The Editor of the Journal of Pharmacology & Experimental Therapeutics wishes to express appreciation to the followingcolleagues who acted as Guest Editors for Specific Fields in 1986.
Martin W. Adler Shri N. Gin Paul L. MunsonLewis Aronow Dora B. Goldstein Larry MuschekMichael A. Beaven Frank R. Goodman Nancy E. OwenC. Paul Bianchi A. James Hance Ronald P. RubinDavid A. Blake Israel Hanin Elaine Sanders-BushDavid B. Bylund Harold F. Hardman Richard ScheifMaynard B. Chenowith Donald Heyneman Lewis E. SeidenTing-Chao Chou Leo E. Hollister Richard E. TesselRonald Y. Chuang Donald J. Jenden Norman J. UretskyTheodore J. Cicero Robert M. Joy Paul M. VanhoutteLeonard Cook Guy C. Le Breton Antonia VernadakisLawrence J. Fischer Ruth R. Levine Martin A. Wasserman
Ray W. Fuller Benedict R. Lucchesi Theodore C. WestGerard L. Gebber K. U. Malik Grant R. WilkinsonJames W. Gibb Donald E. McMillan Henry I. Yamamura
Additionally, sincere thanks are due to 693 of our colleagues not on the Editorial Advisory Board who reviewed articles for theJournal in 1986. Their contributions are acknowledged in the Annual Report of The Journal to the Board of PublicationsTrustees of the American Society for Pharmacology and Experimental Therapeutics.
I 127
INDEX
Volume 241 , April-June, 1987
A23187
leukotriene biosynthesis, coronary arter-ies (dogs, humans), 763
peptidoleukotriene release, lung, high-performance liquid chromatography(guinea pigs), 786
Abernethy, D. R., see Chelly, J. E., 899Acetaminophen
increased liver and kidney damage, obes-ity as risk factor (rats), 921
protein adducts, sensitive immunochemi-cal assay (rabbits), 527
Acetoacetyl coenzyme A thiolase, hypolipi-demic effect, polymethylenemethanethiosulfonates (rats), 1099
AcetylcholineAF64A intraventricular infusion,
changes, synaptic transmission, 181induced vasodilatation, role, endothe-
hum-derived relaxing factor (rab-bits), 516
spontaneous release induced by methyl-mercury, activation of sodium, cal-cium entry (rats), 131
vagal afferent gastric response (cats), 650a1-Acid glycoprotein
enhanced concentration, protein binding,effect of lidocaine (dogs), 289
prazosin elimination (rats), 934Adachi, H., Tomoike, H., Nishijima, H.,
Hayashi, Y., Yamada, A. and Naka-mura M.: Effects of verapamil andnitroglycerin on coronary and sys-temic hemodynamics in consciousdogs, 1072
Adenocarcinoma, lung, disposition,LY256787 and free 4-desacetylvin-
blastine (mice), 695Adenosine
A2 receptor regulation, phosphatidylcho-line secretion, type II pneumocytes(rats), 907
triawloquinazoline, biochemical charac-
terization, 415Adenosine analogs, behavioral and cardio-
vascular effects (monkeys), 76Adenosme triphosphate, P2-purinergic re-
ceptor subtypes, endothelium andsmooth muscle, blood vessels (dogs),
501Adenylate cyclase
activation and binding sites, vasoactive
intestinal peptide, ocular ciliary proc.esses (rabbits), 230
BM 123A effects, heart rate and musca-rinic receptors, myocardium (rab-bits), 804
calmodulin-stimulated, antagonism, tri-
fluoperazine in cerebellar membranes
(rats), 407dietary lipid effects, inotropic responses,
atrium (rats), 838fengabine, effects on cerebral transmis-
sion (rats), 251
parathyroid hormone fragments, calciumtransport, bladder (toads), 448
vasopressin antagonism (monkeys), 797Adrenergic receptors, see AdrenoceptorsAdrenoceptors
a�phaagonist activity, WHR1582A (rats), 97agonist activity of dobutamine, cardiac
output (rats), 861agonists, vasodilator inhibition (dogs),
846postjunctional, differential distribution
(humans), 361pulmonary vasoconstriction, compari-
son (dogs), 6renal, in vivo assessment (rats), 472sensitivity of contraction, receptor a!-
finity (rabbits), 239tissue-dependent activity, buspirone
(rabbits, rats, guinea pigs, dogs), 771
�-1binding in aortas, prazosin (dogs), 875bunazosin, smooth muscle contraction
(rabbits), 1017full and partial agonists, aorta (rab-
bits), 458heterogeneity, brain (rats), 1079, 1092noradrenergic denervation, muscle con-
traction (chicks), 939radioligand binding, potassium efflux
and contraction (rats), 882a�pha-2
anticonvulsant action, muscimol (rats),751
effects of idazoxan, cortical noradrena-line release (rats), 642
noradrenergic suppression, kindling de-velopment (rats), 891
betaagonist8, behavioral effects (rats), 68agonists and antagonists, brain (rats),
755antagonists, alveolar type II pneumo-
cytes, 728antagonists, alveolar type II pneumo-
cytes (rats), 722autoradiographic localization, atrium
(guinea pigs), 1048binding studies, atrium (guinea pigs),
1041dilevalol and, antifibrillatory efficacy
(dogs), 741effect of dietary lipids, inotropic re-
sponses (rats), 838effects of clenbuterol (rats), 187Haemophilus influenzae, trachea
(guinea pigs), 994beta-2, relaxation, isolated human saphe-
nous vein (dogs), 294
effects of antagonists, heart, pheochro-mocytoma (rats), 354
Adrenocorticotropin
release, protein kinase inhibitor, blocked
calcium mobilization, 125
restraint stres8, plasma prolactin re-sponse, nicotine (rats), 438
AF64A, intraventricular infusion, changes
in synaptic transmission, 181AF-DX 116, cardioselective muscarinic an-
tagonist (guinea pigs), 628Ageel, A. M., see Tariq, M., 602Aging
effect, endothelium-mediated relaxation,blood vessels (rats), 387
effect of cimetidine, smoking, theophyl-line and cortisol (humans), 488
Ahlijanian, M. K. and Cooper, D. M. F.:Antagonism of calmodulin-stimu-lated adenylate cyclase by trifluoper-azine, calmidazolium and W-7 in ratcerebellar membranes, 407
Airway, inhalation technique, pharmacoki-netics, cromolyn sodium (humans),1028
Aldosterone, a�pha-1 adrenoceptors, tho-racic aorta, hypertension (rats), 882
Allergy, postanaphylactic phase of inflam-mation, endogenous histamine (rats),967
Alvarado-Garcia, R., see Witkin, J. M., 34Alvares, A. P., see Gondal, J. A., 540Alveolar type II cells, see also Pneumocytes
interactionsbeta adrenergic antagonists, 728beta adrenergic antagonists (rats), 722
Ambrosio, G., see Chiariello, M., 560Amino acids
uptakeparotid gland, lobule system (rats), 655parotid gland, surgical sympathectomy
(rats), 663-y-Aminobutyric acid
fengabineactivity in models, psychopharmacolog-
ical profile (rats), 245effects on cerebral transmission (rats),
251receptor complex, steroid interaction,
structure-activity relationships(rats), 346
tracer-radioactive chloride efflux, cortical
slices (mice), 677Aminoglycosides, induced neuromuscular
blockade, potentiation, protons
(frogs, rats), 686Amitriptyline, antiarrhythmic drugs, use-
dependent effects, cardiac Purkinjefibers (dogs), 282
Amnesia, avoidance behavior, C-terminalfragments, vasopressin and oxytocin(rats), 268
Amphetamine, similar effects, anorectics(pigeons), 817
Amphiphilic drugs, interactions of beta ad-renergic antagonists, alveolar type IIpneumocytes, 728
a-Amylase, amino acid uptake, parotid
gland, lobule system (rats), 655Analgesia
1128 Index
mu opioid receptors, use of $-funaltrex-amine (mice), 374
supraspinal and spinal, mu and detta re-ceptors, (D-Pen2,D-Pen5]enkephalin(mice), 393
Andreasen, F., see Christensen, S., 987Ann, H. S., see Ku, D. D., 961Anorectics, amphetamine-like effects (pi-
geons), 817Antiarrhythmic drugs
lidocaineenhanced a1-acid glycoprotein, protein
binding (dogs), 289interval-dependent effects, cardiac Pur-
kinje fibers (dogs), 275
use-dependent effects, conduction andVmax, cardiac Purkinje fibers (dogs),282
Antibiotics, transport of cefixime, small in-testine, brush-border membrane yes-ides (rats), 594
Anticonvulsant drugs, muscimol, a�pha-2adrenoceptors (rats), 751
Antidepressant drugseffects of clenbuterol and prenalterol, low
response rate, differential reinforce-ment (rats), 68
fengabine, activity in models, psycho-pharmacological profile (rats), 245
Antinociception, levorphanol-induced, se-lective breeding, hot-plate assay
(mice), 477Antiulcer agents, proglumide, cytoprotec-
tive effects (rats), 602
Aorta
alpha-i adrenoceptorscoupling events, full and partial ago-
nists, 458hypertension, thorax (rats), 882prazosin, fl-iodo-[’ThI]-4-hydroxyphenyl-
ethyl-aminomethyl-tetralone (dogs),875
Apelgren, L. D., see Spearman, M. E., 695Apomorphine
acute opiate tolerance, modification of de-velopment, dopamine receptor sensi-tivity (mice), 48
discriminative stimulus, pharmacologicalanalysis (monkeys), 213
Appel, J. B., see Cunningham, K. A., 147Aprindine, cardiac sodium channels, action
potential, ventricular muscles(guinea pigs), 1065
Aquaresis, vaaopressin antagonism (mon-
keys), 797Arachidonic acid, leukotriene biosynthesis,
coronary arteries (dogs, humans), 763Arbilla, S., see Scatton, B., 251Arecoline, nonmuscarinic neurotoxicity, ox-
otremorine (rats), 34Arora, P. K., see Harik, S. I., 669Arteries
digital, postjunctional atpha adrenocep-tors, differential distribution (hu-mans), 361
elastic and muscular, variation in sensi-
tivity, norepinephrine (rabbits), 239
Asano, T., Ikegaki, I., Satoh, S.-!., Suzuki,Y., Shibuya, M., Takayasu, M. andHidaka, H.: Mechanism of action ofa novel antivasospasm drug, HA1077,1033
Aspirin, WHR1582A, gastric antisecretoryand antiulcer effects (rats), 97
Assays
brain slice function, chlorine efflux, �y-
aminobutyric acid (mice), 677enantioselective radioimmunoassay, pen-
tobarbital enantiomers, racemate(humans, rabbits), 779
hot-plate, selective breeding, levorphanol-induced antinociception (mice), 477
immunochemical, acetaminophen-pro-tein adducts (rabbits), 527
Atchison, W. D.: Effects of activation ofsodium and calcium entry on spon-taneous release of acetylcholine in-duced by methylmercury, 131
Atriumbeta adrenoceptors
autoradiographic localization (guinea
pigs), 1048receptor binding studies (guinea pigs),
1041effect of dietary lipids, inotropic re-
sponses (rats), 838left, adaptive supersensitivity, character-
istics (guinea pigs), 453Attention-deficit disorder, children, meth-
ylphenidate, stereoselective disposi-tion, 300
Auranofin, regulation, heme metabolism,liver and kidney (rats), 540
Autoradiography, atpha-1 adrenoceptor het-erogeneity, brain (rats), 1079, 1092
Axons, Myxicola giant, dendrotoxin effects,
potassium and sodium channels, 793
Bache, R. J., see Petein, M., 956Baik, Y. H., see Williams, J. S., 379Balduini, W., Murphy, S. D. and Costa, L.
G.: Developmental changes in mus-
carinic receptor-stimulated phos-phoinositide metabolism in rat brain,421
Balestre, M.-N., see Cory, R. N., 258Balster, R. L., see Beardsley, P. M., 159Balster, R. L., see Rees, D. C., 507
Barbiturates, -y-aminobutyric acid, brainslice functional assay, chlorine efflux(mice), 677
Bar-han, A., see Maren, T. H., 56
Barker, J. L., see Harrison, N. L., 346Barth, T., see Kov#{227}cs,G. L., 569Bartholini, G., see Lloyd, K. G., 245Bartholini, G., see Scatton, B., 251Bay K 8644
characteristics of binding, high and lowaffinity sites, cardiac membranes
(rabbits), 140renin release, kidney cortical slices (rats),
1000
spontaneous release of acetyicholine,methylmercury-induced, sodium ac-tivation and calcium entry (rats), 131
Beardsley, P. M., Balster, R. L. and Salay,J. M.: Separation ofthe response rateand discriminative stimulus effects ofphencyclidine: Training dose as a fac-tor in phencyclidine-saline discrimi-nation, 159
Beardsley, P. M., Scimeca, J. A. and Martin,B. R.: Studies on the agonistic activ-ity of �“-tetrahydrocannabinol in
mice, dogs and rhesus monkeys andits interactions with �9-tetrahytho-cannabinol, 521
Beckeringh, J. J., see IkeZono, K., 294Behavior
Vol. 241
acquisition of conditioned responses, L-PIA (rabbits), 223
avoidance, vasopressin and oxytocin, C-terminal fragments (rats), 268
cardiovascular effects and, adenosine an-alogs (monkeys), 76
discriminative stimulus, apomorphine,pharmacological analysis (monkeys),213
effects of clenbuterol and prenalterol, lowresponse rate, differential reinforce-ment (rats), 68
Belknap, J. K., Danielson, P. W., Laursen,S. E. and Noordewier, B.: Selectivebreeding for levorphanol-induced an-tinociception on the hot-plate assay:Commonalities in mechanism of ac-tion with morphine, pentazocine,ethylketocyclazocine, U-50488H andclonidine in mice, 477
Belpaire, F. M., see De Rick, A. F., 289Bendesky, R. J., see Pendleton, R. G., 110Bennett, T., see Williams, K., 939Benson, R. W., see Roberts, D. W., 527
Benzodiazepine-y-aminobutyric acid, brain slice func-
tional assay, chlorine efflux (mice),677
peripheral-type receptor, interactions ofdiuretics, kidney (rats), 950
Benzphetsmine, amphetamine-like effects,
anorectics (pigeons), 817Berkowitz, B. A., see Ohlstein, E. H., 554Bertko, R., see Willis, R. J., 433Bevan, J. A., see Oriowo, M. A., 239Bevan, R. D., see Oriowo, M. A., 239Beyer, H. S., see Sharp, B. M., 438B-HT 933, a4pha agonists, vasodilator inhi-
bition (dogs), 846Billingham, M. E., see Rosenbaum, J. 5, 354Binapthyl phosphate, enantiomers of threo-
methylphenidate, pharmacology of(rats), 152
1,1-Bis(4-chlorophenyl)-2,2,2-trichloroeth-
ane, free calcium modulation, syn-aptosomes, organochlorine insecti-
cides (rats), 575Bladder, calcium transport, effect, parathy-
roid hormone fragments (toads), 448Blair, I. A., see Thompson, K. A., 84Blood flow
captopril, myocardial infarction and fail-ure (rats), 13
hemodynamic and regional, response topiroximone, congestive heart failure
(dogs), 956hemodynamic effects, isomazole, conges-
tive heart failure (dogs), 20renal a’pha adrenoceptors, in vivo assess-
ment (rats), 472Blood pressure
adenosine analogs, behavioral and cardio-vascular effects (monkeys), 76
central sympathoinhibitory action, ketan-serin, characterization (cats), 736
maintenance of hypertension, sympa-thetic nervous system, pheochromo-cytoma (rats), 870
Blood vesselsendothelium-mediated relaxation, effect
of increasing age (rats), 387postjunctional alpha adrenoceptors, dif-
ferential distribution, limbs (hu-mans), 361
Bloxham, D. P., see Salam, W. H., 1099
1987 Index 1129
Blue, P., see Hank, S. I., 669BM 123A, effects on myocardium, musca-
riitic receptors, adenylate cyclase(rabbits), 804
Bockaert, J., see Cory, R N., 258Bogaert, M. G., see De Rick, A. F., 289Bondy, S. C., see Komulainen, H., 575Bonhaus, D. W., see Platt, K., 751Bowler, J. J., see Wick, P. F., 458Bowling, N., see Hayes, J. S., 861Bower, J. F. and Weiner, N.: Modulation
of the Ca��-evoked release of [3H]dopamine from striatal synapto-
somes by dopamine (D2) agonista
and antagonists, 27Boyajian, C. L, LOUghlin, S. E. and Leslie,
F. M.: Anatomical evidence for alpha-2 adrenoceptor hetemgeneity Differ-ential autoradiographic distributionsof [3H]rauwolscine and [3H]idazoxanin rat brain, 1079
Boyajian, C. L and Leslie, F. M.: Pharma-cological evidence for aipha-2 adre-
noceptor heterogeneity Differential
binding properties of [3Hjrauwol-scine and [3Hjidazoxan in rat brain,1092
Bradykinin, receptor sites, yes deferens(rats, mice, guinea pigs, hamsters),608
Brainalpha-i adrenoceptor heterogeneity, au-
toradiographic distributions (rats),1079, 1092
beta agonista and antagonists, interaction(rats),755
distribution and binding, phenytoin, invitro and in vivo (rats), 704
effect of methamphetamine, neurotensinconcentrations (rats), 443
neurotoxic effects, methylenedioxyme-thylamphetamine (rats, guinea pigs),
338neurotoxicity, 1-methyl-4-phenyl-1,2,3,6-
tetrahydropyridine, mechanisms(rats), 669
opioid receptors, modulation, cannabi-noids (rats), 534
phosphoinositide metabolism, muscarinicreceptor-stimulated, development(rats),421
serotonin uptake sites, in vivo labeling,[3H]-cyanoimipramine (rats), 196
suppression of kindling development, nor-epinephrine, alpha-2 receptors (rats),891
technetium-99m-diethylenetriaminepenta-acetic acid, tyramine neuro-
toxicity (dogs), 42Brandon, D. D., see Kawai, S., 401Braunwalder, A., see Williams, M., 415Breen, T. J., see Bees, D. C., 507Breese, G. it, see Patrick, K. S., 152
Brenner, G. M., see Wince, L C., 838Brodde, O.-E., see Ikezono, K., 294Bronchoconstriction
REV 5901, biochemical and pharmacolog-ical proffle (guinea pigs), 117
U46619-induced, effects of sulfinpyra-zone, platelet activation (humans),623
Brookina, J., see McGonigle, R. J. S., 428Brooks, H. L, see Wynsen, J. C., 846Brtnik, F., see Kov#{225}cs,G. L., 569Brunswick, D. J., see Conway, P. G., 755
Brunswick, D. J., see Wolfe, J., 196Brush-border
cefixime intestinal transport (rats), 594tetraethylammonium transport, effect of
sulfliydryl reagents (rats), 1010Bumol, T. F., see Spearman, M. E., 695Bunazosin, smooth muscle contraction,
proximal uretha (rabbits), 1017Burbach, J. P. H., see de Wied, D., 268Burnstock, G., see Houston, D. A., 501Buspirone, alpha adrenoceptor activity (rab-
bits, rats, guinea pigs, dogs), 771Butler, L. S., see Platt, K., 751Butylpindolol, beta agonists and antago-
fists, interaction, brain (rats), 755Bylund, D. B., see Jones, S. B., 875Bylund, D. B., see Smith, J. M., 882
Caffeineadenosine analogs, behavioral and cardio-
vascular effects (monkeys), 76effects, acquisition, conditioned responses
(rabbits), 223Calcitonin, gene-related peptide, inhibitory
effect on smooth muscles, vas defer-ens (rats), 635
Calciumantagonists, HA1077, pharmacokinetics
(rabbits, dogs, guinea pigs), 1033entry, acetylcholine release, methylmer-
cury (rats), 131entry blockers, enhanced erythropoietin
production, hypoxia (rats), 428free, modulation with synaptosomes, or-
ganochlorine insecticides (rats), 575
glucagon, chronotropic action (rats), 833mobilization, protein kinase inhibitor, an-
terior pituitary tumor cells, 125release of dopamine, striated synapto-
somes, modulation (rats), 27suppression of muscarinic M2 stimula-
tion, histamine H1 receptors, ileum(guinea pigs), 587
transport in bladder, effect, parathyroidhormone fragments (toads), 448
Calcium channelactivator Bay K 8644, characteristics of
binding, cardiac membranes (rab-bits), 140
agonists, ream release, kidney cortical
slices (rats), 1000blockers, correlation, receptor binding
and contractility (rabbits), 91dihydropyridine, role ofendotheium, cor-
onary smooth muscle (porcine), 379Calcium ionophore: see A23187Caldwell, R W., see Patrick, K. S., 152Callahan, P. M., see Cunningham, K. A.,
147Calmidazolium, antagonism, calmodulin-
stimulated adenylate cyclase, cere-bellar membranes (rats), 407
Calmodulinantagonism of adenylate cyclase, trifluo-
perazine, cerebellar membranes(rats), 407
calcium channel agonists, ream release,kidney cortical slices (rats), 1000
Camp, V. M., see Faraj, B. A., 42Canale, E., see Molenaar, P., 1048
Cannabinoidsmodulation, br&a opioid receptors (rats),
534tetrahydrocannabinol, detta-9(11) and
delta-9, agonistic activity (mice, dogs,monkeys), 521
Cannon, P. J., see Piomelli, D., 763Cappelli-Bigazzi, M., see Chiariello, M., 560Captopril, acute regional vascular effects,
myocardial infarction and failure(rats), 13
Carbonic anhydrase, methazola.mide ana-logs, ocular pharmacology (rabbits),56
Cardiac output, alpha agonist activity, do.butamine (rats), 861
Cardiomyopathy, effects of adrenergic re-ceptor antagonists, pheochromocy-toma (rats), 354
Cardiotonics, congestive heart failure,hemodynamic effects, isomazole(dogs), 20
Cardiovascular system, effects, dopamine �-hydrozylase inhibitor (rats), 554
Carter, C., see Dennis, T., 642Casals-Stenzel, J., Muacevic, G. and Weber,
K.-H.: Pharmacological actions ofWEB 2086, a new specific antagonistof platelet activating factor, 974
Cash, W. D., see Williams, M., 415Caster, K. C., see Maren, T. H., 56Catecholamines
AF64A intraventricular infusion,changes, synaptic transmission, 181
alpha-i adrenoceptors, thoracic aorta, hy-pertension (rats), 882
cardiovascular effects, inhibitor, dopa-mine $-hydroxylase (rats), 554
central hyperglycemic action, mechanism,histamine (mice), 582
enantiomers of threo-methylphenidate,pharmacology of (rats), 152
neurotoxicity, methylenedioxymethylam-phetamine, brain (rats, guinea pigs),338
pheochromocytomaadrenergic receptor antagonists, heart
(rats), 354maintenance of hypertension, sympa-
thetic nervous system (rats), 870Caudate nucleus, presynaptic actions of
PCP, in vivo electrochemicalonstration (rats), 714
Cefixime, intestinal transport, brush-bordermembrane vesicles (rats), 594
Central nervous systemalpha adrenoceptor activity (rabbits, rats,
guinea pigs, dogs), 771beta agonists and antagonists, interaction,
brain (rats), 755ketanserin, characterization (cats), 736phenytoin distribution and binding,
brain, in vitro and in vivo (rats), 704Cephalosporin, cefixime intestinal tram-
port, brush-border membrane veal-
des (rats), 594Cerebellum
antagonism, calmodulin-stimulated ade-nylate cyclase, trifluoperazine (rats),407
effects of fengabine (rats), 251interactions of metaphit and phencycli-
dine, sigma agonist (rats), 321Cerebral cortex
inositol phospholipid hydrolysis, acuteand chronic lithium treatments(rats), 1023
noradrenaline release, effects of idazoxan,
1130 Index
presynaptic alpha-2 adrenoceptors
(rats), 642Cerletti, C., see Hatmi, M., 623CGP 28392, renin release, kidney cortical
slices (rats), 1000CGS 13080, phosphodiesterase inhibitor
and, prevention of thrombosis (rab-bits), 855
CGS 15943, biochemical characterization,415
Chang, R. S. L, see Lotti, V. J., 103Chelly, J. E., Hysing, E. S., Abernethy, D.
R., Doursout, M.-F., Hartley, C. J.,Guerret, M. and Merin, R. G.: Roleof isoflurane on hemodynamic prop-erties and disposition of nicardipine,899
Chen, W. Y., see Wince, L. C., 846, 838Wynsen, J. C., Groas, G. J., Brooks,H. L. an, ptor agonists in consciousdogs
Cheng, J. B., Eskra, J. D. and Pillar, J.: Acomparison of antigen and Ca�-ionophore-induced peptidoleuko-
triene release from guinea pig lungpreparations using high-performanceliquid chromatography, 786
Chernow, B., Zaloga, G. P., Malcolm, D.,Wiley, S. C., Clapper, M. and Hola-day, J. W.: Glucagon’s chronotropicaction is calcium dependent, 833
Cherry, P. D. and Gills, C. N.: Evidence forthe role of endothelium-derived re-lazing factor in acetylcholine-in-duced vasodilatation in the intact
lung, 516Chiang, J., see #{248}ie,S., 934Chiariello, M., Ambrosio, G., Cappelli-Bi-
gazzi, M., Nevola, E., Perrone-Fi-lardi, P., Marone, G. and Condorelli,M.: Inhibition of ischemia-inducedphospholipase activation by quina-crine protects jeopardized myocar-
dium in rats with coronary arteryocclusion, 560
Ching, M. S., Mihaly, G. W., Morgan, D. J.,Date, N. M., Hardy, K. J. and Small-wood, R. A.: Low clearance of cime-tidine across the human placenta,1006
Chlordecone, free calcium modulation, syn-aptosomes, organochiorine insecti-cidee (rats), 575
Chlorine, tracer-radioactive efflux, �y-ami-
nobutyric acid, brain slice functionalassay (mice), 677
Chlorisondamine, maintenance of hyper-tension, sympathetic nervous system,pheochromocytoma (rats), 870
2-Chloroadenosine, adenosine A2 receptorregulation, phosphatidylcholine se-
cretion, pneumocytes (rats), 907
1-(2-Chlorophenyl)-1-(4-chlorophenyl)-2,2,2-trichloroethane, free calcium mod-ulation, synaptosomes, organochlo-rime insecticides (rats), 575
Chlorpheniramine, central hyperglycemic
action, mechanism, histamine (mice),582
Chlorphentermine, amphetamine.like ef-fecta, anorectics (pigeons), 817
Cholecystokininendogenous, role, biliary/pancreatic/gas-
tric function (dogs), 110
L-364,718, in uwo pharmacology (mice,
rats, cats, dogs, rabbits), 103Christensen, S., Petersen, J. S., Steiness, E.
and Andreasen, F.: Dose dependenceofproximal and distal tubular effectsof furOsemide in conscious rats, 987
Chromatography
gas, enantiomers of threo-methylpheni-date, pharmacology of (rats), 152
high-performance liquid, peptidoleuko-triene release, lung (guinea pigs), 786
Chrousos, G. P., see Kawai, S., 401Churchill, S., see Kinter, L. B., 797
Cibenzoline, sinoatrial node preparations,electrophysiological study (rabbits),982
Cieslinksi, L. B., see Kopia, G. A., 174Cigarette smoking see SmokingCimetidine
effect of smoking and, theophylline andcortisol, aging (humans), 488
low clearance, human placenta, 1006Clapper, M., see Chernow, B., 833Claustre, Y., see Scatton, B., 251Clenbuterol
effects, central beta-i and beta-2 adrener-gic receptors (rats), 187
effects on performance, low response rate,differential reinforcement (rats), 68
Chine, W. H., Jr., see Yamamoto, R., 826Clineschmidt, B. V., see Lotti, V. J., 103Clineschmidt, B. V., see Pendleton, R. G.,
110Clonidine
levorphanol-induced antinociception, se-lective breeding, hot-plate assay(mice), 477
maintenance of hypertension, sympa-thetic nervous system, pheochromo-cytoma (rats), 870
Clortermine, amphetamine-like effects, an-orectics (pigeons), 817
Cocaine, periarterial nerve stimulation, en-dogenoua norepinephrine release,mesenteric vasculature (rats), 826
Coffin, V. L and Spealman, R D.: Behav-ioral and cardiovascular effects of an-alogs of adenosine in cynomolgusmonkeys, 76
Cohen, M. L, see Pomfret, D. W., 465
Cohn, J. N., see Petein, M., 956Colon
healthy and inflamed, leukotrienes, che-motactic peptide stimulation (rab-bits), 218
L-364,718, in vivo pharmacology (mice,
rats, cats, dogs, rabbits), 103Commins, D. L, Vosmer, G., Virus, R. M.,
Woolverton, W. L, Schuster, C. R
and Seiden, L S.: Biochemical andhistological evidence that methyle.nedioxymethylamphetamine
(MDMA) is toxic to neurons in therat brain, 338
Condorelli, M., see Chiariello, M., 560Conradi, E. C., see Walle, T., 928Contractility, correlation, calcium channel
blockers (rabbits), 91Convulsions, nonmuscarinic neurotoxicity,
oxotremorine (rats), 34Conway, P. G., Tejani-Butt, S. and Brims-
wick, D. J.: Interaction of beta adre-
nergic agonists and antagonists withbrain beta receptors in vice, 755
Cook, C. E., Seltzznan, T. B., Tallent, C. R.,
Vol.241
Lorenzo, B. and Drayer, D. E.: Phar-macokinetics of pentobarbital enan-tiomers as determined by enantiose-
lective radioimmunoaasay after ad-ministration of racemate to humansand rabbits, 779
Cooke, J. P., see Flavahan, N. A., 361Cooper, D. M. F., see Ahlijanian, M. K., 407Corcoran, G. B. and Wong, B. K.: Obesity
as a risk factor in drug-induced organinjury: Increased liver and kidneydamage by acetaminophen in theobese overfed rat, 921
Coronary arteryhemodynamics, verapamil and nitro-
glycerin (dogs), 1072ischemia-induced phospholipase activa-
tion, inhibition, quinacrine (rats),560
leukotriene biosynthesis (dogs, humans),763
leukotriene D4-induced vasoconstriction,inhibition, leukotriene antagonists
(dogs), 174P2-purinergic receptor subtypes, endothe-
lium, smooth muscle (dogs), 501vasorelaxation, magnesium deficiency
(dogs), 961Corticosterone, periarterial nerve stimula-
tion, endogenous norepinephrine re-lease, mesenteric vasculature (rats),826
Corticotropin-releasing factor, protein Id-nasa inhibitor, blocked calcium mo-bilization, anterior pituitary tumorcells, 125
Cortisolskin absorption (mice), 482theophylline and, effect ofcimetidine and
smoking, aging (humans), 488Cory, R. N., Rouot, B., Guillon, G., Slade-
czek, F., Balestre, M..N. and Bock-aert, J.: The 5-hydroxytryptamine (5-HT2) receptor stimulates inositolphosphate formation in intact andbroken WRK1 cells: Determinationof occupancy-response relationshipsfor 5-HT agonists, 258
Costa, E., see Eva, C., 181Costa, E., see Mocchetti, I., 1120Costa, L. G., see Balduini, W., 421Coutts, S., see Van Inwegen, It G., 117Cowart, T. D., see Walle, T., 928Cromolyn sodium, absorption and disposi.
tion kinetics, influence, inhalationtechnique (humans), 1028
C-terminal fragments, vasopressin and ox-ytocin, avoidance behavior (rats), 268
Cunningham, K. A., Callahan, P. M. andAppel, J. B.: Discriminative stimulusproperties of lisUride revisitedi In-volvement of dopamine D2 receptors,147
Cusack, B. J., see Vestal, R. E., 488[3H]-Cyanoimipramine, in vivo labeling, se-
rotonin uptake sites, brain (rats), 196Cyanopindolol
beta adrenoceptorsautoradiographic localization, atrium
(guinea pigs), 1048binding studies, atrium (guinea pigs),
1041Cyclic AMP
adenosine A2 receptor regulation, phos.
1987 Index 1131
phatidylcholine secretion, pneumo-cyt.es(rats), 907
parathyroid hormone fragments, calciumtransport, bladder (toads), 448
protein kinase inhibitor, blocked calcium
mobilization, anterior pituitary cells,125
Cyclic GMPfengabine, effects on cerebral transmis-
sion (rats), 251phorbol ester-induced inhibition, musca-
nc receptors, neuroblastoma cells(mice), 366
Cyclosporine, low-dose, prophylaxis, non.obese diabetic mice, 1106
Cytochrome P-450aromatic phenytoin hydroxylation, star-
eochemistry, phenotypes (humans),
615hepatic metabolism, tolbutaniide, methyl
hydroxylation, 1112
Danielson, P. W., see Belknap, J. K., 477Date, N. M., see Ching, M. S., 1006
Dawson, G. W., see Vestal, R E., 488Debrisoquine, phenytoin hydroxylation,
stereochemistry, phenotypes (hu-mans), 615
Dedek, J., see Scatton, B., 251de Gaetano, G., see Hatmi, M., 623Deilo, C., see De Rick, A. F., 289del Maschio, A., see Hatmi, M., 623Dendrotoxin, potassium channel blockade,
slowed sodium inactivation, Myxicolagiant axons, 793
Denervationnoradrenergic, alpha-i adrenoceptors,
muscle contraction (chicks), 939parotid gland
lobule system, amino acid uptake (rats),655
surgical sympathectomy, amino aciduptake (rats), 663
Dennis, T., L’Heureux, R., Carter, C. andScatton, B.: Presynaptic ajpha-2adrenoceptors play a major role inthe effects of idazoxan on corticalnoradrenaline release (as measuredby in vice dialysis) in the rat, 642
Dennis, T., see Scatton, B., 251Deoxadrol, interactions of metaphit and
phencydidine, sigma agonist actions,cerebellum (rats), 321
Depenbuach, J. W., see Drexler, H., 13Depoortere, H., see Lloyd, K. G., 245Depression, effects of fengabine (rats), 245,
251De Rick, A. F., Belpaire, F. M., Dello, C.
and Bogaert, M. G.: Influence of en-hanced alpha-i-acid glycoproteinconcentration on protein binding,pharmacokinetics and antiar-rhythmic effect of lidocaine in thedog, 289
4-Desacetylvinblastine, LY256787 and, dis-
position (mice), 695Desipromine, dihydroxyphenyiglycol and
intraneuronal metabolism, norepi-nephrine, vas deferens (rats), 547
Deth, R C., see Wick, P. F., 458de Wied, D., Gaffori, 0., Burbach, J. P. H.,
Kov#{227}cs,G. L. and van Rae, J. M.:Structure activity relationship stud-ies with C-terminal fragments of yes-
opressin and oxytocin on avoidancebehaviors of rats, 268
De Wolf, W. E., Jr., see Ohlstein, E. H., 554Dexamethasone
interactions of beta adrenergic antago-
nistsalveolar type II pneumocytes (rats), 722alveolar type II pneumocytes, 728
Diabetes mellitusa-glucohydrolase inhibitor MDL 25,637,
inhibited disaccharidases, blood glu-cose (rats), 915
low-dose cyclosporine, prophylaxis(mice), 1106
streptozotocin-induced, renal handling,netilmicin (rats), 166
Diazepamamphetamine-like effects, anorectics (pi-
geons), 817nonmuscarinic neurotoxicity, oxotremo-
rime (rats), 34Dickson, C. R., see Richards, R., 1028
Dietary fat, effect ofdietary lipids, inotropicresponses, atrium (rats), 838
Diethylenetriamine penta-acetic acid, tyra-mine neurotoxicity (dogs), 42
Diethylpropion, amphetamine-like effects,
anorectics (pigeons), 817Dihydropyridine, calcium channel modula-
tore, role of endothelium, coronarysmooth muscle (porcine), 379
1,4-Dihydropyridine, calcium channel acti-vator, Bay K 8644, binding in cardiacmembranes (rabbits), 140
Dihydroxyphenylglycol, intraneuronal me-tabolism and, norepinephrine, yesdeferens (rats), 547
DiJoseph, J. F., Bash, J. R., and Mir, G. N.:Gastric antisecretory and antiulcereffects of WHR15S2A, a compoundexerting aipha-2 adrenoceptor ago-
fist activity, 97Dilevalol, beta adrenergic receptor blockade,
antifibrillatory efficacy (dogs), 741Diltiazem, Bay K 8644, characteristics of
binding, cardiac membranes (rab-bits), 140
[1-(2,6-Dimethylphenyl)-3-isobutoxyamidi-noureajhydrochloride, WHR1582A,gastric antisecretory and antiulcer ef-
fects (rats), 97Diaaccharidases, intestinal, blood glucose,
a-glucohydrolaae inhibitor (rats), 915Diuretics, interactions, peripheral-type ben-
zodiazepine receptor, kidney (rats),950
Dobutaminealpha agonist activity, cardiac output, iso-
proterenol infusion (rats), 861compared to piroximone, blood flow re-
sponse, congestive heart failure
(dogs), 956Dopamine
AlO, repeated morphine injection, sensi-tization (rats), 204
alpha adrenoceptor activity, comparison,
pulmonary vasoconstriction (dogs), 6enantiomers of threo-methylphenidate,
pharmacology of (rats), 152enkephalin activation, mu opioid receptor
involvement, ventral tegmental area(rats), 328
increased receptor sensitivity, acute opi-ate tolerance, modification of devel-opment (mice), 48
1-methyl-4-phenyl-1,2,3,6-tetrahydropyr-idine neurotoxicity, mechanisms(rats), 669
presynaptic actions of PCP, in vivo dec.trochemical demonstration, caudate
nucleus (rats), 714receptor subtypes, striatal enkephalin
turnover, 1120release from striatal synaptosomes, cal-
cium, modulation (rats), 27Dopamine �-hydroxylaae, inhibitor, cardio-
vascular effects (rats), 554Doursout, M.-F., see Chelly, J. E., 899Drayer, D. E., see Cook, C. E., 779Drexler, H., Depenbusch, J. W., Truog, A.
G., Zelis, R. and Flaiin, S. F.: Acuteregional vascular effects of intrave-nous captopril in a rat model of myo-cardial infarction and failure, 13
Driscoll, E. M., see Lynch, J. J., 741Drug discrimination
apomorphine, pharamcological analysis
(monkeys), 213phencycidine, separation of the response
rate (rats), 159properties of lisuride, involvement, dope-
mine D2 receptors (rats), 147Duckles, S. P., see Hynes, M. R, 387
Duffy, see Kalivas, P. W., 204Duffy, P., see Latimer, L. G., 328
Bash, J. R., see DiJoseph, J. F., 97Egan, J. W., see Smith, E. F. III, 835Ehiert, F. J.: Effects of an alkylating deny-
ative of oxotremorine (BM 123A) onheart nate, muscarinic receptors andadenylate cyclase activity in the nab-bit myocardium, 804
Eiseman, J. L., see Gondal, J. A., 540Eisenhofer, G., Ropchak, T. G., Stull, R. W.,
Goldstein, D. S., Keiser, H. R andKopin, I. J.: Dihydroxyphenylglycoland intraneuronal metabolism of en-dogenous and exogenous norepineph-nine in the nat vas deferens, 547
Electnophysiology
cibenzoline, sinoatnial node preparations(rabbits), 982
interactions of metaphit and phencycli-dine, sigma agonist actions, cerebel-lum (rats), 321
quinidine, comparison, dihydroquinidine(dogs), 84
El-Fakahany, E. E., see Lai, W. S., 366Enantiomers
disposition of methylphenidate, children,attention-deficit disorder, 300
dobutamine, alpha agonist activity, car-diac output (rats), 861
pentobarbital, pharmacokinetica, race-mate (humans, rabbits), 779
pharmacology, threo-methylphenidate
(rats), 152stereochemistry, aromatic phenytoin
hydroxylation, phenotypes (humans),615
Endotheiumcoronary smooth muscle responses, dihy-
dropyridine calcium channel modu-latons (porcine), 379
smooth muscle and, P2-purinergic recep-
ton subtypes, blood vessels (dogs), 501vasorelaxation, coronary arteries, mag-
nesium deficiency (dogs), 961
Endothelium-derived relaxing factor
1132 Index
dihydropyridine calcium channel modu-lators, role of endotheium, coronarysmooth muscle (porcine), 379
effect of increasing age, blood vessels invitro (rats), 387
role, acetylcholine-induced vasodilation,lung (rabbits), 516
Engels, F., Costing, R. S. and Nijkamp, F.P.:Dual effects ofHaemophilus influ-enzae on guinea pig tracheal beta-adrenergic receptor function: In-volvement of oxygen-centered radi-cala from pulmonary macrophages,994
Enkephalinactivation of dopamine neurons, mu
opioid receptor, ventral tegmental
area (rats), 328turnover, dopamine receptor subtypes,
1120Met-Enkephalin, decreased vascular resist-
ance, intra-arterial injection (nab-bits), 314
J�pileptogenesis, suppression of kindling de-velopment, norepinephrine, alpha-2receptors (rats), 891
Epinephnine, effect of dietary lipids, ino-tropic responses, atrium (rats), 838
Epinine, alpha adrenoceptor activity, com-
parison, pulmonary vasoconstniction(dogs), 6
Epithelial cellsalveolar type II
interactions, beta adrenergic receptors(rats), 722
interactions, beta adrenergic receptors,
728membrane, vasoactive intestinal peptide,
ocular ciliary processes (rabbits), 230
Erickson, R., see Ohlstein, E. H., 554Erythropoietin, enhanced production, cal-
cium entry blockers, hypoxia (rats),428
E�kra, J. D., see Cheng, J. B., 786Estradiol, skin absorption (mice), 482Ethylcholine aziridinium ion, changes in
synaptic transmission, intraventric-ular infusion, 181
Ethylketocyclazocine, levorphanol-inducedantinociception, selective breeding,hot-plate assay (mice), 477
Etorphine, analgesic activity, mu receptorinvolvement, �-funaltrexamine(mice), 374
Eva, C., Fabrazzo, M. and Costa, E.:Changes of choinergic, noradrener-gic and serotonergic synaptic trans-mission indices elicited by ethylcho-line azinidinium ion (AF64A) infusedintraventricularly, 181
Evans, S. M. and Johanson, C.-E.: Amphet-amine-like effects of anorectics andrelated compounds in pigeons, 817
Exercise, captopnil, acute regional vasculareffects, myocardial infarction (rats),13
Eyemethazolamide analogs, distribution, ef-
fects on pressure (rabbits), 56ocular ciliary processes, adenylate cyclase
activation, vasoactive intestinal pep-tide (rabbits), 230
Ezekiel, M., see Ohlstein, E. H., 554
Fabisiak, J. P., Vesell, E. S. and Rannels,
D. E.: Interactions of beta adrenergic
antagonists with isolated rat alveolartype II pneumocytes. I. Analysis,characterization and regulation ofspecific betaadrenergic receptors, 722
Fabisiak, J. P., Vesell, E. S. and Rannels,D. E.: Interactions of beta adrenergicantagonists with isOlated rat alveolartype H pneumocytes. II. Receptor-independent accumulation ofbeta ad-renergic antagonists and other cati-omc amphiphilic drugs in lamellarbodies, 728
Fabrazzo, M., see Eva, C., 181Fading, discriminative stimulus effects,
phencycidine (rats), 159Fanestil, D. D., see Lukeman, D. S., 950Faraj, B. A., Schmidt, F. H., Sarper, R.,
Camp, V. M. and Malveaux, E.: Ty-ramine neurotoxicity and first-pass
brain technetium-99m-diethylene-
triamine penta-acetic acid, 42Fatty acids, effect ofdietary lipids, inotropic
responses, atrium (rats), 838Feinmark, S. J., see Piomelli, D., 763Fenfluraniine, amphetamine-like effects,
anorectics (pigeons), 817Fengabine
antidepressant GABAergic agentactivity in models, psychopharmacolog-
ical profile (rats), 245effects on cerebral transmission (rats),
251Fentanyl, analgesic activity, mu opioid re-
ceptor involvement, �-funaltrexam-me (mice), 374
Ferris, R. M., see Patrick, K. S., 152Fetus, cimetidine, low clearance, human
placenta, 1006Fioni, F., see #{248}ie,S., 934Fisher, J. W., see McGomgle, R. J. S., 428Flaim, S. F., see Drexler, H., 13Flavahan, N. A., Cooke, J. P., Shepherd, J.
T. and Vanhoutte, P. M.: Human
postjunctional alpha-i and aipha-2adrenoceptors: Differential distribu-tion in arteries of the limbs, 361
Fleming, W. W., see Hawthorn, M. H., 453Fludzinski, P., see Pomfret, D. W., 465
Flurothyl, stimulus properties, pentobarbi-tel-like (mice), 507
Foley, J. J., see Kopia, G. A., 174Formby, B., Miller, N., Garret, R. and Pe-
terson, C. M.: Effects oflow-dose cy-closponine prophylaxis in nonobesediabetic mice, 1106
Forakolin, left atrium, adaptive supersensi-tivity, characteristics (guinea pigs),453
Francis, J., see Williams, M., 415Fraser, A., see Ordway, G. A., 187Frey, B. M., see Fritz, S., 615Fritz, S., Lindner, W., Roots, I., Frey, B. M.
and Kupfer, A.: Stereochemistry ofaromatic phenytoin hydroxylation invarious drug hydroxylation pheno-types in humans, 615
Fujita, T., see Shebuski, It J., 6Fujiwara, M., see Tsubomura, T., 650$-Funaltrexamine, mu opioid receptor in-
volvement, analgesic activity, opioidligands (mice), 374
Fura-2, free calcium modulation, synapto-somes, organochlonine insecticides
(rats), 575
Vol. 241
FUrOsemide, proximal and distal tubular ef-
fects, dose dependence (rats), 987
G25671, effects of sulfinpyrazone, plateletactivation, U46619 and bronchocon-stniction (humans), 623
GABA, see �y-Azninobutyric acidGaddis, R. R., see Wightman, J. M., 314Gaffney, T. E., see Walle, T., 928Gaffoni, 0., see de Wied, D., 268Gallbladder, L-364,718, in vivo pharmacol-
ogy (mice, rats, cats, dogs, rabbits),103
Gallo-Torres, H. E., see Wills, R J., 433Ganglion, supranodose, gastric excitation,
stimulation ofvagal trunk (cats), 650Gardner, E. J., see Vaysse, P. J.-J., 534Garret, R, see Formby, B., 1106Gas chromatography, see Chromatography
Gastric emptyingL-364,718
in viva pharmacology (mice, rats, cats,dogs, rabbits), 103
role of endogenous cholecystokinin(dogs), 110
Geary, W. A., II, Wooten, G. F., Penn, J.B. and Lothman, E. W.: In vitro andin uwo distribution and binding ofphenytoin to rat brain, 704
Geiger, G., see Rimele, T. J., 771Geilman, R. L, Kallianos, J. A. and Mc-
Namara, J. 0.: Alpha-2 receptors me-diate an endogenous noradrenergicsuppression ofkindling development,891
Gepirone, alpha adrenoceptor activity (nab-bite, rats, guinea pigs, dogs), 771
Gerhardt, G. A., Pang, K. and Rose, G. M.:In vice electrochemical demonstra-
tion of the presynaptic actions ofphencycidine in rat caudate nucleus,714
Gesek, F. A., see Wolff, D. W., 472Ghai, G., see Williams, M., 415Giachetti, A., see Micheletti, R, 628Gibb, J. see Letter, A. A., 443Gilfillan, A. M. and Rooney, S. A.: Func-
tional evidence for adenosine A2 re-ceptor regulation of phosphatidyl-choline secretion in cultured type Hpneumocytes, 907
Gillespie, M. N., Kojima, S., Owasoyo, J. 0.,Tai, H. H. and Jay, M.: Hypoxia pro-yokes leukotriene-dependent neutro-
phil sequestration in perfused rabbithearts, 812
Gillespie, M. N., Moore, C. G., Wright, C.E. and O’Connor, W. N.: Salutaryeffects of prostaglandin E1 in per-fused rat lungs injuredwith hydrogenperoxide, 1
Gus, C. N., see Cherry, P. D., 516Ginsburg, R., see Rosenbaum, J. S., 354Glucagon, calcium, chronotropic action
(rats), 833a-Glucohydrolases, inhibition of intestinal
disaccharidases, suppression, bloodglucose (rats), 915
Glucose, central hyperglycemic action,mechanism, histamine (mice), 582
Glucucorticoid antagonist, RU 486, phar-macokinetic properties (humans),401
Goldberg, L. I., see Woolverton, W. L, 213Goldcompounds, regulation ofheme metab-
1987 Index 1133
olism, monooxygenases, liver andkidney (rats), 540
Goldstein, D. S., see Eisenhofer, G., 547Goods!, J. A., Eiaeman, J. L and Alvares,
A. P.: Regulation of heme metabo-lism and monooxygenases in liverand kidney Influence of therapeuti-cally used gold compounds, 540
Goodman, C., see Wolfe, J., 196Goodwin, R. M., see Spearman, M. E., 695Gordon, R, see Van Inwegen, R. G., 117Goto, K., Kimura, S. and SaitO, A.: Inhibi-
tory effect of calcitonin gene-related
peptide on excitation and contractionof smooth muscles of the rat yes def-erens, 635
Gould, R J., see Letti, V. J., 103Gould, H. J., see Pendleton, R. G., 110Grimes, D., see Rimele, T. J., 771Gross, G. J., see Wynsen, J. C., 846Guanylate cyclase, cyclic GMP formation,
phorbol ester-induced inhibition,
muscarinic receptors (mice), 3665’-Guanylyliznidodiphosphate, left atrium,
adaptive supensensitivity, character-iatic8 (guinea pigs), 453
Guengerich, F. P., see Knodell, R. G., 1112Guerret, M., see Chelly, J. E., 899GUild, S. and Reisine, T.: Molecular mach-
anisms ofcorticotropin-releasing fac-ton stimulation of calcium mobiliza-tion and adrenocorticotropin releasefrom anterior pituitary tumor cells,
125Guillon, G., see Cony, R� N., 258
HA1077, mechanism of action, antivaso-spasm (rabbits, dogs, guinea pigs),1033
Haemophilus influenzae, dual effects, betaadrenoceptors, trachea (guinea pigs),
994Hall, J.,see Kao, J., 482Hall, S. D., see Knodell, R. G., 1112Halopenidol, effect of methamphetamine,
neurotensin concentrations, brain re-gions (rats), 443
Halothane, stimulus properties, pentobar-bital-like (mice), 507
Hanson, G. H., see Letter, A. A., 443
Hanson, H. M., see Lotti, V. J., 103Hardy, K. J., see Ching, M. S., 1006Hank, S. I., Schmidley, J. W., lacofano, L
A., Blue, P., Arena, P. K. and Sayre,L M.: On the mechanisms underly-ing 1-methyl-4-phenyl-1,2,3,6-tetra-hydropynidine neurotoxicity The ef-feet of perinigral infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine, its metabolite and their an-
alogs in the rat, 669Harrington, J. W., see Harrison, N. L., 346
Harris, L T., see McCall, R B., 736Harrison, N. L, Majewska, M. D., Harning-
ton, J. W. and Barker, J. L.: Struc-ture-activity relationships for steroidinteraction with the ‘y-aminobutyricacid� receptor complex, 346
Hartley, C. J, see Chelly, J. E, 899Harvey, J. A., see Whisky, L, 223Hasegawa, J., see Kotake, H., 982Hatmi, M., del Maschio, A., Lefort, J., de
Gaetano, G., Vargaftig, B. B. andCerletti, C.: Effects of sulfinpyrazone
and its metabolite G25671 on platelet
activation and desensitization and onbronchoconstriction induced by theprostaglandin endoperoxide analog
U46619, 623Hawthorn, M. H., Taylor, D. A. and Flem-
ing, W. W.: Characteristics of adap-tive supersensitivity in the leftatrium of the guinea pig, 453
Hayashi, Y., see Adachi, H., 1072Hayes, J. S., see Imai, N., 20Hayes, J. S. and Bowling, N.: Role of the
alpha agonist activity of dobutaminein mediating cardiac output: Effectsof prolonged isoproterenol infusion,861
Heart, see also Myocardium
congestive failureblood flow response, piroximone vs. do-
butamine (dogs), 956hemodynamic effects, isomazole (dogs),
20contractility, HA1077, pharmacokinetic8
(rabbits, dogs, guinea pigs), 1033hypoxic, neutrophil sequestration (nab-
bits), 812intra-artenial injection of met-enkepha-
in, decreased vascular resistance(rabbits), 314
membrane binding, Bay K 8644 (rabbits),140
pheochromocytoma, effects, adrenergicreceptor antagonists (rats), 354
REV 5901, biochemical and pharmacolog-ical profile (guinea pigs), 117
sodium channel blockade, apnindine, yen-tnicular muscles (guinea pigs), 1065
Heart ratebehavioral effects and, adenosine analogs
(monkeys), 76conduction in cardiac Purkinje fibers, li-
docaine, interval-dependent effects(dogs), 275
effects of BM 123A, adenylate cyclase,mu8carinic receptors (rabbits), 804
glucagon and calcium, chronotropic ac-tion (rats), 833
Heaslip, R. J., see Rimele, T. J., 771Heme, metabolism, regulation, gold com-
pounds (rats), 540Hemodynamics
captopril, acute regional vascular effects,myocardial infarction (rats), 13
coronary and systemic, effects, verapamiland nitroglycerin (dogs), 1072
systemic and regional effects, isomazole,congestive heart failure (dogs), 20
Hemoglobin, nitrite conversion to nitric ox-ide, stabilization, 307
Henry, D. E., see Rimele, T. J., 771Heppner, B., see Petein, M., 956Heyman, J. S., see Porreca, F., 393Hidaka, H., see Asano, T., 1033Hinson, J. A., see Roberta, D. W., 527Hippocampua, changes in synaptic trans-
mission, AF64A intraventricular in-
fusion, 181Hirasawa, N., Ohuchi, K., Watanabe, M.
andTsurufuji, S.: Role of endogenoushistamine in postanaphylactic phaseof allergic inflammation in rats, 967
Hirooka, H., see Tsuji, A., 594Histamine
central hyperglycemic action, mechanism(mice), 582
cyclic GMP formation, phonbol ester-in-
duced inhibition, muscaninic recep-
tons (mice), 366endogenous, postanaphylactic phase, al-
lengic inflammation (rats), 967
HL 725, prostacyclin and, prevention of
thrombosis (rabbits), 855Hoffman, B. B., see Prokocimer, P. G., 870
Hoffman, B. B., see Rosenbaum, J. S., 354Holaday, J. W., see Chernow, B., 833
Holgate, S. T., see Richards, R., 1028Hood, W. B., Jr., see Imai, N., 20Hori, R., Maegawa, H., Okano, T., Takano,
M. and Inui, K.-!.: Effect of sulihy-dryl reagents on tetraethylammon-ium transport in rat renal brush ben-den membranes, 1010
Houston, D. A., Burnstock, G. and Van-houtte, P. M.: Different P2-purinergicreceptor subtypes on endotheliumand smooth muscle in canine bloodvessels, 501
Hubbard, J. see Srinivas, N. R, 300
Huffman, W., see Kinter, L. B., 797Hugman, L. E., see Wince, L C., 838Huidobro-Toro, J., see Llona, I., 608Hydralazine, pheochromocytoma, effects on
heart, adrenengic receptor antago-iiists (rats), 354
Hydrogen peroxide, inducedlung injury, sal-utary effects, prostaglandin E1 (rats),1
5-Hydroxylkynurenamine, interaction with1-kynurenine and kynurainine, mul-tiple serotonin receptors, smoothmuscle (rats, guinea pigs), 465
5-Hydroxytryptamine, see SerotoninHynes, M. D., see Zimmerman, D. M., 374Hynes, M. R. and Duckles, S. P.: Effect of
increasing age on the endothelium-mediated relaxation of rat blood yes-sels in vitro
Hyperglycemia, mechanam, histamine(mice), 582
Hypertensioncardiovascular effects, inhibitor, dopa-
mine 13-hydroxylase (rats), 554
mantenance of, sympathetic nervous sys-tam, pheochnomocytoma (rats), 870
Hypoxiaenhanced enythropoietin production, cal-
cium entry blockers (rats), 428neutrophil sequestration, leukotrienes
(rabbits), 812Hysing, E. S., see Chelly, J. E., 899
lacofano, L. A., see Hank, S. I., 669
Ibopamine, alpha adrenoceptor activity,comparison, pulmonary vasocon-striction (dogs), 6
Ibotenic acid, cortical noradrenaline release,effects of idazoxan, presynaptic a!-pha-2 adrenoceptors (rats), 642
IC! 118,551, beta-2 adrenoceptor, relaxation,isolated human saphenous vein(dogs), 294
Idazoxanalpha-i adrenoceptor heterogeneity, brain
(rats), 1079, 1092cortical noradrenaline release, role, pro-
synaptic a4,ha-2 adrenoceptors(rats), 642
Ikegaki, I., see Asano, T., 1033Ikezono, K., Zerkowski, H.-R., Beckeningh,
J. J., Michel, M. C. and Brodde, 0.-
E.: Beta-2 adrenoceptor-mediated re-
1134 Index
laxation ofthe isolated human saphe-nous vein, 294
Ileum, suppression, muscaninic M2 stimula-tion, histamine H1 receptors (guineapigs),587
Imai, N., Liang, C.-S., Stone, C. K., Hayes,J. S. and Hood, W. B., Jr.: Systemicand regional hemodynamic effects ofisomazole in awake dogs with conges-tive heart failure, 20
Imidazolines, alpha-i adrenergic coupling,full and partial agonists, aorta (nab-bits), 458
Indolalkylamines, AF64A intraventricular
infusion, changes, synaptic tranamis-sion, 181
Inhalants, stimulus properties (mice), 507
Inhalation, absorption and disposition Id-netics, cromolyn sodium (humans),1028
Inositol phosphate, stimulation, serotoninreceptor, WRK1 cells, 258
Inositol phospholipid hydrolysis, acute andchronic lithium treatments, cerebralcortex (rats), 1023
Insulin, low-dose cyclosporine, prophylaxis,nonobese diabetic mice, 1106
Intestinesinhibition of disaccharidases, blood glu-
cose, a-glucohydrolase inhibitor(rats), 915
small, transport ofcefixime, brush-bordermembrane vesicles (rats), 594
Inui, K.-!., see Hori, R., 1010�-Iodo-[’�IJ.-4-hydroxyphenyl-ethyl-amino-
methyl-tetralo ne, alpha-i adreno-
ceptor binding, aortas (dogs), 875Isapirone, alpha adrenoceptor activity (rab-
bits, rats, guinea pigs, dogs), 771Ishii, K. and Kato, R.: Suppression by mus-
carinic M2 stimulation of the con-tractile mechanism via histamine H1receptors in the longitudinal muscleof guinea pig ileum, 587
Isoamyl nitrite, stimulus properties, pento-barbital-like (mice), 507
Isoflurane, hemodynamic properties, dispo-sition, nicardipine (dogs), 899
Isomazole, hemodynamic effects, congestiveheart failure (dogs), 20
Isoproterenol
effect of dietary lipids, inotropic re-sponses, atrium (rats), 838
effects of clenbuterol, central beta-i andbeta-2 adrenergic receptors (rats),187
effects ofprolonged infusion, dobutamine,cardiac output (rats), 861
left atrium, adaptive supersensitivity,characteristics (guinea pigs), 453
Itoh, T., see Kimoto, Y., 1017Itoh, Y., see Nishibori, M., 582Izb#{233}ki,F., see Kov#{233}cs,G. L., 569
Jani8, R. A., see Sarmiento, J. G., 140Jay, M., see Gillespie, M. N., 812Johanson, C.-E., see Evans, S. M., 817Jolly, S., see Van Inwegen, R. G., 117Jones, A. W., see Jones, S. B., 875Jones, A. W., see Smith, J. M., 882
Jones, S. B., see Smith, J. M., 882Jones, S. B., Smith, J. M., Jones, A. W. and
Bylund, D. B.: Alpha-i adrenergic re-cepton binding in aortas from rat anddog Comparison of [3H]prazosin and
aminomethyl-tetralo ne, 875Jordan, S., see Bees, D. C., 507
Josepovitz, C., see Pastoniza-Munoz, E., 166Jost, K., see Kov#{227}cs,G. L., 569
Kaliyas, P. W., see Latimer, L. G., 328
Kalivas, P. W. and Duffy, P.: Sensitizationto repeated morphine injection in therat: Possible involvement of AlO do-pamine neurons, 204
Kallianos, J. A., see Gellman, R L, 891Kaloyanides, G. J., see Pastoniza-Munoz, E.,
166
Kamien, J. B., see Woolverton, W. L., 213Kao, J. and Hall, J.: Skin absorption and
cutaneous first pass metabolism oftopical steroids: in Vitro studies withmouse skin in organ culture, 482
Kato, R., see Ishii, K., 587Katnitzky, A. R., see Maren, T. H., 56Kawai, S., Nieman, L. K., Brandon, D. D.,
Udelsman, R, Loriaux, D. L. andChrousos, G. P.: Pharmacokineticproperties of the antiglucocorticoidand antiprogesterone steroid RU 486in man, 401
Keiser, H. R, see Eisenhofer, G., 547
Kendall, D. A. and Nahorski, S. R: Acuteand chronic lithium treatments influ-ence agonist and depolarization-stimulated inositol phospholipid hy-drolysis in rat cerebral cortex, 1023
Ketanserin, central sympathoinhibitory ac-tion, characterization (cats), 736
Keung, A. C., see Wick, P. F., 458Khandwala, A., see Van Inwegen, R G., 117Kidney
alpha adrenoceptors, in vivo assessment(rats), 472
brush border membranes, tetraethylam-monium transport, sulfhydryl re-agents (rats), 1010
drug toxicity, acetaminophen, obesity(rats), 921
interactions of diuretics, peripheral-typebenzodiazepine receptor (rats), 950
netilmicin, streptozotocin-induced diabe-tea mellitus (rats),166
propranolol metabolism in smokers,clearance of metabolites (humans),928
proximal and distal tubular effects, dose
dependence, furosemide (rats), 987regulation of heme metabolism, gold corn-
pounds (rats), 540renin release from cortical slices, calcium
channel agonists (rats), 1000Kim, M. B., see Wang, Y., 321Kimoto, Y., Nozaki, M. and Itoh, T.: Actions
of the alpha-i adrenoceptor blockerbunazosin on the norepinephrine-in-duced contraction of smooth musclesin the rabbit proximal urethra, 1017
Kimuna, S., see Goto, K., 635Kindling, noradrenergic suppression of de-
velopment, alpha-2 receptors (rats),891
Kinten, L. B., Churchill, S., Stamen, F. L.,Moore, M. and Huffman, W.: Vase-
pres8in antagonism in the squirrelmonkey (Saimiri sciureus), 797
Knisely, J. S., see Rees, D. C., 507Knodell, R. G., Hall, S. D., Wilkinson, G.
R. and Guengerich, F. P.: Hepatic
Vol. 241
metabolism of tolbutamide: Charac-terization of the form of cytochrome
P.450 involved in methyl hydroxyl-ation and relationship to in vivo dis-
position, 1112Koch, W. J., see Williams, J. S., 379Kodama, I., Toyama, J. and Yamada, K.:
Competitive inhibition of cardiac so-chum channels by aprindine and li-docaine studiedusinga maximum up-stroke velocity of action potential inguinea pig ventricular muscles, 1065
Kojima, S., see Gillespie, M. N., 812Kornulainen, H. and Bondy, S. C.: Modula-
tion of levels of free calcium within
synaptosomes by organochlorine in-secticides, 575
Kopia, G. A., Valocik, R. E., Torphy, T. J.,Cieslinksi, L. B., Sarau, H. M., Foley,J. J. and Wasserman, M. A.: Inhibi-tion of leukotriene D4-induced coro-nary vasoconstriction by leukotrieneantagonists in the anesthetized dog,174
Kopin, I. J., see Elsenhofer, G., 547Kotake, H., Matsuoka, S., Ogino, K., Tak-
ami, T., Hasegawa, J. and Mashiba,H.: Electrophysiological study of ci-benzoline in voltage-clamped rabbitsinoatrial node preparations, 982
Kov#{226}cs,G. L., Sarnyai, Z., IZb#{233}ki,F., Szab#{243},
G., Telegdy, G., Barth, T., Jost, K.and Brtnik, F.: Effects of oxytocin-related peptides on acute morphinetolerance: Opposite actions by oxy-tocin and its receptor antagonists,569
Kov#{227}cs,G. L, see de Wied, D., 268
Kreider, M. S., see Wolfe, J., 196
Kruse, L I., see Ohistein, E. H., 554
Kruszyna, H., see Kruszyna, R., 307Kruszyna, It, Kruszyna, H., Smith, R P.,
Thron, C. D. and Wilcox, D. E.: Ni-trite conversion to nitric oxide in redcells and its stabilization as a nitro-
sylated valency hybrid of hernoglo-bin, 307
Ku, D. D. and Ann, H. S.: Magnesium defi-ciency produces endothelium-de-pendent vasorelaxation in caninecoronary arteries, 961
Kupfer, A., see Fritz, S., 615Kurahashi, K., see Tsubornura, T., 650
Kurtzman, N. A., see Sabatini, S., 448Kynuramine, interaction with 5-hydroxy-
kynurenamine and 1-kynurenine,
multiple serotonin receptors, smoothmuscle (rats, guinea pigs), 465
L-364,718in vice pharmacology (mice, rats, cats,
dogs, rabbits), 103role of endogenous cholecystokinin,
biliary/pancreatic/gastric function
(dogs), 110Labetalol, antifibnillatory efficacy, beta ad-
renergic receptor blockade, methyl-scopolamine (dogs), 741
Lai, W. S. and El-Fakahany, E. E.: Phorbolester-induced inhibition of cyclicGMP formation mediated by musca-rinic receptors in murine neuroblas-toma cells, 366
Lamellar bodies, interactions of beta adre-
1987 Index 1135
nengic antagonists, alveolar type IIpneumocytes, 728
Langer, S. Z., see Scatton, B., 251Langerhans cells, low-dose cyclosporine,
prophylaxis, nonobese diabetic mice,1106
Latimer, L G., Duffy, P. and Kalivas, P.W.: Mu opioid receptor involvementin enkephalin activation of dopamineneurons in the ventral tegmentalarea, 328
Laursen, S. E., see Belknap, J. K., 477Leander, J. D., see Zimmerman, D. M., 374LeDuc, L E., see Zipser, R D., 218Lee, D. K. H., see Rimele, T. J., 771Lee, M. A., see Witkin, J. M., 34Lefort, J., see Hatmi, M., 623Leslie, F. M., see Boyajian, C. L., 1079,1092Letter, A. A., Merchant, K., Gibb, J. W. and
Hanson, G. it: Effect of methamphe-tamine on neurotensin ooncentra-tions in rat brain regions, 443
Leukotniene B4, neutrophil sequestration,hypoxic hearts (rabbits), 812
Leukotriene C4, salutary effects of prosta-glandin E1, hydrogen peroxide-in-duced lung injury (rats), 1
Leukotniene D4antigen and calcium ionophore-induced
release, comparison, lung (guinea
pigs), 786induced coronary vasoconstriction, inhi-
bition, leukotniene antagonists(dogs), 174
REV 5901, biochemical and pharmacolog-ical profile (guinea pigs), 117
Leukotrienes
biosynthesis, coronary arteries (dogs, hu-mans), 763
chemotactic peptide stimulation, healthyand inflamed colons (rabbits), 218
Levine, A. S., see Sharp, B. M., 438Levorphanol, induced antinociception, se-
lective breeding, hot-plate assay(mice), 477
Levy, G., see Ramzan, I. M., 236Lewis, H. A., see Richards, H., 1028L’Heureux, R, see Dennis, T., 642Liang, C.-S., see Imal, N., 20Lidocaine
antiarrhythmic drugs, use-dependent ef-fects, cardiac Purkinje fibers (dogs),
282cardiac sodium channels, block by aprin-
dine, ventricular muscles (guinea
pigs), 1065
enhanced a1-acid glycoprotein concentra-tion, protein binding, antiarrhythmic
effect (dogs), 289interval-dependent effects, conduction,
cardiac Purkinje fibers (dogs), 275Ligands
alpha-i adrenoceptor binding, aortas
(dogs), 875analgesic activity, mu receptor involve-
ment, �1-funaltrexamine (mice), 374Lindner, W., see Fritz, S., 615Lipids, unsaturated fat diet, inotropic re-
spouses, atrium (rats), 838Liposomes, calcium mobilization, protein
kinase inhibitor, anterior pituitary
tumor cells,125Lipoxygenase
leukotriene biosynthesis, coronary arter-ies (dogs, humans), 763
neutrophil sequestration, hypoxic hearts(rabbits), 812
Lisuride, discriminative stimulus proper-ties, dopamine D2 receptors (rats),147
Lithium, inositol phospholipid hydrolysis,cerebral cortex (rats), 1023
Liu, P. S., see Rhinehart, B. L., 915Liver
drug toxicity, acetaminophen, obesity
(rats), 921experimental disease, neurotoxicity, the-
ophylline (rats), 236metabolism of tolbutamide, methyl hy-
droxylation, 1112regulation of heme metabolism, gold corn-
pounds (rats), 540unbound prazosin elimination, a1-acid
glycoprotein (rats), 934Llona, I., Vavrek, R., Stewart, J. and Hui-
dobro-Toro, J. P.: Identification ofpro- and postsynaptic bradykinin re-ceptor sites in the vas deferens: Evi-dance for different structural prereq-
uiaites,608Uoyd, K. G., see Scatton, B., 251lloyd, K. G., Zivkovic, B., Sanger, D., Dc-
poortere, H. and Bartholini, G.: Fen-gabine, a novel antidepressant GA-BAergic agent. I. Activity in modelsfor antidepressant drugs and psycho-pharmacological proffle, 245
Lorenzo, B., see Cook, C. E., 779
Loriaux, D. L., see Kawai, S., 401Lothman, E. W., see Geary, W. A., II, 704Lotti, V. J., Pendleton, R. G., Gould, R. J.,
Hanson, H. M., Chang, R S. L andClineschmidt, B. V.: In vivo phar-macology of L-364,718, a new potentnonpeptide peripheral cholecystoki-nin antagonist, 103
Loughlin, S. E., see Boyajian, C. L., 1079Lucchesi, B. R., see Lynch, J. J., 741Lukeman, D. S. and Fanestil, D. D.: Inter-
actions of diuretics with the periph-eral-type benzodiazepine receptor inrat kidney, 950
Lungacetylcholine-induced vasodilatation,
role, endotheium-derived relaxingfactor (rabbits), 516
adenocarcinorna, disposition, LY256787and free 4-desacetylvinblastine(mice), 695
hydrogen peroxide-induced injury, salu-
tary effects, prostaglandin E1 (rats),1
peptidoleukotriene release, antigen andcalcium ionophore-induced (guineapigs), 786
LY 53857, ketansenin, central sympathoin-hibitory action, characterization
(cats), 736LY256787, free 4-desacetylvinblastine and,
disposition (mice), 695Lynch, J. J., Nelson, S. D., MacEwen, S. A.,
Dniscoll, E. M. and Lucchesi, B. R:Antifibnillatory efficacy of concomi-ts.nt beta adrenengic receptor block-ade with dilevalol, the R,R-isomer oflabetalol, and muscarinic receptor
blockade with methylscopolamine,741
MacEwen, S. A., see Lynch, J. J., 741
Macrophages, pulmonary, oxygen radicals,beta adrenoceptors (guinea pigs), 994
Maegawa, H., see Hori, R., 1010Magnesium, deficiency, vasorelaxation, con-
onary arteries (dogs), 961
Majewska, M. D., see Harrison, N. L., 346
Malcolm, D., see Chernow, B., 833Malveaux, E., see Faraj, B. A., 42Maren, T. H., Bar-Ilan, A., Caster, K. C.
and Katritzky, A. R.: Ocular phar-macology of methazolamide analogs:Distribution in the eye and effects onpressure after topical application, 56
Mark, M. R.: Amino acid uptake in dener-vated rat parotid glanth I. Prepara-tion andevaluation ofa lobule systemfor in vitro studies, 655
Mark, M. R.: Amino acid uptake in the ratparotid gland II. Effects of surgicalsympathectorny and parasympathec-
tomy, 663Marone, G., see Chiariello, M., 560Martin, B. see Beardsley, P. M., 521Martin, J. R and Takernori, A. E.: Modifi-
cation of the development of acuteopiate tolerance by increased dopa-mine receptor sensitivity, 48
Mashiba, H., see Kotake, H., 982Matsumura, Y., Unu, T., Shinyama, H.,
Saskaki, Y. and Monimoto, S.: Inhibi-tory effects of calcium channel ago-fists on renin release from rat kidneycortical slices, 1000
Matsuoka, S., see Kotake, H., 982Maze, M., see Prokocimer, P. G., 870Mazindol, amphetamine-like effects, ano-
rectics (pigeons), 817McAllen, K. M., see Sharp, B. M., 438McCall, R B. and Harris, L. T.: Character-
ization of the central sympathoinhi-bitory action of ketanserin, 736
McGonigle, a. J. S., Brookins, J., Pegram,B. L and Fisher, J. W.: EnhanCederythropoietin production by calciumentry blockers in rats exposed to hy-
poxia, 428McNamara, J. 0., see Gellman, R L, 891
McNamara, J. 0., see Platt, K., 751MDL 19,205, compared to dobutamine,
blood flow response, congestive heartfailure (dogs), 956
MDL 25,637, suppression of blood glucose,inhibition, intestinal disacchanidases(rats), 915
MDMA, see Methylenedioxymethylamphe.t.amine
Mefenorex, amphetamine-like effects, ano-rectics (pigeons), 817
Mephenytoin, phenytoin hydroxylation,stereochemistry, phenotypes (hu-mans), 615
S-Mephenytoin, hepatic metabolism, tol-butamide, methyl hydroxylation,1112
Mepyramine, central hyperglycemic action,mechanism, histamine (mice), 582
Mercer, G. D., see Vestal, R. E., 488
Merchant, K., see Letter, A. A., 443Menin, R. G., see Chelly, J. E., 899Mesentery, endogenous norepinephnine re-
lease, periarterial nerve stimulation(rats), 826
Metaphit, interactions with phencycidine,sigma agonist actions, cerebellum(rats), 321
1136 Index
Met-enkephalin, see EnkephalinMethadone, analgesic activity, mu opioid
receptor involvement, �9-funaltrex-amine (mice), 374
Methamphetamine, effect, neurotensin con-centrations, brain (rats), 443
Methazolamide analogs, ocular pharmacol-ogy, distribution in eye, effects onpressure (rabbits), 56
Methoxamine, noradrenergic denervation,alpha-i adrenoceptors, muscle con-traction (chicks), 939
a,fl-Methylene, P2-purinergic receptor sub-types, endotheium and smooth mus-dc, blood vessels (dogs), 501
Methylenedioxymethylamphetamine, neu-rotoxiceffects, neurons in brain (rats,guinea pigs),338
Methytmercury, spontaneous release of ac-etylcholine, sodium activation, cal-ciurn entry (rats), 131
Methylphenidate, stereoselective disposi-tion, children, attention-deficit dis-order, 300
threo-Methylphenidate, enantiomers, phar-macology of (rats), 152
i-Methyl-4-phenyl-1,2,3,6-tetrahydropyni-dine, neurotoxicity, mechanisms(rats), 669
Methylscopolaxnine, rnuscariic receptor
blockade, antifibrillatory efficacy,beta adrenergic receptors (dogs), 741
Metopnine, central hyperglycemic action,
mechanism, histamine (mice), 582
Metyrapone, central hyperglycemic action,
mechanism, histamine (mice), 582Mexiletine, antiarrhythmic drugs, use-de-
pendent effects, cardiac PUrkinje fi-bars (dogs), 282
Michel, M. C., see Ikezono, K., 294Micheletti, H., Montagna, E. and Giachetti,
A.: AF-DX 116, a cardioselectivemuacarmnic antagonist, 628
Midha, K. K., see Sninivas, N. It, 300Mihaly, G. W., see Ching, M. S., 1006
Miller, N., see Formby, B., 1106Mm, B. H., see Willis, R. J., 433Mir, G. N., see DiJoseph, J. F., 97Mmcx, free calcium modulation, synapto-
sornes, organochlorine insecticides
(rats), 575Mittag, T. W., Tormay, A. and Podos, S.
M.: Vasoactive intestinal peptide andintraocular pressure: Adenylate cy-cl.�ae activation and binding sites for
vasoactive intestinal peptide in mem-branes ofocular diliaryprocesses, 230
Mocchetti, I., Naranjo, J. R. and Costa, E.:Regulation of stniatal enkephalinturnover in rats receiving antag-
onists of specific dopamine receptorsubtypes, 1120
Molenaar, P., Canale, E. and Summers, R.J.: Autoradiographic localization ofbeta-i and beta-2 adrenoceptors inguinea pig atrium and regions of theconducting system, 1048
Molenaar, P. and Summers, H. J.: Charac-terization of beta-i and beta-2 adren-oceptors in guinea pig atrium: Func-tional and receptor binding studies,1041
Monoclonal antibodies, LY256787 and free4-desacetylvinblastine, disposition(mice), 695
Monooxygenases, regulation of heme me-tabolism, gold compounds, liver andkidney (rats), 540
Montagna, E., see Micheletti, R., 628Moore, C. G., see Gillespie, M. N., 1Moore, M., see Kinter, L B., 797Morgan, D. J., see Ching, M. S., 1006Monimoto, S., see Matsumura, Y., 1000
Morley, J. E., see Sharp, B. M., 438Morphine
amphetamine-like effects, anorectics (pi-
geons), 817analgesic activity, mu opioid receptor in-
volvement, fi-funaltrexamine (mice),374
levorphanol-induced antinociception, se-
lective breeding, hot-plate assay(mice), 477
sensitization to repeated injection, AiOdopamine neurons (rats), 204
tolerance, effects, oxytocin-related pep-tides (mice), 569
Mosberg, H. I., see Porreca, F., 393Muacevic, G., see Casals-Stenzel, J., 974Murphy, S. D., see Ba1dUini, W., 421Muscimol, anticonvulsant action, alpha-2
adrenoceptors (rats), 751Muscle, suppression of rnuscaninic M2 stim-
ulation, histamine H1 receptors,ileum (guinea pigs), 587
Muscle, smoothalpha-i adrenergic coupling events, full
and partial agonists, aorta (rabbits),458
aortic, calcium channel blockers, cornea-tion (rabbits), 91
coronary, role of endotheium, dihydro-pyridine calcium channel modulators(porcine), 379
endotheium and, P2-puninergic receptorsubtypes, blood vessels (dogs), 501
expansor secundariorum, noradrenergicdenervation, alpha-i adrenoceptors(chicks), 939
interaction of kynurenine derivatives,multiple serotonin receptors (rats,
guinea pigs), 465norepinephrine-induced contraction,
bunazosin, proximal uretha (rabbits),1017
vascular
muscaniic receptor subtypes, saphe-nous vein (dogs), 64
postjunctional alpha adrenoceptors,limbs (humans), 361
variation in sensitivity, norepinephnine(rabbits), 239
vas deferens, inhibitory effect, calcitoningene-related peptide (rats), 635
Myocardium, see also Heart
beta adrenoceptors, autoradiographic lo-calization, atrium (guinea pigs), 1048
effects of BM 123A, muscarinic receptors,adenylate cyclase (rabbits), 804
hypoxic, neutrophil sequestration (nab-bits), 812
infarction
antifibnillatory efficacy, dilevalol(dogs), 741
captopnil, acute regional vascular ef-fects (rats), 13
ischemia, phospholipase activation, quin-acme (rats), 560
MyxicoLa, giant axons, dendrotoxin effects,potassium and sodium channels, 793
Vol. 241
Nahorski, S. R, see Kendall, D. A., 1023Nakamura, M., see Adachi, H., 1072Naphthoxylactic acid, renal clearance, pro-
pranolol metabolism in smokers (hu-mans), 928
Naranjo, J. R., see Mocchetti, I., 1120Nattel, S.: Interval-dependent effects of li-
docaine on conduction in canine car-
disc PUrkinje fibers: Experimentalobservations and theoretical analy-
sis, 275Nattel, S.: Relationship between use-dc-
pendent effects of antiarrhythmic
drugs on conduction and � in ca-nine cardiac PUrkinje fibers, 282
Nelson, S. D., see Lynch, J. J., 741Nerves
adrenergic, muscarinic receptor subtypes,saphenous vein (dogs), 64
periartenial, endogenous norepinephrinerelease, mesenteric vasculature
(rats), 826Netilmicin, renal handling, streptozotocin-
induced diabetes mellitus (rats), 166
Neuroblastoma cells, muscaninic receptors,cyclic GMP formation, phorbol ester-induced (mice), 366
Neuromuscular junction, aminoglycoside-induced blockade, potentiation, pro-tons (frogs, rats), 686
NeuronsAlO dopamine, repeated morphine injec-
tion, sensitization (rats), 204-y-aminobutynic acid� receptor complex,
structure-activity relationships, ste-roid interaction (rats), 346
toxicity, methylenedioxymethylamphe-tamine (rats, guinea pigs), 338
Neurotensin, effect of methamphetamine,brain regions (rats), 443
Neurotoxicity1-methyl-4-phenyl-1,2,3,6-tetrahydropyr-
idine, mechanisms (rats), 669nonmuscarmnic, oxotremonine (rats), 34theophylline, experimental liver disease
(rats), 236tyramine, brain technetium-99m-diethy-
lenetriainine penta-acetic acid(dogs), 42
Neurotransmitters, presynaptic actions of
PCP, in vioc electrochemical dem-onstration, caudate nucleus (rats),714
Neutrophils
role of endogenous histamine, postana-phylactic phase, allergic inflam-
mation (rats), 967sequestration, hypoxic hearts (rabbits),
812Nevola, E., see Chianiello, M., 560Nicardipine, disposition, role of isoflurane,
hemodynamic properties (dogs), 899Nicorandil, differential effects on presser
responses, alpha adrenoceptor ago-nists (dogs), 846
Nicotine
inhibition, plasma prolactin response, re-
straint stress (rats), 438nonmuscarinic neurotoxicity, oxotremo-
rime (rats), 34Nieman, L K., see Kawai, S., 401Nifedipine
Bay K 8644, charactenisties of binding,cardiac membranes (rabbits), 140
differential effects on presser responses,
1987 Index 1137
alpha adrenoceptor agonists (dogs),846
Nijkamp, F. P., see Engels, F., 994Nishibori, M., Itoh, Y., OiShi, R. and Saeki,
K.: Mechanism of the central hyper-glycemic action of histamine in mice,582
Nishijima, H., see Adachi, H., 1072Nitrendipine, calcium channel blockers,
correlation, receptor binding andcontractility (rabbits), 91
Nitrites
conversion to nitric oxide, red cells, sta-bill.zation, 307
stimulus properties, inhalants (mice), 507Nitroglycerin
differential effects on presser responses,alpha adrenoceptor agonists (dogs),846
verapamil and, coronary and systemichemodynamics (dogs), 1072
Nolan, T. E., see Pendleton, R. G., 110Noordewier, B., see Belknap, J. K., 477Noradrenaline
fengabine, effects on cerebral transmis-sion (rats), 251
inositol phospholipid hydrolysis, lithiumtreatments, cerebral cortex (rats),1023
release, effects of idazoxan, presynapticalpha-2 adrenoceptors (rats), 642
Norepinephrine
AF64A intraventricular infusion,changes, synaptic transmission, 181
alpha-i adrenoceptorsactivity (rabbits, rats, guinea pigs,
dogs), 771anticonvulsant action, rnuscimol (rats),
751thoracic aorta, hypertension (rats), 882
amino acid uptakeparotid gland, lobule system (rats), 655parotid gland, surgical sympathectomy
(rats), 663central hyperglycemic action, mechanism,
histamine (mice), 582effect of dietary lipids, inotropic re-
spouses, atrium (rats), 838enantiomers of threo-methylphenidate,
pharmacology of (rats), 152endogenous, release from mesenteric vas-
culature, periartenial nerve stimula-tion (rats), 826
endogenous and exogenous, dihydroxy-phenylglycol, vas deferens (rats), 547
induced smooth muscle contraction, a!-pha-1 adrenoceptors, bunazosin (nab-
bits), 1017left atrium, adaptive supersensitivity,
characteristics (guinea pigs), 453postjunctional alpha adrenoceptors, dif-
ferential distribution, limbs (hu-mans), 361
suppression of kindling development, at-pha-2 receptors (rats), 891
variation in sensitivity, contraction, vas-cular smooth muscle (rabbits), 239
Nozaki, M., see Kimoto, Y., 1017
Obesity, drug toxicity, acetaminophen(rats), 921
O’Connor, W. N., see Gillespie, M. N., 1O’Donnell, J. M., see Ordway, G. A., 187O’Donnell, J. M.: Effects ofclenbuterol and
prenalterol on performance during
differential reinforcement of low re-sponse rate in the rat, 68
Ogino, K., see Kotake, H., 982Ohlstein, E. H., Kruse, L I., Ezekiel, M.,
Sherman, S. S., Erickson, R, Dc-Wolf, W. E., Jr. and Berkowitz, B.A.: Cardiovascular effects of a newpotent dopamine �-hydroxylase in-hibitor in spontaneously hypenten-sive rats, 554
Ohuchi, K., see Hirasawa, N., 967#{216}ie,S., Fiori, F. and Chang, J.: Decreased
elimination of unbound prazosin inthe presence of a1-acid glycoproteinin the rat in vivo, 934
Oishi, R, see Nishibori, M., 582Okamoto, T., see Tsubornura, T., 650Okano, T., see Hori, H., 1010Olfactory bulbectomy, fengabine, activity in
models, psychopharmacological pro-file (rats), 245
Olsen, R. W., see Yang, J. S.-J., 677Omnass, J. R., see Porreca, F., 393Oosting, R. S., see Engels, F., 994Opiates, acute tolerance, modification of de-
velopment, dopamine receptor sensi-tivity (mice), 48
Opioidsintra-arterial injection of met-enkepha-
lin, decreased vascular resistance(rabbits), 314
sigma agonist, metaphit and phencyci-dine, cerebellum (rats), 321
Ordway, G. A., O’Donnell, J. M. and Fraser,A.: Effects of clenbuterol on centralbeta-i and beta-2 adrenergic recep-
tore of the nat, 187Oriowo, M. A., Bevan, J. A. and Bevan, R.
D.: Variation in sensitivity of alphaadrenoceptor-mediated contractionofthe vascular smooth muscle of nab-bit elastic and muscular arteries isrelated to receptor affinity, 239
O’Rourke, S. T. and Vanhoutte, P. M.: Sub-types of muscaninic receptors on ad-renergic nerves and vascular smoothmuscle of the canine saphenous vein,
64Owasoyo, J. 0., see Gillespie, M. N., 812Oxazepam, stimulus properties, pentobar-
bital-like (mice), 507Oxotremorine
alkylating derivative BM 123A, effects onmyocardium (rabbits), 804
nonmuscarinic neurotoxicity (rats), 34Oxygen, radicals, beta adrenoceptor func-
tion, Haemophilus influenzae (guineapigs), 994
Oxytocineffects of related peptides, acute men-
phine tolerance (mice), 569vasopressin and, C-terminal fragments,
avoidance behavior (rats), 268
Palmer, M. H., see Wang, Y., 321Pancreas
L-364,718in vice pharmacology (mice, rats, cats,
dogs, rabbits), 103role of endogenous cholecystokinin
(dogs), 110Pang, K., see Gerhardt, G. A., 714Panzer-Knodle, S., see Papaioannou, S., 91Papaioannou, S., Panzer-Knodle, S. and
Yang, P.-C.: Calcium channel block-
ers: Correlation among receptorbinding, calcium uptake and contrac-tiity in vitro, 91
Parasympathectorny, parotid gland, aminoacid uptake (rats), 663
Parathyroid, hormone fragments, calciumtransport, bladder (toads), 448
Park, B. K., see Vestal, R E., 488Parkinson’s disease, neurotoxicity, 1-
methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine, mechanisms (rats), 669
Parmar, N. S., see Tariq, M., 602Parotid gland
amino acid uptakelobule system (rats), 655sympathectomy, parasympathectomy
(rats), 663Pastoniza-Munoz, E., Josepovitz, C., Ram-
sammy, L. and Kaloyanides, G. J.:Renal handling of netilmicin in therat with streptozotocin-induced dia-betes mellitus, 166
Patrick, K. S., Caldwell, R. W., Ferris, R.M. and Breese, G. R: Pharmacologyof the enantiomers of threo-rnethyl-phenidate, 152
Patterson, J. B., see Zipser, R. D., 218Payne, A. J.,see Rhinehart, B. L., 915PCP, see Phencyclidine[D-Pen2,D-Pen5J-Enkephalin, mu and delta
receptors, supraspinal and spinal an-algesic effects (mice), 393
Pegram, B. L, see McGomgle, R. J. S., 428Pendleton, R G., Bendesky, R J., Schaffer,
L., Nolan, T. E., Gould, R. J. andClineschmidt, B. V.: Roles of endog-enous cholecystokinin in biliary, pan-creatic and gastric function: Studieswith L-364,718, a specific cholecys-tokinin receptor antagonist, 110
Pendleton, R. G., see Lotti, V. J., 103Pentazocine, levorphanol-induced antinoci-
ception, selective breeding, hot-plateassay (mice), 477
Pentobarbitalenantiomers, pharmacokinetics, racemate
(humans, rabbits), 779
stimulus properties, inhalants (mice), 507Peptidoleukotrienes, release from lung
preparations, antigen and calcium io-nophore-induced (guinea pigs), 786
Perlin, J. B., see Geary, W. A., II, 704Perrone-Filardi, P., see Chiariello, M., 560Petein, M., Heppner, B., Bache, R. J., Cohn,
J. N. and Pierpont, G. L.:namic and regional blood flow re-aponse to piroximone (MDL,19205)in dogs with congestive heart failure:
A comparison with dobutamine, 956Peterson, C. M., see Formby, B., 1106
pH, aminoglycoside-induced neuromuscularblockade, potentiation, protons(frogs, rats), 686
Phencyclidineamphetamine-like effects, anorectics (pi-
geons), 817discriminative stimulus effects, separa-
tion of response rate (rats), 159interactions with metaphit, sigma agonist
actions, cerebellum (rats), 321presynaptic actions, in vivo electrochem-
ical demonstration, caudate nucleus(rats), 714
Phendirnetrazine, amphetamine-like ef-fects, anorectica (pigeons), 817
1138 Index
Phentermine, amphetamine-like effects, an-
orectics (pigeons), 817Phentolamine, aLpha-i adrenoceptor bind-
ing, aortas (dogs), 875Phenylephrine
alpha adrenoceptorsactivity (rabbits, rats, guinea pigs,
dogs), 771postjunctional, limb differential distri-
bution (humans), 361thoracic aorta, hypertension (rats), 882
alpha agonista, vasodilator inhibition(dogs), 846
N�-(L-Phenylisopropyl)adenosine, effects,acquisition, conditioned responses
(rabbits), 223Phenylpropanolamine, amphetamine-like
effects, anorectics (pigeons), 817Phenytoin
distribution and binding, in vitro and invivo, brain (rats), 704
hydrozylation, stereochemistry, pheno-types (humans), 615
Pheochromocytomaeffects ofadrenergic receptor antagonists,
heart (rats), 354maintenance of hypertension, sympa-
thetic nervous system (rats), 870Phorbol esters, induced inhibition, cyclic
GMP formation, muscaninic recep-
tore (mice), 366Phosphatidylcholine, secretion in type II
pneumocytes, adenosine A2 receptor
regulation (rats), 907Phosphodiesterase
congestive heart failure, hemodynamic ef-fect.s, isomazole (dogs), 20
inhibitor, prostacydlin and, prevention ofthrombosis (rabbits), 855
Phosphoinositidealpha-i adrenergic coupling, full and par-
tie�l agonists, aorta (rabbits), 458
muscaninic receptor-stimulated metabo-11am, developmental changes, brain(rats), 421
Phospholipase, ischemia-induced activa-don, infarct size reduction, quina-
crime (rats), 560L-PIA, see N’-(L-Phenylisopropyl)
adenosinePierpont, G. L, see Petein, M., 956Pillar, J., see Cheng, J. B., 786Piocarpine, nonmuscarinic neurotoxicity,
oxotremonine (rats), 34Pindolol, beta agonists and antagonists, in-
teraction, brain (rats),755Piomelli, D., Feinniark, S. J. and Cannon,
P. J.: Leukotniene biosynthesis by ca-nine and human coronary arteries,763
Piroximone, comparedto dobutamine, bloodflow response, congestive heart fail-ure (dogs), 956
Pituitary, anterior, blocked calcium mobili-zation, protein kinase inhibitor, 125
Placenta, low clearance, cimetidine (hu-mans), 1006
Platelet activating factor, antagonist of,WEB 2086, pharmacological actions(humans), 974
Platelets, activation, bronchoconstniction,
effects of sulfinpyrazone (humans),
623Patt, K., Butler, L S., Bonhaus, D. W. and
McNamara, J. 0.: Evidence implicat-
ing alpha-2 adrenergic receptors inthe anticonvulsant action of intra.nigral muscimol, 751
Pneumocyte8, phosphatidylcholine secre-
tion, adenosine A2 receptor regula-tion (rats), 907
Podos, S. M., see Mittag, T. W., 230
Polymethylenemethane thiosulfonates, hy-polipidemic effect, inhibitors, aceto-
acetyl coenzyme A thiolase (rats),1099
Pomfret, D. W., Schneck, K. W., Fludzinski,P. and Cohen, M. L: Interaction of5-hydroxykynurenamine, L-kynu-renine and kynuramine with multipleserotonin receptors in smooth mus-dc, 465
Porreca, F., Heyman, J. S., Mosberg, H. I.,Omnaas, J. R. and Vaught, J. L: Roleof mu and delta receptors in the su-praspinal and spinal analgesic effectsof ID-pen2, D-pen5jenkephalin in themouse, 393
Potassium
calcium channel blockers, receptor bind-ing and contractility, correlation(rabbits), 91
efflux, alpha-i adrenoceptors, hyperten-
sion (rats), 882Potassium channel, dendrotoxin blockade,
sodium inactivation, Myxicola giantaxons, 793
Potter, D. W., see Roberts, D. W., 527Prazosin
alpha adrenoceptorsactivity (rabbits, rats, guinea pigs,
dogs), 771binding, aortas (dogs), 875postjunctional, limb differential distni-
bution (humans), 361thoracic aorta, hypertension (rats), 882
ketansenin, central sympathoinhibitoryaction, characterization (cats), 736
maintenance of hypertension, sympa-thetic nervous system, pheochromo-cytoma (rats), 870
unbound, decreased elimination, a1-acidglycoprotein (rats), 934
Prenalterol, effects on performance, low re-sponse rate, differential reinforce-ment (rats), 68
PrOCainamide, antiarrhythmic drugs, use-
dependent effects, cardiac PUrkinjefibers (dogs), 282
Progesterone antagonist, RU 486, pharma-cokinetic properties (humans), 401
Proglumide, antiulcercytoprotective effects,gastric and duodenal (rats), 602
Prokocimer, P. G., Maze, M. and Hoffman,B. B.: Role of the sympathetic nerv-ous system in the maintenance ofhypertension in rats harboring phe-ochromocytoma, 870
Prolactin, stress response, inhibition, nic-otine (rats), 438
Promethazine, central hyperglycemic ac-tion, mechanism, histamine (mice),582
Propranololeffects of clenbuterol and prenalterol, low
response rate, differential reinforce-ment (rats), 68
selective induction of metabolism, smok-ing, renal clearance (humans), 928
Prostacyclin, combined with phosphodies-
Vol.241
terase inhibitor, prevention of throm-bosis (rabbits), 855
Prostaglandin E1, salutary effects, hydrogenperoxide-inducedlung injury (rats), 1
Prostaglandin E2 analog, tnimoprostil, phar-macokinetics, antisecretory activity(dogs), 433
Prostaglandinachemotactic peptide stimulation, healthy
and inflamed colons (rabbits), 218U46619-induced bronchoconstriction, ef-
fects of sulfinpyrazone, platelet acti-vation (humans), 623
Protein, adducts, acetaminophen, sensitiveassay (rabbits), 527
Protons, neuromuscular blockade, amino-glycoside-induced, potentiation
(frogs, rats), 686Psychoyos, S., see Williams, M., 415Pumford, N. R., see Roberts, D. W., 527Purkinje fibers
conduction in, lidocaine, interval-depend-ent effects (dogs), 275
electrophysiology of quinidine, compari-son, dihydroquinidine (dogs), 84
Quinacnine, inhibition, ischemia-inducedphospholipase activity, myocardium(rats), 560
Quinidineantiarrhythmic thugs, use-dependent ef-
facts, cardiac Purkinje fibers (dogs),282
electrophysiology, comparison, dihydro-quinidine (dogs), 84
Quinn, D., see Srinivas, N. It, 300
Racemate, pentobarbital enantiomers,pharmacokinetics (humans, rabbits),779
Radioligandsalpha-i adrenoceptors
binding, aortas (dogs), 875correlation with potassium effluix, hy-
pertension (rats), 882Ramsammy, L, see Pastoriza-Munoz, E.,
166Ramzan, I. M., Yasuhara, M. and Levy, G.:
Kinetics of drug action in diseaseatate8. XIX. Effect of experimental
liver disease on the neurotoxicity oftheophylline in rats, 236
Rannels, D. E., see Fabisiak, J. P., 722,728Rauwolacine
alpha-i adrenoceptorsheterogeneity, brain (rats), 1079, 1092postjunctional, limb differential distri-
bution (humans), 361Receptors
adenosineacquisition of conditioned responses, L-
PIA (rabbits),223triazoloquinazoline, biochemical char-
actenization, 415adenosine A2, phosphatidylcholine scene-
tion, type H pneumocytes (rats), 907affinity, variation in sensitivity, norepi-
nephrine (rabbits), 239alpha adrenergic, see Adrenoceptorsantagonists, acute morphine tolerance,
oxytocin-related peptides (mice), 569benzodiazepine, interactions of diuretics,
kidney (rats), 950beta adrenergic, see Adrenoceptors
1987 Index 1139
binding, calcium channel blockers, come-lation (rabbits), 91
bradykinin, structural prerequisites, vasdeferens (rats, mice, guinea pigs,hamsters), 608
dopamineacute opiate tolerance, modification of
development (mice), 48stniatal enkephalin turnover, regula-
tion, 1120dopamine D2
apomorphine, discriminative stimulus(monkeys), 213
lisuride, discriminative stimulus prop-erties (rats), 147
GABAA, st�UctU��tivity relationships,steroid interaction (rats), 346
histamine H1, suppression of muscaninicM2 stimulation, ileum (guinea pigs),587
mu and delta� supraspinal and spinal an-algesic effects, enkephalin (mice),393
mu opioid
enkephalin activation ofdopamine neu-rons, ventral tegmental area (rats),328
fi-funaltrexamine, analgesic activity ofligands (mice), 374
muscarinic
AF-DX 116 (guinea pigs), 628antifibnillatory efficacy, dilevalol
(dogs), 741cyclic GMP formation, neuroblastoma
cells (mice), 366effects of BM 123A, myocardium (rab-
bits), 804neurotoxicity, oxotremomine (rats), 34phosphoinositide metabolism, develop-
mental changes in brain (rats), 421subtypes on adrenergic nerves, saphe-
nous vein (dogs), 64muscarinic M2, histamine H1 receptors,
ileum (guinea pigs), 587opioid, modulation by cannabinoids,
brain (rats), 534P2-purinergic, endotheium and smooth
muscle, blood vessels (dogs), 501P1 puninoceptor, adenosine, surfactant se-
cretion (rats), 907serotonin
kynuremne derivatives, smooth muscle
(rats, guinea pigs), 465stimulation, inositol phosphate forms-
tion, 258Red blood cells, nitrite conversion to nitric
oxide, stabilization, 307Reel, J. K., see Zimmerman, D. M., 374Race, D. C., Knisely, J. S., Balster, R L,
Jordan, S. and Breen, T. J.: Pento-barbital-like discriminative stimulus
properties of halothane, 1,1,1-tricho-lorethane, isoamyl nitrite, flurothyl
and oxazepam in mice, 507Reflexes, baroreflex, isoflurane, nicardipine
disposition (dogs), 899
Reisine, T., see Guild, S., 125Rernn, release from kidney cortical slices,
calcium channel agonists (rats), 1000Renwick, A. G., see Richards, R, 1028Reserpine
dihydroxyphenylglycol and intnaneuronalmetabolism, norepinephrine, vas def-erens (rats), 547
left atrium, adaptive supersensitivity,characteristics (guinea pigs), 453
REV 5901, biochemical and pharmacologi-cal profile (guinea pigs), 117
Reye’s syndromebrain technetium-99m-diethylenetnia-
mine penta-acetic acid
tyramine neurotoxicity (dogs), 42Rhinehart, B. L., Robinson, K. M., Liu, P.
S., Payne, A. J., Wheatley, M. E. andWagner, S. R.: Inhibition of intes-tinal disaccharidases and suppres-
sion of blood glucose by a new a-
glucohydrolase inhibitor-MDL 25,637,915
Richards, R, Dickson, C. R, Renwick, A.
G., Lewis, R A. and Holgate, S. T.:Absorption and disposition kineticsofcromolyn sodium and the influenceof inhalation technique, 1028
Rifampicin, antiarrhythmic effect of lido-caine, enhanced a1-acid glycoprotein,protein binding (dogs), 289
Riinele, T. J., Henry, D. E., Lee, D. K. H.,
Geiger, G., Heaslip, H. J. and Grimes,D.: Tissue-dependent alpha adreno-receptor activity ofbuspirone andre-lated compounds, 771
Robbins, R K., see Wince, L. C., 838Roberts, D. W., Pumfond, N. It, Potter, D.
W., Benson, H. W. and Hinson, J. A.:A sensitive immunochemical assayfor acetaminophen-protein adducts,527
Robinson, K. see Rhinehart, B. L, 915Roden, D. M., see Thompson, K. A., 84Rolipram, effects, acquisition, conditioned
responses (rabbits), 223Rooney, S. A., see Gilfillan, A. M., 907
Roots, I., see Fritz, S., 615Ropchak, T. G., see Eisenhofen, G., 547Rose, G. M., see Gerhardt, G. A., 714Rosenbaum, J. S., Ginsburg, R, Billingham,
M. E. and Hoffman, B. B.: Effects ofadrenergic receptor antagonists oncardiac morphological and functionalalterations in rats harboring pheo-chromocytoma, 354
Rouot, B., see Cory, R. N., 258RU 486, pharmacokinetic properties (hu-
mans), 401Ruffolo, R. R., Jr., see Shebuski, R. J., 6
Sabatini, S., Yang, W.-C. and Kurtzman, N.A.: Effect of parathyroid hormonefragments on calcium transport intoad bladder, 448
Saeki, K., see Nishibori, M., 582Saito, A., see Goto, K., 635Salam, W. H. and Bloxham, D. P.: Hypoli-
pidemic effect of polymethylenerne-
thane thiosulfonates: Inhibitors ofacetoacetyl coenzyme A thiolase,
1099Salay, J. M., see Beardsley, P. M., 159Sangen, D., see Uoyd, K. G., 245Saphenous vein
isolated human, relaxation, beta-2 adre-nocepton, 294
muscarinic receptor subtypes, adrenergicnerves, vascular smooth muscle(dogs), 64
P2-puninengic receptor subtypes, endothe-lium, smooth muscle (dogs), 501
Sarau, H. M., see Kopia, G. A., 174
Sarmiento, J. G., Shrikhande, A. V., Janis,R A. and Triggle, D. J.: [3H]BAY K8644, a 1,4-dihydropyridine Ca�channel activator Characteristics ofbinding to high and low affinity sites
in cardiac membranes, 140Sarnyai, Z., see Kov#{225}cs,G. L, 569Sarper, R, see Faraj, B. A., 42Saskaki, Y., see Matsumura, Y., 1000Satoh, S.-!., see Asano, T., 1033Sayre, L. M., see Hank, S. I., 669Scatton, B., Lloyd, K. G., Zivkovic, B., Den-
nis, T., Claustre, Y., Dedek, J., Ar-bills, S., Langer, S. Z. and Bartholini,G.: Fengabine, a novel antidepressantGABAergic agent. II. Effect on cere-bral noradrenergic, serotonergic andGABAergic transmission in the rat,251
Scatton, B., see Dennis, T., 642SCH 23390, dopamine receptor subtypes,
regulation, atniatal enkephalin turn-over, 1120
Schadt, J. C., see Wightman, J. M., 314Schaffer, L., see Pendleton, R G., 110Schauf, C. L: Dendrotoxin blocks potas-
sium channels and slows sodium in-activation in Myxicola giant axons,793
Schmidley, J. W., see Hank, S. I., 669Schmidt, F. see Faraj, B. A., 42Schneck, K. W., see Pomfret, D. W., 465Schuster, C. R, see Commins, D. L., 338Schwartz, A., see Williams, J. S., 379Scimeca, J: A., see Beardsley, P. M., 521Seiden, L S., see Commins, D. L., 338Seizures
kindling development, noradrenergicsuppression, a4,ha-2 receptors (rats),891
neurotoxicity, theophylline, experimentalliver disease (rats), 236
Seltzman, T. B., see Cook, C. E., 779Serotonin
AF64A intraventricular infusion,changes, synaptic transmission, 181
agonists, stimulation, inositol phosphateformation, 258
dopamine D2 receptors, lisuride, discrim-
inative stimulus properties (rats), 147fengabine, effects on cerebral transmis-
sion (rats), 251neurotoxicity, methylenedioxymethylani-
phetamine, brain (rats, guinea pigs),338
nonadrenergic denervation, alpha-iadrenoceptors, muscle contraction(chicks), 939
uptake sites, in vivo labeling, [3HJ-cy-anoimipramine (rats), 196
Sharp, B. M., Reyer, H. S., Levine, A. S.,Morley, J. E. and McAllen, K. M.:Attenuation of the plasma prolactin
response to restraint stress afteracute and chronic administration ofnicotine to rats, 438
Shebuski, R. J., Fujita, T., Smith, J. M., Jr.and Ruffolo, R R, Jr.: Comparison
of the alpha adrenoceptor activity ofdopamine, ibopamine and epinine inthe pulmonary circulation ofthe dog,6
Shepherd, J. see Flavahan, N. A., 361Sherman, S. see Ohlstein, E. H., 554Shibuya, M., see Asano, T., 1033
1140 Indsx
Shinyama, H., see Matsumura, Y., 1000Shrikhande, A. V., see Sarmiento, J. G., 140Sinoatnial node cells, electrophysiological
study, cibenzoline (rabbits), 982SK&F 88046 and SK&F 102922, coronary
vasoconstriction, leukotriene D4-in-
duced, inhibition (dogs), 174Skin, absorption, cutaneous first pass me-
tabolism, topical steroids (mice), 482Sladeczek, F., see Cony, R. N., 258Smallwood, R A., see Ching, M. S., 1006Smith, E. F. ifi and Egan, J. W.: Compari-
son of the effects of a thromboxanesynthase inhibitor or prostacydlin incombination with a phosphodiester-see inhibitor for prevention of exper-imental thrombosis and suddendeath in rabbits, 835
Smith, J. M., Jones, S. B., Bylund, D. B.and Jones, A. W.: Characterizationofthe alpha-i adrenergic receptors inthe thoracic aorta of control and al-dosterone hypertensive rats: Come-lation ofmadioligand binding with pa-tassium efflux and contraction, 882
Smith, J. M., Jr., see Shebuski, H. J., 6Smith, J. M., see Jones, S. B., 875Smith, R. P., see Kruszyna, It, 307Smoking
effect on oxidation of theophylline, corti-aol, aging (humans), 488
propranolol metabolism, renal clearanceof metabolites (humans), 928
Sodiumactivation, acetyicholine release, methyl-
mercury (rats), 131proximal and distal tubular effects, dose
dependence, furosemide (rats), 987Sodium channel
antiarrhythmic drugs, use-dependent ef-fects, cardiac Purkinje fibers (dogs),282
block by apnindine, action potential, yen-tricular muscles (guinea pigs), 1065
slowed inactivation, dendrotoxin, Myxi-cola giant axons, 793
Sonnino, P., see Van Inwegen, H. G., 117Spealman, R. D., see Coffin, V. L., 76Spearman, M. E., Goodwin, R M., Apel-
gren, L D. and Bumol, T. F.: Dispo-sition of the monoclonal antibody-
vines alkaloid conjugate KS1/4-DAVLB (LY256787) and free 4-de-sacetylvinblastine in tumor-bearingnude mice, 695
Spiroperidol, acute opiate tolerance, modi-fication of development, dopamine
receptor sensitivity (mice), 48Sniivas, N. R, Quinn, D., Hubbard, J. W.
and Midha, K. K.: Stereoselectivedisposition of methylphenidate inchildren with attention-deficit disor-den, 300
ST-587, alpha adrenoceptor activity (rab-bits, rats, guinea pigs, dogs), 771
Stasaen, F. L, see Kinter, L B., 797Steiness, E., see Christensen, S., 987Stereochemistry, aromatic phenytoin hy-
droxylation, hydroxylation pheno-types (humans), 615
Steroidsstructure-activity relationships for inter-
action, -y-aminobutynic acidA recep-tom complex, 346
topical, skin absorption (mice), 482
Stewart, J., see Lions, I., 608Stomach
gastric excitation, stimulation of vega!trunk, chronic supranodose vagot-omy (cats), 650
WHR1582A, gastric antisecretory and an-tiulcer effects (rats), 97
Stone, C. K., see Imai, N., 20Stone, G. A., see Williams, M., 415Strandhoy, J. W., see Wolff, D. W., 472Strange, P. G., see Williams, K, 939Streptomycin, aminoglycoside-induced neu-
romuscular blockade, potentiation,protons (frogs, rats), 686
Streptozotocin, induced diabetes mellitus,renal handling, netilmicin (rats), 166
Stress, restraint, plasma prolactin response,nicotine (rats), 438
Stniatum, dopamine release from synapto-somes, calcium, modulation (rats), 27
StuB, R. W., see Eisenhofem, G., 547Substantia nigra, alpha-2 adrenoceptors,
anticonvulsant action, muscimol
(rats), 751Sulfinpyrazone, effects on platelet activa-
tion, bronchoconstriction, U46619(humans), 615
Suihydryl reagents, tetraethylammoniumtransport, renal brush border mem-branes (rats), 1010
Summers, R. J., see Molenaar, P., 1041, 1048Sunflower oil, effect of dietary lipids, mo-
tropic responses, atrium (rats), 838Surfactant, adenosine A2 receptor regula-
tion, phosphatidylcholine secretion,pneumocytes (rats), 907
Suzuki, Y., see Asano, T., 1033Sympathectomy, parotid gland, amino acid
uptake (rats), 663
Sympathetic nervous system, role in main-tenance of hypertension, pheochro-mocytoma (rats), 870
Synaptosomesenantiomers of threo-methylphenidate,
pharmacology of (rats), 152free calcium modulation, organochlonine
insecticides (rats), 575Szab#{243},G., see Kovics, G. L, 569
Tachycardia, glucagon and calcium, chron-otropic action (rats), 833
Tai, H. H., see Gillespie, M. N., 812Takami, T., see Kotake, H., 982Takano, M., see Hori, R., 1010Takayasu, M., see Asano, T., 1033Takemoni, A. E., see Martin, J. H., 48Talbot, P. A.: Potentiation of aminoglyco-
side-induced neuromuscular block-ads by protons in vitro and in viuo,686
Tallent, C. R, see Cook, C. E., 779Tamai, I., see Tsuji, A., 594Tariq, M., Parmar, N. S. and Aged, A. M.:
Gastric and duodenal antiulcer andcytoprotective effects of proglumidein rats, 602
Taylor, D. A., see Hawthorn, M. H., 453Tejani-Butt, S., see Conway, P. G., 755Telegdy, G., see KovIcs, G. L, 569Terasaki, T., see Tauji, A., 594Terbutaline, adenosine A2 receptor regula-
tion, phosphatidylcholine secretion,pneumocytes (rats), 907
Testosterone, skin absorption (mice), 482Tetraethylammonium, transport, renal
Vol.241
brush border membranes, sulfliydryl
reagents (rats), 1010Tetrahydrocannabinol
brain opioid receptors, modulation (rats),534
delta-9(11) interactions with delta-9, ag-onistic activity (mice, dogs, mon-keys), 521
Theophyllineadenosine A2 receptor regulation, phos-
phatidylcholine secretion, pneumo-cytes (rats), 907
cortisol and, effect of cimetidine andsmoking, aging (humans), 488
effects, acquisition, conditioned responses(rabbits), 223
neurotoxicity, experimental liver disease(rats), 236
Thiazide, interactions of diuretics, peniph-eral-type benzodiazepine receptor,kidney (rats), 950
Thiolase, hypolipidemic effect, polymethy-lenemethane thiosulfonates (rats),1099
Thompson, K. A., Blair, I. A., Woosley, RL and Roden, D. M.: Comparative invitro electrophysiologjr of quinidine,its major metabolites and dihydro-quinidine, 84
Thrombosis, prevention of, prostacydlin andphosphodiesterase inhibitor (nab-bits), 855
Thromboxanechemotactic peptide stimulation, healthy
and inflamed colons (rabbits), 218U46619-induced bronchoconstriction, ef-
fects of sulfinpyrazone, platelet acti-vation (humans), 623
Thromboxane synthase, inhibitor, phospho-diesterase inhibitor and, thrombosisprevention (rabbits), 855
Thron, C. D., see Kruszyna, R., 307Timolol, effects of adrenergic receptor an-
tagonists, heart, pheochromocytoma
(rats), 354Tolbutamide, hepatic metabolism, methyl
hydroxylation, 1112Tomoike, H., see Adachi, H., i072Tormay, A., see Mittag, T. W., 230Torphy, T. J., see Kopia, G. A., 174Toxicity, acetaminophen-protein adducta,
sensitive immunochemical assay(rabbits), 527
Toyama, J.,see Kodama, I., 1065Trachea, dual effects of Haemophilus influ-
enzae, beta adrenoceptor function(guinea pigs), 994
Triazolodiazepinea, WEB 2086, antagonist,platelet activating factor (humans),974
Triazoloquinazoline, biochemical character-ization, 415
i,1,1-Trichloroethane, stimulus properties,pentobarbital-like (mice), 507
Trifluopenazine, antagonism, calmodulin-stimulated adenylate cyclaae, cere-belier membranes (rats), 407
ephalosporin antibiotic, across brush-bordermembrane vesicles from rat small in-testine, 594
Tsurufuji, S., see Hirasawa, N., 967Tyramine, neurotoxicity, brain technetium-
99m-diethylenetniamine penta-aceticacid (dogs), 42
1987 Index 1141
U46619, induced bronchoconstriction, nal,proglumide, cytoprotective effects
(rats), 602WHR1582A, gastric antisecretory effects
(nats), 97
Uretha, smooth muscle contraction, alpha-1 adrenoceptors, bunazosin (rabbits),1017
Uriu, see Matsumura, Y., 1000
Vega! trunk, gastric excitation, chronic su-pranodose vagotomy (cats), 650
Valocik, R. E., see Kopia, G. A., 174Vanhoutte, P. M., see Flavahan, N. A., 361Vanhoutte, P. M., see Houston, D. A, 501Vanhoutte, P. M., see O’Rourke, S. T., 64Van Inwegen, R G., KhandWala, A., Con-
don, R., Sonnino, P., Coutts, S. andJolly, S.: REV 9501: An orally effec-tive peptidoleukotriene antagonist,
detailed biochemical/pharmacologi.cal profile, 117
van Ree, J. M., see de Wied, D., 268Vargaftig, B. B., see Hatmi, M., 623Vas deferens
bradykinin receptor sites, structural pre-requisites (rats, mice, guinea pigs,hamsters), 608
calcitonin gene-related peptide, inhibi-tory effect, smooth muscle ofvas def-erens (rats), 635
endogenous and exogenous norepineph-nine, dihydroxyphenylglycol, intra-neuronal metabolism (rats), 547
Vasoactive intestinal peptide, intraocularpressure and, ocular ciiary processes,adenylate cyclase activation (nab-bits), 230
Vasoconstriction
coronary, leukotriene D4-induced, leuko-triene antagonists (dogs), 174
pulmonary, alpha adrenoceptors,.compar-ison (dogs), 6
Vasodilation. acetylcholine-induced, role, endotheium-
derived relaxing factor (rabbits), 516cholinergic, endotheium-mediated relax-
ation, effect of age (rats), 387
Vasodilators, effects on presser responses,
alpha adrenocepton agonists (dogs),846
Vasopressinantagonism (monkeys), 797oxytocin and, C-terminal fragments,
avoidance behavior (rats), 268Vasorelaxation, endotheium-dependent,
coronary arteries, magnesium defi-ciency (dogs), 961
Vasospasm, HA1O77, mechanism of action
(rabbits, dogs, guinea pigs), 1033Vaught, J. L., see Porreca, F., 393Vavrek, R.see Uona, I., 608Vaysae, P. J.-J., Gardner, E. L and Zukin,
R. S.: Modulation of rat brain opioidreceptors by cannabinoids, 534
Ventral tegmental area, enkephalin activa-tion, dopamine neurons, mu opioidreceptor (rats), 328
Ventricular fibrillation, dilevalol, receptorblockade, methylacopolamine (dogs),741
VerapamilBay K 8644, characteristics of binding,
cardiac membranes (rabbits), 140enhanced erythropoietin production, cx-
posure to hypoxia (rats), 428nitroglycerin and, coronary and systemic
hemodynamics (dogs), 1072Vesell, E. S., see Fabisiak, J. P., 722, 728Vestal, R. E., Cusack, B. J., Mercer, G. D.,
Dawson, G. W. and Park, B. K.: Ag-ing and drug interactions. I. Effect ofcimetidine and smoking on the oxi-dation oftheophylline and cortisol inhealthy men, 488
Virus, R. see Commins, D. L., 338Vosmer, G., see Commins, D. L., 338
W-7, antagonism, calmodulin-stimulatedadenylate cyclase, cerebellar mem-branes (rats), 407
Wagner, S. R., see Rhinehart, B. L., 915Walle, T., Walls, U. K., Cowart, T. D., Con-
radi, E. C. and Gaffney, T. E.: Selec-tive induction of propranolol metab-olism by smoking Additional effectson renal clearance of metabolites, 928
Walle, U. K., see Walle, T., 928Wang, Y., Kim, M. B. and Palmer, M. R:
Interactions of metaphit with phen-cycidine and sigma agonist actionsin rat cerebellum: Determination ofspecificity and selectivity, 321
Warltier, D. see Wynsen, J. C., 846Wasserman, M. see Kopia, G. A., 174Watanabe, M., see Hirasawa, N., 967Water flow, parathynoid hormone frag-
ments, calcium transport, bladder(toads), 448
WEB 2086, pharmacological actions, antag-onist, platelet activating factor (hu-mans), 974
Weber, K.-H., see Casals-Stenzel, J., 974Weiner, N., see Bowyen, J. F., 27Wheatley, M. see Rhinehart, B. L., 915WHR1582A, gastric antisecretony and an-
tiulcer effects (rats), 97Wick, P. F., Keung, A. C., Bowler, J. J. and
Deth, R. C.: Alpha-i adrenergic cou-pling events induced by full and par-tial agonists in rabbit aorta, 458
Wightman, J. M., Schadt, J. C. and Gaddis,R. R.: Decreased vascular resistanceafter intra-artenial injection of [metjenkephalin in the hindquarters ofconscious rabbits, 314
Wilcox, D. E., see Kruszyna, R., 307Wilkinson, G. see Knodell, R. G., 1112Willey, S. C., see Chernow, B., 833Williams, J. S., Baik, Y. H., Koch, W. J.
and Schwartz, A.: A possible role forthe endothelium in porcine coronarysmooth muscle responses to dihydro-
pynidine calcium channel modula-tore, 379
Williams, K., Bennett, T. and Strange, P.G.: Effects of noradrenergic denen-vation on alpha-i adrenoceptors andreceptor-stimulated contraction ofchick expansor secundarionum mus-dc, 939
Williams, M., Francis, J., Ghai, G., Braun-walden, A., Psychoyos, S., Stone, G.A. and Cash, W. D.: Biochemicalcharacterization of the triazoloquin-
azoline, CGS 15943, a novel, non-xanthine adenosine antagonist, 415
Wills, R. J., Gallo-Torres, H. E., Bentko, R.and Min, B. H.: Pharmacokineticsand antisecretory activity of tnimo-prostil in Heidenhain-pouch dogs,433
Wince, L C., Hugman, L. E., Chen, W. Y.,Robbmns, R. K. and Brenner, G. M.:Effect of dietary lipids on inotropicresponses of isolated rat left atrium:Attenuation of maximal responses byan unsaturated fat diet, 838
Winsky, L. and Harvey, J. A.: Effects of N�-(L-phenylisopropyl)adenosmne, cal-feine, theophylline and rolipram onthe acquisition of conditioned re-spouses in the rabbit, 223
Within, J. M., Alvarado-Garcia, R., Lee, M.A. and Witkin, K. M.: Nonmuscar-inic neurotoxicity of oxotremorine,34�
Witkin, K. M., see Witkin, J. M., 34Wolfe, J., Kreider, M. S., Goodman, C. and
Brunswick, D. J.: Labeling in uwo ofserotonin uptake sites in rat brainafter administration of [3Hjcyanoim-ipramine, 196
Wolff, D. W., Gesek, F. A. and Strandhoy,J. W.: In vivo assessment of rat renalalpha adrenoceptors, 472
Wong, B. see Corcoran, G. B., 921Woolverton, W. L., Kamien, J. B. and Gold-
berg, L I.: Pharmacological analysisof the apomonphine discriminativestimulus in rhesus monkeys, 213
WRK1 cells, serotonin receptor, stimula-tion, inoaltol phosphate formation,258
Yamada, A., see Adachi, H., 1072Yamada, see Kodama, I., 1065Yamamoto, R and Chine, W. H., Jr.: Release
of endogenous NE from the mesen-teric vasculature of WKY Kyoto andSHR in response to PNS, 826
Yang, J. S..J. and Olsen, R W.: ‘,‘-Amino-butyric acid receptor-regulated �C1�
flux in the mouse cortical slices, 677Yang, P.-C., see Papaioannou, S., 91Yang, see Sabatini, S., 448Yasuhara, M., see Ramzan, I. M., 236Yohimbine
alpha-i adrenoceptorsbinding, aortas (dogs), 875thoracic aorta, hypertension (rats), 882
maintenance of hypertension, sympa-thetic nervous system, pheochromo-cytoma (rats), 870
Zaloga, G. P., see Chernow, B., 833Zelis, R. see Dnexlen, H., 13
Zerkowski, H.-R., see Ikezono, K., 294Zimmerman, D. M., Leander, J. D., Reel, J.
K. and Hynes, M. D.: Use of a-fun-altrexamine to determine mu opioidreceptor involvement in the analgesic
activity of various opioid ligands, 374Zipser, R D., Patterson, J. B. and LeDuc,
L. E.: Chemotactic peptidetion ofleukotrienes from healthy andinflamed rabbit colons, 218
Zivkovic, B., see Lloyd, K. G., 245Zivkovic, B., see Scatton, B., 251Zukin, R. S., see Vayasse, P. J.-J., 534