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How to make new discoveries in (human) anatomy
Matt Wedel Western University of Health Sciences,
Pomona, California
OR
Can we develop predictive guidelines to help us make new
anatomical discoveries?
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2013
2018
2019
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Why, after centuries of careful study, are we still making new discoveries in human anatomy?
• Humans are complex; lots of stuff to find
• Not everything that gets found gets published
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Filters to the publication of new discoveries
Palaeontology • What gets fossilized
• What gets discovered
• What gets collected
• What gets prepared
• What gets published
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Filters to the publication of new discoveries
Palaeontology • What gets fossilized
• What gets discovered
• What gets collected
• What gets prepared
• What gets published
Human anatomy • What gets preserved
• What gets noticed
• What gets recognized as
possibly important
• What gets published
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Why, after centuries of careful study, are we still making new discoveries in human anatomy?
• Humans are complex; lots of stuff to find
• Not everything that gets found gets published
![Page 8: How to make new discoveries in (human) anatomy...How to make new discoveries in (human) anatomy Matt Wedel Western University of Health Sciences, Pomona, California OR Can we develop](https://reader036.vdocuments.us/reader036/viewer/2022081523/5fdd4c07c9d24661f44c6c12/html5/thumbnails/8.jpg)
Case Study 1:
Anterolateral ligament of the knee
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A new knee ligament described this decade! (sorta)
”In 1879, years before the discovery of X-rays, Dr. Paul Segond described…‘a pearly, resistant, fibrous band which invariably showed extreme amounts of tension during forced internal rotation (of the knee)’.” - Claes et al. (2013: p. 321)
Right knee in right lateral view (Claes et al. 2013: fig. 2)
Anterolateral Ligament
prox
imal
distal
lateral collateral ligament
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Endoscopic knee surgery
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Med student view
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Distractors: superficially similar structures in the same region
Right knee in right lateral view
Anterolateral Ligament
lateral collateral ligament
patella
femur
tibia fibula
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Distractors: superficially similar structures in the same region
Right knee in right lateral view
Anterolateral Ligament
lateral collateral ligament
1. joint capsule
femur
patella
tibia fibula
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Distractors: superficially similar structures in the same region
Right knee in right lateral view
Anterolateral Ligament
lateral collateral ligament 2. iliotibial tract
1. joint capsule
femur
patella
tibia fibula
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Why wasn’t the anterolateral ligament of the knee recognized sooner?
• Anatomically complex region • Rarely dissected completely • Known distractors in the same
area
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Case Study 2:
Pararecurrent nerve (recurrent pharyngeal nerve)
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Neck viscera in right lateral view
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Neck viscera in left lateral view
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Neck viscera in left lateral view
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Innervation of the larynx and trachea in a dog, modified from Lemere (1932: fig. 1)
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Innervation of the larynx and trachea in a dog, modified from Lemere (1932: fig. 1)
recurrent laryngeal N
(to larynx only)
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Innervation of the larynx and trachea in a dog, modified from Lemere (1932: fig. 1)
recurrent laryngeal N
(to larynx only)
pararecurrent N (to esophagus/trachea)
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Why wasn’t the pararecurrent nerve in humans recognized sooner?
• Anatomically complex region • Rarely dissected completely • Known distractors in the same
area
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Case Study 3:
Long cutaneous branch of the obturator nerve
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2013 case
Left lower limb in anteromedial view
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2013 case
cutaneous branch of obturator N
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2014 case
Left lower limb in anteromedial view
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2014 case
cutaneous branch of obturator N
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2014 case
cutaneous branch of obturator N
saphenous branch of femoral N
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great saphenous
vein
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great saphenous
vein
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Elalfy et al. (2015: fig. 2)
Endoscopic vein harvesting
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Why wasn’t the long obturator nerve recognized sooner?
• Challenging, fragile structure • Rarely dissected completely • Known distractors in the same
area
cutaneous branch of obturator N
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Places to look for new discoveries in (human) anatomy
• Complex regions that are rarely dissected fully – joints, distal tendon insertions, nerve plexes
• Recent evolutionary changes from close relatives – e.g., pararecurrent nerve
• Opportunities for “replaced” structures – blood vessels, nerves (especially cutaneous nerves)
These principles probably work at least as well for non-human organisms as they work for humans!
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Places to look for new discoveries in (human) anatomy
• Talk to surgeons (or other morphologists), ask them what they’ve seen that they didn’t expect
• Get to know the literature and look where no-one else is looking
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“I am firmly convinced that the best book in medicine is the book of Nature, as writ large in the bodies of men. You remember the answer of the immortal Hunter, when asked what books the student should read in anatomy – he opened the door of the dissecting-room and pointed to the tables.” — Sir William Osler, 1901
spinal nerve in an ostrich neck
Acknowledgments • Cadaver donors for giving their bodies to science • Niña McCoy, WesternU Willed Body Donation Program • WesternU Institutional Review Board