Dr. Graham Tipples, Summary CV January 2018
1
Graham Tipples
14008 78th Ave
Edmonton, AB, T5R 3C1
Canada
Education / Certification
BSc (Honors) Biochemistry
1989
University of Manitoba
PhD Medical Microbiology
1994
University of Manitoba
FCCM (Fellow of the Canadian College of Microbiologists)
2006
Clinical microbiology training 2003-6 coordinated through the Department of Medical
Microbiology, University of Manitoba
D(ABMM) (Diplomate of the American Board of Medical Microbiology)
2007
FCCM-ABMM reciprocity agreement
Management Experience
July 2012 - ongoing
Medical / Scientific Director
Provincial Public Health Laboratory, Alberta Health Services
March 2012 – May 2012
Acting Scientific Director General
National Microbiology Laboratory, Public Health Agency of Canada
May 2010 – June 2012
Executive Director
National Microbiology Laboratory, Public Health Agency of Canada
May 2009 – April 2010
Acting Executive Director
National Microbiology Laboratory, Public Health Agency of Canada
2
October 2003 – April 2012
Director, Surveillance and Reference Services
National Microbiology Laboratory, Health Canada / Public Health Agency of Canada
Academic Affiliations
Adjunct Professor (1998-2007); Assistant Professor (2007-2017)
Department of Medical Microbiology, University of Manitoba
Associate Adjunct Professor (2012-2020)
Department of Medical Microbiology and Immunology, University of Alberta
Associate Investigator (2012-ongoing)
Li Ka Shing Institute of Virology, University of Alberta
Research Experience
March 1997 – February 2010
Research Scientist
Chief, Viral Exanthemata Section
National Microbiology Laboratory, Health Canada / Public Health Agency of Canada
Research, surveillance and diagnostics of measles, rubella, human herpes viruses-6/7, and
varicella-zoster viruses
August 1994 - February 1997
Post-doctoral Fellow (Dr DLJ Tyrrell)
Department of Medical Microbiology and Immunology
University of Alberta
Molecular biological studies of hepatitis B virus
July 1989 - July 1994
PhD Student (Dr GA McClarty)
Department of Medical Microbiology
University of Manitoba
Biochemical and molecular biological studies of nucleotide metabolism in Chlamydia
trachomatis
Dr. Graham Tipples, Summary CV January 2018
3
Awards
April 2015, “Canadian College of Microbiologists Distinguished Microbiologist Award, 2015, in
recognition of his outstanding professional contributions to the field of microbiology in the areas
of research, teaching and leadership in furthering microbiology at the national and international
levels.”
June 2005, Deputy Minister’s Award of Team Excellence for implementation of a lab
information management system, Health Canada.
June 2003, Assistant Deputy Minister’s Special Team Excellence Award as part of the Health
Canada response to the 2003 outbreak of SARS, Health Canada.
May 2001, Most Promising Scientist Award, Office of the Chief Scientist, Health Canada.
February 1995 - February 1997, Alberta Heritage Foundation for Medical Research Fellowship
June 1995, Apotex Fermentation Inc Award for Molecular Biology
University of Manitoba Faculty of Medicine Student Research Award
July 1990 - June 1994, Manitoba Health Research Council Studentships
International Activities
"Meeting of experts to discuss the essential data elements for the regional protocol for
documenting and verifying the interruption of endemic measles and rubella transmission in the
Americas", 27-29 August 2008, Washington, DC.
Meetings of the Global Measles/Rubella Laboratory Network, 25-26 August 2005, 28-30 August
2006, 26-28 September 2007, 24-26 September 2008, Geneva, Switzerland.
Steering Committee Member for the "2004 Michigan-Ontario Border Health Conference:
enhancing early warning infectious disease surveillance", 9-10 September 2004, Detroit,
Michigan, USA.
WHO Temporary Advisor for "Standardization of the nomenclature for genetic characteristics of
wild-type rubella viruses" meeting, 2-3 Sepember 2004, Geneva Switzerland.
WHO Temporary Advisor for the "5th Meeting of the WHO Product Development Group for
Measles Aerosol Vaccine", 5-6 April 2004, and the "Consultation on Vaccination Against
Rubella by Aerosol", 7-8 April 2004, Geneva, Switzerland.
PAHO Temporary Advisor for the "Panel of Experts on Rubella Elimination and Measles
4
Eradication in Latin America and the Caribbean", 3-4 March 2004, Washington, DC, USA.
WHO Temporary Advisor for the "4th Meeting of the WHO Product Development Group for
Aerosol Measles Vaccine", Baltimore, USA, June 19, 2003.
Collaboration on WHO measles aerosolized vaccine study, 2003 - 2004.
Collaboration on rubella in pregnancy study in Rio de Janeiro, Brazil, January 2003 - 2005.
Collaboration on measles molecular epidemiology studies in Kenya, Kenyan Medical Research
Institute and WHO/EPI, January 2002 to March 2003.
WHO short-term consultant, measles serology workshop, Laos, May 22-June 2, 2001.
WHO short-term consultant, measles serology workshop, Cambodia, September 8-22, 2000.
WHO Temporary Advisor and Canadian Reference Laboratory Representative for a "Meeting on
preventing congenital rubella syndrome: immunization strategies, surveillance needs", Geneva,
Switzerland, January 12-14, 2000.
WHO short-term consultant to assess measles laboratory surveillance in Pakistan (October 7-16,
1999) and Iran (October 17-24, 1999).
WHO Temporary Advisor for the global measles elimination program meeting -
"Standardization of the nomenclature for the genetic characteristics of wild-type measles",
Geneva, Switzerland, May 26-27, 1998.
Canadian Measles Reference Laboratory Representative for the Pan-American Health
Organization Technical Advisory Group on Vaccine Preventable Diseases Meetings.
Guatemala City, Guatemala, September 8-12, 1997; Ottawa, Canada, April 12-16, 1999;
Iguasu Falls, Brazil, October 2-5, 2000; Mexico City, November 2-6, 2004; Guatemala City,
Guatemala, July 24-27, 2006.
Canadian Measles Reference Laboratory Representative for the 3rd Meeting on Advances in
Measles Control and Elimination. Atlanta, U.S.A., August 27-29, 1997.
Professional Activities
Member of the Alberta Provincial Pediatric Enteric Infection Team (APPETITE) Strategic
Advisory Committee. Multi-disciplinary collaborative (University of Calgary, University of
Alberta, Provincial Laboratory for Public Health (Alberta Health Services)) research project
funded by Alberta Innovates. 2014 – present.
Member of the Association of Public Health Laboratories (APHL) Workforce Development
Dr. Graham Tipples, Summary CV January 2018
5
Committee, July 2016 to June 2017.
Member of the Association of Public Health Laboratories (APHL) subcommittee for the
development of a Doctorate of Public Health (DrPH) course through the University of South
Florida, 2017.
Provincial Co-chair of the Canadian Public Health Laboratory Network (CPHLN), May 2016 –
May 2018.
Team Lead for College of American Pathologists (CAP) assessment of Oregon State Public
Health Laboratory, May 6, 2014.
Lead organizer for the "Severe H1N1 Disease: Preventing Cases, Reducing Mortality"
symposium, Winnipeg, Canada, September 2-3, 2009.
Scientists as Leaders Program
January 2008 - May 2011
Science ADM Advisory Committee in partnership with the Leadership Network of the Public
Service Human Resources Management Agency of Canada (executive management training
includes Direxion program) – Direxion, Gatineau, Quebec, November 17-28, 2008.
ISO17025 Lead Auditor Training Course (RABQSA Certified Quality Management System
Lead Auditor Course with Specific Reference to ISO/IEC 17025), Washington, D.C., November
13-17, 2006.
Invited expert for assessment and consultation of the Newfoundland Provincial Public Health
Laboratory quality system (ISO15189), June 2006.
Invited expert for assessment of the Winnipeg Health Sciences Centre Clinical Microbiology
Laboratory quality system (CAP and ISO15189), June 2005.
Invited laboratory expert for rubella and VZV, Goals and Objectives Consensus Conference for
Vaccine Preventable Diseases, Public Health Agency of Canada, Quebec City, 12-14 June 2005.
Numerous Public Health Agency of Canada committees
NML Director responsible for:
Implementation and maintenance of the ISO17025 and ISO9001 quality systems.
Development, implementation and maintenance of the NML Laboratory Information
Management System (LIMS).
Development and implementation of the Laboratory Liaison Technical Officer program
(LLTO) - PHAC technical staff located in provincial public health labs.
Reference services provided by national external reference centres.
6
Federal Co-chair of the Canadian Public Health Laboratory Network Reference Centre Advisory
Subcommittee, October 2004 - present.
Federal Co-chair of the Canadian Public Health Laboratory Network Laboratory Standardization
Subcommittee, June 2004 - present.
Member of the National Microbiology Laboratory SARS investigation team (March-June 2003)
and the H1N1 swine influenza laboratory response team (April – present 2009).
Member of the Editorial Board of the Journal of Clinical Microbiology, 2001-2009.
Ad hoc reviewer for the Journal of Virological Methods, Journal of Clinical Virology, Journal of
General Virology and Clinical Infectious Diseases.
Ad hoc grant reviewer for the “CIHR Grand Challenges Canada Transition to Scale”, February
2017.
Board member of the Canadian Association for Clinical Microbiology and Infectious Diseases:
Past-President 2008-2010, President 2006 - 2008, Vice-President 2004-2006, Councillor 2002-
2004. Member of the Scientific Planning and Central Planning Committees for the CACMID-
AMMI conjoint conferences 2006-2010. Member of the CACMID Awards and Nominations
Committee, 2017-2019.
Department of Medical Microbiology, University of Manitoba.
Medical Microbiology Visiting Professors Committee (2001-2005).
Chair of the organizing committee for the herpesvirus mini-symposium, Nov’05
Medical Microbiology Residency Training Program Committee (2004-2012)
Acting Director General, National Microbiology Laboratory. January 26 - February 11, 2001;
June 26, 2007; extensively during 2009.
Acting Chief, Division of Viral Diagnostics, National Microbiology Laboratory. Alternating
months beginning October 2000 to June 2001.
Member of the Working Group on Measles Elimination in Canada (WGMEC) and chair of the
WGMEC lab issues subgroup, 1997 to 2000.
Organizer and co-chair of the "Expert Working Group on HHV-6 and 7 Laboratory Diagnosis
and Testing" meeting, Winnipeg, March 7-8, 2000. Coordinated the publication of the meeting
proceedings in the Can Commun Dis Rep 2000;26S4:1-27.
Organizer and chair of the “Expert Working Group on Rubella in Canada” meeting, Winnipeg,
November 22, 2001.
Co-chair of the Occupational Safety and Health Committee for the Virus Building (December
Dr. Graham Tipples, Summary CV January 2018
7
1997 - May 1998) and the Candian Science Centre for Human and Animal Health (June 1998 -
Decmember 1999).
8
Supervision of Graduate Students
David Safronetz, MSc (graduated), Sept 2000 to December 2002. Now working as a Research
Scientist and Section Chief, National Microbiology Laboratory, Public Health Agency of
Canada.
Joanne Hiebert, MSc (graduated), May 2001 to December 2003. Now working as a Biologist,
National Microbiology Laboratory, Public Health Agency of Canada.
Tracie EisBrenner, PhD (graduated), July 2005 – October 2013. Now working as a Biologist,
National Microbiology Laboratory, Public Health Agency of Canada.
Chris Hoban, MSc (graduated), Sept 2006 - May 2008. Entered medical school after completion
of MSc.
Graduate Student Committee Member
Claire Sevenhuysen, MSc candidate (Medical Microbiology), 2002 to 2006.
Lena Shah, MSc candidate (Community Health Sciences), 2004 to 2006.
Publications
Published peer-reviewed manuscripts
Hasing ME, BE Lee, Y Qiu, M Xia, G Tipples, X Jiang, XL Pang. Changes in norovirus
genotype diversity in gastroenteritis outbreaks in Alberta, Canada - an augury? (Submitted to
Journal of Infectious Diseases)
Stang A, M Trudeau, OG Vanderkooi, BE Lee, L Chui, XLi Pang, V Allen, CAD Burnham, DM
Goldfarb, J MacDonald, B Parsons, A Petrich, F Pollari, PI Tarr, G Tipples, R Zhou, SB
Freedman. Diagnostic Interpretation Guidance for Pediatric Enteric Pathogens: a Modified
Delphi Consensus Process. (submitted to BMC Infectious Diseases)
German GJ, M Gilmour, G Tipples, HJ Adam, H Almohri, J Bullard, T Dingle, D Farrell,
G Girouard, D Haldane, L Hoang, PN Levett, R Melano, J Minion, R Needle, SN Patel, R
Rennie, RC Reyes, J Longtin, MR Mulvey. Canadian recommendations for laboratory
interpretation of multiple or extensive drug resistance in clinical isolates of Enterobacteriaceae,
Acinetobacter species and Pseudomonas aeruginosa. Can Commun Dis Rep. 2018;44(1):29-34.
Sikora C, G Tipples, X-L Pang, A Andonov. Hepatitis A virus infection associated with
cannabis use. Can Commun Dis Rep. 2017;43(11):245-6.
Dr. Graham Tipples, Summary CV January 2018
9
Pabbaraju K, S Wong K Gill, K Fonseca, GA Tipples and R Tellier. Simultaneous detection of
Zika, Chikungunya and Dengue viruses by a multiplex real-time RT-PCR assay. J Clin Virol
83:66-7 (2016).
Pabbaraju K, S Wong, SJ Drews, G Tipples and R Tellier. Full genome analysis of enterovirus
D-68 strains circulating in Alberta, Canada. J Med Virol 88:1194-203 (2016).
Hatchette TF, SJ Drews, E Grudeski, T Booth, C Martineau, K Dust, R Garceau, J Gubbay, T
Karnauchow, M Krajden, P Levett, T Mazzulli, R McDonald, A McNabb, S Mubareka, R
Needle, A Petrich, S Richardson, C Rutherford, M Smieja, R Tellier, G Tipples and JJ Leblanc.
Detection of enterovirus D68 in Canadian Laboratories. J Clin Microbiol 53:1748-51 (2015).
Drews SJ, K Simmonds, HR Usman, K Yee, S Fathima, G Tipples, R Tellier, K Pabbaraju, S
Wong, and J Talbot. Characterization of enterovirus activity, including enterovirus D68 in
pediatric patients in Alberta, Canada, in 2014. J Clin Microbiol 53:1042-5 (2015).
Lai FY, DC Dover, B Lee, K Fonseca, N Solomon, SS Plitt, J Jaipaul, GA Tipples, CL Charlton.
Determining rubella immunity in pregnant Alberta women 2009–2012. Vaccine 33:635–641
(2015).
Adachi D, JW Tang, R Lundeberg, G Tipples, CL Charlton and SJ Drews. Comparison of the
IMDx influenza A, influenza B, and respiratory syncytial virus A/B assay on the m2000 platform
with real-time reverse transcriptase PCR assays. J Clin Microbiol 52:4441-2 (2014).
Tang JW, D Adachi, H Gunning, C Marian-Dyer, S Hume, S Taylor, S Haase, L Vicen, M
Benedet, A Chow, M Somerville, M Hicks, and G Tipples. Discrepant HIV results resolved by
human DNA Testing. J Clin Virol 61:311-2 (2014).
Pabbaraju K, R Tellier, S Wong, Y Li, N Bastien, JW Tang, SJ Drews, Y Jang, CT Davis, K
Fonseca and GA Tipples. Full-genome analysis of avian influenza A(H5N1) virus from human,
North America, 2013. Emerg Infect Dis 20;887-891 (2014).
Chow VT, GA Tipples, C Grose. Bioinformatics of varicella-zoster virus: single nucleotide
polymorphisms define clades and attenuated vaccine genotypes. Infect Genet Evol 18:351-6
(2013).
Kruk T, S Ratnam, J Preiksaitis, A Lau, T Hatchette, G Horsman, P Van Caeseele, B Timmons,
and G Tipples. Continuous Monitoring of the Performance of Rubella IgG and Hepatitis B
Surface Antibody Assays Using Trueness Controls: Results of a Multicentre Trial. Clin Vaccine
Immunol 19:1624-1632 (2012).
Wielders CC, RS van Binnendijk, BE Snijders, GA Tipples, J Cremer, E Fanoy, S Dolman, WL
Ruijs, HJ Boot, HE de Melker, SJ Hahné. Mumps epidemic in orthodox religious low-
vaccination communities in the Netherlands and Canada, 2007 to 2009.
10
EuroSurveillance 16(41) (2011).
Tipples GA. Rubella diagnostic issues in Canada. J Infect Dis 204:S659–S663 (2011).
Macey JF, T Tam, T Lipskie, G Tipples, T EisBrenner. Rubella Elimination, the Canadian
Experience. J Infect Dis 204:S585–S592 (2011).
Breuer J, C Grose, P Norberg, G Tipples, Schmid DS. A proposal for a common nomenclature
for viral clades that form the species varicella-zoster virus: summary of VZV Nomenclature
Meeting 2008, Barts and the London School of Medicine and Dentistry, 24-25 July 2008.
J Gen Virol 91:821-8 (2010).
Dallaire F, G De Serres, FW Tremblay, F Markowski, G Tipples. Long-lasting measles outbreak
affecting several unrelated networks of unvaccinated persons. J Infect Dis 200:1602-5 (2009).
Angelini P, F Kavadas, N Sharma, SE Richardson, G Tipples, C Roifman, Y Dror, Y Nofech-
Mozes. Aplastic anemia following varicella vaccine. Pediatr Infect Dis J 28:746-8 (2009).
Bastien N, Bowness D, Burton L, Bontovics E, Winter AL, Tipples G, Minielly D, Gregg B,
Cramer C, Schincariol C, Li Y. Parotitis in a child infected with triple-reassortant influenza A
virus in Canada in 2007. J Clin Microbiol 47:1896-8 (2009).
Hahné, S, J Macey, R van Binnendijk,, R Kohl, S Dolman, Y van der Veen, G Tipples, H Ruijs,
T Mazzulli, A Timen, A van Loon, H de Melker. Rubella outbreak in the Netherlands, 2004-
2005: high burden of congenital infection and spread to Canada. Pediatr Infect Dis J 28:795-800
(2009).
Ota K, V Kim, S Lavi, L Ford-Jones, G Tipples, R Tellier. Vaccine-strain varicella zoster virus
causing recurrent herpes zoster in an immunocompetent 2-year-old. Pediatr Infect Dis J 27:847-
8 (2008).
Leblanc JJ, J Pettipas, RJ Davidson, GA Tipples, J Hiebert, TF Hatchette. Detection of mumps
virus RNA by real-time one-step reverse transcriptase PCR using the LightCycler platform. J
Clin Microbiol 46:4049–4051 (2008).
Hatchette T, GA Tipples, G Peters, J Zhou, Alsuwaidi, T Mailman. Foscarnet salvage therapy
for acyclovir-resistant varicella zoster: report of a novel thymidine kinase mutation and review of
the literature. Pediatr Infect Dis J 27(1):75-7 (2008).
Humar A, D Kumar, M Gray, G Moussa, R Kumar, B Welsh and GA Tipples. A Prospective
Assessment of Cytomegalovirus Immune Evasion Gene Transcription Profiles in Transplant
Patients With Cytomegalovirus Infection. Transplantation 83:1200-6 (2007).
Mubareka S, H Richards, M Gray, GA Tipples. Evaluation of Commercial Rubella IgG Avidity
Assays. J Clin Microbiol 45:231-3 (2007).
Dr. Graham Tipples, Summary CV January 2018
11
Tyler SD, GA Peters, C Grose, A Severini, MJ Gray, C Upton, GA Tipples. Genomic
cartography of varicella-zoster virus: a complete genome based analysis of strain variability
with implications for attenuation and phenotypic differences. Virology 359:447-58 (2007).
Peters GA, SD Tyler, C Grose, A Severini, M Gray, C Upton, GA Tipples. A full-genome
phylogenetic analysis of varicella-zoster virus reveals a novel origin of replication-based
genotyping scheme and evidence of recombination between major circulating clades. J Virol
80:9850-60 (2006).
Rota J, L Lowe, P Rota, W Bellini, S Redd, G Dayan, R van Binnendijk, S Hahné, G Tipples, J
Macey, R Espinoza, D Posey, A Plummer, J Bateman, J Gudiño, E Cruz-Ramirez, I Lopez-
Martinez, L Anaya-Lopez, TH Akwar, S Giffin, V Carrión, AM Bispo de Filippis, A Vicari, C
Tan, B Wolf, K Wytovich, P Borus, F Mbugua, P Chege, J Kombich, C Akoua-Koffi, S Smit, H
Bukenya, J Bwogi, FN Baliraine, J Kremer, C Muller, S Santibanez. Identical genotype B3
sequences from measles patients in 4 countries, 2005. Emerg Infect Dis 12:1779-81 (2006).
Robinson JL, BE Lee, JK Preiksaitis, S Plitt and GA Tipples. Prevention of congenital rubella
syndrome – what makes sense on 2006? Epidemiol Rev 28:81-7 (2006).
Coates AL, G Tipples, K Leung, M Gray, E Louca. How many infective viral particles are
necessary for successful mass measles immunization by aerosol? Vaccine 24:1578-15885 (2006).
Hahné S, J Macey, G Tipples, P Varughese, A King, R van Binnendiijk, H Ruijs, J van
Steenbergen, A Timen, AM van Loon and H de Melker. Rubella outbreak in an unvaccinated
religious community in the Netherlands spreads to Canada. Eurosurveillance Weekly 10(20)
(2005).
Leung K, E Louca, M Gray, G Tipples, AL Coates. Use of the next generation pharmaceutical
impactor for particle size distribution measurements of live viral aerosol vaccines. J Aerosol Med
18(4):414-26 (2005).
Grose C, S Tyler, G Peters, J Hiebert, GW Stephens, WT Ruyechan, W Jackson, J Storlie and
GA Tipples. Complete DNA sequence analyses of the first two varicella-zoster virus
glycoprotein E (D150N) mutant viruses found in North America: Evolution of genotypes with an
accelerated cell spread phenotype. J Virol 78:6799-807 (2004).
Loparev VN, A Gonzalez, M Deleon-Carnes, GA Tipples, H Fickenscher, EG Torfason and DS
Schmid. Global Identification of Three Major Genotypes of Varicella-Zoster Virus: Longitudinal
Clustering and Strategies for Genotyping. J Virol 78:8349-58 (2004).
Tipples GA, M Garbutt, M Gray, PA Rota, and the Canadian Measles Surveillance Program.
Genotyping of measles virus in Canada: 1979 to 2002. J Infect Dis 189 (Suppl. 1):S171-S176
(2004).
12
King A, P Varughese, G DeSerres, G Tipples, J Waters and Members of the Working Group on
Measles Elimination. Measles elimination in Canada. J Inf Dis 189 (Suppl. 1):S236-S242 (2004).
Tipples GA, R Hamkar T Mohktari-Azad, M Gray, G Parkyn and S Ratnam. Evaluation of
rubella IgM serology assays. J Clin Virol 30:233-238 (2004).
Tipples GA, D Safronetz and M Gray. A real-time PCR assay for the detection of varicella-
zoster virus DNA and differentiation of vaccine, wild-type and control strains. J Virol Meth
113:113-6 (2003).
Mbugua F, F Okoth, M Gray, T Kamau, A Kalu, R Eggers, P Borus, J Kombich, A Langat, P
Maritim, J Lesiamon and GA Tipples. Molecular epidemiology of measles virus in Kenya. J
Med Virol 71:599-604 (2003).
Tipples GA, R Hamkar, T Mohktari-Azad, M Gray, G Parkyn, C Head and S Ratnam.
Assessment of measles IgM serology assays. J Clin Microbiol 41:4790-2 (2003).
Safronetz D, M Petric, R Tellier, B Parvez and GA Tipples. Mapping ganciclovir resistance in
human herpesvirus 6 U69 protein kinase. J Med Virol 71:434-9 (2003).
Severini A, C Sevenhuysen, M Garbutt, and G Tipples. Structure of replicating intermediates of
human herpesvirus type 6. Virology 314:443-50 (2003).
Safronetz D, A Humar and GA Tipples. Differentiation and quantification of human herpesvirus
6A, 6B and 7 by real-time PCR. J Virol Methods 112:99-105 (2003).
Walters KA, GA Tipples, MI Allen, LD Condreay, WR Addison and L Tyrrell. Generation of
stable cell lines expressing lamivudine-resistant hepatitis B virus for antiviral-compound
screening. Antimicrob Agents and Chemother 47:1936-42 (2003).
Mehta A, B Conyers, DLJ Tyrrell, KA Walters, GA Tipples, RA Dwek, TM Block. Structure
activity relationship of a new class of anti-hepatitis B virus agents. Antimicrob Agents
Chemother 46:4004-6 (2002).
Tipples GA, GM Stephens, C Sherlock, M Bowler, B Hoy, D Cook and C Grose. A new variant
of varicella-zoster virus. Emerg Infect Dis 8:1504-5 (2002).
Best JM, S O’Shea, G Tipples, N Davies, S Al-Khusaiby, A Krause, L Hesketh, L Jin, G Enders.
Interpretation of rubella serology in pregnancy - pitfalls and problems. BMJ 325:147-8 (2002).
Booth SA, Drebot MA, Tipples GA, Ng LK. Application of DNA Array Technology for
Diagnostic Microbiology. Can J Infect Dis 11:291-294 (2000).
13
Ratnam S, GA Tipples, C Head, M Fauvel, M Fearon, and BJ Ward. Performance of indirect
IgM serology tests and IgM capture assays for laboratory diagnosis of measles. J Clin Microbiol
38:99-104 (2000).
Tipples GA. The public health role for measles surveillance in Canada. Paediatrics and Child
Health 4:43-45 (1999).
Allen MI, M Deslauriers, CW Andrews, GA Tipples, KA Walters, DLJ Tyrrell, N Brown, and
LD Condreay. Identification and characterization of mutations in HBV resistant to lamivudine.
Hepatology 27:1670-1677 (1998).
Drebot MA, and GA Tipples. Application of molecular diagnostics for the surveillance of
hantavirus and measles virus in Canada. Can J Infect Dis 9:71-75 (1998).
Bain VG, NM Kneteman, MM Ma, K Gutfreund, JA Shapiro, KP Fischer, GA Tipples, H Lee,
LD Jewell, and DLJ Tyrrell. Efficacy of lamivudine in chronic hepatitis B patients with active
viral replication and decompensated cirrhosis undergoing liver transplantation. Transplantation
62:1456-1462 (1996).
Tipples GA, MM Ma, KP Fischer, VG Bain, NM Kneteman, and DLJ Tyrrell. Mutation in HBV
RNA-dependent DNA polymerase confers resistance to lamivudine in vivo. Hepatology 24:714-
717 (1996).
Wylie JL, LL Wang, GA Tipples, and GA McClarty. A single point mutation in CTP synthetase
of Chlamydia trachomatis confers resistance to cyclopentenyl cytosine. J Biol Chem 271:15393-
15400 (1996).
Tipples GA, and GA McClarty. Cloning and expression of the Chlamydia trachomatis gene for
CTP synthetase. J Biol Chem 270:7908-7914 (1995).
Tipples GA, and GA McClarty. The obligate intracellular bacterium Chlamydia trachomatis is
auxotrophic for three of the four ribonucleoside triphosphates. Mol Microbiol 8:1105-1114
(1993).
Tipples GA, and GA McClarty. Isolation and initial characterization of a series of Chlamydia
trachomatis selected for hydroxyurea resistance by a stepwise procedure. J Bacteriol 173:4932-
4940 (1991).
McClarty GA, and GA Tipples. In situ studies on the incorporation of nucleic acid precursors
into Chlamydia trachomatis DNA. J Bacteriol 173:4922-4931 (1991).
McKinnon DM, P Spevak, and GA Tipples. Conversion of some azaheterocyclic-acetic esters
and acetonitriles into fused heterocycles. Can J Chem 66:2339-2344 (1988).
14
Book Chapters
Pellett P and GA Tipples. Human herpesviruses 6, 7 and 8. In Manual of Clinical Microbiology,
8th, 9th, 10th and 11th editions. American Society for Microbiology Press, 2003, 2007, 2011 and
2015.
Tipples GA, J Hiebert. Detection of measles, mumps and rubella viruses. In JR Stephenson and
A Warnes (Eds.), Diagnostic Virology Protocols, 2nd edition. Springer Science and Business
Media, 2011. Methods Mol Biol. 2011;665:183-93.
Ma MM, GA Tipples, KP Fischer, and DLJ Tyrrell. Viral Hepatitis. In VL Yu, TC Merigan and
S Barriere (Eds.), Antimicrobial Therapy and Vaccines. Baltimore: Williams and Wilkins, 1999.
Publication as a member of the NML SARS investigation team
Poutanen SM, DE Low, B Henry, et al, the National Microbiology Laboratory and the Canadian
SARS Study Team. Identification of severe acute respiratory syndrome in Canada. N Engl J Med
348:1995-2005 (2003).
Marra MA, SJM Jones, CR Astell, et al. The genome sequence of the SARS-associated
coronavirus. Science 300:1399-1404 (2003).
Abstracts
Ko F, G Tipples, SJ Drews. Identifying optimal turnaround time indicators for respiratory viral
and Bordetella batched testing. Canadian Association of Clinical Microbiology and Infectious
Diseases (CACMID) / Association of Medical Microbiologists of Canada (AMMI) Meeting,
Vancouver, BC, Canada, May 2 – 5, 2018.
Hasing E, R Zhuo, G Tipples, S Freedman, B Lee, X Pang. Emergence of a novel norovirus
GII.P16/GII.2 strain in Alberta, Canada in 2016. Alberta Virology Conference, University of
Alberta, Edmonton, Alberta, June 1-2, 2017.
Hasing E, B Lee, Y Qiu, M Xia, G Tipples, X Jiang, X Pang. Molecular epidemiology of
Norovirus Outbreaks in Alberta, Canada: 2012-2016. DRIvE Day in Laboratory Services &
Pathology, University of Alberta, April 21-22, 2017.
Pabbaraju K, K Gill, K Fonseca, GA Tipples, R Tellier. Detection of Zika, Chikungunya and
Dengue viruses in returning travelers to Alberta, Canada. ASM Clinical Virology Symposium,
Savannah, Georgia, USA, May 7-10, 2017.
15
Pang XL, E Hasing, Y Qiu, G Tipples, BE Lee. Norovirus outbreak in Alberta, Canada – which
strain will win the Indy race?, Canadian Association of Clinical Microbiology and Infectious
Diseases (CACMID) / Association of Medical Microbiologists of Canada (AMMI) Meeting,
Toronto, ON, Canada, May 3 – 6, 2017.
Pang XL, E Hasing, Y Qiu, G Tipples, BE Lee. Norovirus game of thrones in Alberta, Canada.
6th International Calicivirus Conference, Savannah, GA, USA, October 9-13, 2016.
Hinshaw D, R Harrison, K Fonseca, M Joffe, M Lavoie, G Predy, G Tipples, S Tsekrekos.
Follow-up of healthcare workers caring for the first patient diagnosed with avian influenza A
H5N1 in North America. Canadian Public Health Association – Public Health 2016, Toronto,
ON, June 13-16, 2016.
Pang XL, G Tipples, BE Lee. Pre-vaccine group A rotavirus G- and P-genotypes circulating in
Alberta, Canada, from 2004 TO 2015. 32nd Clinical Virology Symposium, Daytona Beach,
USA, May 19-22, 2016.
Harrison R, M Joffe, M Lavoie, K Fonseca, G Tipples, S Tsekrekos, Y Li, D Hinshaw, G Predy,
D Hinshaw. Serologic Follow-up of Healthcare Workers (HCWs) Exposed to Influenza A H5N1.
Canadian Association of Clinical Microbiology and Infectious Diseases (CACMID) /
Association of Medical Microbiologists of Canada (AMMI) Meeting, Vancouver, BC, Canada,
March 30 – April 2, 2016.
Hatchette et al. Detection of Enterovirus D68 in Canadian Laboratories. Canadian Association of
Clinical Microbiology and Infectious Diseases (CACMID) / Association of Medical
Microbiologists of Canada (AMMI) Meeting, Charlottetown, PEI, Canada, April 16 - 18, 2015.
Pabbarajua K, S Wong, SJ Drews, G Tipples, R Tellier. Full genome analysis of Enterovirus D-
68 strains circulating in Alberta, Canada. Canadian Association of Clinical Microbiology and
Infectious Diseases (CACMID) / Association of Medical Microbiologists of Canada (AMMI)
Meeting, Charlottetown, PEI, Canada, April 16 - 18, 2015.
Pabbaraju K, S Wong, P Gordon, R Pon, K Fonseca, J Tang, G Tipples, R Tellier. Full genome
sequencing of a highly pathogeneic avian influenza A (H5N1) virus directly from the
nasopharyngeal swab, bronchoalveolar lavage and cerebrospinal fluid specimens. 30th Clinical
Virology Symposium, Daytona Beach, USA, April 27-30, 2014.
Pabbaraju K, R Tellier, S Wong, Y Li, N Bastien, JW Tang*, SJ Drews, Y Jang, CT Davis, GA
Tipples. The First Reported Case of Avian A/H5N1 Reported in North America. XVI
International Symposium on Respiratory Viral Infections, March 13-16, 2014, Seoul, Republic
of Korea. (oral session presentation by JWT)
Schulz H, J Hiebert, J Beirnes, L Mendoza, GA Tipples, A Severini. Molecular Evolution of
Measles Virus during the 2011 Outbreak in Quebec. Canadian Student Health Research Forum:
16
Manitoba Student Research Poster Presentation, University of Manitoba, Winnipeg, Canada,
June 4, 2013.
Eisbrenner T, A. Shane, S Desai, YA Li, J Macey, T Lipskie, N Khalil, J Isaac-Renton, M Petric,
M. Krajden, Y Chang, K Macdonald, M Naus, V Sahni, K Fonseca, J May-Hadford, C Grant, T
St Jean, L Lachance, S Nolt, L Robberts, L Gilbert, C O’ Keefe, GA Butler, J Beirnes, J Hiebert,
A Severini, S Mukhi, G Tipples. The MARS Pilot Project: Using Laboratory Data To Estimate
The Performance Of National Measles And Rubella Surveillance. Canadian Association of
Clinical Microbiology and Infectious Diseases (CACMID) / Association of Medical
Microbiologists of Canada (AMMI) Meeting, Quebec City, Canada, April 4 - 6, 2013.
Hiebert J, J Beirnes, L Mendoza, H Schulz, S Desai, L Sherrard, GA Tipples, A Severini.
Molecular epidemiology of measles virus in Canada: 2003-2012. Clinical Virology Symposium.
Daytona Beach, USA, April 28 – May 1, 2013.
EisBrenner TL, A Shane, S Desai, YA Li, J Macey, T Lipskie, N Khalil, J Isaac-Renton, M
Petric, M Krajden, K Macdonald, M Naus, V Sahni, S David, D Puddicombe, N Lesnikova, K
Fonseca, J May-Hadford, CS Grant, T St. Jean, L Lachance, SL Nolt, L Robberts, L Gilbert, C
O’Keefe, GA Butler, J Beirnes, J Hiebert, A Severini, SN Mukhi, GA Tipples. Real-time,
integrated measles and rubella surveillance in Canada: Implementation of the MARS pilot
project. 10th Canadian Immunization Conference, Vancouver, Canada, December 3-5, 2012.
Wielders CCH, RS van Binnendijk, BEP Snijders, GA Tipples, J Cremer, E Fanoy, HJ Boot, HE
de Melker, SJM Hahné. Mumps epidemic in an orthodox religious low-vaccination community
in the Netherlands 2007-2009: Assessment of the burden of disease, transmission to vaccinated
individuals, and spread to Canada. 29th Annual Meeting of the European Society for Paediatric
Infectious Diseases, The Hague, The Netherlands, June 7-11, 2011.
Naus M, V Sahni, R Gustafson, E Brodkin, R Parker, M Fyfe, W Osei, M Krajden, M Petric, G
Tipples and Measles Outbreak Group. An Outbreak of Measles in British Columbia, Canada: An
Unwelcome Consequence of the 2010 Winter Olympics. 48th Annual Meeting of the Infectious
Diseases Society of America in Vancouver, British Columbia, Canada on October 21-24, 2010.
Gubbay JB, K Ogbulafor, E Lombos, RR Higgins, R Eshaghi, D Alexander, E Kristjanson, S
Racey, J Maregmen, G Lim, S Patel, J Hiebert, G Tipples, DE Low, S Deeks and T Mazzulli. A
Review of Laboratory Testing During a Mumps Outbreak. 26th Clinical Virology Symposium,
Daytona Beach, USA, April 25-28, 2010.
Lau A, T Hatchette, W Dimech, T Kruk, A Chow, H Gunning, F Sidaway, T Dow, M Dawood,
A Dowling, F Stead, M Roy, K Quinn, G Tipples. The Use of External Reference Controls for
Anti-Rubella IgG and Anti-HBs IgG to Improve Quality Assurance. Public Health Agency of
Canada Research Forum. Winnipeg, Canada, March 17-18, 2009.
Lau A, T Hatchette, W Dimech, T Kruk, A Chow, H Gunning, F Sidaway, T Dow, M Dawood,
A Dowling, F Stead, M Roy, K Quinn, G Tipples. The Use of External Reference Controls for
17
Anti-Rubella IgG and Anti-HBs IgG to Improve Quality Assurance. Clinical Virology
Symposium. Daytona Beach, USA, April 19-22, 2009.
Lau A, T Hatchette, W Dimech, T Kruk, A Chow, H Gunning, F Sidaway, T Dow, M Dawood,
A Dowling, F Stead, M Roy, K Quinn, G Tipples. The Use of External Reference Controls for
Anti-Rubella IgG and Anti-HBs IgG to Improve Quality Assurance. 26th International Congress
of Chemotherapy and Infection and the Canadian Association of Clinical Microbiology and
Infectious Diseases (CACMID) / Association of Medical Microbiologists of Canada (AMMI)
Meeting. Toronto, Canada, June 18-21, 2009.
Higgins RR, E Chong-King, J Hiebert, GA Tipples, SJ Drews. Evaluation of real-time RT-PCR
assays, on the ABI 7900HT platform, for the detection of measles directly in clinical specimens
109th General Meeting of the American Society of Microbiology, Philadelphia, Pennsylvania,
May 17-21, 2009.
Tipples GA. Challenges of diagnostic testing for HHV-6. 6th International Conference on HHV-
6/7, Baltimore, USA, June 19-22, 2008 [invited presentation].
Beirnes J, J Hiebert, C Sevenhuysen, GA Tipples. Genotyping of mumps virus in Canada.
Public Health Agency of Canada Research Forum. Ottawa, Canada, March 17-18, 2008.
Beirnes J, J Hiebert, C Sevenhuysen, GA Tipples. Genotyping of mumps virus in Canada. 24th
Clinical Virology Symposium, Daytona Beach, FL, April 27 - 30, 2008.
Hiebert J, J Beirnes, GA Tipples. Genotyping of measles virus in Canada: 2002-2008. 24th
Clinical Virology Symposium, Daytona Beach, FL, April 27 - 30, 2008.
Hiebert J, J Beirnes, G Tipples. Genotyping of measles virus in Canada: 2002-2008. Canadian
Association of Clinical Microbiology and Infectious Diseases (CACMID) / Association of
Medical Microbiologists of Canada (AMMI) Meeting, Vancouver, Canada, February 27 - March
1, 2008.
Hiebert J, C Fung, C Sevenhuysen, J Beirnes, T Hatchette, G Tipples. Validation of RT-PCR
methods for molecular diagnostics and epidemiology of mumps virus. Canadian Association of
Clinical Microbiology and Infectious Diseases (CACMID) / Association of Medical
Microbiologists of Canada (AMMI) Meeting, Vancouver, Canada, February 27 - March 1, 2008.
Hoban CJ, G Tipples, L Mendoza, B Tan, A McGeer. Presence of varicella-zoster virus and
rubella virus IgG immunoglobulins in WinRho SDF product. Canadian Association of Clinical
Microbiology and Infectious Diseases (CACMID) / Association of Medical Microbiologists of
Canada (AMMI) Meeting, Halifax, Canada, March 14-18, 2007.
Hiebert J, G Tipples. Validation of RT-PCR methods for molecular diagnostics and
epidemiology of measles virus. Canadian Association of Clinical Microbiology and Infectious
18
Diseases (CACMID) / Association of Medical Microbiologists of Canada (AMMI) Meeting,
Halifax, Canada, March 14-18, 2007.
EisBrenner T, GA Tipples, J Beirnes, J Hiebert, GA Peters, SD Tyler, JF Macey. Update on
molecular epidemiology of measles, mumps, rubella and varicella-zoster viruses in Canada. 7th
Immunization Conference, Winnipeg, Canada, December 3-6, 2006. [GT oral presentation]
Humar A, G Tipples, M Gray, G Moussa, B Welsh, S Venkataraman, D Kumar. A prospective
assessment of CMA immune evasion gene expression profiles in transplant patients with CMV
infection. World Transplant Congress. Boston, USA, July 22-27, 2006.
Macey J, S Dolman, GA Tipples. Outbreak of Rubella in southwestern Ontario in 2005;
Challenges for Rubella Elimination in Canada. Pan-American Health Organization Technical
Advisory Group on Vaccine Preventable Diseases Meeting. Guatemala City, Guatemala, July 24-
27, 2006.
Macey J, S Dolman, GA Tipples. Outbreak of Rubella in southwestern Ontario in 2005;
Challenges for Rubella Elimination in Canada. Public Health Agency of Canada Research
Forum. Winnipeg, Canada, March 20-21, 2006.
Peters GA, SD Tyler, C Grose, A Severini, MJ Gray, R Garceau, V Tcherepanov, C Upton, GA
Tipples. Complete genomic analysis of 18 varicella-zoster virus isolates provides insight into
attenuation, recombination and genotyping strategies. Public Health Agency of Canada Research
Forum. Winnipeg, Canada, March 20-21, 2006.
Hahné S, J Macey, Y van der Veen, R van Binnendijk, G Tipples, S Dolman, H Ruijs, A Timen,
AW van Loon, H de Melker. Rubella outbreak in the Netherlands: new rubella genotype spread
to Canada and led to congenital rubella infections. International Conference on
Emerging Infectious Diseases, Atlanta, USA, March 19-22, 2006.
GA Peters, SD Tyler, C Grose, A Severini, MJ Gray, R Garceau, V Tcherepanov, C Upton, GA
Tipples. Complete genomic analysis of 18 varicella-zoster virus isolates: insight into mechanism
of attenuation and genotyping strategies. Canadian Association of Clinical Microbiology and
Infectious Diseases (CACMID) / Association of Medical Microbiologists of Canada (AMMI)
Meeting, Victoria, Canada, March 15-19, 2006.
Lemos XRMR, MM Siqueira, GRS Sá, M Gray, GA Tipples. Evaluation of rubella IgG avidity
maturation over time in pregnant women. Brazilian Meeting of Virology, Brazil, November 22-
25, 2005.
Peters GA, SD Tyler, M Gray, C Grose, GA Tipples. Complete DNA sequence analysis of 11
varicella-zoster virus isolates provides insight into mechanisms of attenuation. 30th International
Herpesvirus Workshop, Turku, Finland, July 30th to August 5, 2005.
19
Mubareka S, GA Tipples, H Richards, M Gray. Evaluation of commercial rubella IgG avidity
assays. Canadian Association of Clinical Microbiology and Infectious Diseases (CACMID) /
Association of Medical Microbiologists of Canada (AMMI) Meeting, in Ottawa, Canada, April
14-17, 2005.
Lemos X, M Siqueira, GRS Sa, M Gray, GA Tipples. Assessment of rubella IgG avidity
maturation in pregnant women. Canadian Association of Clinical Microbiology and Infectious
Diseases (CACMID) / Association of Medical Microbiologists of Canada (AMMI) Meeting, in
Ottawa, Canada, April 14-17, 2005. [GT oral presentation]
Mailman T, T Hatchette, G Peters, J Zhou, GA Tipples. VZV acylcovir resistance. Canadian
Association of Clinical Microbiology and Infectious Diseases (CACMID) / Association of
Medical Microbiologists of Canada (AMMI) Meeting, in Ottawa, Canada, April 14-17, 2005.
[GT oral presentation]
Tipples GA, P van Caeseele, V Loparev, M Dawood, W Mar, T Kruk, M Gray, B Wells, P
Carriere, B Cistarelli and P McCusker. Lab Confirmed Reinfection of Varicella: a Case Study.
Canadian Association for Clinical Microbiology and Infectious Diseases, Regina, Saskatchewan,
November 7-10, 2004. [GT oral presentation]
Grose C, S Tyler, G Peters, J Hiebert, GW Stephens, WT Ruyechan, W Jackson, J Storlie and
GA Tipples. Complete DNA sequence analyses of the first two varicella-zoster virus
glycoprotein E (D150N) mutant viruses found in North America: Evolution of genotypes with an
accelerated cell spread phenotype. 29th Annual International Herpesvirus Workshop, Reno,
Nevada, July 25-30, 2004.
Humar A, D Kumar, D Safronetz and G Tipples. An assessment of herpesvirus co-infections in
patients with CMV disease: correlation with clinical and virologic outcomes. American
Transplant Congress, Boston, May 15-19, 2004.
Tipples GA, MA Drebot, N Bastien, Y Li, S Jones, H Feldmann, A Kabani, T. Booth, A.
Andonov, M Fearon, F Jamieson, J Isaac-Renton, M Krajden, A McNabb, M Petric, F Plummer
and the NML SARS investigation team. Analysis of SARS-associated coronavirus laboratory
testing at the National Microbiology Laboratory (NML). Canadian Association for Clinical
Microbiology and Infectious Diseases, Montreal, Quebec, November 2-5, 2003. [GT oral
presentation]
Tipples GA, R Hamkar, T Mohktari-Azad, M Gray, J Ball, C Head and S Ratnam. Performance
of Rubella IgM Enzyme Immunoassays. Canadian Association for Clinical Microbiology and
Infectious Diseases, Montreal, Quebec, November 2-5, 2003.
Tipples GA, D Safronetz, D Kumar, J Ball and A Humar. Diagnostics of Beta-herpesviruses in
Solid Organ Transplant Patients. Canadian Association for Clinical Microbiology and Infectious
Diseases, Montreal, Quebec, November 2-5, 2003.
20
Tipples GA, D Safronetz and M Gray. Detection and Genotypic Analysis of Varicella-Zoster
Virus by Real-time PCR. Canadian Association for Clinical Microbiology and Infectious
Diseases, Montreal, Quebec, November 2-5, 2003.
Mbugua F, F Okoth, M Gray, T Kamau, A Kalu, R Eggers, P Borus, J Kombich, A Langat, P
Maritim, J Lesiamon and GA Tipples. Molecular epidemiology of measles virus in Kenya. 24th
African Health Sciences Congress, Addis Ababa, Ethiopia, September 28 to October 2, 2003.
Safronetz D, M Petric, R Tellier, B Parvez and G Tipples. Human herpesvirus 6 and resistance
to ganciclovir. Health Canada Research Forum, Ottawa, ON, November 18-19, 2002.
Tipples G, G Parkyn, M Gray, R Hamkar, T Mokhtari-Azad and S Ratnam. Laboratory aspects
of the measles elimination program. Health Canada Research Forum, Ottawa, ON, November
18-19, 2002.
Tipples G, J Hiebert, G Parkyn, G Peters, S Tyler and C Grose. Genomic approaches to studying
varicella-zoster virus: implications for diagnostics and surveillance. Health Canada Research
Forum, Ottawa, ON, November 18-19, 2002.
Tipples G, R. Hamkar, T. Mokhtari-Azad, M. Gray, G. Parkyn, C. Head, and S. Ratnam.
Assessment of IgM enzyme immunoassays for the diagnosis of measles. Canadian Association
for Clinical Microbiology and Infectious Diseases, Halifax, NS, November 3-6, 2002.
Parkyn G and G Tipples. Development of a Recombinant Antigen Based ELISA for the
Detection of HHV-6-specific antibodies. Canadian Association for Clinical Microbiology and
Infectious Diseases, Halifax, NS, November 3-6, 2002.
Safronetz D, M Petric, R Tellier, B Parvez and G Tipples. Possible ganciclovir resistant human
herpesvirus 6 in an infant. Canadian Association for Clinical Microbiology and Infectious
Diseases, Halifax, NS, November 3-6, 2002.
GA Tipples, G Peters, S Tyler, JS Hiebert, G Parkyn, C Grose. Sequencing of the first North
American VZV genome. 27th International Herpesvirus Workshop, Cairns, Australia, July 2002.
S Koesters, G Tipples, M Gray, KR Fowke. Active HHV-6 infection does not correlate with
HIV disease progression in a Kenyan commercial sexworker cohort. 11th Annual Conference on
HIV/AIDS Research, Winnipeg, Manitoba, April, 2002.
Tipples GA, J Hiebert, LE Maranan, D Cook and R Garceau. Varicella-zoster virus genotyping.
Canadian Association for Clinical Microbiology and Infectious Diseases, Victoria, BC,
November 4-8, 2001.
Severini A, M Garbutt and GA Tipples. Structure of replicative intermediates of human
herpesvirus 6. 4th International Conference on Human Herpesviruses 6, 7 and 8, Paris, France,
21
May 10-12, 2001.
Tipples GA, GM Stephens, R Reynolds, C Sherlock, M Bowler, B Hoy, D Cook, M Cossitt and
R Garceau. Clinical varicella-zoster virus isolate with a mutation in the 3B3 monoclonal
antibody epitope of glycoprotein E. 4th International Conference on Varicella, Herpes Zoster and
Post-Herpetic Neuralgia, La Jolla, California, March 3-5, 2001.
Tipples GA, M Gray, M Cossitt, M Song, K Makowski, S Forgie, D Cook and R Garceau.
Genotyping of varicella-zoster virus in Canada: 1900-2000. 4th International Conference on
Varicella, Herpes Zoster and Post-Herpetic Neuralgia, La Jolla, California, March 3-5, 2001.
Varughese P, A King, G Tipples, Working Group on Measles Elimination in Canada. Measles in
Canada: 1990-2000. 4th Canadian National Immunization Conference, Halifax, Nova Scotia,
December 3-6, 2000.
Tipples GA. Differentiation of wild-type and vaccine strain viruses: measles, rubella and
varicella-zoster. 4th Canadian National Immunization Conference, Halifax, Nova Scotia,
December 3-6, 2000.
Tipples GA and SHS Lee. Rubella Lab Diagnostics in a Pregnant Woman: Case Report.
Canadian Association for Clinical Microbiology and Infectious Diseases, Ottawa, Ontario,
November 5-9, 2000.
Tipples GA, GM Stephens, R Reynolds, C Sherlock, M Bowler, B Hoy and D Cook. Detection
of a Clinical Varicella-Zoster Virus with a Mutation in the 3B3 Monoclonal Antibody Epitope.
Canadian Association for Clinical Microbiology and Infectious Diseases, Ottawa, Ontario,
November 5-9, 2000.
Tipples G, Gray M and Garbutt M. Genotyping of measles virus in Canada. Canadian
Association for Clinical Microbiology and Infectious Diseases, 67th Conjoint Meeting,
Edmonton, Alberta, October 31 - November 4, 1999. Can J Infect Dis Sept/Oct 1999, volume 10,
supplement D.
Garbutt M, Gray M and Tipples G. Optimization of HHV-6 culture conditions. Canadian
Association for Clinical Microbiology and Infectious Diseases, 67th Conjoint Meeting,
Edmonton, Alberta, October 31 - November 4, 1999. Can J Infect Dis Sept/Oct 1999, volume 10,
supplement D.
Ratnam S, Tipples G, Head C, Fauvel M, Fearon M and Ward BJ. Performance of measles IgM
enzyme immuno-assays. Canadian Association for Clinical Microbiology and Infectious
Diseases, 67th Conjoint Meeting, Edmonton, Alberta, October 31 - November 4, 1999. Can J
Infect Dis Sept/Oct 1999, volume 10, supplement D.
Tipples G. Molecular epidemiology of measles in Canada. 15th Annual Clinical Virology
22
Symposium, Clearwater Beach, Florida, May 9-12, 1999.
Ratnam S, GA Tipples, C Head, M Fauvel, M Fearon, and BJ Ward. Performance of indirect
IgM serology tests and IgM capture assays for laboratory diagnosis of measles. 13th Meeting of
the PAHO Technical Advisory Group on Vaccine Preventable Diseases, Hull, Quebec, April 12-
16, 1999.
Tipples GA. The Role of clinicians and public health professionals in the laboratory surveillance
of measles in Canada. 3rd Canadian National Immunization Conference, Calgary, Alberta,
December 6-9, 1998.
Walters K, Tipples G, Allen MI, Condreay LD, Tyrrell DLJ. Generation of stable lamivudine-
resistant hepatitis B virus cell lines for antiviral screening. 49th Annual Meeting of the American
Association for the Study of Liver Diseases, Chicago, Illinois, November 6-10, 1998.
Fischer KP, Stickney J, Tipples GA, Tyrrell DLJ. Cloning, sequencing and sequence
comparison of a Canadian isolate of duck hepatitis B virus. Submitted to GenBank, February 8,
1998.
MI Allen, M Deslauriers, CW Andrews, F Baldanti, GA Tipples, KA Walters, DLJ Tyrrell, N
Brown for the lamivudine Development Group, and LD Condreay. Identification and biologic
characterization of mutations in HBV resistant to lamivudine. 48th Annual Meeting of the
American Association for the Study of Liver Diseases, Chicago, Illinois, November, 1997.
MM Ma, GA Tipples, KP Fischer, VG Bain, NM Kneteman, and DLJ Tyrrell. Lamivudine
resistant HBV infection of hepatic allografts: one year follow-up. Canadian Digestive Diseases
Week, Quebec City, Quebec, February 26-March 1, 1997.
Tipples GA, MM Ma, KP Fischer, KS Gutfreund, VG Bain, NM Kneteman, and DLJ Tyrrell.
Mutation in HBV RNA-dependent DNA polymerase confers resistance to lamivudine in vivo.
47th Annual Meeting of the American Association for the Study of Liver Diseases, Chicago,
Illinois, November 8-12, 1996.
Gutfreund KS, KP Fischer, GA Tipples, MM Ma, NM Kneteman, LD Jewell, DLJ Tyrrell, and
VG Bain. Late breakthrough of HBV viremia with lamivudine as a single agent for prevention of
graft reinfection in liver transplantation for cirrhosis secondary to hepatitis B. 47th Annual
Meeting of the American Association for the study of liver diseases, Chicago, Illinois, November
8-12, 1996.
Gutfreund KS, KP Fischer, GA Tipples, MM Ma, VG Bain, NM Kneteman, and DLJ Tyrrell.
Lamivudine results in a complete and sustained suppression of hepatitis B virus replication in
patients requiring orthotopic liver transplantation for cirrhosis secondary to hepatitis B. 46th
Annual Meeting of the American Association for the study of liver diseases, Chicago, Illinois,
November 3-7, 1995.
23
Tipples GA, and GA McClarty. Chlamydia trachomatis are auxotrophic for three of the four
nucleoside triphosphates. Tenth International Meeting of the International Society for STD
Research, Helsinki, Finland, August 29-September 1, 1993.
Tipples GA, and GA McClarty. Chlamydia trachomatis are auxotrophic for three of the four
nucleoside triphosphates. The 92nd General Meeting of the American Society for Microbiology,
New Orleans, Louisiana, May 26-30, 1992.
Tipples GA, and GA McClarty. Deoxynucleotide metabolism in Chlamydia trachomatis. First
European Symposium on Enzymes in Deoxyribonucleotide Synthesis, Les Deux-Alpes, France,
April 6-11, 1991.
McClarty GA, and GA Tipples. Chlamydia trachomatis ribonucleotide reductase: A class I
Enzyme? Eighth Annual Conference on Ribonucleotide Reductase, Uppsala, Sweden, April,
1990.
Reports and Other Publications
Fonseca K, JD Kellner, J Talbot, K Simmonds, M Anselmo, S Kuhn, S Drews, S Fathima, K
Pabbaraju, G Tipples, R Tellier, S Wong. Human Enterovirus 68 - Canada: (Alberta). Promed,
Sept 16, 2014.
Fonseca K, M Lavoie, J Talbot, J Fuller, R Harrison, M Joffe, K Pabbaraju, R Tellier, G Tipples,
S Tsekrekos, S Wong, N Bastien, and Y Li. Avian Influenza, Human (13): Canada ex China
(Beijing, H5N1, Fatal, Case Report. Promed, Jan 11, 2014.
Tipples GA, J Beirnes, J Hiebert, T Hatchette, J Pettipas, J Macey, S Deeks, T Lipskie, W
Bellini, P Rota and J Rota. Laboratory guidelines for the diagnosis of mumps. May 24, 2007
(http://www.nml-lnm.gc.ca/english/mumps.htm).
Tipples GA. Guidelines for Laboratory Diagnosis of Rubella. May 13, 2005.
Tipples GA. Rubella laboratory diagnostics. Can Commun Dis Rep 2002;28S4:14-15.
Tipples GA. (WHO short-term consultant). Mission Report: Measles Laboratory Serology
Workshop, Vientiane, Laos. WHO, Western Pacific Regional Office, May 2001.
Tipples GA. (WHO short-term consultant). Mission Report: Measles Laboratory Serology
Workshop, Phnom Penh, Cambodia. WHO, Western Pacific Regional Office, September 2000.
Tipples GA. Overview of current HHV-6/7 diagnostic methods. Can Commun Dis Rep
2000;26S4:7-8.
24
Varughese P, King A, Tipples GA. Progress towards measles eradication: Canada. PAHO EPI
Newsletter 2000;22(4):1-2.
Tipples GA. Laboratory aspects of the measles elimination program in Canada. Can Commun
Dis Rep 1999;25-5:45-46.
Working Group on Measles Elimination in Canada. Measles surveillance: Guidelines for
laboratory support. Can Commun Dis Rep 1999;25-24:201-216.
Duclos P, Gaulin C and Tipples G (WHO short-term consultants). Review of measles
surveillance activities in Pakistan. WHO, Regional Office for the Eastern Mediterranean,
October 1999.
Tipples G and Featherstone D (WHO short-term consultants). Assessment of measles laboratory
surveillance in the Islamic Republic of Iran. WHO, Regional Office for the Eastern
Mediterranean, October 1999.
Working Group on Measles Elimination in Canada. Measles surveillance: guidelines for
laboratory support. Can Commun Dis Rep 1998;24-5:33-44.
Tipples GA. Measles virus: standardization of genotyping nomenclature. Update: Vaccine-
Preventable Diseases 6(4) (1998).
Morris HM, and GA Tipples. Choosing to write the paper format thesis. J Nursing Education
37:173-175 (1998).
Working Group on Measles Elimination in Canada. Measles surveillance: guidelines for
laboratory support - summary. Update: Vaccine-Preventable Diseases 6(2):13-14 (1998).
Tipples GA. Genotyping of Measles Virus. Update: Vaccine-Preventable Diseases 6(1):6
(1998).
Tipples GA. The Viral Exanthema Laboratory at LCDC. Update: Vaccine-Preventable Diseases
5(3):5 (1997).
Research project funding
Health Canada Biotechnology Funds
“The use of novel recombinant DNA/protein reagents for the development of improved
diagnostic tests for viral diseases”
$137,000 per year for 3 years (1999-2001), $411,000 total
co-investigators: Graham Tipples, Michael Drebot, Heinz Feldmann, Yan Li
Health Canada Biotechnology Funds
25
“DNA chip technology for enhanced surveillance of human pathogens: genotyping and
identification of antimicrobial resistance genes”
$137,000 per year for 3 years (1999-2001), $411,000 total
co-investigators: Graham Tipples, Michael Drebot, Lai King Ng, Mike Mulvey
Health Canada Office of the Chief Scientist Funds
“Assessment of measles diagnostics tests”
$15,000 (2001-2)
primary investigator: Graham Tipples
Health Canada Office of the Chief Scientist Strategic Science Funds
“Genomic sequencing of measles and herpesviruses”
$35,000 (2002-3)
primary investigator: Graham Tipples
Health Canada Biotechnology Funds
“Genomics of infection and immunity”
Sub-project: “Detection of emerging vaccine-induced immune escape mutants”
$186,000 per year for 3 years (2002-5), $558,000
sub-project co-investigators: Graham Tipples, Raymond Tsang, Anton Andonov, Carla Osiowy
WHO product development group for measles aerosol vaccine, research contract
“Evaluation of the ‘Mexican’ aerosol delivery device for measles vaccination”
primary investigator: Allan Coates (Hospital for Sick Children, Toronto)
virology subcontract: Graham Tipples, $20,000 (2004)