Deat
hs p
er 1
000
patie
nt y
ears
ESRDDialysisTransplantGeneral Medicare
Prevalent ESRD patients from day one, 2011, USRDS 2013 ADR Figure 5.2
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35 36 38 40 [VALUE]
35 36 37 39 40 37 42 46 47 50 66 69 70 72 75
75 78 82 84 [VALUE]
10
30
50
70
90
2000 2002 2004 2006 2008
Dialysis HemodialysisPeritoneal Dialysis Deceased Donor TransplantLiving Donor Transplant
2016 USRDS ADR Table 6.1
5 year survival rates for ESRD by modality
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The Rising Deceased Donor Kidney Discard Rate in the U.S.
3159 kidneys were discarded in 2015 Stewart, D. Transplantation 2017; 101(3):575-587
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NKF Consensus Conference to Decrease Kidney Discards May 18-19, 2017 Conference Co-Chairs: Matthew Cooper, MD Stephen Pastan, MD
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May 18-19, 2017 in Baltimore, MD Over 65 participants representing: Kidney patients and families Transplant surgeons and nephrologists Organ procurement organization (OPO) leadership Federal government
Centers for Medicare and Medicaid Services (CMS) Health Resources and Services Administration (HRSA) National Institutes of Health (NIAID/NIDDK)
American Society of Transplantation (AST) American Society of Transplant Surgeons (ASTS) United Network for Organ Sharing (UNOS) Scientific Registry of Transplant Recipients (SRTR) Payers
NKF Consensus Conference to Decrease Kidney Discards
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NKF Consensus Conference to Decrease Kidney Discards
Work Groups: 1. Donor Evaluation and Procurement
•Work Group Co-Chairs: Ryutaro Hirose, Kevin O’Connor
2. Recipient Selection and Allocation •Work Group Co-Chairs: Richard Formica, John Friedewald
3. Education and Research •Work Group Co-Chairs: Sumit Mohan, Jesse Schold
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Work Group 1: Donor Evaluation and Procurement
Co-Chairs: Ryutaro Hirose, Kevin O’Connor
Participants: David Adam Axelrod Ginny Bumgardner Kevin Cmunt Renee F. Dupee Elling Eidbo Richard Hasz Nichole Jefferson Bertram Kasiske Kevin A. Myer
Howard M. Nathan Richard V. Perez John D. Rosendale Lainie Friedman Ross Peter G. Stock Sean Van Slyck Dennis C Wagner
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Objective – Work Group 1
Help more patients by increasing the number of deceased donor kidneys transplanted # kidneys tx’d = (# donors x 2) – (# kidneys not recovered) – (# recovered kidneys discarded) Three strategic categories: Increase donors Increase kidney recovery from donors Decrease kidney discards
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Objective – Work Group 1
Help more patients by increasing the number of deceased donor kidneys transplanted # kidneys tx’d = (# donors x 2) – (# kidneys not recovered) – (# recovered kidneys discarded) Three strategic categories: Increase donors Increase kidney recovery from donors Decrease kidney discards
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Wide Variation in Kidney Utilization
kidneys tx’d = (# donors x2) – (# kidneys not recovered) – (# recovered kidneys discarded) OPO A (2015 & 2016: 340 donors)
680 – 89 – 195 = 396 (58% utilization) OPO B (2015 & 2016: 209 donors)
418 – 17 – 34 = 367 (88% utilization)
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Kidney Donor Profile Index (KDPI)
KDPI Variables •Donor age •Height •Weight •Ethnicity •History of Hypertension •History of Diabetes •Cause of Death •Serum Creatinine •HCV Status •DCD Status
The pathologic findings are NOT included in KDPI
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1.6%7.2%
12.5%17.8%
24.5%29.5%
36.3%
46.1%
55.0%
69.9%
91.5% 90.0% 89.0% 87.9% 86.6% 85.2% 83.7% 81.9%78.9%
76.3%71.9%
0%
10%
20%
30%
40%
50%
60%
70%
80%
90%
100%
Kidney Donor Profile Index (KDPI)
Graft Survival & Discard Rates by KDPI
Gradual decline in graft survival, yet steep increases in kidney discard rates
Discard rate
2-year graft survival
Source: Darren Stewart, UNOS Research
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Impact of KDPI Labeling on Kidney Discard
June 21, 2019
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Graft outcomes with even the lowest quality kidneys exceed average dialysis patient survival
KDPI
1, 9
7%
KDPI
1, 9
5%
KDPI
1, 9
1%
KDPI
1, 8
3%
KDPI
10,
97%
KDPI
10,
90%
KDPI
10,
90%
KDPI
10,
83%
KDPI
50,
95%
KDPI
50,
90%
KDPI
50,
87%
KDPI
50,
81%
KDPI
90,
88%
KDPI
90,
82%
KDPI
90,
76%
KDPI
90,
64%
KDPI
99,
83%
KDPI
99,
76%
KDPI
99,
72%
KDPI
99,
61%
78%
66%
57%
42%
40%
60%
80%
100%
1 year 2 years 3 years 5 years
Patie
nt o
r Gra
ft S
urvi
val
KDPI 1KDPI 10KDPI 50KDPI 90KDPI 99Hemodialysis
https://www.usrds.org/2017/view/v2_05.aspx Donor reference population: All deceased kidney donors recovered for transplant in 2016. Based on OPTN data including primary, adult, deceased donor, kidney alone transplants, as of April 20, 2018.
Better
Worse
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More History than Science??
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0
10
20
30
40
50
60
2005
2006
2007
2008
2009
2010
2011
2012
2013
2014
2015
2016
2017
2018%
Pro
cure
d Ki
dney
s
Kidney Biopsy and Discard Rates over Time
Biopsy Discard
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0
10
20
30
40
50
60
70
80
90
100
2010
2011
2012
2013
2014
2015
2016
2017
2018
Kidn
ey p
er Y
ear (
%)
Kidney Biopsy and Discard Rates by Year, KDPI>85
Biopsy Discard
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Practice Change •Biopsy practices (short term)
•Reduce/eliminate clinically irrelevant biopsies •Jointly establish protocols to reach reasonable guidelines •Create local DSA based approval process (Biopsy criteria) •Example: No biopsy if:
•Age < 60 •Serum Cr < 2.0 •KDPI < 85% •(exception: CMO approval upon request)
•Disseminate background information/recommendations to community (not just transplant professionals)
•Proposed biopsy study: RCT of deceased donor kidney biopsies
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Practice Change
•Pulsatile preservation of kidneys •Establish effective kidney perfusion protocols
•Pump criteria •Example: DCD •KDPI >85% •Terminal Cr > 2.0 •AKI •CMO exception
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Logistics of Pumping
•Logistical practices •Pump location •Transport kidneys on pump across DSA boundaries •Optimize OR timing for commercial flights •Pump kidneys when extended CIT is anticipated
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Practice Change Minimizing Mandatory Share Discards
•Always have a Plan ‘B’ •Backup all high-KDPI and high-CPRA kidneys locally
•Grant local backup to national centers •CIT increases significantly when no backup (17.9 vs 25.6 hrs)1
•Machine perfusion to mitigate timing challenges 1,2
•Send peripheral blood early for crossmatching in advance (3 programs) •Added cost (~$1000/donor)
•Encourage infrastructure to allow for more virtual xmatch
1 Paramesh et al. OPO Strategies to Prevent Unintended Use of Kidneys Exported for High PRA (>98% cPRA) Recipients. Am J Transplant; doi: 10.1111/ajt.14220 2 Cannon et al. Machine perfusion: Not just for marginal kidney donors. Am Surg 2015; 81: 550–556
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Practice Change
Strengthen OPO-Transplant Center relationships •Utilization feedback using UNOS OPO reports to review acceptance and discard behaviors •Use new tools developed by SRTR for joint review of clinical activity, acceptance practices, etc.
Review All Local Offers to assure no opportunity missed!
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Practice Change PHS Increased Risk kidneys
PHS increased-risk donors (IRDs) are almost 20% of the donor pool Discard rates higher for IRDs than non-IRD counterparts Wasteful to discard these: there should be someone on the list who would benefit Apply evidence-based decision support to accept Patients need clear information about risk/benefit of IRD kidney compared to dialysis
Transplantation is NOT risk-free limitations of Behavioral Health, Assessment from next of kin, etc.
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Center acceptance behaviors
•Identify centers seeking growth •Can’t assume all centers seeking growth
•Capitalize on forthcoming acceptance behavior reports coming •from SRTR and make changes to allocation •May change reliance on the “OPO Expedited Placement List” •OPO Subcommittee Expedited Placement Workgroup
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Long Term Change: Economic Factors
•Reduce economic disincentives •Adjustment of SAC costs by kidney quality •Should there be some ‘reward’ for accepting kidneys likely to be discarded
•Revision of payment for renal transplant
•Develop DRG with and without complications (or high risk for discard) for renal transplant •Carve out biologic agents from DRG/Global Payments
•Disseminate best practices for efficient use of high risk organs
•Dual Kidney Transplantation / Peds En-bloc Transplantation •Early discharge to outpatient dialysis •Centers of Excellence for High Risk for Discard Organs
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June 21, 2019
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Current Kidney Allocation Considerations
June 21, 2019
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Economic Considerations - Recipient
June 21, 2019
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Axelrod et al. AJT 2016
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Economic Considerations - Recipient
June 21, 2019
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Axelrod et al. AJT 2016
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Economic Considerations - Donor
June 21, 2019
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Axelrod et al. AJT 2016
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Adult Dual Unilateral Kidney Transplant (DUKT) – High KDPI Donors
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Adult Dual Unilateral Kidney Transplant (DUKT) – High KDPI Donors
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Pediatric En-bloc Kidneys
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Pediatric En-bloc Kidneys
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Long Term Change: Technology & Innovation
•Warm perfusion •Device development •Centralized organ recovery suites Less travel •Centralized infectious disease testing labs
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Work Group 2: Recipient Selection and Allocation
Co-Chairs: Richard Formica, John Friedewald
•Participants: •Mark Aeder •Adam Bingaman •Gabriel M. Danovitch •Jon Friedman •Howard M. Gebel •Sharon Klarman •David Klassen •Daniela Ladner •Allan Massie •Jennifer E. Milton
•Charles Modlin •Cathi Murphey •Emilio D. Poggio •Fiona Portington •Luke Preczewski •Timothy L. Pruett •Axel Rahmel •Lloyd E. Ratner •Peter Reese •Darren E. Stewart
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Good Kidney Intermediate Kidney HR Discard Kidney
Broad Acceptance Aggressive Center, Risk Taking Surgeon
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Odds of discard of kidneys is highest in UNOS regions with the lowest transplant rates
Mohan et al. Transplantation. 2014 Sep 27;98(6):640-5 Mohan et al. Kidney Int. 2018 Jul;94(1):187-198
0.031 – 0.055
0.056 – 0.071
0.072 – 0.089
0.090 – 0.133
Annualized Transplant Rates Adjusted Odds of Discard
Better
Worse Odds of discard calculated using data from 2000 through 2015 Annualized transplantation rates calculated from 2000 through 2010
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Expectations
•Align expectations across the continuum (patient, center, payers, regulators, dialysis centers, OPOs)
•What are we solving to? •Maximize 1 year graft/patient survival?
•What should we solve to? •Optimize ESRD patient survival? •Optimize organ utilization? •Getting patients off dialysis or avoiding dialysis? •Maximizing value to all parties? •Maximize quality of life? •Needs to be measured and defined
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Outcomes
•Continuing to define “time zero” for outcomes as the day of transplant will continue our cycle of misaligned quality metrics •Some time prior to transplant as time zero may be more relevant to patients – getting off dialysis •Still need better quantification of patient preferences
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Oversight, Oversight, Oversight!
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Consequences, Consequences, Consequences!
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Patients, Patients, Patients!
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Do we really know our comparator?
Schold J CJASN 2014, 9 (10) 1773-1780
Transplant center
tiers
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Do we really know our comparator?
Schold J CJASN 2014, 9 (10) 1773-1780
Transplant center
tiers
Dialysis!
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Possible New Benchmarks/ Balanced Scorecard
•Number of referrals from dialysis centers •Number of pre-emptive referrals •Time to evaluation •Time to listing •Listing rates (need to be risk adjusted) •Time to transplant •Transplant rate •Active vs. Inactive candidates
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Recipient Selection
•Listing criteria are not uniform among centers •Candidates unaware of differences from center to center •Is education and universal access more important? •A menu of transplant center practices (what is offered, who is accepted at that center – data driven)
•Guidelines are not mandatory, but centers must have criteria and follow their own criteria •Centers of Excellence?
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Know Your Data!!!
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Know Your Data!!!
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Report of Organ Offers
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Kidney Offer Acceptance Metrics: High Acceptance
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Kidneys are harder to place on the weekend
King et al. CJASN 2018 Accepted
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15.2% 16.3% 16.9% 17.4% 18.8% 18.4% 16.2% 1
1.09
1.13 1.17
1.29 1.25
1.08 1.05 1.04
1.06
1.19 1.18
1.07
1
1.1
1.2
1.3
10%
12%
14%
16%
18%
20%O
dds o
f dis
card
Day of Procurement
Perc
enta
ge d
iscar
ded
Percentage discardedOR of discardaOR of discard
Mohan et al. Kidney Int. 2016 Jul;90(1):157-63
Kidneys procured over the weekend are more likely to be discarded even after adjusting for quality
Higher quality kidneys discarded on the weekend Discard data calculated using data from 2000 through 2013
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Excellent quality kidneys from deceased donors are being discarded
Better Worse
Most common reasons cited for discard are donor characteristics and biopsy findings
Discard data calculated using data from 2000 through 2015 Mohan S et al. Kidney Int. 2018 Jul;94(1):187-198
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Work Group 3: Research and Education
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Accurate Assessment of organ quality
•Biopsy – as currently performed its contribution to assessing quality is unclear – and very far from being a “gold standard”
•Advocate for a trial to evaluate biopsy utility •Biopsy technique/preparation/interpretation/reporting should be standardized •Central read by a renal pathologist – using digital pathology
•Gross organ photo for donor net
•There is some variability in the utilization of gross photos of kidneys on donor net •Develop guidelines/standards for presenting gross photos: Adequately removing fatty tissue, highlighting vasculature mandatory
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Accurate Assessment of organ quality
•Biopsy – as currently performed its contribution to assessing quality is unclear – and very far from being a “gold standard”
•Advocate for a trial to evaluate biopsy utility •Biopsy technique/preparation/interpretation/reporting should be standardized •Central read by a renal pathologist – using digital pathology
•Gross organ photo for donor net
•There is some variability in the utilization of gross photos of the kidneys on the donor net •Develop guidelines/standards for presenting gross photos: Adequately removing fatty tissue, highlighting vasculature: •Make posting the gross picture of the kidney on the donor net mandatory
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Education/Research Needs
•Develop and evaluate interventions designed to increase acceptance of kidneys that are at disproportionate risk of discard (IRD, high KDPI, etc.) •Recognize patients are not the principal barrier to reducing organ turndown rates •Identify factors contributing to variability in organ acceptance practices within/between providers and programs
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Patients prioritize waitlist over posttransplant outcomes for selecting a transplant center
11% 9%
15% 11%
15%
40%
15% 16% 12%
14% 18%
26%
0%
10%
20%
30%
40%
PatientExperience
PracticalConsiderations
TransplantCenter
Experience
TransplantCenter
Reputation
TransplantCenter
Outcomes
Time on theWaitlist
Perc
ent
CKD patientsTransplant recipients
Husain SA et al. Am J Transplant. 2018 Nov;18(11):2781-2790
Only published national survey identifying patient centered criteria on selecting a transplant center Over 500 respondents for survey conducted in 2017
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•Develop and evaluate interventions designed to modify provider behavior (i.e., increased acceptance of IRD kidneys)
•Education alone will not reduce turndown rates •Knowledge is a necessary but insufficient agent of behavioral change
•Impact of incentive structure •Evaluate benefit of new monitoring and feedback systems
•Identify and disseminate provider and center best practices re: organ acceptance
Education/Research Needs
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Offer Acceptance Decision Tool The Idea: Enter donor, recipient, and offer characteristics and get projected likelihood of graft function and survival if accepting the offer or declining the offer.
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Growth in the need… and the waitlist
[VALUE]
[VALUE]
[VALUE]
0
20
40
60
80
100
120
140
1995 1998 2001 2004 2007 2010 2013 2016
Thou
sand
s Waitlist Additions
Incidence of ESRD
USRDS 2016 ADR UNOS Data Sept 2017
Number of patients NOT being waitlisted
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Conference Recommendations
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Conference Recommendations
•OPO Initiatives/Directives: •Communication
•Improve ‘real-time’ communication with Tx Center at time of organ offer (Go back to the phone)
•Collaborate with Tx Center to review all discards in the DSA
•Expand OPO and Tx Center relationships beyond the DSA Region
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Conference Recommendations
•OPO Initiatives/Directives: •Allocation
•Expand the use of virtual crossmatching, esp. with high cPRA recipients
•Routinely send prospective crossmatch material to several programs with recipients on matchrun
•Grant ‘local backup’ to centers for exported organs to minimize CIT
•Always identify ‘local backup’ for organs within DSA for high CPRA recipients or high KDPI organs
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Conference Recommendations
•OPO Initiatives/Directives: •Financial
•Develop risk-stratified (high risk of discard) Organ Acquisition Costs for organs that substantially increase the costs for Tx Centers
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Conference Recommendations
•Transplant Programs: •Management
•Waitlist management practices should work to educate patients on the acceptance of higher risk organs to prevent delays (HCV+, PHS IR, high KDPI)
•Develop and implement decision-support tools to help physicians evaluate benefits of accepting higher risk organs for particular recipient
•Disseminate best practices from Tx Centers that routinely accept high risk organs (COIIN)
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Conference Recommendations
•UNOS
•Create expedited placement pathways to directly offer kidneys with high KDPI, or at risk of discard, to small subset of centers that opt-in. Centers must maintain high rates of acceptance to remain.
•Identify organs that become a high risk for discard during standard allocation, and shunt them to patients at ‘rescue centers’ that utilize high risk organs.
•Standardize provision of gross photos of procured kidneys and post on DonorNet.
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Conference Recommendations
•SRTR
•Develop Quality of Life (QOL) metrics to support use of higher risk organs expected to have higher rates of graft loss.
•Re-evaluate all transplant center metrics that ‘punish’ transplant centers that utilize high risk organs.
•Monitor and report organ acceptance as an index of transplant center performance.
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Conference Recommendations
•NIH/Research
•Standardize technical aspects of obtaining and interpreting renal biopsies, and focus on their use of ruling in, rather than ruling out.
•Complete a randomized trial of renal biopsy use in organ procurement and acceptance.
•Fund research into organ procurement methodology.
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Conference Recommendations
•Payors
•Develop a risk-adjusted payment system to compensate Tx Centers for the increased costs of higher risk kidneys.
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Thank-you!