IIPCzechRepublic:AcademyofScienceAndyLiu’19
DepartmentofChemicalandBiologicalEngineering
Nové Hrady andInstituteofMicrobiology•ExperimentalandModelingresearch•ParticipationintheannualVisegrad ConferenceandSummerSchool•GreatopportunitiestomeetresearchersfromEurope
TheCastle:bothlaboratoryandresidentialhall
ThetownandInstitute
Workresponsibilities•Reactionmechanismofhuman3’-phosphoadenosine5’-phosphosulfatesynthaseI(hPAPSSI)•ComputationalChemistry:ahybridquantummechanicsandmolecularmechanicsapproach(QM/MM)•AnalyticaltransitionstructuresearchusingSchrödingerBiologicalSuite StructureofhPAPSSI
BonafideTransitionstructure
Abriefdescriptionofcomputationchemistry• Usingmodelsofvaryingdegreesofaccuracytopredict
andunderstandmolecularbehavioratpico-secondtonano-secondscale
Impactontheorganization•Elucidationofbonafidetransitionstructure•Generatedadetailedapplicationnoteforcontinuationofthesameproject
•IntroducedapackagethatwasrarelyusedattheInstituteforfuturework(AmbermoleculardynamicsusingQM/MM)
•WinnerofBestPresentationAwardattheconclusionofsummerschool
Interactionbetweenligandandcriticalproteinresidues
VisegradConference•Posterpresentations
•Lecturesonexperimentalandmodelingwork
•NetworkingwithscholarsandresearchersalloverEuropeandbeyond
Mostvaluableexperience:meetingpeoplefromallovertheWorld
TravelinginEurope
Vienna Prague VaticanCity
Impactonacademicsandcareerpath•Openedupanewwayformeinthefieldoftheoreticalstudies•Reaffirmedmydecisiontopursueacareerinmedicine•Motivatedmetostudybiologyinamorequantitativemanner
Sideprojectusingskillslearntfromwork:peptideembeddedinmembrane
Acknowledgments•ManythankstoProf.RudiEttrich,Prof.DavidReha,PrincetonIIPofficeandsponsorsformakingthisexperiencepossible.
•SpecialthankstoallSummerSchoolstudents,REUstudentsandPrincetonIIPstudentsforthecompanyandwonderfulmemories.
