Heather BrodkinComputationally Guided Protein-Specific Labeling with NPsAdam HendricksSynthesis of Spin Labeled Nanosensors for the Estrogen ReceptorTatyana ChernenkoRaman Micro-spectroscopicTechniques forDrug-delivery ApplicationsAgnes RafalkoGold NPs for imaging cell surface oligosaccharides for early diagnosis of cancer
Paula LamptonUsing NPs to Analyze Key
Immune System Molecules in Embryonic Stem CellsAnthony D’OnofrioNanoparticle Antimicrobial DevelopmentSucharita SahaVisualization and Enhancement of Spinal Cord Regeneration using Nanoparticles
Robert Camp: MIE Quantifying Collagen’s Mechanosensitivity to Enzymatic Cleavage by MMPsSavidra Lucatero: ChemE Transport Behavior of
Drugs and NPsIntestinal MucusYogesh Patel: ECEBasal Cell CarcinomaBrian Plouffe:Chem E Microfluidic Cell Separation Using Functionalized Magnetic NPs
Lilian van VlerkenDevelopment of a Polymeric NP Formulation to Overcome Multidrug Resistance of Cancer via a Multifunctional Therapy Mattia MiglioreIntranasal Delivery of GDNF for the Treatment of Parkinson’s DiseaseLuis BritoEndothelial
Nitric Oxide Synthase (eNOS) Gene Therapy with Gelatin-Based NanovectorsLara JabrMitochondriotropic Gold NP Vectors
Thomas BarchetRole of Polyunsaturated Fatty Acid-Containing nano-emulsions in Drug Delivery and Neuroprotection in Alzheimer’s Disease.
Associates: The IGERT Associate Program is intended for Undergraduates and Masters students interested in the area of nanomedicine. The program has supported over 32 students from 8 different departments that include Physics, Chemistry, Biotechnology, Pharmaceutical Sciences, Mechanical and Industrial Engg, Electrical and Computer Engg, Chemical Engg and Biology. The research experience has influenced several of these students to pursue graduate education.
IGERTNANOMEDICINE
VISION
Inter-disciplinary researchNanoplatforms for targeted delivery; Optical
sensors and therapies; Magnetic nanoplatforms; Nanoplatforms for
Antimicrobial, Implant and Neural applications; Ethical and Policy issues in Nanomedicine
Internships and
outreachCommunity engagementIntellectual
propertyCultural diversity
International outlook
Communication Skills Professional Conduct
Reports Publications
Presentations Research
Integrity Ethics
Multi-disciplinary coursesIntroduction to Nanomedical Technology ;
Nanosystems Design for Biomedical Applications; Scientific Skills, Ethics, and
Commercialization; Nanomedicine Seminar
FacilitiesThe Nanomedicine Core Facility has been established to provide nanoparticles and nanomaterials for various interdisciplinary research projects. Facility includes: Hitachi 2nm Hi Res FESEM, SQUID, AFM, STM, TEM, NSOM
OutreachIGERT Outreach provides education and leadership skills to both students and teachers from participating schools in the Greater Boston area. Outreach activities including RET, the Young Scholars Program, Field Trip hosting, and Science Fair Mentoring have proven to be a very positive experience to all involved.
Partners and Collaborators
An Interdisciplinary Doctoral Training Program
Research
Program VisionThe Integrative Graduate Education, Research & Training (IGERT) program in Nanomedicine Science and Technology was established at Northeastern University in 2005 (Phase 1) with funding from the National Science Foundation.The IGERT Nanomedicine program aims to train the next generation of scientists and technologists who are skilled in research at the interface of nanotechnology, biology and medicine, who are aware of the path to translate fundamental knowledge to marketplace products, who are informed of the ethical and social issues relating to the discipline, and who have a strong sense of community involvement as well as a global perspective.The program received funding for a second phase Phase 2 (2010-2015), with additional partners – Tuskegee University and University of Puerto Rico, Mayaguez, as well as faculty from Harvard Medical School, to establish a national multi-site training program. International partners have also expressed an eagerness to replicate the model in their institutions.
The Faculty
www.igert.neu.edu
Funded by the National Science
Foundation
IGERT Faculty Collaborators/AdvisorsBiology: K. Lewis, D. O'Malley, C. Warner, E.CramChemistry: M. Diem, G. Jones, R. Hanson, M.OndrechenPhysics: D. Heiman, L. Menon, M. Williams Pharmaceutical Sciences: A. Makryannis, V. Torchilin, B.Waszczak,Chemical Engg: R. Carrier, S. Murthi , L.P.MurphyMech and Ind Engg: J.Ruberti Elec and Comp Engg: C. Di Marzio, N. Sun (TU) Materials Science and Engg: Vijaya RangariIntegrative Biosciences: Clayton Yates, Timothy Turner(UPRM) Applied Chemistry: Oscar Perales-Perez, Marco
DeJesus, Felix Roman Chemical Engg: Carlos Rinaldi, Madeline TorresMaterials Science: Surinder Singh, Marcelo SuarezVISITING FACULTY MENTORST. Hassan – MGH M. Makrigiorgos- DFCI N. Soukos – Forsyth O. Farokhzad – BWH S. Sengupta – BWH M. Harisinghani – MGH N.Goldberg – BIDMC A. Patri - NCL
Director and PI: Srinivas SridharCo-PIs: Mansoor Amiji , Laura H. Lewis, Carlos Rinaldi, Tamara Floyd-Smith
Dattatri Nagesha (Research Coordinator), Rita Kaderian (Program Coordinator)
Nanoplatforms
• Polymers, lipids, organelles, self-assembling ampiphiles,
• Magnetic nanoparticles
• Quantum dots• Nanoporous
coatings on implants
Characterization toolkit
• Nanoscale Microscopies: SEM, TEM, AFM, STM, NSOM,
• Fluorescence confocal and optical microscopy
• Zeta Potential, SQUID, Coulter
Cellular and Phyiological Mechanisms
• Apoptosis• Delivery to
nucleus, mitochondria or ribosome
• Endocytosis, Cellular uptake
• Gene Silencing• Organ
biodistribution and pharmacokinetics
Medical Challenge
• Photodynamic Therapies
• Image guided drug delivery
• Localized energy delivery
• Nano-enhanced implants
• Nanomedicine Ethics and Policy
The tightly-integrated interdisciplinary team of medical researchers, pharmaceutical scientists, physicists, chemists, and chemical engineers, has an extensive range of expertise to facilitate research on nanomedicine: • Nanotechnology platforms such as polymeric nanoparticles, lipid nanoparticles, metal nanoparticles, and self-
assembling nanosystems, • Synthetic chemistry to design and optimize new strategies for nanoparticle preparation and functionalization, • Cancer diag-nostic and imaging techniques using nano-particles as reporter platforms and contrast enhancing agents, • Therapeutic targeted and intra-cellular drug and gene delivery using nanocarriers, • Nanoparticles for electromagnetic hyper/hypothermia and imaging• Theoretical modeling of nanoparticle processes in biological and medical environments, and of drug and gene delivery, • Clinical diagnosis and therapy of prostate, breast, and liver cancer.
Doctoral Trainees
Engineering
The IGERT Nanomedicine PhD program recruits students from various disciplines (Biology, Chemistry, Physics, Engg, and Pharmaceutical Sciences) to work collaboratively on Nanomedicine related projects. The IGERT Ph.D Trainee will graduate with a Ph.D. degree in their core subject with specialization in Nanomedicine Science and Technology. In Phase – I, 26 Ph.D. students representing 3 colleges and 9 Departments have been trained. IGERT fellows have contributed to excellent research that has resulted in over 50 journal publications , 1 patent approved, 2 patents filed, 15 book chapters, 3 books and over 125 conference presentations and posters. A few representative projects are listed below.
Biology
Chemistry
Pharmaceutical Sciences