Gene name Acession number C57BL/6 p value MyD88-/- p value i1/ni1 i2/ni2 i3/ni3 median i1/ni1 i1/ni2 i3/ni3 median Birc2 NM_007465 0.81 0.92 0.79 0.81 0.050 0.78 1.17 0.66 0.78 0.034Birc3 NM_007464 1.01 1.27 1.15 1.15 0.020 0.68 0.99 0.57 0.68 0.056Casp1 BC008152 2.46 2.36 2.09 2.36 0.032 1.48 0.81 2.51 1.48 0.023Casp8 BC006737 1.46 1.5 1.77 1.5 0.032 1.24 1.75 0.98 1.24 0.042Ccl11 AV006589 1.3 1.24 1.23 1.24 0.030 0.94 1.06 1.01 1.01 0.056Ccl12 C77789 4.15 2.79 3.91 3.91 0.045 2.03 4.01 2.42 2.42 0.032Ccl2 AF065933 4.54 2.47 3.12 3.12 0.040 1.45 2.25 1.27 1.45 0.021Ccl5 NM_013653 1.06 0.88 0.8 0.88 0.050 1.18 1.39 0.47 1.18 0.08Ccl7 AF128193 1.7 1.56 1.49 1.56 0.005 1.06 1.28 1 1.06 0.07Ccl8 NM_021443 1.63 1.51 1.04 1.51 0.050 3.49 7.74 1.07 3.49 0.0001Chuk NM_007700 1.22 1.28 0.98 1.22 0.003 1.03 137 0.6 1.03 0.07Cxcl1 NM_008176 3.14 2.13 1.65 2.13 0.027 0.79 1.27 2.3 1.27 0.02Cxcl2 NM_009140 1.76 1.49 0.91 1.49 0.015 0.92 1.21 1.54 1.21 0.04Erbb2ip BC028256 1 0.99 1.3 1 0.519 0.91 0.88 0.48 0.88 0.056Hsp90aa1 C77384 2.88 2.42 1.9 2.42 0.042 0.77 1.97 0.76 0.77 0.052Hsp90ab1 BI154147 1.48 1.45 1.17 1.45 0.067 1.3 1.5 0.77 1.3 0.07Hsp90b1 BE995678 0.96 1.46 0.84 0.96 0.063 1.98 2.05 0.95 1.98 0.0032Ikbkb AF088910 0.7 0.77 0.62 0.7 0.007 1.38 1.51 1.08 1.38 0.01Ikbkg NM_010547 1.59 1.76 1.62 1.62 0.001 0.82 1.2 0.9 0.9 0.03Il18 NM_008360 2.03 1.47 1.08 1.47 0.179 0.87 1.28 1.03 1.03 0.068Il18bp AF110803 4.09 4.01 3.86 4.01 0.006 0.83 1.12 0.87 0.87 0.059Il18r1 NM_008365 1.37 1.43 1.19 1.37 0.066 0.92 1.76 0.98 0.98 0.02Il1b BC011437 2.59 1.92 2.07 2.07 0.001 0.56 0.79 4.35 0.79 0.024Il6 NM_031168 2.02 1.36 1.51 1.51 0.050 0.88 1.21 1.58 1.21 0.09Map3k7 D76446 1.99 1.89 1,167 1.99 0.034 0.98 1.38 0.68 0.98 0.002Map3k7ip1 AK009321 1.16 1.17 1.06 1.16 0.271 0.88 1.21 0.77 0.88 0.056Map3k7ip2 BM213179 0.94 1.02 0.84 0.94 0.361 0.64 1.12 0.55 0.64 0.048Map3k7ip3 AU067719 1.59 1.66 1.13 1.59 0.050 0.62 0.89 0.8 0.8 0.023Mapk1 NM_011949 1.73 1.82 1.82 1.82 0.016 1.64 1.76 0.76 1.64 0.001Mapk10 BI414398 0.96 0.86 0.84 0.86 0.008 0.74 1 0.77 0.77 0.045Mapk11 BM940281 1.38 1.46 1.04 1.38 0.043 0.86 1.05 1.01 1.01 0.08Mapk12 BC024514 1.26 1.47 0.83 1.26 0.001 0.65 1.01 1.04 1.01 0.09Mapk13 BB453775 1.9 1.44 1.69 1.69 0.040 0.88 0.93 0.92 0.92 0.045Mapk14 AV329330 2.67 2.53 2.62 2.62 0.041 1.06 0.79 0.85 0.85 0.034Mapk3 BC021640 0.82 0.68 0.61 0.68 0.418 0.66 0.98 0.66 0.66 0.021Mapk8 NM_011950 1.9 1.85 1.49 1.85 0.003 0.86 0.91 0.75 0.86 0.056Mapk9 BC012235 2.36 2.41 2.38 2.38 0.001 0.87 1.37 0.77 0.87 0.045Mefv NM_019453 2.38 1.56 1.37 1.56 0.050 0.86 1.21 1.25 1.21 0.08Naip1 AF135491 1.17 1.55 1.07 1.17 0.104 0.5 1.13 0.64 0.64 0.005Naip2 NM_010872 1.63 1.7 1.39 1.63 0.052 0.89 1.13 0.4 0.89 0.054Naip5 NM_010870 0.68 0.72 0.59 0.68 0.002 0.55 0.79 0.48 0.55 0.045Nfkb1 L28118 1.18 1.33 1.37 1.33 0.040 0.83 1.2 0.84 0.84 0.003Nfkbia NM_010907 0.93 0.92 0.82 0.92 0.050 0.82 0.72 0.78 0.78 0.053Nfkbib NM_010908 1.55 1.47 1.42 1.47 0.038 0.96 1.19 1.04 1.04 0.0345Nlrc4 NM_031389 1.38 1.4 0.85 1.38 0.254 0.91 0.89 0.78 0.89 0.0545Nlrp3 AF486632 1.68 1.36 1.23 1.36 0.080 1.33 1.91 0.95 1.33 0.0237Pstpip1 U87814 0.93 0.96 0.89 0.93 0.457 0.94 1.23 0.58 0.94 0.04Pycard (Asc) BG084230 1.76 1.66 1.8 1.76 0.034 0.73 1.2 0.73 0.73 0.034Ripk2 NM_138952 1.7 1.5 1.01 1.5 0.049 1.12 1.63 0.86 1.12 0.06Sugt1 BE853371 2 2.44 2.06 2.06 0.006 0.71 1.23 0.88 0.88 0.043Tnf NM_013693 2.07 1.65 1.63 1.65 0.097 1.15 1.3 1.08 1.15 0.01Tnfaip3 NM_009397 2.56 1.84 1.54 1.84 0.040 1.05 1.22 1.11 1.11 0.0237Traf6 BG916928 1.5 1.42 1.32 1.42 0.003 0.9 1.37 0.98 0.98 0.0467Trip6 NM_011639 1.27 1.24 0.98 1.24 0.080 0.65 0.77 0.63 0.65 0.0135

Table S1. DNA microarray during murine malaria The expression value for each gene was determined by calculating the average of differences in intensity (perfect match intensity – mismatch intensity) between its probe pairs. The expression analysis file created from each sample (chip) was imported into GeneSpring 7.2 (Agilent Technologies, Inc., Palo Alto, CA) for further data characterization. A new experiment was generated after importing data from the same organ in which data were normalized by the array to the 50% percentile of all measurements on that array. Lists of genes that were either induced or suppressed between samples from non-infected vs. 6 days infected mice of same genotype were created by filtration-on-fold function within the presented list. The differential expression was evaluated in grouped samples from each mouse genotype (Wt or Knockout mice) and time point (non-infected vs 6 days post infection) using ANOVA.

Table S1 - Microarray analysis of P. chabaudi infected mice