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Importance of Treating Iron Deficiency Anaemia
in Pregnancy
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Iron Deficiency Anaemia
Iron Deficiency Anaemia Is the Most Prevalent Micronutrient Deficiency Affecting Just Over
2 BILLION
People Of the World.
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WHO Mortality Data
Around
0.8 MILLION
Deaths Are Attributed to
Iron Deficiency Each Year
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WHO Mortality Data
In Terms of the Loss of Healthy Life Years (Dalys), IDA Results
in 25 MILLION
Dalys Lost Each Year.
DALYs = Disability Adjusted Life Years The sum of years of potential life lost due to premature mortality and the years of productive life lost due to disability.
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Economic Cost
The Economic Cost of Iron Deficiency Is Huge Because It Decreases the
PRODUCTIVITY
And COGNITIVE
Function
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Economic Loss
Annual Economic Loss Due to IDA in Four Countries of South Asia Namely Bangladesh, India, Pakistan and Sri Lanka Is
$4.2 BillionWith a loss of almost 0.6 % of
its GDP due to IDA
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Prevalence
“Almost
One Out of Two
Women of Child Bearing
Age Suffer From Anemia”
National Institute Of Population StudiesNational Institute Of Population Studies
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Risk
629 Pregnant Women Were Studied
• 313 Were (Hb <11 G/dl) Anaemic Group
• 316 Were (Hb >11 G/dl) Non-anaemic Group
For Anaemic Women
Preterm Delivery Was 4 Times Higher
LBW was 1.9 Times Higher
Risk of IUD Was 3.7 Times Higher
Tropical Medicine and International Health vol9(4) 486–490 apr 04 Aga Khan University, Karachi, Pakistan
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Folate Deficiency
Folate Deficiency Causes
Neural Tube Defect (NTD)
to the Baby If the Pregnant Mother Has Low Folic Acid Status at the
TIME OF CONCEPTION
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Developing Countries
In Many Developing Countries the Women Even Do Not Know That She Is Having a Baby.
CDC Scientists Have Estimated That Every Year
500,000 Severe Birth Defects
Are Caused by Folic Acid Deficiency.
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Folic Acid In NTD
0%
23%36%
52%57%
82% 85%
0%
15%
30%
45%
60%
75%
90%
0 mg 0.2 mg 0.4 mg 0.8 mg 1 mg 4 mg 5 mg
Increase in Daily Folic Acid Intake
Perc
en
tag
e o
f N
TD
s Th
at
Wou
ld B
e P
reven
ted
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Ironur-IPS
Is a compound containing
Iron Protein Succinylate
+ Folic Acid
developed by Biocon.
Is a compound containing
Iron Protein Succinylate
+ Folic Acid
developed by Biocon.
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Ironur-IPS
Each 15 ml contains
Iron Protein Succinylate ………… 800 mg
Folic Acid ………………………………...5
mg
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Iron Content
Each 1 ml contain: 2.67 mg iron *
Each 5 ml contains: 13.33 mg iron *
Each 7.5 ml contain: 20 mg iron *
Each 10 ml contains: 26.67 mg iron *
Each 15 ml contain: 40 mg iron *
*elemental iron
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Description
Ironur IPS (Iron Protein Succinylate) Is an Iron Compound Specially Bonded to Chemically Modified Protein Casein (Milk Protein) in a Process Called Succinylation, Which Dramatically Stabilizes the Complex
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Description
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Efficacy
BJOG. 2002 Sep;109(9):1009-14.
Increase in Haemoglobin in Severe Anaemia in Pregnancy
2.3g/dl
0.5g/dl
0
0.5
1
1.5
2
2.5
1 2
Iron Protein Succinylate + Folate
Iron Protein Succinylate
Hae
mog
lobi
n C
once
ntra
tion
g/dl
P = 0.07
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Efficacy
BJOG. 2002 Sep;109(9):1009-14.
1.42g/dl
0.8g/dl
0
0.5
1
1.5
2
1 2
Iron Protein Succinylate + Folate
Iron Protein Succinylate
Hae
mog
lobi
n C
once
ntra
tion
g/dl
P < 0.001
Increase in Haemoglobin in Overall Population of Pregnant Women
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Ironur IPS Vs IPC
Ironur-ips Led Not Only to a
FASTER INCREASE
of Hemoglobin, Hematocrit, MCV, Serum Iron, and Ferritin Than Iron Hydroxide Polymaltose Complex, but the Laboratory Values Remained Higher in Group A (Ironur-IPS) Than in B (Iron Hydroxide Polymaltose Complex) even After 2 Months of Treatment.
Int J Clin Pharmacol Ther. 1998 Jun;36(6):320-5.
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Safety Profile
• Excellent Safety Profile in 93% Patients
Adverse Events
7%
Gastric Tolerability
93%
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Additional Benefits
Ironur-IPS
• Additional Folic Acid is present for
additional benefits
• Free From
Sodium & Potassium and Sugar
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Who Needs Ironur IPS
Where demands of iron is increased
– Women, especially those with the history of child bearing challenges
– People with diets that are low in both meat and ascorbic acid
– Elderly
– Who donate blood more than 3 times a year
– Growing children
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Why Ironur IPS
• Unsurpassed Efficacy
• Excellent gastric tolerability
• Improved Absorption
• Additional benefits of Folic Acid
• Superior Safety Profile
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Doses
Adults: 15 – 30 ml /day
Children: 1.5 ml/Kg/day in 2divided doses