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Genetics analysis and reproduction:
What is preimplanation genetic diagnosis?
Personal Genetics Education Project (pgEd)Harvard Medical School - Wu Labwww.pged.orgComplete lesson plans at: www.pged.org/curricula
Genetics analysis and reproduction:
What is preimplanation genetic diagnosis?
Personal Genetics Education Project (pgEd)Harvard Medical School - Wu Labwww.pged.orgComplete lesson plans at: www.pged.org/curricula
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Discussion Questions:
• If you could choose specific traits or qualities that you would want your child to have, what would you choose? Why?
• Are there any you would not want your child to have? What are they? Why?
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personal genetics education project
What is preimplantation genetic diagnosis (PGD)?
What is preimplantation genetic diagnosis (PGD)?
• PGD is a method to test for certain genetic traits in an embryo, almost always for genetic disease.
• An embryo is created via in vitro fertilization.
• Genetic testing occurs when embryo is 2-4 days old, typically at the 8-cell stage.
• A single cell is removed and tested.
• The results of testing are used to decide which embryos, if any, to implant in prospective mother’s uterus.
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personal genetics education project
PGD being performed on a 3-day old embryoPGD being performed on a 3-day old embryo
Image via http://www.obgyn.net/Frontiers_In_Reproductive_Medicine/images/PGD.gif
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personal genetics education project
Real Families impacted by PGD: Molly and Adam Nash and the Hashmis
Real Families impacted by PGD: Molly and Adam Nash and the Hashmis
http://news.bbc.co.uk/olmedia/955000/images/_955928_nash150.jpg
http://www.telegraph.co.uk/news/graphics/2007/08/01/nivf101.jpg
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personal genetics education project
What % of IVF clinics provide testing for the following reasons?
What % of IVF clinics provide testing for the following reasons?
aneuploidy
autosomal disorders
chromosomal rearrangement
X-linked diseases
non-medical sex selection
avoid adult-onset disease
HLA typing
HLA typing w/o single gene test
Select for a disability
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personal genetics education project
Public attitudes regarding acceptable uses of PGD:
Public attitudes regarding acceptable uses of PGD:
fatal HLA matchadult onset disease
sex Intelligence/strength
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Wants a total ban on PGD
Supports government regulation of safety and quality
Thinks government should regulate ethicsonly
Supports no government regulation
Believes government should regulate safety, quality and ethics
Opinion poll: What role, if any, should the US government play in regulating
preimplantation genetic diagnosis (PGD)?
Opinion poll: What role, if any, should the US government play in regulating
preimplantation genetic diagnosis (PGD)?
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personal genetics education project
Discussion Questions Discussion Questions
• What are the potential opportunities and challenges of PGD?
• Now that we’ve discussed the issue a bit, did you change your opinion about whether you’d want to choose certain traits for your child?
• If your parents used this on you - should they tell you? Or is it no big deal?
• Do we need rules to guide how this is used? If yes, what sort of rules? Whose job would it be to enforce them?
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personal genetics education project
For more information, please visit us at www.pged.org