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GRAM POSITIVE COCCIerly
•Gram positive and negative bacteria: The cell wall very different:
. Peptidoglycanvery strong,thick and rigid.. Teichoic acid surface
antigen.
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Species cause of human disease:
• Staphylococcus aureus• Streptococcus pneumoniae• Streptococcus pyogenic• ect
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Structure and function
• Capsule antiphagocytosis• Peptidoglycan stimulate production of
endogenous pyrogens• Protein spesific:A,M,F antiphagocytosis,anticomplementary
• Teichoic acid attachment to mucosal
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Pathogenesis and Immunity
The virulence is determined by:a variety of structural molecule and elaborated toxins and enzymes. virulence factors
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• Toxins- Exotoxin : 1. Cytotoxin
2. Enterotoxin food poisoning.resistant to gastric &jejunal enzymes..heat stable.stimulate intestinal
peristaltic
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• Enzymes. Coagulase fibrin layer. Catalase H2O2. Hyaluronidase spreading factors. Lipase . Fibrinolysin. Penicillinase. Ig A protease. Hemolysin : Streptolysin O antigenic
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Important features of pathogenesis
• Staphylococcus aureus1. Pyogenic (abscess)
- local skin infection surgical wound infection
- disseminated sepsis2. Toxigenic food poisoning
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• Staphylococcus epidermidisPyogenic iv catheter sites & prostetic
devices• Staphylococcus saprophyticus
Pyogenic UTI(Urinary Tract Infection )
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• Streptococcus pyogenes1.Pyogenic
. Local : skin,pharing
. Disseminated : sepsis2. Toxigenic3. Immune-mediated(post Streptococcal infection,non suppurative)
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Poststreptococcal diseaseImmunologic response to streptococcal M
protein that cross-react with human tissues.1. Acute Glomerulonephritis
antigen-antibody complexes on glomerular.2. Acute Rheumatic Fever
autoimmune disease
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• Streptococcus pneumoniaePyogenic : . Pneumonia
. Otitis media . Meningitis