Format

H PP G S 96 L

96-well filter plates (2, 6, 20, or 50 µL)

H PP G S 96 L

Miniaturized prepacked columns (50, 200, and 600 µL)

H PP G S 96 L

Bottles of chromatography resins

H PP G S 96 L

Prepacked columns (1 and 5 mL)

H PP G S 96 L

Prepacked columns (4.7 mL with 10 cm bed height)

H PP G S 96 L

Single-use membranes

Single-use, prepacked columns ≥ 1 L

Product name PreDictor plates

PreDictor RoboColumn™ units

Bulk pack HiTrap™ columns HiScreen™ columns

ReadyToProcess adsorbers

ReadyToProcess columns

Application High-throughput screening

High-throughput process development

Batch purification and self-packing

Process development, screening

Method optimization

Process development, clinical manufacturing

Clinical manufacturing

Format guide – For ordering information, visit gelifesciences.com

Guide to modern BioProcess™ chromatography resins

gelifesciences.comGE, the GE Monogram, ÄKTA, BioProcess, Capto, HiTrap, HiScale, HiScreen, MabSelect, MabSelect SuRe, MabSelect Xtra, PreDictor, and ReadyToProcess are trademarks of General Electric Company.RoboColumn is a trademark of Repligen GmbH. All other third-party trademarks are the property of their respective owners. © 2016–2018 General Electric Company. GE Healthcare Bio-Sciences AB, Björkgatan 30, 751 84 Uppsala, SwedenFor local office contact information, visit gelifesciences.com/contact.KA5602281118PO 29231394 AB

Capto Core 700

Capto Core 400

LambdaFabSelect

MabSelect SuRe™ LX

MabSelect SuRe pcc

Fragment containing

kappa light chain

Fragment containing

lambda light chain

A�nity for metal ions

Albumin/ NAD+

enzymes

Cation exchanger

For plasma proteins

Batch processes

Continuous processes

MabSelect Xtra™

MabSelect™

High titers

Low to medium titers

First choice

Limited number of

cycles

Long lifetime/

easy cleaning

Capto Heparin

VIISelect

VIIISelect

IXSelect

Capto Chelating

Capto Blue

Antithrombin III

Factor IX

Blood coagulation

factors

Capture

Capto S

ReadyToProcess™ Adsorber S*

Capto Q

Capto DEAE

PreDictor™ AIEX Screening

Capto S ImpAct

Capto SP ImpRes

Capto Q ImpRes

Capto Q ImpRes

Capto Q

Capto SP ImpRes

Capto S ImpAct

Capto S

ReadyToProcess Adsorber Q*

ReadyToProcess Adsorber S*

ReadyToProcess Adsorber Q*

Anion exchanger

Cation exchanger

Capto Q XP

Intermediate puri�cation

PolishingAnion exchanger

Screen di�erent

IEX resins

Bind/elute mode

Flow-through mode

Weak ion exchanger(when selectivityis unsatisfactory

with Capto Q)

Strongion exchanger

Intermediate puri�cation.

Screen di�erent

HIC resins

Capture

Polishing.Screen

di�erent HIC resins

Intermediate puri�cation

Polishing

Capto Butyl

Capto Butyl ImpRes

Capto Butyl

Capto Phenyl

Capto Phenyl

Capto Phenyl ImpRes

Capto Butyl ImpRes

ReadyToProcess Adsorber Phen*

Capto Phenyl ImpRes

Capto PlasmidSelect

Capto Octyl

PreDictor HIC Screening Low Hydrophobicity

PreDictor Screening High Hydrophobicity

PreDictor Capto HIC Screening

Optimal HIC resin for target protein is

known

Optimal HIC resin for target protein is

known

Bind/elute mode

Flow- through

mode

Capture

Bind/elutemode

Flow- through

mode

Screen di�erent

MM resins

Capto MMC

Capto adhere ImpRes

Capto adhere

Capto adhere ImpRes

Capto MMC ImpRes

Capto MMC ImpRes

Capto MMC

CaptureCapto AVB

KappaSelect

PreDictor Capto AIEX Polishing Screening

PreDictor Capto CIEX Polishing Screening

PreDictor CIEX Screening

IEX selection kit

Capto Core 700

Capto Core 400

MabSelect™ PrismA

MabSelect SuRe

First choice for optimal produc-tivity, cleaning,

and sanitization in continuous and batch processes

For good performance and

assurance

Highselectivity

at broadpH/saltwindow

Capto™ L

Second choice

High-resolution polishingof mAbs

Highselectivity

at broadpH/saltwindow

For largemolecules/

viruses

For largemolecules/

viruses

Forsupercoiled

plasmid DNA†

Postprotein A

puri�cationof mAbs

High-resolutionpolishingof mAbs

For largemolecules/

viruses

Largemolecules

Largemolecules

mAbseparation

mAbseparation

Largemolecules

Highselectivity

at broadpH/saltwindow

Highselectivity

at broadpH/saltwindow

Optimal MM* resin for target protein is

known

Screen di�erent

MM resins

PreDictor Capto AIEX Polishing Screening

PreDictor Capto CIEX Polishing Screening

PreDictor Capto AIEX Polishing Screening

PreDictor Capto CIEX Polishing Screening

Screen di�erent

IEX resins

Cation exchanger

Forrecombinant

proteins

PreDictor Capto AIEX Polishing Screening

PreDictor Capto CIEX Polishing Screening

Largemolecules

For adeno- associated

viruses

For monoclonal antibodies

and Fc fusion proteins

For antibody fragments

Bind/elute mode

Flow-through mode

Screen di�erent

IEX resins

Screen di�erent

HIC resins

Anion exchanger

ACA�nity

chromatographyA�nity

chromatography

IEXIon exchange

chromatography

HICHydrophobic

interactionchromatography

MMMultimodal

chromatography

Save time with integrated design of experiments (DoE)

NOTE! Additional selection of resins are available for most applications.Size exclusion chromatography resins are not covered in this guide to modern resins. For availability please refer to gelifesciences.com/bioprocess

60

5040

30

20

10

pH

11.0

10.8

10.6

10.4

10.2

10.0

RSD = 14.5

20 30 40 50 60NaCl in wash (mM)

Optimize your methods efficiently using the DoE tool integrated into ÄKTA™ avant chromatography system. This feature allows you to plan and automatically run an experimental series that maximizes the amount of information obtained from a minimum number of experiments.

Capture: isolate, concentrate, and stabilize Intermediate: remove bulk impurities Polishing: achieve final high-level purity

* Available in formats from 80 µL to 5 L† Thiophilic aromatic adsorption