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Foot and Mouth DiseaseAgeing of Lesions
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Foot and Mouth DiseaseAgeing of Lesions
Revised January 2005
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Contents
1
PAGE No.
PREFACE 3
INTRODUCTION 4
PLATE No. ANIMAL SITE OF LESIONS AGE OF LESIONS (DAYS)
1 Steer Tongue 1 7
2 Steer Mouth 1 + 2 8
3 Steer Mouth 2 9
4 Steer Mouth 2 10
5 Steer Tongue 3 11
6 Steer Mouth 4 12
7 Steer Tongue 10 13
8 Steer Foot 2 14
9 Steer Foot 2 15
10 Steer Foot 2 16
11 Steer Foot 3 17
12 Steer Foot 5 18
13 Steer Foot 7 19
14 Steer Foot 7 20
15 Steer Foot 11 21
16 Cow Teat 1 22
17 Sheep Dental pad 1 23
18 Sheep Dental pad and gum 2 24
19 Sheep Tongue 2 25
20 Sheep Dental pad 2 26
21 Sheep Dental pad 3 27
22 Sheep Tongue 12 28
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PAGE No.
PLATE No. ANIMAL SITE OF LESIONS AGE OF LESIONS (DAYS)
23 Sheep Foot 1 29
24 Sheep Foot 2 30
25 Sheep Foot 2 31
26 Sheep Foot 2 32
27 Sheep Foot 3 33
28 Sheep Foot 4 34
29 Sheep Foot 6 35
30 Sheep Foot 10 36
31 Goat Mouth 2 37
32 Goat Foot 1 38
33 Pig Snout 1 39
34 Pig Snout, gum, lips 1 40
35 Pig Snout, lips 2 41
36 Pig Snout, lips 3 42
37 Pig Snout, lips 4 43
38 Pig Tongue 1 44
39 Pig Tongue 3 45
40 Pig Tongue 4 46
41 Pig Tongue 8 47
42 Pig Foot 1 48
43 Pig Foot 2 49
44 Pig Foot 3 50
45 Pig Foot 6 51
46 Pig Foot 8 52
47 Pig Foot 9 53
48 Pig Foot 9 54
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Preface
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This booklet contains a series of photographs which illustrate thelesions of Foot and Mouth disease in livestock, from their initialappearance until their regression and healing. It is intended to assistveterinarians carrying out clinical inquiries to estimate the age ofthe lesions.
The photographs were taken at the Institute for Animal Health atPirbright and the booklet was compiled in collaboration with theVeterinary Exotic Diseases Division and the State Veterinary Service.Particular acknowledgement is made to Dr Alex Donaldson whocompiled the booklet and to Jennifer Ryder for the photographs.
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Introduction
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When investigating Foot and Mouth Disease (FMD), the best estimateof the age of lesions, particularly of the oldest, is an essential part ofthe case history and a pre-requisite for epidemiological investigationof the origin of infection. Furthermore, establishment of the age oflesions and the number and species of animals affected is the basisfor any assessment of the duration and weight of virus excretion andprediction of further spread.
The pictures in this booklet are those that might be expected undercertain circumstances, however the clinical manifestation of particularstrains of the virus may result in less typical lesions, especially insheep. In these cases, lesions may be transient and rapid secondaryinfection or contamination can confuse the clinical picture.
The photographs have been taken of animals infected by contactexposure. The examples are representative of the type of lesionswhich might be expected at usual sites in the different species,between the stages of vesicle (blister) formation, rupture and healing.The age of the lesion in days is displayed below each image. Oncethe vesicles have ruptured, the rate of healing can be influenced bymany factors. Therefore it is generally only possible to give anapproximate estimate of the age of a lesion. Between days 0 and 5 itshould be possible to date them accurately within a margin of oneday, but after this period the ability to date them precisely decreases.
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The following descriptions for estimating the age of legions are basedon those of Kitching and Mackay (State Veterinary Journal, 5,Number 3, October 1995, pages 4 – 8).
Day of Clinical Disease Appearance of lesion
Day 1 Blanching of epithelium followed by formation offluid filled vesicle
Day 2 Freshly ruptured vesicles characterised by rawepithelium, a clear edge to the lesion and nodeposition of fibrin
Day 3 Lesions start to lose their sharp demarcation andbright red colour. Deposition of fibrin starts tooccur.
Day 4 Considerable fibrin deposition has occurred andregrowth of epithelium is evident at the peripheryof the lesion.
Day 7 Extensive scar tissue formation and healing hasoccurred. Some fibrin deposition is usually stillpresent.
An estimation of the age of vesicular lesions can be made using thetable above. It is important to bear in mind that ageing of lesions canonly be approximate as other factors, such as secondary infection,can alter the rate at which the lesions heal.
In pigs most information can be obtained by studying foot lesions,especially those involving the coronary band. If the lesion is still at the
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coronary band it is unlikely to be more than about one week old,thereafter the break in continuity of the horn gradually grows downthe claw at a rate of approximately 1 mm per week. Consequently byallowing a week for the lesion to grow out of the coronary band andthen a week for each millimetre from the coronary band a very roughestimate of the age of an old lesion can be made.
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Plate 1Tongue of steer with 1-day-old vesicle which ruptured when thetongue was drawn from the mouth.
Plates
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Plate 2Steer with 2-day-old ruptured vesicle along upper gum and several1-day-old unruptured vesicles on the tongue.
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Plate 3Two-day-old ruptured vesicles on the tongue, lower gum and lowerlip of a steer. Note sharp edges to ulcerated areas.
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Plate 4A further example of 2-day-old lesions in the mouth of a steer. Again note sharp margins of lesions and red raw appearance ofexposed dermis.
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Plate 5Tongue of steer with 3-day-old lesions. Sero-fibrinous exudation intothe lesions has resulted in a loss of earlier red raw appearance andalso sharpness of margination. Early granulation evident.
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Plate 6Same animal as in plate 5 with 4-day-old lesions.Note progressive loss of lesion margination and extensive fibrininfilling.
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Plate 7Steer’s tongue with a 10-day-old lesion characterised by loss ofpapillae, indentation at the site of the lesion and fibrous tissueproliferation.
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Plate 8Foot of a steer with a 2-day-old unruptured vesicle in the inter-digitalspace.
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Plate 9A different steer also with a 2-day-old inter-digital vesicle.
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Plate 10The heel bulbs of a steer’s foot with unruptured 2-day-old vesicles.
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Plate 11The same foot as in Plate 10, 1 day later. The epithelium overlying thevesicle is friable and easily stripped off.
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Plate 12A 5-day-old lesion on a steer’s foot. Signs of early granulation areevident.
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Plate 13A 7-day-old lesion on a steer’s foot. Healing is progressingunderneath the necrotic epithelium.
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Plate 14Another example of a 7-day-old inter-digital foot lesion on a steer.
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Plate 15An 11-day-old foot lesion on the heel bulb of a steer.Note healing and under-running of horn tissue.
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Plate 16One-day-old vesicles on the teat of a cow. Rupturing has not takenplace but several vesicles have coalesced.
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Plate 17Sheep’s mouth with two small unruptured vesicles on the dental padat 1 day of age.Note blanched, glistening appearance of lesions.
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Plate 18Two-day-old lesion on the dental pad and upper gum of a sheep. Themargins of the lesion are sharp.
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Plate 19Further examples of 2-day-old lesions, in this case on a sheep’stongue.
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Plate 20A 2-day-old lesion on the dental pad of a sheep.
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Plate 21The same sheep as in Plate 20, 1 day later.Note rapid loss of edge definition of lesion.
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Plate 22Sheep’s tongue with two 12-day-old lesions only discernible by loss ofpapillae and indentation of tongue surface.
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Plate 23Sheep’s foot with 1-day-old unruptured vesicle along the coronary band.Note necessity to reflect hair to view the lesion.
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Plate 24Two-day-old lesions in the inter-digital space and along the coronarybands of a sheep’s foot.Note blanching and swelling.
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Plate 25Sheep’s foot with coronary band vesicles of 2 days of age, one ofwhich has ruptured.
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Plate 26Sheep’s foot with 2-day-old coronary band lesion.Note the necessity to reflect the hair in order to view the lesion.
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Plate 27Same foot as in Plate 26, one day later i.e. 3-day-old lesion.Note sero-fibrinous exudate and swelling.
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Plate 28A 4-day-old coronary band lesion on a sheep’s foot. Swelling hasdecreased and signs of early healing are evident.
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Plate 29A 6-day-old lesion on the coronary band of a sheep’s foot.Note scab formation and rapid rate of healing.
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Plate 30A sheep’s foot with a 10-day-old healed coronary band lesion.Note under-running of horn tissue.
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Plate 31Goat with 2-day-old lesions on tongue and upper and lower lips.
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Plate 32Goat’s foot with 1-day-old unruptured coronary band vesicle.Comment: foot-and-mouth disease vesicles in goats are generally lesspronounced than in sheep and heal and regress even more rapidly.
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Plate 33One-day-old unruptured vesicles on the snout of a pig.
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Plate 34One-day-old vesication of a pig’s snout, gum and lips.
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Plate 35Same animal as shown in Plate 34, 1 day later, i.e. 2-day-old vesicles.Note necrosis of epithelium at lesion sites.
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Plate 36Same animal as in Plate 35 with 3-day-old lesions.Note extensive necrosis of affected epithelium.
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Plate 37The same animal as in Plate 36, 1 day later i.e. 4-day-old lesions. Scab formation and healing evident.
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Plate 38Mouth of pig showing single, 1-day-old, unruptured vesicle at edgeof tongue.
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Plate 39Three-day-old lesions on the tongue of a pig. Sero-fibrinous in-fillingand early healing are evident in the lesions at the edge.
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Plate 40Four-day-old lesions on the tongue of a pig. Fibrinous in-filling is extensive.Note similarity with bovine lesions of same age in plate 6.
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Plate 41Tongue of pig showing 8-day-old healed lesions.
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Plate 42One-day-old coronary band lesions on a pig’s feet.
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Plate 43Unruptured vesicle on the supernumerary digit of a pig’s foot. Twodays of age.
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Plate 44Pig’s feet with 3-day-old lesions along the coronary bands of mainand supernumerary digits.
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Plate 45Six-day-old lesions on a pig’s feet.Note sero-fibrinous in-filling.
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Plate 46Pig’s feet with 8-day-old lesions. Under-running of horn tissue isevident as well as extensive scab formation and healing.
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Plate 47Pig’s feet with 9-day-old lesions.
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Plate 48The same pig’s feet as shown in Plate 47, also at 9 days.
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Plate 5Tongue of steer with 3-day-old lesions. Sero-fibrinous exudation intothe lesions has resulted in loss of earlier red raw appearance and alsosharpness of margination. Early granulation evident.
Foot and Mouth DiseaseAgeing of LesionsContact us
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