From genes to ecosystems,From the laboratory into the community,
From the West towards Europe…
Presentation of OUEST-genopole®
December 2008
Page 2OUEST-genopole® presentation December 2008
What is OUEST-genopole®?History
1998 - First genopole at Evry based on an original
concept:
To gather, in the same place, research laboratories, biotech
companies and universities
1999 - Creation of the National network genopole
Objective: to coordinate genomics and post-genomics
activities at a national level
8 genopoles labelled between 1999 and 2002
Page 3OUEST-genopole® presentation December 2008
OUEST-genopole®
…labelled on January 1st, 2002Director: Michel RENARD
What is OUEST-genopole®?The French genopoles
With the support of :
Page 4OUEST-genopole® presentation December 2008
GIS IBiSA
Health biology and Agro infrastructures
IBiSA was created in May 2007 further to the dissolution of the
CNRG (regrouping the CNS, CNG and RNG) and, consequently, the
National network genopole
IBiSA members: Inserm, CNRS, Inra, CEA, Inria, INCa (National
Cancer Institute), CPU (University presidents conference), as well as two
departments dependent on the Ministry of research.
2008 labelling campaign:
Open to core facilities that don't yet have the national label (RIO)
Allows to apply for ANR and INCa future tenders or to benefit from
privileged ITA support
The respect of the core facilities charter is a necessary condition to get
the label
5 OUEST-genopole core facilities labelled in October 2008
Website: http://www.ibisa.net
Page 5OUEST-genopole® presentation December 2008
What is OUEST-genopole® ?
January 2002: OUEST-genopole® is labelled
Interregional programme: both Brittany and Pays de la Loire regions
Associates the major research bodies (Afssa, CNRS, Ifremer, Inra,
Inria, Inserm), the 5 main universities of western France, as well as
university hospitals and "grandes écoles" (i.e. higher education
establishments)
Network of over 50 research units: 2,000 people including 800
researchers and teaching researchers
Genopoles meet the following conditions:
A large-scaled biology project
A excellent campus for training and research
A high-level bioinformatics unit
A structured project for biotechnology company creation
Page 6OUEST-genopole® presentation December 2008
Two regions: Brittany and Pays de la LoireWhat is OUEST-genopole®?
QUIMPER
PLOUFRAGAN
RENNES
NANTES
ANGERS
BREST
ROSCOFF
LORIENT
Page 7OUEST-genopole® presentation December 2008
To support the research in genomics and post-genomics, the
setting-up and creation of new biotechnology companies
To mutualize the resources and the skills
To participate collectively to the technological evolution
To integrate the genopole network and take part in European
research programs
To attract young researchers
What do we do at OUEST-genopole®?Missions and objectives
Agriculture – Food processing
Photo Inserm
Human Health
INRIA / Photo : A. Eidelman
Bioinformatics
Marine Biology
Page 8OUEST-genopole® presentation December 2008
What is OUEST-genopole® ?
Marine Biology
AgricultureFood-processing
HumanHealth
Bioinformatics
4 main fields
5 technological core facilities = 20 technical facilities
Page 9OUEST-genopole® presentation December 2008
Technological core facilities
Production of viral vectors (Nantes) Production of synthetic vectors (Brest - Rennes) Xenope Transgenesis (Rennes) Rat Transgenesis (Nantes) Functional imaging PRISM (Rennes) Cell biochips (Rennes) (emerging) Histopathology (Rennes)
Sequencing/Genotyping
Transcriptomics
Proteomics
Functionalexploration
Bioinformatics
High-throughput protein identification (Rennes) Customized monoclonal antibodies (Angers) Biopolymers - Interactions - Structural biology (Nantes) Recombinant protein production (Nantes) Protein chips (Nantes) Interactome (Nantes)
Transcriptomics (Nantes and Rennes)
Sequencing (Roscoff, Nantes and Rennes) /Genotyping (Le Rheu) (emerging)
National core facility (Rennes)
In yellow: IBiSA pre-labelled core facilities
**
**
**
*: core facilities labelled by IBiSA in October 2008
Page 10OUEST-genopole® presentation December 2008
Technological core facilities
Collective purchase of equipment
Development of specific abilities
Recruiting of 29 engineers
Access to core facilities: 50% guaranteed
Page 11OUEST-genopole® presentation December 2008
To study the structure and the functioning of genomes from
marine organisms (bacteria, seaweeds and invertebrates)
To identify the genetic variety of various coastal, oceanic
and deep natural populations, and to understand their
adaptations to the environment
To look for new molecules for biotechnology or human
health fields
Marine biology7 research units
Marine Biology
Page 12OUEST-genopole® presentation December 2008
Agriculture – Food processing17 research units
To study biological organisms of economical importance in
France, especially in Western France:
Field vegetable and crops, fruit trees, ornamental plants
Fish, pigs, chicken
Micro-organisms used in milk transformation
To work on agricultural products of high quality and safety,
with reduced environmental impacts
Agriculture
Page 13OUEST-genopole® presentation December 2008
Human health25 research units
To characterize specific genetic diseases in Western France, e.g.
iron-metabolism disorders, cardiovascular and hematological
diseases, cystic fibrosis
To confirm an internationally-recognized, scientific expertise in
cancerology, reproductive biology and development,
immunotherapy, transplantation, autoimmunity, muscle diseases,
and gene therapy
To play a major role in the Cancéropôle Grand Ouest national
programme:
Cellular therapy
Valorisation of sea products
Pharmacogenomics and pharmacogenetics
Tumoral vectorisation
Human health
Page 14OUEST-genopole® presentation December 2008
Bioinformatics5 research units
To search and extract signatures for identification and
prediction
To construct specialised databases and development of data
banks devoted to transcriptome analysis, powerful structures
for knowledge and data management
To study gene and protein functions (classification, modelling
of interactions in cellular and molecular systems)
Bioinformatics
© INRIA / IRISA
Page 15OUEST-genopole® presentation December 2008
From Western France to Europe……OUEST-genopole® takes part in many projects
European projects Aquafirst
NoE "Marine Genomics Europe"
NoE "MED-VET-NET"
NoE NanoToLife
RISET (Immune Tolerance)
TOXDROP
"INTERREG" project (in progress)
National projects
Agenae (Analyse
du GENome des Animaux d'Elevage)
Cancéropôle Grand Ouest
GenoGRID
Génoplante
GIS Génomique Marine…
Competitiveness clusters
Atlantic Biotherapies
(Nantes / Angers)
Pôle Mer Bretagne
(Brest / Roscoff)
Végépolys (Angers)
Valorial, l'aliment de demain
(Brittany)
Page 16OUEST-genopole® presentation December 2008
Crossroads between life qciences, ecology, environment, bioinformatics
and high technologies within a multicultural European network.
Devoted to the development and spreading of high-throughput approaches
for the investigation of the biology of marine organisms.
Aimed at promoting, developing, and spreading throughout the European
Union a better understanding of the functioning of marine ecosystems and
the biology of marine organisms.
Involves about 450 scientists from 44 institutions of 16 countries (within and
outside Europe).
Coordinated by Dr Catherine Boyen, Station Biologique de Roscoff, CNRS,
France, and funded under the framework programme FP6 by the European
commission.
Network of Excellence Marine Genomics Europe (MGE)
ww
w.m
arin
e-g
enom
ics-euro
pe.o
rg
Page 17OUEST-genopole® presentation December 2008
Education and valorisation
OUEST-genopole® promotes the creation and development of
new training programmes in all fields of life sciences
OUEST-genopole® helps academic laboratories and researchers
to respond to entrepreneurial opportunities and facilitates the
emergence of start-up companies in collaboration with our
regional incubators and venture capitalists
OUEST-genopole® plays a vital role in the dynamism of Western
France and thus contributes to the economic development of our
bio-region
Page 18OUEST-genopole® presentation December 2008
Valorisation
Company creation (stemming from research activities of core facilities): Innova Proteomics (High-throughput protein identification facility) ProtNeteomix (Protein chips facility) Korilog (Bioinformatics facility) Cimna (Transcriptomics facility) Cytune Pharma (Interactome facility) …
Technological and/or commercial partnerships: Production of clinical vectors in the field of gene therapy (with the French Blood
Establishment) Transcriptomics facility: clinical transfer of activities to Nantes and Rennes
university hospitals Production of viral vectors facility and CleanCells Xenope Transgenesis facility and Biopredic International Rat Transgenesis facility and Genoway Functional imaging PRISM facility and Spin Safety Other partnerships:
Page 19OUEST-genopole® presentation December 2008
OUEST-genopole® assets
Genomics and post-genomics targeted on major
economical sectors:
Marine Biology – Agriculture – Human Health – Bioinformatics
Keys to successKeys to success: : to to capitalise oncapitalise on complementarities complementarities
within a network culturewithin a network culture
Multisite and multiactivity
Will for sharing and competingfor scientific excellence
Page 20OUEST-genopole® presentation December 2008
The annual meeting of Western France researchers and biotech companies to:
Present the advancement of scientific projects led within OUEST-genopole® as well as the future prospects
Accelerate development projects while discovering the services proposed by the research units and technological core facilities
Better know innovative companies linked to OUEST-genopole® fields Meet future partners and prospective customers
Gen2Bio 2008The annual Biotech symposiumorganised by OUEST-genopole®
www.gen2bio.org
Page 21OUEST-genopole® presentation December 2008
Christelle Hays – Internal and external communications
02 23 23 45 85 – [email protected]
Jocelyne Le Seyec – Scientific coordination and technological core facilities
02 23 23 45 81 – [email protected]
Eric Mathieu – Valorisation and education
02 41 72 86 17 – [email protected]
Céline Quéron – Chef de projet européen
02 23 23 33 42 – [email protected]
Marilène Vallois – Personal assistant
02 23 48 51 21 – [email protected]
Quality assurance (to be hired)
More information…
Page 22OUEST-genopole® presentation December 2008
Thank you for your attention!