![Page 1: HumMod – Golem Edition Human Physiology Model](https://reader035.vdocuments.us/reader035/viewer/2022062517/56813240550346895d98af3c/html5/thumbnails/1.jpg)
Univerzita Karlova v Praze, 1. lékařská fakulta, Laboratoř biokybernetiky a počítačové podpory výuky
HumMod – Golem Edition Human Physiology Model
J.Kofránek, M.Mateják, P.Privitzer, T.KulhánekJ.Šilar, F.Ježek, S.Matoušek
![Page 2: HumMod – Golem Edition Human Physiology Model](https://reader035.vdocuments.us/reader035/viewer/2022062517/56813240550346895d98af3c/html5/thumbnails/2.jpg)
History
• 1972 – A.Guyton & col.: Overall circulation• 1978 – N.Ikeda & col.: Body fluids• from 1997 – J.Kofranek & col.:Physiolibrary• 2005 – S.Andersen & col.: OSA• 2008 – T.Coleman & col.: QHP 2008 beta 2• 2010 – T.Coleman & col. : HumMod
Charles University of Prague, 1. Medicine Faculty, Laboratory of Biocybernetics and Computer aid Teaching
![Page 3: HumMod – Golem Edition Human Physiology Model](https://reader035.vdocuments.us/reader035/viewer/2022062517/56813240550346895d98af3c/html5/thumbnails/3.jpg)
DS 2009• T.Coleman
![Page 4: HumMod – Golem Edition Human Physiology Model](https://reader035.vdocuments.us/reader035/viewer/2022062517/56813240550346895d98af3c/html5/thumbnails/4.jpg)
DS 2009
VascularCompartments QHPViewSpl
anch
nicV
eins
Equations
2833 files in 772 folders2833 files in 772 folders
![Page 5: HumMod – Golem Edition Human Physiology Model](https://reader035.vdocuments.us/reader035/viewer/2022062517/56813240550346895d98af3c/html5/thumbnails/5.jpg)
HumMod GolemEdition
CardioVascular
Metabolism
Heat
Water
Proteins
Charles University of Prague, 1. Medicine Faculty, Laboratory of Biocybernetics and Computer aid Teaching
Gases
Electrolytes
Nerves
Hormones
Status
![Page 6: HumMod – Golem Edition Human Physiology Model](https://reader035.vdocuments.us/reader035/viewer/2022062517/56813240550346895d98af3c/html5/thumbnails/6.jpg)
Oxygen
Carbondioxyd
Titratable Hydrogen Ion
Respiratory Center
Charles University of Prague, 1. Medicine Faculty, Laboratory of Biocybernetics and Computer aid Teaching
Gases
![Page 7: HumMod – Golem Edition Human Physiology Model](https://reader035.vdocuments.us/reader035/viewer/2022062517/56813240550346895d98af3c/html5/thumbnails/7.jpg)
Concentration Conpartement
Tissues Oxygen
Blood O2 Diffusion
Alveolar Ventilation
Breathing
Blood O2 Measurement
Charles University of Prague, 1. Medicine Faculty, Laboratory of Biocybernetics and Computer aid Teaching
Oxygen
![Page 8: HumMod – Golem Edition Human Physiology Model](https://reader035.vdocuments.us/reader035/viewer/2022062517/56813240550346895d98af3c/html5/thumbnails/8.jpg)
Concentration Conpartement
Tissues: H+ in blood, IST and ICF
Renal Acidification: H+ and NH4+
Blood pH Measurement
Charles University of Prague, 1. Medicine Faculty, Laboratory of Biocybernetics and Computer aid Teaching
Titratable Hydrogen Ion
![Page 9: HumMod – Golem Edition Human Physiology Model](https://reader035.vdocuments.us/reader035/viewer/2022062517/56813240550346895d98af3c/html5/thumbnails/9.jpg)
Model Setup/Inputs• Initial state values (~150)
– Masses, Volumes, ..– Steady State
• Parameters and Constants (~4000)– Characterizations of Elementary things– Identification (Also Indirect Meassurement)
• Simple Environment Model– Meat, Air, Exercise, Intravenous Nutritions,
Transfusion, Dialysis, Hemorrhage, ...
Charles University of Prague, 1. Medicine Faculty, Laboratory of Biocybernetics and Computer aid Teaching
![Page 10: HumMod – Golem Edition Human Physiology Model](https://reader035.vdocuments.us/reader035/viewer/2022062517/56813240550346895d98af3c/html5/thumbnails/10.jpg)
HumMod.Library
• Domains:– Hydraulic (mmHg, ml/min, ..)– Concentration (mol/ml, mol/min, ..)– Osmotic (mol/ml, ml/min, ..)– Termoenergetic (K, kCal/min, ..)
• Simple blocks:– Resistance, Accumulation, Pump, Outflow, Absorbtion, Chemical
reaction ..
Charles University of Prague, 1. Medicine Faculty, Laboratory of Biocybernetics and Computer aid Teaching
![Page 11: HumMod – Golem Edition Human Physiology Model](https://reader035.vdocuments.us/reader035/viewer/2022062517/56813240550346895d98af3c/html5/thumbnails/11.jpg)
HumMod Golem Edition
![Page 12: HumMod – Golem Edition Human Physiology Model](https://reader035.vdocuments.us/reader035/viewer/2022062517/56813240550346895d98af3c/html5/thumbnails/12.jpg)
heart
pulmonaryCir?
systemicCircula?
systemicCirculation
redCells
bloodPropert?
busConnector
![Page 13: HumMod – Golem Edition Human Physiology Model](https://reader035.vdocuments.us/reader035/viewer/2022062517/56813240550346895d98af3c/html5/thumbnails/13.jpg)
Carotid Artery ?
(initial 10?
Sy?
8?m?_?ml
periph?
peripheral
volumeC?
85?veins
00
1?_?ml
coll?
gra?
40
legsArtysml/?
0
hyd?
(initial 5?(initial ?
100legsVeins
ml/?
hyd?0
k=9?
G
leftC?
leftCoro?right?
rightCor?
splanchnicCirculation
Low erTorsoVeinHeight
Exercise_MusclePump_Effect
SystemicArtys_Pressure
SystemicVeins_Pressure
Gravity_Gz
LeftHeart_BloodFlow
q_inq_out
busConnector
![Page 14: HumMod – Golem Edition Human Physiology Model](https://reader035.vdocuments.us/reader035/viewer/2022062517/56813240550346895d98af3c/html5/thumbnails/14.jpg)
(initial 10? GITract
GITract
06?m?_?mlS?
liver
SplanchnicVeins_Pressure
PortalVein_V0
q_inq_out
busConnector
![Page 15: HumMod – Golem Edition Human Physiology Model](https://reader035.vdocuments.us/reader035/viewer/2022062517/56813240550346895d98af3c/html5/thumbnails/15.jpg)
A2Effect
ADHEf?
11.2min.?____ml
Anesth?
Viscosity
Vascul?
AplhaR?
GITract
PO2On?
AlphaBlocade_Effect
AlphaPool_Effect
GangliaGeneral_NA
ADHPool_Log10Conc
A2Pool_Log10Conc
GITract_PO2
GITract_Function_Failed
Anesthesia_VascularConductance
Viscosity_ConductanceEffect
q_in q_out
organBloodFl?
BloodFlow
![Page 16: HumMod – Golem Edition Human Physiology Model](https://reader035.vdocuments.us/reader035/viewer/2022062517/56813240550346895d98af3c/html5/thumbnails/16.jpg)
TotalAgonism
HU?
NE?
TotalAgonism
+
NE?
HU?
sw itch1
booleanConst?
Sw itch
Setting
Symps?
curveActivity
Sym
psEffect
GangliaGeneral_NA
AlphaPool_Effect
AlphaBlockade_Effect
yBase
y
![Page 17: HumMod – Golem Edition Human Physiology Model](https://reader035.vdocuments.us/reader035/viewer/2022062517/56813240550346895d98af3c/html5/thumbnails/17.jpg)
Univerzita Karlova v Praze, 1. lékařská fakulta, Laboratoř biokybernetiky a počítačové podpory výuky
Thank you for attention
Marek Mateják [email protected] Jiří Kofránek [email protected] Privitzer
![Page 18: HumMod – Golem Edition Human Physiology Model](https://reader035.vdocuments.us/reader035/viewer/2022062517/56813240550346895d98af3c/html5/thumbnails/18.jpg)
HumMod Golem Edition
![Page 19: HumMod – Golem Edition Human Physiology Model](https://reader035.vdocuments.us/reader035/viewer/2022062517/56813240550346895d98af3c/html5/thumbnails/19.jpg)
...
tissuesMetabolismliverMetabolism
Glucose
KetoAcids
CellProte? GILumen
Urea
Lipidsheat
lactate
aminoAcids
busConnector
![Page 20: HumMod – Golem Edition Human Physiology Model](https://reader035.vdocuments.us/reader035/viewer/2022062517/56813240550346895d98af3c/html5/thumbnails/20.jpg)
GlycogenGLU_TO_GLY
LM_Glycogen?
LM_Glycogen?
LM_FA_Gluc? LM_Gluconeo?AA_TO_GLUGLU_TO_FA
Insulin?
Insulin?
Insulin?
75min
____mg
70min
____mg
42min
____mg
MassE?Glucos?LiverF?
Insulin?75min
____mg
MassE?Glucos?
LiverF?
Glucag?
Epinep?
.?
0? 0.6Glucos?LiverF?
Glucag?Glucos?Amino?LiverF?
LM_KetoacidsFA_TO_KA
1?LiverF?
FattyA?Glucag?
2.2min
____mg
m?
m?
LM_FA_Amin?AA_TO_FA
Insulin?
34min
____mg
0.? Amino?LiverF?
0.3
0.3
GLY_TO_GLU
1?
gl?
LiverFunctionEffectPortalVein_Glucagon
PortalVein_Glucose
PortalVein_Glucose
PortalVein_Glucose
EpiPool_Epi
liver_GlucoseToCellStorageFlow
s?s?
s? s?
Glucose
LM_Fatty?
Ketoacids
busConnector
s?
AminoAc?
s?
Urea
LM_Keto?
![Page 21: HumMod – Golem Edition Human Physiology Model](https://reader035.vdocuments.us/reader035/viewer/2022062517/56813240550346895d98af3c/html5/thumbnails/21.jpg)
curve
curve
product
yBase
y
u
![Page 22: HumMod – Golem Edition Human Physiology Model](https://reader035.vdocuments.us/reader035/viewer/2022062517/56813240550346895d98af3c/html5/thumbnails/22.jpg)
HumMod Golem Edition
![Page 23: HumMod – Golem Edition Human Physiology Model](https://reader035.vdocuments.us/reader035/viewer/2022062517/56813240550346895d98af3c/html5/thumbnails/23.jpg)
vasopressin
aldosteroneangiotens?
atriopeptin
erythropo?
glucagoninsulin
renin
thyrotropin thyroxine
catechols
leptin
busConnector
![Page 24: HumMod – Golem Edition Human Physiology Model](https://reader035.vdocuments.us/reader035/viewer/2022062517/56813240550346895d98af3c/html5/thumbnails/24.jpg)
InsulinPool
secretionsynth?
clear?
Portal?InsulinS?
k=?
gain
KAEffect
MassE?
1
Glucos?
Functio?
BasicF? 0.0?
uU/l k=1?
mU?
u?
I
k=(1/20)/Libr?
InsulinSynthe?
-
feedback
Ik=(1/?
LM_I?
-
feedback1
PortalVein_PlasmaFlow
ECFV_Vol
PortalVein_Insulin
Insulins?
busConnector
Insulin
LM_Insulin_InsulinDela?
![Page 25: HumMod – Golem Edition Human Physiology Model](https://reader035.vdocuments.us/reader035/viewer/2022062517/56813240550346895d98af3c/html5/thumbnails/25.jpg)
curve
curveproduct
yBase
y
u