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Genetic Circuit Challenge Workshop
Thursday 24 Nov 2011
Bentham seminar room 1
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What is Synthetic Biology ?
A new area of biological research that combines science & engineering
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Science
Biology is the understanding of what living systems are and how they work. A discovery science.
Recombinant DNA technology is the beginning of using (usually) single cloned genes in new hosts to make a product.
Synthetic Biology is how we could build novel biological entities based on the knowledge we now have of biological systems.
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Engineering
The use of Engineering Principals for these designs and constructions.Engineering Principals - parts are standardised and can
be put together in a modular way to create the final device or machine.
Use the Engineering Cycle way of thinking.
This has led to the idea of the need for standardising parts in synthetic biology.
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Major Areas in SynBio
Genetic circuits: Oscillators, Biosensors, etc.
Metabolic pathway construction: de novo designs, new drugs, bioenergy, etc.
Structured devices: Proteins, DNA, macromolecules, etc.
Artificial cells: Novel bacteria, Synthetic genomes, etc.
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modified microbes to make bio-fuels or to clean up toxic waste
new diagnostic devices based on enzymes and cells
cells designed to make chemicals and drugs that are currently made from petrochemicals.
biological devices to be used in electronic or optical devices.
Examples
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International Genetically Engineered Machine
Registry of Standard Biological Parts
(http://partsregistry.org/Main_Page)
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Search by Catalogues
Search by Part’s name
Search by text, name, subparts, superparts
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UCL iGEM 2010 --- Project Hypoxon
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Cambridge 2009 --- E. Chromi
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Useful Websites
http://partsregistry.org/Main_Page (Registry)
http://www.ebi.ac.uk/embl/ (EMBL-EBI)
http://www.ncbi.nlm.nih.gov/ (NCBI)
http://ecocyc.org/ (database for E.coli K-12 MG1655)
http://igem.org/Main_Page (iGEM main page)
http://2011.igem.org (specific year of iGEM competition)