Download - Fluconazole vs Terbinafin
Fakultas Kedokteran dan KesehatanUniversitas Muhammadiyah Jakarta
2014
Comparison the Efficacy of Fluconazole and Terbinafine in Patients with Moderate to Severe
Seborrheic DermatitisNarges Alizadeh, Hamed Monadi Nori, Javad Golchi, Shahriar S. Eshkevari, Ehsan Kazemnejad, Abbas
Darjani
Department of Dermatology, Razi Hospital, Guilan University of Medical Science, Rahst, IranDepartment of Preventive and Community Medicine, Guilan University of Medical Science, Rahst, Iran
Clinical Study
Dipresentasikan oleh :
Riyan Sopiyan, S.KedDokter Pembimbing :
Dr. Endang Triwahyuni, SpKK, M.Kes
IntroductionDermatitis seboroik merupakan kelainan inflamasi kronik kulit yang terbatas pada
area tertentu di kulit seperti skalp, wajah, tubuh atas, dan flexure. Hal ini diduga berkaitan dengan produksi sebum berlebih dan jamur Malassezia yang normal
berada di tubuh.
KortikosteroidPrednison 20 – 30
mg/hari
Isotretinoin0.1-0.3 mg/kgBB/hari
Narrow Band UVB (TL-01)
3x/minggu selama 8 minggu
Ketokonazole200mg/hari
Flukonazole300 mg/minggu 4 minggu
Terbinafine250mg/hariVS
Material and Method
?Pasien dermatitis
seboroik tanpa riwayat
penggunaan steroid, antifungal atau obat topikal atau sistemik lain untuk minimal 2 minggu sebelum
studi
Memiliki riwayat CRF, gagal hati,
psoriasis, infeksi HIV, alergi
terbinafine atau flukonazole,
sedang menyusui.
Include exclude
*tes lab: CBC, BUN, Cr, AST, ALT, dan ALK-Ph
Study Population
Material and MethodSeverity Index
Seborrheic Dermatitis Area Severity Index (SDASI score)
(mild = 0 – 79, moderate = 8-15.9 , severe > 16)
Itching grading (0 = absent, 1 = mild, 2 = moderate, 3 =
severe)
Statistical analysis
Independent T-Test
Turkey-Kramer test
Mann-Whitney test
Wilcoxon test
ANOVASPSS V.16 P<0.05
Result
DiscussionPada studi ini, kedua obat yang diuji baik terbinafine maupun fluconazole efektif
sebagai pengobatan independen dimana terbinafine menurunkan SDASI lebih baik dibandingkan dengan fluconazole
Terbinafine merupakan antifungal spektrum luas yang
memiliki efek antiinflamasi dan bersifat lipofilik
Fluconazole harus diresepkan dengan dosis yang lebih tinggi
untuk mencapai MIC (minimum inhibitory concentration) optimal
Pola pemberian fluconazole 1x perminggu merupakan keuntungan
tersendiri bagi pasien.
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