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Fluid therapy in central neural system infections in
children
Infectious diseases department
Dr. Nguyễn Song Hưng
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increased intracranial pressure:
ICP > 20mmHg
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three trials with a total of 420 children
no significant difference between maintenance versus restrictive fluid regimens for the outcome of death and acute
severe neurological complications
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some evidences favouringmaintenance fluid therapy
over restricted fluids for chronic severe neurological
events
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Hundred ten children (1–12 yr) with acute CNS infec-tions having raised intracranial pressure and a
modified Glasgow Coma Scale score less than or equal to 8 were enrolled
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Patients were randomized:
Group 1: cerebral perfusion pressure–targeted therapy (n = 55) (maintaining
cere-bral perfusion pressure ≥ 60 mm Hg, using normal saline bolus and
vasoactive therapy—dopamine, and if needed noradrenaline)
Group 2: intracranial pressure–targeted therapy (n = 55) (maintaining intra-
cranial pressure < 20 mm Hg using osmotherapy while ensuring normal
blood pressure)
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CONCLUSION
• No significant difference between maintenance versus restrictive fluid regimens for the outcome of death and acute severe neurological complications but favouring maintenance fluid therapy over restricted fluids for chronic severe neurological events in acute bacterial meningitis
• This study shows that CPP-targeted therapy, which relied on more frequent use of vasopressors and lesser use of osmotherapy and hyperventilation, was superior to ICP - targeted therapy for management of raised ICP in children with acute CNS infection
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Thank you for listening