CURRICULUM VITAE
FRANCIS XAVIER KEELEY, JR., M.D., FRCS (UROLOGY)
February 2016
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PERSONAL INFORMATION
NAME Francis Xavier Keeley, Jr.
BORN 26 May 1964, Camden, New Jersey, USA
ADDRESS 139 Westbury Road, Westbury-on-Trym, Bristol BS9 3AN
EMAIL [email protected]
GMC NO. 4455460
EDUCATION St. Joseph’s Preparatory School, Philadelphia, PA
Duke University, Durham, North Carolina, B. A. (Chem) 1986
University of Aberdeen, Scotland, 1985
Washington University School of Medicine, St. Louis, M. D. 1990
QUALIFICATIONS AND ACCREDITATION
Fellow of the Edinburgh Royal College of Surgeons.
Fellowship without examination, 2001.
Fellow of the American Board of Urology (Board certified urologist), 2000;
recertification, 2008
Mediated entry onto GMC Specialist Register 1998
Endourological Society Fellowship 1998
Fellow of the Intercollegiate Board of Urology (FRCS Urology) 1997
Diplomate, National Board of Medical Examiners (U.S.) 1991
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PROFESSIONAL EMPLOYMENT
PRESENT APPOINTMENT
Consultant Urologist (1998 - )
Bristol Urological Institute, North Bristol NHS Trust
Southmead Hospital, Westbury-on-Trym, Bristol BS10 5NB
CLINICAL RESPONSIBILITIES
Apart from general urology my clinical responsibilities include the following
urological subspecialties:
• Laparoscopic urological surgery: I have a regular practice in laparoscopic
surgery for a variety of indications, including nephrectomy for benign and
malignant disease, pyeloplasty, partial nephrectomy, renal cryoablation and
adrenalectomy.
• Stone disease:
• Extracorporeal shock-wave lithotripsy: The Bristol Urological Institute
has a Storz lithotriptor for the treatment of renal and ureteral calculi, the
only fixed-site machine in the Southwest of England. The lithotriptor
provides the backbone to a comprehensive stone treatment and
prevention service.
• Joint clinic in metabolic stone disease with Dr. Helen Campbell of
nephrology.
• Percutaneous and ureteroscopic stone extraction: Bristol serves as a
referral centre for complex kidney stone disease. I carry out minimally
invasive treatment of urinary calculi in all locations using the latest
nephroscopes and ureteroscopes, both rigid and flexible, as well as the
holmium:YAG laser.
• Minimally invasive treatment of upper urinary tract transitional cell carcinoma:
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Selected patients with upper tract tumors can be treated endoscopically, thereby
preserving their kidneys. Patients are referred from across the UK to the Bristol
Urological Institute for diagnosis and treatment.
• Minimally invasive treatment of upper urinary tract obstruction: Carefully
selected patients with ureteropelvic junction (UPJ) obstruction and ureteral
strictures can be treated endoscopically. Laparoscopic pyeloplasty has emerged
as our preferred treatment option for patients with primary and secondary UPJ
obstruction. We have one of the most extensive experiences with this procedure
in the UK.
PREVIOUS APPOINTMENTS
1996-1998 Endourology Fellow, Scottish Lithotriptor Centre,
Western General Hospital, Edinburgh
1995-1996 Chief urology resident
Thomas Jefferson University Hospital, Philadelphia
1992-1995 Urology resident
Thomas Jefferson University Hospital
1990-1992 General Surgical Intern and Junior Resident
Thomas Jefferson University Hospital
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OTHER PROFESSIONAL ACTIVITIES
2011 – 2015: HONORARY SECRETARY, BRITISH ASSOCIATION OF UROLOGICAL
SURGEONS. I served as an officer and Trustee of BAUS with primary responsibility
for overseeing the Annual Scientific Meeting. I was regularly involved in issues
involving urological services and the NHS, such as commissioning of services and
training. I have taken a leadership role for the following areas: the public reporting
of individual surgeons’ outcomes; meeting with the Department of Health regarding
the setting of tariffs, especially in endourology and kidney cancer; the BAUS Section
of Endourology; liaising with NICE; and UROLINK, which supports urology in the
developing world.
2014 – PRESENT: CHAIRMAN, BAUS DATA AND AUDIT COMMITTEE. I oversee the
annual publication of surgeon’s outcomes, which now includes nephrectomy,
percutaneous nephrolithotomy, radical prostatectomy, radical cystectomy,
urethroplasty, and surgery for stress urinary incontinence.
2008 - 2011: LEAD CONSULTANT, DEPARTMENT OF UROLOGY, BRISTOL UROLOGICAL
INSTITUTE, NORTH BRISTOL NHS TRUST. I helped to facilitate a merger of the two
departments of urology in Bristol. I carried out a detailed review and redesign of
waiting list management. This process had tangible results, including a reduction in
waiting times for review cystoscopy from 6 months overdue to within the target
month; setting internal targets for urgent non-cancer cases; and instituting a safe
transfer of care policy.
Our department has a da Vinci robot, principally to do robotic radical prostatectomy
(RRP). Concerns were raised about the safe introduction of RRP by low-volume
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surgeons, so I developed guidelines for training and oversaw the safe expansion of
the technique.
2005 – 2008: COUNCIL MEMBER, BRITISH ASSOCIATION OF UROLOGICAL SURGEONS.
While serving on BAUS Council, I collaborated to publish the BAUS Guidelines for
laparoscopic training as well as for mentorship (see publications below). I have also
contributed to the development of patient information for recovery from
laparoscopic nephrectomy, in collaboration with the Royal College of Surgeons of
England and the Department of Health. I have contributed towards the BAUS
annual meeting for each of the past 14 years.
2004 - 13: BJU International (Journal). I served as a trustee and Honorary Treasurer
(2010-13) of the Executive Committee, which oversees the publication of the journal.
As Honorary Treasurer of the BJU International Company (2010-13), a charity
dedicated to promoting urological education and research, I was responsible for an
annual budget of roughly £2m and reported to the Trustees. This role involved
regular communication with the Chief Executive and Chairman. I had to educate
myself in financial matters as the Honorary Treasurer of the BJUI during challenging
times for publishers. I reported to the Trustees 4 times per year and led the
appointment of new auditors and an investment advisor.
2003 – PRESENT: NATIONAL INSTITUTE FOR CLINICAL EXCELLENCE (NICE). I have been
asked to provide expert advice on a wide range of interventional procedures. From
2008 to 2012, I served on the Interventional Procedures Advisory Committee.
2000- PRESENT: LAPAROSCOPIC TRAINING. I have participated in laparoscopic
training through BAUS-sponsored courses as well as acting as a mentor for
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consultant urologists. I have run a laparoscopy lecture course at the BAUS annual
meeting and performed live surgery in over 15 courses at national and international
meetings.
As the regional training center for urology, NBT typically attracts specialist
registrars at the end of their training. I have trained 26 specialist registrars and 11
fellows in endourology; 14 of them have been appointed as consultants with an
interest in endourology.
I have acted as a mentor for 30 consultant urologists, assisting in 67 cases at hospitals
around the UK and abroad. The mentoring process involves demonstrating
laparoscopic procedures in Bristol, then tutoring consultants as they carry out the
same procedures at their own hospital.
I have organized courses in laparoscopic renal cryoablation and acted as a preceptor
for 10 consultants.
2005- 2007: BAUS LAPAROSCOPY TRAINER. I oversaw the hands-on teaching courses
for BAUS in the UK and in Europe. Roughly 9 courses took place each year.
2005-PRESENT: FACULTY OF THE EUROPEAN SOCIETY FOR URO-TECHNOLOGY (ESUT),
an endourology subspecialty group within the European Association of Urology
which focuses on laparoscopic training.
2009-PRESENT: CLINICAL RESEARCH OFFICE OF THE ENDOUROLOGICAL SOCIETY
(CROES): Committee member for ureteroscopic procedures. I help CROES design
and run international studies and registries which have led to over 30 publications.
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2005 – 2015: JOURNAL OF ENDOUROLOGY. I was on the Editorial Board and
contributed to the Endourology Survey Section.
2010-PRESENT: JOURNAL OF ENDOUROLOGY, VIDEOUROLOGY JOURNAL. I am on the
Editorial Board.
2010-PRESENT: CANADIAN JOURNAL OF UROLOGY. I am on the Editorial Board. Since
2015, I am an Associate Editor.
2011-PRESENT: ARCHIVIO ITALIANO UROLOGIA (JOURNAL). I am on the International
Editorial Board.
2000- 2004: ETHICS COMMITTEE, SOUTHMEAD. This involved monthly meetings and
work outside the meeting, including the review of all applications from the
Department of Surgery.
2000- 2007: CLINICAL GOVERNANCE, DEPARTMENT OF UROLOGY. This commitment
involved preparing and overseeing our clinical governance sessions including
Morbidity and Mortality meetings. Within this role, I oversaw clinical audit,
reporting of adverse events, and appraisal. I have attended courses on clinical audit
and appraisal.
2000- 2011: BAUS SECTION OF ENDOUROLOGY. I served on the audit committee,
which has carried out an audit on laparoscopic nephrectomy and the equipment
available for the treatment of stones. I have developed a database for the treatment
of PUJ obstruction as well as for upper tract TCC, which are used for the prospective
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analysis of outcomes. I have overseen the development and reporting of the BAUS
national audit of laparoscopic nephrectomy (see publications below). As mentioned
above, I have overseen laparoscopic training courses for the Section.
1997- PRESENT: ENDOUROLOGICAL SOCIETY. I served on the Board of Directors (2010-
14) which oversees an annual meeting, teaching courses, and the Journal of
Endourology. I have served on the organizing committee/faculty on 15 occasions for
the World Congress of Endourology. I performed live surgery during the 2005 and
2009 meetings. I was on the organizing committee for the 2015 meeting to be held in
London.
2004- PRESENT: COCHRANE REVIEWS. Reviewer for Cochrane reviews. I have co-
authored 3 Cochrane reviews.
2000-2001: BAUS Today (Magazine). Educational Analysis Editor.
2000-2003: BJU INTERNATIONAL (Journal). I served on the Editorial Board.
2005 – 2006: EUROPEAN UROLOGY (Journal). I served on the Editorial Board.
1997- PRESENT: REVIEW OF MANUSCRIPTS for BJU International, Journal of Urology,
European Urology, Journal of Endourology, Urology, Surgical Endoscopy, British
Journal of Surgery, British Journal of Medical and Surgical Urology, Urological
Research, InnoVait, and Journal of Pediatric Urology.
1999-2001: ENDOUROLOGY FORUM. Quarterly meetings were held to discuss new
technologies and techniques, as well as to plan studies and audits.
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PUBLICATIONS
Original papers published or accepted by peer reviewed journals
1. Chancellor MB, Rivas DA, Keeley FX, Lotfi MA, Gomella LG. Similarity of the
American Urological Association Symptom Index among men with benign
prostate hyperplasia (BPH), urethral obstruction not due to BPH and detrusor
hyperreflexia without outlet obstruction. Br J Urol 74: 200-202; 1994.
2. Keeley FX, Gomella LG, Kulp-Hugues D, and Bagley DH. Laparoscopic division
of crossing vessels at the ureteropelvic junction. J Endourol 10: 163-168, 1996.
3. Keeley FX, Jr., Kulp-Hugues D, Bibbo M, McCue PA, and Bagley DH. Diagnostic
accuracy of ureteroscopic biopsy in upper tract transitional cell
carcinoma. J Urol 157: 33-37, 1997.
4. Keeley FX, Bibbo M, McCue PA, Bagley DH. The use of p53 in the diagnosis of
upper tract transitional cell carcinoma. Urology 49: 181-186, 1997.
5. Keeley FX, Bibbo M, Bagley DH. Ureteroscopic treatment and surveillance of
upper tract transitional cell carcinoma. J Urol 157: 1560-65, 1997.
6. Keeley FX Jr, Bagley DH. Adjuvant mitomycin C following endoscopic treatment
of upper tract transitional cell carcinoma. J Urol 158: 2074-7, 1997.
7. Keeley FX Jr, Tolley DA. Laparoscopic nephroureterectomy: Making
management of upper tract transitional cell carcinoma entirely minimally
invasive. Keeley FX Jr, Tolley DA. J Endourol 12: 139-141, 1998.
8. Keeley FX Jr, Tolley DA. A Review of our first 100 cases of laparoscopic
nephrectomy: defining risk factors for complications. Br J Urol 82: 615-618, 1998.
9. Keeley FX Jr, Sharma NK, Tolley DA. Hand-assisted laparoscopic
nephroureterectomy. Br J Urol Int 83: 504-505, 1999.
10. Keeley FX; Pye SD; Smith G; Tolley DA. Optimizing results of lithotripsy using
robust electromagnetic probe. J Endourol 1999;13:261-7
11. Mohan-Pillai K; Keeley FX; Moussa SA; Smith G; Tolley DA. Endourological
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management of severely encrusted ureteral stents. J Endourol 1999; 13:377-9
12. Keeley FX; Tolley DA. Retroperitoneal laparoscopy. BJU Int 1999; 84: 212-5
13. Keeley FX; Pillai M; Smith G; Chrisofos M; Tolley DA. Electrokinetic lithotripsy:
safety, efficacy and limitations of a new form of ballistic lithotripsy. BJU Int 1999;
84: 261-3
14. Keeley FX; Gialas I; Pillai M; Chrisofos M; Tolley DA. Laparoscopic
ureterolithotomy: the Edinburgh experience. BJU Int 1999; 84: 765-9
15. Keeley FX; Moussa SA; Smith G; Tolley DA. Clearance of lower-pole stones
following shock wave lithotripsy: effect of the infundibulopelvic angle. Eur Urol
1999; 36: 371-5
16. Keeley FX; Moussa SA; Miller J; Tolley DA. A prospective study of endoluminal
ultrasound versus computerized tomography angiography for detecting crossing
vessels at the ureteropelvic junction. J Urol 1999; 162: 1938-41
17. Keeley FX Jr., Tolley DA. Endoscopic management of upper tract transitional cell
carcinoma. J Neph Urol Transpl 2000; 1: 21-27.
18. Keeley FX; Tolley DA; Moussa SA. Patient selection before endopyelotomy: can
it improve the outcome? BJU Int 2000; 86: 773-6
19. Keeley FX; Tilling K; Elves A; Menezes P; Wills M; Rao N; Feneley R. Preliminary
results of a randomized controlled trial of prophylactic shock wave lithotripsy
for small asymptomatic renal calyceal stones. BJU Int 2001;87:1-8
20. Joshi HB; Stainthorpe A; Keeley FX; MacDonagh R; Timoney AG. Indwelling
ureteral stents: evaluation of quality of life to aid outcome analysis. J Endourol
2001 Mar;15(2):151-4
21. Joshi HB; Newns N; Stainthorpe A; MacDonagh RP; Keeley FX; Timoney AG.
The development and validation of a patient-information booklet on ureteric
stents. BJU Int 2001; 88: 329-34
22. Henderson A, Gujral S, Mitchelmore AE and Keeley FX, Jr. Endourological
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techniques in the management of stent complications in the renal transplant
patient. Transplantation 2002; 15: 664-6.
23. Kumar PVS, Keeley FX Jr., Timoney AG. Safe flexible ureterorenoscopy with a
dual-lumen access catheter and a safety guidewire. BJU International 2001; 88:
638.
24. Parkin J, Keeley FX Jr., Timoney AG. Laparoscopic pelvic lymphadenectomy for
locally advanced prostate cancer. BJU Int 2002; 89:14-7; discussion 17-8.
25. Parkin J, Keeley FX, Timoney AG. Flexible ureteroscopes: a user's guide. BJU Int.
2002; 90:640-3.
26. Okeke AA, Timoney AG, Keeley FX. Hand-assisted laparoscopic nephrectomy:
complications related to the hand-port site. BJU Int. 2002; 90:364-7.
27. Collins JW, Keeley FX Jr. Is there a role for prophylactic shock wave lithotripsy
for asymptomatic calyceal stones? Curr Opin Urol. 2002; 12:281-6.
28. Parkin J, Keeley FX Jr, Timoney AG. Re-auditing a regional lithotripsy service.
BJU Int. 2002; 89:653-7.
29. Parkin J, Keeley FX, Timoney AG. Analgesia for shock wave lithotripsy. J Urol.
2002; 167:1613-5.
30. Joshi HB, Okeke A, Newns N, Keeley FX Jr, Timoney AG. Characterization of
urinary symptoms in patients with ureteral stents. Urology. 2002; 59:511-6.
31. Kumar PV, Joshi HB, Timoney AG, Keeley FX Jr. Endoluminal ultrasonography
with reusable probe: preliminary results. J Endourol 2002; 16: 667-71.
32. Joshi HB, Newns N, Stainthorpe A, MacDonagh RP, Keeley FX Jr., Timoney AG.
Ureteric stent symptoms questionnaire: Development and validation of a multi-
dimensional quality of life measure. J Urol 2003; 169:160-4.
33. Joshi HB, Stainthorpe A, MacDonagh RP, Keeley FX Jr., Timoney. Indwelling
ureteral stents: Evaluation of symptoms, quality of life and utility. J Urol 2003;
169:1065-9.
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34. Parkin J, Evans S, Kumar PVS, Timoney AG, Keeley FX Jr. Endoluminal
ultrasound prior to retrograde endopyelotomy: can the results match
laparoscopic pyeloplasty? BJU Int 2003; 91: 389-91.
35. Okeke AA, Mitchelmore AE, Keeley FX, Timoney AG. A comparison of
aspiration and sclerotherapy with laparoscopic de-roofing in the management of
symptomatic simple renal cysts. BJU Int. 2003; 92:610-3.
36. Parkin J, Keeley FX. Indwelling catheter-associated urinary tract infections. Br J
Community Nursing 2003; 8:166-7, 170-1.
37. Collins JW, Keeley FX Jr, Timoney A. Cost analysis of flexible ureterorenoscopy.
BJU Int. 2004; 93(7):1023-6.
38. Thomas A, Keeley FX. Multiple bladder stones. Images in Clinical Medicine, in
Minerva. British Medical Journal 2004; 328:176.
39. Keoghane SR, Keeley FX, Timoney AG, Browning A, Tolley DA, Joyce A,
Downey P. The BAUS Section of Endourology audit of laparoscopic
nephrectomy. BJU Int, 2004, 94(4):577-81
40. Davenport K, Timoney AG, Keeley FX. A review of conventional and alternative
methods for providing analgesia in renal colic. BJU Int, 2005; 95(3):297-300.
41. Davenport K, Keeley FX. Evidence for the use of silver-alloy-coated urethral
catheters. J Hosp Infect. 2005; 60(4):298-303.
42. Collins JW, MacDermott S, Bradbrook RA, Keeley FX Jr., Timoney AG. A
comparison of the effect of 1.5% glycine and 5% glucose irrigants on plasma
serum physiology and the incidence of transurethral resection syndrome during
prostate resection. BJU Int. 2005; 96(3):368-72.
43. Davenport K, Minervini A, Timoney AG, Keeley FX. Our experience with
retroperitoneal and transperitoneal laparoscopic pyeloplasty for pelvi-ureteric
junction obstruction. Eur Urol 2005; 48:973-7.
44. Davenport K, Timoney AG, Keeley FX Jr, Joyce AD, Downey P. A 3-year review
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of The British Association of Urological Surgeons Section of Endourology
Laparoscopic Nephrectomy Audit. BJU Int. 2006; 97: 333-7.
45. Minervini A, Davenport K, Keeley FX Jr, Timoney AG. Antegrade versus
retrograde endopyelotomy for pelvi-ureteric junction (PUJ) obstruction. Eur Urol
2006; 49: 536-42
46. Collins JW, MacDermott S, Bradbrook RA, Keeley FX Jr., Timoney AG. Is using
ethanol-glycine irrigating fluid monitoring and 'good surgical practice' enough
to prevent harmful absorption during transurethral resection of the prostate?
BJU Int 2006; 97: 1247-51.
47. Davenport K, Keeley FX Jr, Timoney AG. A comparative in vitro study to
determine the beneficial effect of calcium-channel and alpha(1)-adrenoceptor
antagonism on human ureteric activity. BJU Int 2006; 98: 651-5.
48. Collins JW, MacDermott S, Bradbrook RA, Keeley FX Jr., Timoney AG. The effect
of the choice of irrigation fluid on cardiac stress during transurethral resection of
the prostate. A comparison between 1.5% glycine and 5% glucose. J Urol. 2007;
177: 1369-73.
49. Davenport K, Minervini A, Keoghane S, Parkin J, Keeley FX, Timoney AG. Does
rate matter? The results of a randomized controlled trial of 60 versus 120 shocks
per minute for shock wave lithotripsy of renal calculi. J Urol. 2006; 176: 2055-8;
discussion 2058.
50. Nabi G, Downey P, Keeley F, Watson G, McClinton S. Extra-corporeal shock
wave lithotripsy (ESWL) versus ureteroscopic management for ureteric calculi.
Cochrane Database Syst Rev. 2007;(1): CD006029.
51. Painter DJ, Timoney AG, Denton K, Alken P, Keeley FX Jr. The modern
management of upper urinary tract urothelial cancer: tumour diagnosis, grading
and staging. BJU Int. 2007; 99: 973-7.
52. Arancibia MF, Bolenz C, Michel MS, Keeley FX Jr., Alken P. The modern
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management of upper tract urothelial cancer: surgical treatment. BJU Int. 2007;
99: 978-81.
53. Davenport K, Timoney AG, Keeley FX Jr. Effect of smooth muscle relaxant drugs
on proximal human ureteric activity in vivo: a pilot study. Urol Res. 2007; 35:
207-13.
54. Keeley FX Jr., Rimington PD, Timoney AG, McClinton S. British Association of
Urological Surgeons laparoscopic mentorship guidelines. BJU Int 2007; 100: 247-
8.
55. Keeley FX Jr., Eden CG, Tolley DA, Joyce AD. The British Association of
Urological Surgeons: guidelines for training in laparoscopy. BJU Int. 2007; 100:
379-81.
56. Harryman O, Khastgir J, Keeley FX. Endourological Management of Ureteric
Obstruction Secondary to Candida Bezoar in a Transplant Kidney. Curr
Urol 2007; 1: 48-49.
57. Arumainayagam N, Minervini A, Davenport K, Kumar V, Masieri L, Serni S,
Carini M, Timoney AG, Keeley FX Jr. Antegrade versus Retrograde Stenting in
Laparoscopic Pyeloplasty. J Endourol 2008; 22: 671-4.
58. Williams SK, Denton KJ, Minervini A, Oxley J, Khastigir J, Timoney AG, Keeley
FX Jr. Correlation of upper-tract cytology, retrograde pyelography, ureteroscopic
appearance, and ureteroscopic biopsy with histologic examination of upper-tract
transitional cell carcinoma. J Endourol 2008; 22: 71-6.
59. Painter DJ, Denton K, Timoney AG, Keeley FX. Ureteroscopic management of
upper-tract urothelial cancer: an exciting nephron-sparing option or an
unacceptable risk? J Endourol. 2008; 22: 1237-40.
60. Giannarini G, Valent F, Keeley FX, Milesa C, Mogorovich, A; Manassero F,
Barbone F, Joshi HB, Timoney AG. The Italian Linguistic Validation of the
Ureteric Stent Symptoms Questionnaire. J Urol 2008; 180: 624-8.
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61. Minervini A, Davenport K, Pefanis G, Keeley FX Jr., Timoney AG. Prospective
study comparing the bladeless optical access trocar versus Hasson open trocar
for the establishment of pneumoperitoneum in laparoscopic renal procedures.
Arch It Urol Androl 2008; 80: 95-98.
62. Desai M, Hinck B, Keeley FX, Monga M. Terapeutická endourologie: obstrukce
ureteropelvické junkce. Urol List 2008; 6(3): 38–42.
63. Keeley FX, Hinck B, Desai M, Monga M. Terapeutická endourologie: karcinom z
p�echodných bun�k lokalizovaný v horních cestách mo�ových. Urol List 2008;
6(3): 48–53.
64. Gulur DM, Young JG, Painter DJ, Timoney AG, Keeley FX. How successful is the
conservative management of Pelvi-Ureteric Junction Obstruction (PUJO) in
adults? BJU Int. 2009; 103: 1414-6; discussion 1416.
65. Keeley FX Jr., Timoney AG, Rane A, Tolley DA. Mentorship in Urological
Laparoscopic Surgery: Lessons Learned. BJU Int. 2009; 103: 1111-3.
66. Harryman O, Davenport K, Keoghane SR, Keeley FX Jr., Timoney AG. A
Comparative Study of Quality of Life Issues Relating to Open versus
Laparoscopic Nephrectomy - Prospective Pragmatic Study. J Urol 2009; 181: 998-
1003; discussion 1003.
67. Keeley FX Jr, Assimos DG. Clinical trials of the surgical management of
urolithiasis: current status and future needs. Adv Chronic Kidney Dis. 2009; 16:
65-9.
68. Keeley FX Jr, Thornton M. Radiation safety: implications for urologists and
patients. J Urol 2009; 181: 443-4.
69. Crow P, Bayley J, Keeley F Jr. Smoking and urological disease. BJU Int 2009; 103:
1317-9.
70. Laguna MP, Beemster P, Kumar P, Klingler HC, Wyler S, Anderson C, Keeley
FX, Bachmann A, Rioja J, Mamoulakis C, Marberger M, de la Rosette JJ.
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Perioperative morbidity of laparoscopic cryoablation of small renal masses with
ultrathin probes: a European multicentre experience. Eur Urol 2009; 56: 355-61.
71. Gulur D, Crow P, Keeley FX. Minimally invasive ablative technique for the
treatment of small renal masses. Arch Ital Urol Androl 2009; 81: 100-6.
72. Liatsikos EN, Kallidonis P, Stolzenburg JU, Ost M, Keeley F, Traxer O, Bernardo
N, Perimenis P, Smith AD. Percutaneous Management of Staghorn Calculi in
Horseshoe Kidneys: A Multi-Institutional Experience. J Endourol. 2010; 24: 531-6.
73. Puichaud A, Larré S, Bruyère F, Auger J, Bret N, Chevreste A, Doré B, Briffaux R,
Keeley F, Irani J. [The French linguistic validation of the Ureteric Stent Symptom
Questionnaire (USSQ)] Prog Urol. 2010; 20: 210-3.
74. Crow P, Keeley FX. Prevention and handling of complications of renal focal
therapies. J Endourol. 2010; 24: 765-7.
75. Davenport K, Keeley FX Jr, Timoney AG. Audit of safety, efficacy, and cost-
effectiveness of local anaesthetic cystodiathermy. Ann R Coll Surg Engl. 2010; 92:
706-9.
76. Dellis A, Joshi HB, Timoney AG, Keeley FX Jr. Relief of stent related symptoms:
review of engineering and pharmacological solutions. J Urol 2010; 184: 1267-72.
77. Davenport K, Kumar V, Collins J, Melotti R, Timoney AG, Keeley FX Jr. New
Ureteral Stent Design Does Not Improve Patient Quality of Life: A Randomized,
Controlled Trial. J Urol 2011 185: 175-8.
78. Lallas CD, Pak RW, Pagnani C, Hubosky SG, Yanke BV, Keeley FX, Bagley DH.
The minimally invasive management of ureteropelvic junction obstruction in
horseshoe kidneys. World J Urol. 2011; 29: 91-5.
79. Giannarini G, Keeley FX Jr, Valent F, Manassero F, Mogorovich A, Autorino R,
Selli C. Predictors of morbidity in patients with indwelling ureteric stents: results
of a prospective study using the validated Ureteric Stent Symptoms
Questionnaire. BJU Int. 2011; 107: 648-54.
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80. Philippou P, Payne D, Keeley F. "Let's get it straight": the story of the spiral
ureter. Can J Urol. 2012; 19: 6118-20.
81. Aboumarzouk OM, Kata SG, Keeley FX, McClinton S, Nabi G. Extracorporeal
shock wave lithotripsy (ESWL) versus ureteroscopic management for ureteric
calculi. Cochrane Database Syst Rev. 2012 May 16;5:CD006029
82. Hotston MR, Keeley FX. Laparoscopic partial nephrectomy without ischemia.
Review. Arch Esp Urol 2013; 66: 146-51.
83. Calvert RC, Wong KY, Chitale SV, Irving SO, Nagarajan M, Biyani CS, Browning
AJ, Young JG, Timoney AG, Keeley FX, Burgess NA. Multilength or 24 cm
ureteric stent? A multicentre randomised comparison of stent-related symptoms
using a validated questionnaire. BJU Int. 2013; 111: 1099-104.
84. Philippou P, Payne D, Davenport K, Keeley FX, Timoney AG. Does previous
failed ESWL have a negative impact of on the outcome of ureterorenoscopy? A
matched pair analysis. Urolithiasis 2013; 41: 531-8.
85. Vannahme M, Mathur S, Davenport K, Timoney AG, Keeley FX. The
management of secondary pelvi-ureteric junction obstruction – A comparison of
pyeloplasty and endopyelotomy. BJU Int 2014; 113: 108-112.
86. Sanguedolce F, Millán-Rodriguez F, Santillana-Altimira JM, Fantova-Alonso A,
Sánchez-Martín FM, Angerri-Feu O, Lopez Martinez JM, Keeley FX, Joshi HB,
Villavicencio-Mávrich H. The Spanish Linguistic Validation of the Ureteral Stent
Symptom Questionnaire. J Endourology 2014; 28: 237-42.
87. Dellis AE, Keeley FX Jr, Manolas V, Skolarikos AA. The role of alpha-blockers in
the treatment of stent-related symptoms. A prospective randomized control
study. Urology 2014; 83: 56-61.
88. de la Rosette J, Denstedt J, Geavlete P, Keeley F, Matsuda T, Pearle M, Preminger
G, Traxer O; CROES URS Study Group. The clinical research office of the
endourological society ureteroscopy global study: indications, complications,
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and outcomes in 11,885 patients. J Endourol. 2014; 28: 131-9.
89. El-Nahas AR, Elsaadany MM, Tharwat M, Mosbah A, Metwally AH, Hawary A,
Keeley FX Jr, Sheir KZ. Validation of the Arabic linguistic version of the Ureteral
Stent Symptoms Questionnaire. Arab J Urol. 2014; 12(4): 290-3.
90. Henderson JM, Fowler S, Joyce A, Dickinson A, Keeley FX; BAUS. Perioperative
Outcomes of 6042 Nephrectomies in 2012: Surgeon-reported results in the United
Kingdom from the BAUS Nephrectomy Database. BJU Int. 2015 ; 115 : 121-6.
91. Hadjipavlou M, Khan F, Fowler S, Joyce A, Keeley FX, Sriprasad S. Partial vs
radical nephrectomy for T1 renal tumours: an analysis from the British
Association of Urological Surgeons Nephrectomy Audit. BJU Int. 2015; Mar 6.
doi: 10.1111/bju.13114.
92. Henderson JM, Fabricius MJ, Fowler S, Keeley FX, Dickinson A. The
complications of laparoscopic renal surgery: A review of 10 years of audit data in
the UK. J Clin Urol 2016: 9: 23-31.
Invited articles and Letters:
1. Keeley FX Jr, Tolley DA. Techniques of endopyelotomy. (Letter) Br J Urol Int
83: 879, 1999.
2. Joshi HB; Stainthorpe A; Keeley FX. Re: Incorporation of patient preferences
in the treatment of upper urinary tract calculi: a decision analytical view
(letter). J Urol 2000; 164(2): 460
3. Kumar PV; Keeley FX; Timoney AG. Re: Retrograde ureteropyeloscopy for
lower pole caliceal calculi (letter). J Urol 2000; 164(4): 1318
4. Painter DJ; Keeley Jr FX. New concepts in the treatment of ureteral calculi.
Curr Opin Urol 2001;11:373-8
5. Keeley FX Jr. Editorial Comment on: Finelli A, Honey RJ. Thoracoscopy-
assisted high intercostal percutaneous renal access. J Endourol. 2001; 15: 581-
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4; discussion 584-5.
6. Keeley FX. Contemporary trends in laparoscopic urologic surgery (book
review). BJU Int. 2002; 90:766.
7. Keeley FX. How to choose a flexible ureteroscope. Urology News 2002.
8. Keeley FX; Keoghane SR. Training in laparoscopic urology: How to get
started. Urology News 2003.
9. Keeley FX, Jr. Editorial Comment on Carini M, Minervini A, Masieri L,
Lapini A, Semi S. Simple enucleation for the treatment of PT1a renal cell
carcinoma: our 20-year experience. Eur Urol 2006; 50: 1263-8; discussion
1269-71.
10. Keeley FX Jr., Timoney AG. Routine stenting after ureteroscopy: think again.
Eur Urol. 2007; 52: 642-4.
11. Keeley FX Jr. Editorial Comment on: Jain A, Shah TK. Effect of air bubbles in
the coupling medium on efficacy of extracorporeal shock wave lithotripsy.
Eur Urol 2007; 51: 1680-6; discussion 1686-7.
12. Giannarini G, Mogorovich A, Selli C, Keeley FX Jr. Re: Indwelling ureteral
stents and sexual health: a prospective, multivariate analysis. M. C.
Sighinolfi, S. Micali, S. De Stefani, A. Mofferdin, M. Grande, M. Giacometti,
N. Ferrari, M. Rivalta and G. Bianchi. J Urol 2007; 178: 229-231 (letter).
13. Rané A, Eng MK, Keeley FX Jr. Port site metastases. Curr Opin Urol 2008; 18:
185-9.
14. Rane A, Keeley FX Jr. Is robotically assisted laparoscopic pyeloplasty
effective for the treatment of pelvi-ureteric junction obstruction? Nat Clin
Pract Urol 2008.
15. Paterson RF, Matsuda T, Marcovich R, Patel A, Tiselius HG, Keeley FX Jr,
Michel MS, Lee DI. Survey of endourology. J Endourol 2008; 22: 231-42.
16. Crow P, Keeley FX. Does the rate of shock wave delivery affect outcomes in
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patients receiving shock wave lithotripsy for urinary calculi? Nature Clin
Prac Urol. 2008; 5: 478-9.
17. Giannarini G, Mogorovich A, Selli C, Keeley FX Jr. Letter to the Editor Re:
Indwelling ureteral stents and sexual health: a prospective, multivariate
analysis. J Urol. 2008; 180: 1188-9.
18. Kumar V, Keeley FX Jr. Percutaneous nephrolithotomy: why do we use rigid
dilators? J Endourol 2008; 22: 1877-9; discussion 1885, 1889.
19. Keeley FX Jr, Minervini A. Editorial comment on Gabr AH, Gdor Y, Strope
SA, Roberts WW, Wolf JS Jr. Patient and pathologic correlates with
perioperative and long-term outcomes of laparoscopic radical nephrectomy.
Urology 2009; 74: 640-1; author reply 642.
20. Joshi HB, Keeley FX, Timoney AG. Re: a novel drug eluting ureteral stent: a
prospective, randomized, multicenter clinical trial to evaluate the safety and
effectiveness of a ketorolac loaded ureteral stent: A. E. Krambeck, R. S.
Walsh, J. D. Denstedt, G. M. Preminger, J. Li, J. C. Evans and J. E. Lingeman J
Urol 2010; 183: 1037-1043. J Urol. 2010 Nov;184(5):2217-8; author reply 2218.
21. Keeley FX Jr. Editorial comment. Jeon HG, Lee SR, Kim KH, Oh YT, Cho NH,
Rha KH, Yang SC, Han WK. Benign lesions after partial nephrectomy for
presumed renal cell carcinoma in masses 4 cm or less: prevalence and
predictors in Korean patients. Urology 2010 Sep; 76(3): 579.
22. Phipps S, Tolley DA, Young JG, Keeley FX Jr. The management of ureteric
stones (invited manuscript). Ann R Coll Surg Engl 2010 Jul; 92(5): 368-72.
23. Keeley FX Jr. Editorial comment. Comment on Benign lesions after partial
nephrectomy for presumed renal cell carcinoma in masses 4 cm or less:
prevalence and predictors in Korean patients. Urology 2010 Sep; 76(3): 579.
24. Joshi HB, Keeley FX, Timoney AG. Editorial comment. Re: a novel drug
eluting ureteral stent: a prospective, randomized, multicenter clinical trial to
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evaluate the safety and effectiveness of a ketorolac loaded ureteral stent: A.
E. Krambeck, R. S. Walsh, J. D. Denstedt, G. M. Preminger, J. Li, J. C. Evans
and J. E. Lingeman J Urol 2010; 183: 1037-1043. J Urol. 2010 Nov;184(5):2217-
8; author reply 2218.
25. Keeley FX Jr. Endoscopic biopsy of upper tract tumors: why bother? Can J
Urol. 2012 Dec;19(6):6566.
26. Keeley FX Jr. Stent placement under local: too painful to be practical? Can J
Urol. 2014; 21: 71.
27. Keeley FX Jr. Global CROES Ureteroscopy Registry Demonstrates Striking
Cooperation Among Endourologists. Eur Urol. 2014; 66: 110-1.
28. Keeley FX Jr. Public reporting of individual surgeons' outcomes in the UK.
Can J Urol. 2014; 21: 7429.
Chapters:
1. Keeley FX, Gill IS, and Gomella LG. Laparoscopic preperitoneal
lymphadenectomy. In: Textbook of Endourology. Editors: Sosa, Jenkins,
Perlmutter, and Albala. W.B. Saunders. Chapter 31, pp 505-510; 1996.
2. Keeley FX and Gomella LG. Epidemiology of Prostate Cancer. In: Urologic
Cancers. Ernstoff MS, Heaney JA, and Peschel RE (eds). W.W. Norton, New
York. Chapter 1, p.1, 1997.
3. Keeley FX, Jr. and Tolley DA. Stone disease and minimally invasive surgery.
In: Urology Highlights, 1996. Shah J (ed.). Healthcare Press. p 74-79, 1997.
4. Keeley FX, Jr., Tolley DA. Stone disease and minimally invasive surgery. In:
Urology Highlights, 1997. Shah J (ed.). Healthcare Press. p 76-82, 1998.
5. Keeley FX Jr., Tolley DA. Extracorporeal shock wave lithotripsy of renal
calculi. In Vaughn ED, Perlmutter A, Marberger M, An Atlas of Urology. In
press, 1999.
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6. Keeley FX, Jr., Tolley DA. Stone disease and minimally invasive surgery. In:
Urology Highlights, 1998-99. Shah J (ed.). Healthcare Press. p 81-87, 1999.
7. Keeley FX, Kumar PVS. Urinary stone disease: upper urinary tract
obstruction. In: ‘Essential Surgical Practice’. (Eds) Sir Alfred Cuschieri, Prof
Robert JC Steele and Prof AR Moosa. Arnold, 2002: 1269-1281
8. Keoghane SR, Keeley FX. Laparoscopic Management of Calculus Disease. In
Glenn’s Operative Urology, 6th Edition, Laparoscopy Section, Leonard G.
Gomella, Section Editor.
9. Keeley FX. Ureteral stones in pregnancy. In WHO Consultation on Stone
Disease, 2002.
10. Keeley FX. Medullary sponge kidney. In 5-Minute Urology Consult. Editor
Leonard G. Gomella, Lippincott Williams & Wilkins, 2000.
11. Keeley FX. Pneumaturia. In 5-Minute Urology Consult. Editor Leonard G.
Gomella, Lippincott Williams & Wilkins, 2000.
12. Dickerson D, Keeley FX. Penile and upper urinary tract cancer. In The year in
urology 2002.
13. Timoney AG, Keeley FX. Urolithiasis and endourology. In The year in
urology 2002.
14. Keeley FX, Timoney AG, Schwaibold H. Laparoscopy and robots. In The year
in urology 2002.
15. Goh M, Keeley FX. Laparoscopic radical prostatectomy. In The year in
urology 2003.
16. Davenport K, Keeley FX. Diagnostic Ureteroscopy. In Smith’s Textbook of
Endourology, 2nd edition.
17. Harryman O, Keeley FX Jr. Stones in Pregnancy. In WHO Consultation on
Stone Disease, 2008.
18. Young JG, Keeley FX Jr. Transabdominal Pyeloplasty. In Essentials of
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Pediatric Endoscopic Surgery. Eds. Amulya K. Saxena and Michael
E. Höllwarth. Springer Berlin Heidelberg 2008. pp. 409-413.
19. Chua WJ, Keeley FX. Endometriosis affecting the urinary tract. In
Laparoscopic Surgery for Benign Gynaecology. 2011. Edited by Sanjay Vyas.
20. Goh MHC, Pellatt RA, Keeley FX. Transitional Cell Cancer. In Ureteroscopy:
Indications, Instrumentation, and Technique. 2012. Edited by Manoj Monga.
21. Hotston M, Keeley FX. Upper tract TCC epidemiology. In Percutaneous
Renal Surgery edited by Manoj Monga. 2013
22. Mathur S, Keeley FX. Stenting. Urinary Stones: Medical and Surgical
Management (edited by Michael Grasso and David Goldfarb). 2013.
23. John Michael Henderson and Francis X. Keeley Jr . Topical Chemotherapy. In
Upper Urinary Tract Urothelial Carcinoma. Edited by Michael Grasso III and
Demetrius H Bagley. Springer, 2015.
BOOK EDITOR
1. Rane A, Keeley FX Jr., Painter D. Top Tips in Laparoscopic Urology. 2007
Euromed Communications, Surrey, England.
2. Rane A, Desai M, Monga M, Keeley FX Jr. Top Tips in Endourology. 2008
Euromed Communications, Surrey, England.
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RESEARCH GRANTS
• Successful application to the Southmead Hospital Research Foundation
(£7,000) for the assessment of quality of life in patients with ureteral stents.
• Successful submission to the Southmead Hospital Research Foundation to
continue collecting follow-up data from the MRC Asymptomatic Kidney
Stone Study (£7,000).
• Successful application to Bard Ltd (£30,000) for the development of a multi-
dimensional questionnaire to assess patients’ symptoms related to ureteral
stents.
• Participation in a multicenter study of stent-related symptoms sponsored by
Microvasive/Boston Scientific (£3,000).
• Alpha blocker (Tamsulosin) versus placebo randomized controlled trial.
Supported by Astellas Pharmaceuticals. Adopted by the National Institute
for Health Research (NIHR).
• Co-applicant for successful National Institute for Health Research Health
Technology Assessment Grant, CONSERVE, comparing surgery with needle
ablation in the treatment of small renal masses.
• Co-applicant for successful National Institute for Health Research Health
Technology Assessment Grant, SUSPEND, comparing calcium channel
blocker and alpha blocker to placebo in the management of ureteric stones.
Member of the Trial Steering Committee.
• Co-applicant for successful National Institute for Health Research Health
Technology Assessment Grant, POUT, comparing chemotherapy to standard
care for patients with invasive upper tract transitional cell carcinoma.
Member of the Trial Management Group.
• Co-applicant for National Institute for Health Research Health Technology
Assessment Grant, TISU, comparing ureteroscopy to shock wave lithotripsy
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for ureteric stones.
• Co-applicant for successful National Cancer Research Institute Grant, UK
Active Surveillance Study for Small Renal Masses.
• EuRECA, the European Renal Cryoablation Registry. Grant for £125,000 from
Galil Medical.
RESEARCH
My research activity includes the following aspects of upper urinary tract disorders:
• The qualitative aspects of surgeon-reported outcomes.
• Cryoablation and partial nephrectomy in the treatment of kidney tumors.
• The diagnosis and minimally invasive management of upper urinary tract
transitional cell carcinoma.
• The evaluation and treatment of ureteropelvic junction obstruction.
• The development of new techniques in laparoscopic urological surgery.
• The minimally invasive management of stone disease.
• The investigation of mechanisms responsible for stone fragmentation from
extracorporeal shock wave lithotripsy (SWL).
• The role of anatomic factors in stone clearance following SWL.
• Comparison of irrigating fluids during TURP.
• Endoluminal ultrasound in the evaluation of UPJ obstruction and the staging
of upper tract transitional cell carcinoma.
• The quality of life of patients with urinary stone disease, especially in
patients requiring ureteral stents.
• The evaluation of ureteral physiology and pharmacology.
• The evaluation of medical expulsive therapy for ureteral stones.
Current research projects include:
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• The qualitative aspects of surgeon-reported outcomes.
• Cryoablation of kidney tumors as part of a European cryoablation registry
(EuRECA). I serve as chair of the Steering Committee.
• Analysis of predictive factors for complications following nephrectomy.
• Management of patients with failed previous treatment for PUJ obstruction.