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Explain the gross anatomy and functions of the respiratory system.
Discuss the structure and functions of the upper and lower respiratory tracts in detail, including a description of the histology in each region.
Identify the pleural cavities, its membranes and the muscles of ventilation.
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Respiratory System Function
Major Functions
Upper respiratory system:1. Air conditioning2. Defense against
pathogens
Lower respiratory system:1. Speech & other
respiratory sounds 2. Gas exchange3. Maintenance of
homeostasis, e.g. pH Fig 24-1
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Respiratory Epithelium
Structure?
Mucus produced by ________
Mucus escalator
Defense by means of •filtering hairs•ciliary escalator•sticky mucous
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Nasal Conchae
Superior, middle and inferior
Other name: “Turbinate bones” because they create ______
Advantage ?
! Respirator breathing !
Fig 24.3
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Upper Respiratory System
1) Nose external and internal nares turbinates or conchae (superior, middle, and inferior) nasal septum hard palate
2) Pharynx - shared passageway for respiratory and digestive systems
nasopharynx - part above uvula and posterior to internal nares oropharynx – portion visible in mirror when mouth is wide open
uvula - posterior edge of soft palate laryngopharynx – between the hyoid bone & the esophagus
Fig 24.3c
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Lower Respiratory System
Anything below Pharynx
Larynx: Cartilaginous cylinder (from C4- C7)
Made up of 9 cartilages– 3 large unpaired (know these!)– 3 small paired (involved in construction of voice box
Stabilized by ??
C3
C4C5
C6C7
Fig 24.4
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Trachea
Passageway to lungs (attached via ligament to ?)
Lining ?
Incomplete cartilage rings (C-shaped) - completed by trachealis muscle. Significance?
Annular ligament
Fig 24-7
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Tracheal Blockage
oorr
Heimlich Maneuver Heimlich Maneuver or abdominal thrustor abdominal thrust
TracheostomyTracheostomy
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From Bronchi to Lungs
1 bronchi (enter lungs at hilus, complete cartilage
rings)
2 bronchi (from now on cartilage plates)
3 bronchi
Bronchioles
Terminal bronchioles
Respiratory bronchioles
Alveolar ducts
Alveolar sacs
Conducting portion
Respiratory portion
Fig 24.9
Fig 24.11
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Paired Lungs
Situated in _________
Subdivided into lobes (each supplied by 2 bronchus)
Right lung: 3 lobes (rel. broad and short)
Left lung: 2 lobes (long and narrow)
Right and left lung separated by __________
Lung hilus
Why?Fig 24-8
Fig 24-8
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Alveolar Organization
Alveoli are site of gas exchange
Close association with capillaries
Lots of elastic fibers in alveolar wall
Alveolar cells Type I cells – respiratory epitheliocytesType II cells – septal cells – produce surfactantAlveolar Macrophages – dust cells – phagocytic
Fig 24-11
Fig 24-12
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Respiratory Membrane
Different from respiratory epithelium
Super thin. Made up of 4 layers:
1. epithelium of alveolus 2. its basement membrane
back to back and fused to the
3. basement membrane of capillary endothelium
4. endothelium of capillary
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Chronic progressive enlargement of alveoli accompanied by destruction of their wall
Due to prolonged exposure to respiratory irritants (??)
Emphysema
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Pleural Cavities and Membranes
Two cavities separated by mediastinum
Lining of cavities?
pleurisy
Pneumothorax
Conducting blood supply to the lungs via bronchial arteries. Venous return to pulmonary veins (consequence ?)
Fig 24-13
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Pulmonary Embolism
Causes for development of emboli in veins of legs:
Immobilization
Trauma
Long surgeries
Oral contraceptives
Obesity
Cigarette smoking
Hypertension
See p. 805
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Respiratory Muscles
Diaphragm: depresses inhalation
External intercostals: elevate ribs inhalation
Internal intercostals: depress ribs active exhalation
Accessory muscles - serratus anterior, scalenes, pectoralis minor, sternocleidomastoid, internal and external obliques, transverse abdominus, rectus abdominus
Fig 24-14
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