![Page 1: Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC ...TDMSE Version: 3.0.2.0_001 PWG Approval Date: 11/26/2007 Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL](https://reader034.vdocuments.us/reader034/viewer/2022051823/5fed56a1c69d0e2eda06e943/html5/thumbnails/1.jpg)
F1_Rev.1_R2NTP Study Number: C20316
Lock Date: 03/06/2006
Cage Range: ALL
Date Range: ALL
Reasons For Removal: ALL
Removal Date Range: ALL
Treatment Groups: Include ALL
Study Gender: Both
TDMSE Version: 3.0.2.0_001
PWG Approval Date: 11/26/2007
Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:13:55
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/15/05 / 06/16/05Species/Strain: RATS/F 344/N Lab: BAT
![Page 2: Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC ...TDMSE Version: 3.0.2.0_001 PWG Approval Date: 11/26/2007 Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL](https://reader034.vdocuments.us/reader034/viewer/2022051823/5fed56a1c69d0e2eda06e943/html5/thumbnails/2.jpg)
DAY ON TEST
FISCHER 344 RATS MALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
UNTREATEDANIMAL ID
00201
00202
00203
00204
00205
00206
00207
00208
00209
00210 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + 10
Intestine Large, Cecum + + + + + + + + + + 10
Intestine Large, Colon + + + + + + + + + + 10
Intestine Large, Rectum + + + + + + + + + + 10Parasite Metazoan 1 1 1.0
Intestine Small, Duodenum + + + + + + + + + + 10
Intestine Small, Ileum + + + + + + + + + + 10
Intestine Small, Jejunum + + + + + + + + + + 10
Liver + + + + + + + + + + 10Hepatodiaphragmatic Nodule X 1Inflammation 1 1 1 1 1 1 1 1 8 1.0
Pancreas + + + + + + + + + + 10Infiltration Cellular, Mononuclear Cell 1 1 1 1 4 1.0
Salivary Glands + + + + + + + + + + 10Submandibular Gland, Vacuolization
Cytoplasmic2 1 2 2 1 5 1.6
Stomach, Forestomach + + + + + + + + + + 10
Stomach, Glandular + + + + + + + + + + 10
Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:13:55
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/15/05 / 06/16/05Species/Strain: RATS/F 344/N Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 2
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DAY ON TEST
FISCHER 344 RATS MALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
UNTREATEDANIMAL ID
00201
00202
00203
00204
00205
00206
00207
00208
00209
00210 * TOTALS
CARDIOVASCULAR SYSTEM
Blood Vessel + + + + + + + + + + 10
Heart + + + + + + + + + + 10Cardiomyopathy 1 1 1 1 1 2 2 1 1 1 10 1.2
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + 10Angiectasis 1 1 1 1 4 1.0
Adrenal Medulla + + + + + + + + + + 10
Islets, Pancreatic + + + + + + + + + + 10Infiltration Cellular, Mononuclear Cell 1 1 1.0
Parathyroid Gland + + + M + + + + + + 9
Pituitary Gland + + + + + + + + + + 10
Thyroid Gland + + + + + + + + + + 10
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Epididymis + + + + + + + + + + 10Inflammation 1 1 1.0
Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:13:55
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/15/05 / 06/16/05Species/Strain: RATS/F 344/N Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 3
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DAY ON TEST
FISCHER 344 RATS MALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
UNTREATEDANIMAL ID
00201
00202
00203
00204
00205
00206
00207
00208
00209
00210 * TOTALS
Preputial Gland + + + + + + + + + + 10
Prostate + + + + + + + + + + 10Inflammation 1 1 2 1.0
Seminal Vesicle + + + + + + + + + + 10
Testes + + + + + + + + + + 10
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10
Lymph Node, Mandibular M M M M M M M M M M 0
Lymph Node, Mesenteric + + + + + + + + + + 10
Spleen + + + + + + + + + + 10
Thymus + + + + + + + + + + 10
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + 10
Skin + + + + + + + + + + 10
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + 10
Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:13:55
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/15/05 / 06/16/05Species/Strain: RATS/F 344/N Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 4
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DAY ON TEST
FISCHER 344 RATS MALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
UNTREATEDANIMAL ID
00201
00202
00203
00204
00205
00206
00207
00208
00209
00210 * TOTALS
NERVOUS SYSTEM
Brain + + + + + + + + + + 10
RESPIRATORY SYSTEM
Lung + + + + + + + + + + 10Infiltration Cellular, Histiocyte 1 1 2 1.0Inflammation 1 1 2 1.0Metaplasia, Osseous 1 1 1 1 1 5 1.0
Nose + + + + + + + + + + 10
Trachea + + + + + + + + + + 10
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + 10
Harderian Gland + + + + + + + + + + 10
URINARY SYSTEM
Kidney + + + + + + + + + + 10Infiltration Cellular, Mononuclear Cell 1 1 1.0Mineralization 1 1 1 1 1 1 1 1 1 9 1.0Nephropathy 1 1 1 1 1 1 1 1 1 1 10 1.0Renal Tubule, Degeneration 1 1 2 1.0
Urinary Bladder + + + + + + + + + + 10Infiltration Cellular, Mononuclear Cell 1 1 1.0
Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:13:55
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/15/05 / 06/16/05Species/Strain: RATS/F 344/N Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 5
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Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:13:55
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/15/05 / 06/16/05Species/Strain: RATS/F 344/N Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 6
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DAY ON TEST
FISCHER 344 RATS MALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
0 %ANIMAL ID
00211
00212
00213
00214
00215
00216
00217
00218
00219
00220 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + 10
Intestine Large, Cecum + + + + + + + + + + 10
Intestine Large, Colon + + + + + + + + + + 10
Intestine Large, Rectum + + + + + + + + + + 10
Intestine Small, Duodenum + + + + + + + + + + 10
Intestine Small, Ileum + + + + + + + + + + 10
Intestine Small, Jejunum + + + + + + + + + + 10
Liver + + + + + + + + + + 10Hematopoietic Cell Proliferation 1 1 1.0Hepatodiaphragmatic Nodule X 1Inflammation 1 1 1 1 1 1 1 1 8 1.0
Pancreas + + + + + + + + + + 10Atrophy 1 1 1.0Infiltration Cellular, Mononuclear Cell 1 1 1 1 1 5 1.0
Salivary Glands + + + + + + + + + + 10Submandibular Gland, Vacuolization
Cytoplasmic1 1 2 1.0
Stomach, Forestomach + + + + + + + + + + 10
Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:13:55
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/15/05 / 06/16/05Species/Strain: RATS/F 344/N Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 7
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DAY ON TEST
FISCHER 344 RATS MALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
0 %ANIMAL ID
00211
00212
00213
00214
00215
00216
00217
00218
00219
00220 * TOTALS
Stomach, Glandular + + + + + + + + + + 10Glands, Ectasia 1 1 2 1.0
CARDIOVASCULAR SYSTEM
Blood Vessel + + + + + + + + + + 10
Heart + + + + + + + + + + 10Cardiomyopathy 1 2 1 1 1 1 1 1 1 1 10 1.1
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + 10Angiectasis 1 1 2 1.0
Adrenal Medulla + + + + + + + + + + 10
Islets, Pancreatic + + + + + + + + + + 10Infiltration Cellular, Mononuclear Cell 1 1 1.0
Parathyroid Gland + + + + + + + M + + 9
Pituitary Gland + + + + + + + + + + 10Cyst 1 1 1.0
Thyroid Gland + + + + + + + + + + 10
GENERAL BODY SYSTEM
NONE
Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:13:55
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/15/05 / 06/16/05Species/Strain: RATS/F 344/N Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 8
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DAY ON TEST
FISCHER 344 RATS MALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
0 %ANIMAL ID
00211
00212
00213
00214
00215
00216
00217
00218
00219
00220 * TOTALS
GENITAL SYSTEM
Epididymis + + + + + + + + + + 10Infiltration Cellular, Mononuclear Cell 1 1 1.0Inflammation 1 1 2 1.0
Preputial Gland + + + + + + + + + + 10Inflammation, Focal, Chronic 2 1 2.0
Prostate + + + + + + + + + + 10
Seminal Vesicle + + + + + + + + + + 10
Testes + + + + + + + + + + 10
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10
Lymph Node, Mandibular M M M M M M M M M M 0
Lymph Node, Mesenteric + + + + + + + + + + 10
Spleen + + + + + + + + + + 10Hematopoietic Cell Proliferation 1 1 1.0
Thymus + + + + + + + + + + 10
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + 10
Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:13:55
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/15/05 / 06/16/05Species/Strain: RATS/F 344/N Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 9
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DAY ON TEST
FISCHER 344 RATS MALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
0 %ANIMAL ID
00211
00212
00213
00214
00215
00216
00217
00218
00219
00220 * TOTALS
Skin + + + + + + + + + + 10
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + 10
NERVOUS SYSTEM
Brain + + + + + + + + + + 10
RESPIRATORY SYSTEM
Lung + + + + + + + + + + 10Infiltration Cellular, Histiocyte 1 1 1.0Inflammation 1 1 1 1 1 5 1.0Metaplasia, Osseous 1 1 1 1 1 5 1.0
Nose + + + + + + + + + + 10
Trachea + + + + + + + + + + 10
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + 10
Harderian Gland + + + + + + + + + + 10
URINARY SYSTEM
Kidney + + + + + + + + + + 10Infiltration Cellular, Mononuclear Cell 1 1 1.0
Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:13:55
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/15/05 / 06/16/05Species/Strain: RATS/F 344/N Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 10
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DAY ON TEST
FISCHER 344 RATS MALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
0 %ANIMAL ID
00211
00212
00213
00214
00215
00216
00217
00218
00219
00220 * TOTALS
Mineralization 1 1 1 1 4 1.0Nephropathy 1 1 1 1 1 1 1 1 1 1 10 1.0Renal Tubule, Degeneration 1 1 1 1 4 1.0
Urinary Bladder + + + + + + + + + + 10Infiltration Cellular, Mononuclear Cell 1 1 1.0
Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:13:55
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/15/05 / 06/16/05Species/Strain: RATS/F 344/N Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 11
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DAY ON TEST
FISCHER 344 RATS MALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
6.25 %ANIMAL ID
00221
00222
00223
00224
00225
00226
00227
00228
00229
00230 * TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + 10Inflammation 1 1 1 1 1 1 1 1 1 1 10 1.0
CARDIOVASCULAR SYSTEM
NONE
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + 10
Thyroid Gland + + + + + + + + + + 10Ultimobranchial Cyst X X 2
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
NONE
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10
INTEGUMENTARY SYSTEM
Skin + + + + + + + + + + 10
Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:13:55
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/15/05 / 06/16/05Species/Strain: RATS/F 344/N Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 12
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DAY ON TEST
FISCHER 344 RATS MALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
6.25 %ANIMAL ID
00221
00222
00223
00224
00225
00226
00227
00228
00229
00230 * TOTALS
Site Of Application, Inflammation, ChronicActive
1 1 1.0
Site Of Application - Epidermis, Hyperplasia 1 1 2 1.0
MUSCULOSKELETAL SYSTEM
NONE
NERVOUS SYSTEM
NONE
RESPIRATORY SYSTEM
NONE
SPECIAL SENSES SYSTEM
NONE
URINARY SYSTEM
Kidney + + + + + + + + + + 10Mineralization 1 1 1 1 1 1 1 7 1.0Nephropathy 1 1 1 1 1 1 1 1 1 1 10 1.0Renal Tubule, Degeneration 1 1 1 1 1 5 1.0
Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:13:55
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/15/05 / 06/16/05Species/Strain: RATS/F 344/N Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 13
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DAY ON TEST
FISCHER 344 RATS MALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
12.5 %ANIMAL ID
00231
00232
00233
00234
00235
00236
00237
00238
00239
00240 * TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + 10Hematopoietic Cell Proliferation 1 1 1.0Inflammation 1 1 1 1 1 1 1 1 1 1 10 1.0
CARDIOVASCULAR SYSTEM
NONE
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + 10
Thyroid Gland + + + + + + + + + + 10
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Testes + 1Germinal Epithelium, Right, Atrophy 3 1 3.0
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10
INTEGUMENTARY SYSTEM
Skin + + + + + + + + + + 10
Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:13:55
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/15/05 / 06/16/05Species/Strain: RATS/F 344/N Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 14
![Page 15: Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC ...TDMSE Version: 3.0.2.0_001 PWG Approval Date: 11/26/2007 Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL](https://reader034.vdocuments.us/reader034/viewer/2022051823/5fed56a1c69d0e2eda06e943/html5/thumbnails/15.jpg)
DAY ON TEST
FISCHER 344 RATS MALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
12.5 %ANIMAL ID
00231
00232
00233
00234
00235
00236
00237
00238
00239
00240 * TOTALS
Site Of Application, Inflammation, ChronicActive
1 1 1 1 4 1.0
Site Of Application - Epidermis, Hyperkeratosis 1 1 1.0Site Of Application - Epidermis, Hyperplasia 2 1 1 1 4 1.3Site Of Application - Epidermis, Ulcer 1 1 1.0
MUSCULOSKELETAL SYSTEM
NONE
NERVOUS SYSTEM
NONE
RESPIRATORY SYSTEM
NONE
SPECIAL SENSES SYSTEM
NONE
URINARY SYSTEM
Kidney + + + + + + + + + + 10Mineralization 1 1 1 1 1 1 1 1 1 9 1.0Nephropathy 1 1 1 1 1 1 1 1 1 1 10 1.0Renal Tubule, Degeneration 1 1 1 1 1 1 6 1.0
Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:13:55
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/15/05 / 06/16/05Species/Strain: RATS/F 344/N Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 15
![Page 16: Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC ...TDMSE Version: 3.0.2.0_001 PWG Approval Date: 11/26/2007 Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL](https://reader034.vdocuments.us/reader034/viewer/2022051823/5fed56a1c69d0e2eda06e943/html5/thumbnails/16.jpg)
DAY ON TEST
FISCHER 344 RATS MALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
25 %ANIMAL ID
00241
00242
00243
00244
00245
00246
00247
00248
00249
00250 * TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + 10Inflammation 1 1 1 1 1 1 1 7 1.0
CARDIOVASCULAR SYSTEM
NONE
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + 10
Thyroid Gland + + + + + + + + + + 10
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
NONE
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10
INTEGUMENTARY SYSTEM
Skin + + + + + + + + + + 10Hair Follicle, Site Of Application, Hyperplasia 1 2 1 1 1 2 2 1 1 9 1.3
Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:13:55
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/15/05 / 06/16/05Species/Strain: RATS/F 344/N Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 16
![Page 17: Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC ...TDMSE Version: 3.0.2.0_001 PWG Approval Date: 11/26/2007 Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL](https://reader034.vdocuments.us/reader034/viewer/2022051823/5fed56a1c69d0e2eda06e943/html5/thumbnails/17.jpg)
DAY ON TEST
FISCHER 344 RATS MALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
25 %ANIMAL ID
00241
00242
00243
00244
00245
00246
00247
00248
00249
00250 * TOTALS
Sebaceous Gland, Site Of Application,Hyperplasia
2 2 3 2 1 1 2 2 2 9 1.9
Site Of Application, Inflammation, ChronicActive
1 1 1 1 2 1 3 1 2 9 1.4
Site Of Application - Dermis, Fibrosis 1 1 2 1 1 1 1 7 1.1Site Of Application - Epidermis, Hyperkeratosis 1 1 1 1 1 2 1 7 1.1Site Of Application - Epidermis, Hyperplasia 2 2 2 2 2 2 1 2 3 2 10 2.0Site Of Application - Epidermis, Ulcer 3 1 3.0
MUSCULOSKELETAL SYSTEM
NONE
NERVOUS SYSTEM
NONE
RESPIRATORY SYSTEM
NONE
SPECIAL SENSES SYSTEM
NONE
URINARY SYSTEM
Kidney + + + + + + + + + + 10Accumulation, Hyaline Droplet 1 1 1 1 1 1 1 1 1 2 10 1.1Infiltration Cellular, Mononuclear Cell 1 1 1.0Mineralization 1 1 1 1 1 1 1 1 8 1.0Nephropathy 1 1 1 1 1 1 1 1 1 1 10 1.0
Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:13:55
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/15/05 / 06/16/05Species/Strain: RATS/F 344/N Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 17
![Page 18: Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC ...TDMSE Version: 3.0.2.0_001 PWG Approval Date: 11/26/2007 Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL](https://reader034.vdocuments.us/reader034/viewer/2022051823/5fed56a1c69d0e2eda06e943/html5/thumbnails/18.jpg)
DAY ON TEST
FISCHER 344 RATS MALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
25 %ANIMAL ID
00241
00242
00243
00244
00245
00246
00247
00248
00249
00250 * TOTALS
Renal Tubule, Casts Granular 1 1 1 1 1 5 1.0Renal Tubule, Degeneration 1 1 1 1 1 1 1 7 1.0
Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:13:55
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/15/05 / 06/16/05Species/Strain: RATS/F 344/N Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 18
![Page 19: Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC ...TDMSE Version: 3.0.2.0_001 PWG Approval Date: 11/26/2007 Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL](https://reader034.vdocuments.us/reader034/viewer/2022051823/5fed56a1c69d0e2eda06e943/html5/thumbnails/19.jpg)
DAY ON TEST
FISCHER 344 RATS MALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
50 %ANIMAL ID
00251
00252
00253
00254
00255
00256
00257
00258
00259
00260 * TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + 10Hematopoietic Cell Proliferation 1 1 1.0Inflammation 1 1 1 1 1 1 1 7 1.0
CARDIOVASCULAR SYSTEM
NONE
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + 10
Thyroid Gland + + + + + + + + + + 10
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
NONE
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10Hyperplasia 1 1 1.0
INTEGUMENTARY SYSTEM
Skin + + + + + + + + + + 10
Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:13:55
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/15/05 / 06/16/05Species/Strain: RATS/F 344/N Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 19
![Page 20: Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC ...TDMSE Version: 3.0.2.0_001 PWG Approval Date: 11/26/2007 Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL](https://reader034.vdocuments.us/reader034/viewer/2022051823/5fed56a1c69d0e2eda06e943/html5/thumbnails/20.jpg)
DAY ON TEST
FISCHER 344 RATS MALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
50 %ANIMAL ID
00251
00252
00253
00254
00255
00256
00257
00258
00259
00260 * TOTALS
Hair Follicle, Site Of Application, Hyperplasia 3 3 2 3 2 2 2 1 1 1 10 2.0Sebaceous Gland, Site Of Application,
Hyperplasia3 3 2 3 3 3 3 3 3 2 10 2.8
Site Of Application, Inflammation, ChronicActive
3 2 2 2 3 2 2 3 2 2 10 2.3
Site Of Application - Dermis, Fibrosis 2 2 2 3 3 3 2 2 3 2 10 2.4Site Of Application - Epidermis, Hyperkeratosis 2 1 1 2 3 1 2 1 1 2 10 1.6Site Of Application - Epidermis, Hyperplasia 3 3 3 3 3 3 3 3 3 2 10 2.9Site Of Application - Epidermis, Ulcer 3 1 3 3 2 3 3 7 2.6
MUSCULOSKELETAL SYSTEM
NONE
NERVOUS SYSTEM
NONE
RESPIRATORY SYSTEM
NONE
SPECIAL SENSES SYSTEM
NONE
URINARY SYSTEM
Kidney + + + + + + + + + + 10Accumulation, Hyaline Droplet 2 2 2 2 2 2 1 2 2 2 10 1.9Mineralization 1 1 1 1 1 1 1 1 8 1.0Nephropathy 2 2 2 2 2 2 2 2 2 2 10 2.0
Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:13:55
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/15/05 / 06/16/05Species/Strain: RATS/F 344/N Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 20
![Page 21: Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC ...TDMSE Version: 3.0.2.0_001 PWG Approval Date: 11/26/2007 Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL](https://reader034.vdocuments.us/reader034/viewer/2022051823/5fed56a1c69d0e2eda06e943/html5/thumbnails/21.jpg)
DAY ON TEST
FISCHER 344 RATS MALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
50 %ANIMAL ID
00251
00252
00253
00254
00255
00256
00257
00258
00259
00260 * TOTALS
Renal Tubule, Casts Granular 2 2 1 3 1 1 2 1 1 2 10 1.6Renal Tubule, Degeneration 1 1 1 1 1 1 1 1 1 1 10 1.0
Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:13:55
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/15/05 / 06/16/05Species/Strain: RATS/F 344/N Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 21
![Page 22: Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC ...TDMSE Version: 3.0.2.0_001 PWG Approval Date: 11/26/2007 Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL](https://reader034.vdocuments.us/reader034/viewer/2022051823/5fed56a1c69d0e2eda06e943/html5/thumbnails/22.jpg)
DAY ON TEST
FISCHER 344 RATS MALE
0093
0093
0079
0093
0093
0093
0093
0093
0079
0093
100 %ANIMAL ID
00261
00262
00263
00264
00265
00266
00267
00268
00269
00270 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + 10
Intestine Large, Cecum + + + + + + + + + + 10
Intestine Large, Colon + + + + + + + + + + 10
Intestine Large, Rectum + + + + + + + + + + 10Parasite Metazoan 1 1 1.0
Intestine Small, Duodenum + + + + + + + + + + 10
Intestine Small, Ileum + + + + + + + + + + 10
Intestine Small, Jejunum + + + + + + + + + + 10
Liver + + + + + + + + + + 10Inflammation 1 1 1 1 1 1 1 1 1 9 1.0Necrosis, Focal 1 1 1.0
Pancreas + + + + + + + + + + 10Atrophy 2 1 2.0Infiltration Cellular, Mononuclear Cell 1 1 2 3 1.3
Salivary Glands + + + + + + + + + + 10Submandibular Gland, Vacuolization
Cytoplasmic2 2 2 2 4 2.0
Stomach, Forestomach + + + + + + + + + + 10
Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:13:55
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/15/05 / 06/16/05Species/Strain: RATS/F 344/N Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 22
![Page 23: Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC ...TDMSE Version: 3.0.2.0_001 PWG Approval Date: 11/26/2007 Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL](https://reader034.vdocuments.us/reader034/viewer/2022051823/5fed56a1c69d0e2eda06e943/html5/thumbnails/23.jpg)
DAY ON TEST
FISCHER 344 RATS MALE
0093
0093
0079
0093
0093
0093
0093
0093
0079
0093
100 %ANIMAL ID
00261
00262
00263
00264
00265
00266
00267
00268
00269
00270 * TOTALS
Stomach, Glandular + + + + + + + + + + 10
CARDIOVASCULAR SYSTEM
Blood Vessel + + + + + + + + + + 10
Heart + + + + + + + + + + 10Cardiomyopathy 2 1 1 2 1 1 2 1 1 1 10 1.3Epicardium, Hyperplasia 2 1 2.0
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + 10
Adrenal Medulla + + + + + + + + + + 10
Islets, Pancreatic + + + + + + + + + + 10
Parathyroid Gland + + + + + + + + + + 10
Pituitary Gland + + + + + + + + + + 10
Thyroid Gland + + + + + + + + + + 10
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Epididymis + + + + + + + + + + 10
Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:13:55
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/15/05 / 06/16/05Species/Strain: RATS/F 344/N Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 23
![Page 24: Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC ...TDMSE Version: 3.0.2.0_001 PWG Approval Date: 11/26/2007 Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL](https://reader034.vdocuments.us/reader034/viewer/2022051823/5fed56a1c69d0e2eda06e943/html5/thumbnails/24.jpg)
DAY ON TEST
FISCHER 344 RATS MALE
0093
0093
0079
0093
0093
0093
0093
0093
0079
0093
100 %ANIMAL ID
00261
00262
00263
00264
00265
00266
00267
00268
00269
00270 * TOTALS
Inflammation 1 1 2 1.0
Preputial Gland + + + + + + + + + + 10Inflammation, Focal, Chronic 2 1 1 3 1.3
Prostate + + + + + + + + + + 10
Seminal Vesicle + + + + + + + + + + 10
Testes + + + + + + + + + + 10
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10Hyperplasia 1 1 1 1 1 2 1 7 1.1
Lymph Node, Mandibular M M M M M M M M M M 0
Lymph Node, Mesenteric + + + + + + + + + + 10
Spleen + + + + + + + + + + 10
Thymus + + + + + + + + + + 10
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + 10
Skin + + + + + + + + + + 10Hair Follicle, Site Of Application, Hyperplasia 2 3 2 2 2 1 1 2 1 9 1.8Sebaceous Gland, Site Of Application,
Hyperplasia3 3 3 3 3 3 3 3 3 3 10 3.0
Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:13:55
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/15/05 / 06/16/05Species/Strain: RATS/F 344/N Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 24
![Page 25: Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC ...TDMSE Version: 3.0.2.0_001 PWG Approval Date: 11/26/2007 Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL](https://reader034.vdocuments.us/reader034/viewer/2022051823/5fed56a1c69d0e2eda06e943/html5/thumbnails/25.jpg)
DAY ON TEST
FISCHER 344 RATS MALE
0093
0093
0079
0093
0093
0093
0093
0093
0079
0093
100 %ANIMAL ID
00261
00262
00263
00264
00265
00266
00267
00268
00269
00270 * TOTALS
Site Of Application, Inflammation, ChronicActive
2 3 3 3 3 2 2 3 3 3 10 2.7
Site Of Application - Dermis, Fibrosis 2 2 2 3 2 2 2 3 3 3 10 2.4Site Of Application - Epidermis, Hyperkeratosis 3 3 3 3 3 3 3 3 3 3 10 3.0Site Of Application - Epidermis, Hyperplasia 3 3 3 2 3 3 3 3 3 9 2.9Site Of Application - Epidermis, Ulcer 3 3 3 3 3 3 3 3 8 3.0
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + 10
NERVOUS SYSTEM
Brain + + + + + + + + + + 10
RESPIRATORY SYSTEM
Lung + + + + + + + + + + 10Hemorrhage 3 1 3.0Infiltration Cellular, Histiocyte 1 2 2 1.5Inflammation 1 1 1 1 4 1.0Metaplasia, Osseous 1 1 1 1 4 1.0Pigmentation, Hemosiderin 2 1 2.0Serosa, Inflammation, Granulomatous 2 1 2.0
Nose + + + + + + + + + + 10Inflammation, Chronic Active 1 1 2 1.0
Trachea + + + + + + + + + + 10
SPECIAL SENSES SYSTEM
Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:13:55
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/15/05 / 06/16/05Species/Strain: RATS/F 344/N Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 25
![Page 26: Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC ...TDMSE Version: 3.0.2.0_001 PWG Approval Date: 11/26/2007 Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL](https://reader034.vdocuments.us/reader034/viewer/2022051823/5fed56a1c69d0e2eda06e943/html5/thumbnails/26.jpg)
DAY ON TEST
FISCHER 344 RATS MALE
0093
0093
0079
0093
0093
0093
0093
0093
0079
0093
100 %ANIMAL ID
00261
00262
00263
00264
00265
00266
00267
00268
00269
00270 * TOTALS
Eye + + + + + + + + + + 10
Harderian Gland + + + + + + + + + + 10
URINARY SYSTEM
Kidney + + + + + + + + + + 10Accumulation, Hyaline Droplet 3 3 3 3 3 3 3 3 3 3 10 3.0Infiltration Cellular, Mononuclear Cell 1 1 1.0Mineralization 2 1 1 1 1 1 1 1 8 1.1Nephropathy 2 2 2 2 2 2 2 2 2 2 10 2.0Renal Tubule, Casts Granular 4 3 3 4 3 4 3 3 4 4 10 3.5Renal Tubule, Degeneration 1 1 1 1 1 1 1 1 1 1 10 1.0
Urinary Bladder + + + + + + + + + + 10Infiltration Cellular, Mononuclear Cell 1 1 1.0Serosa, Mineralization, Focal 1 1 1.0
*** END OF MALE DATA ***
Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:13:55
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/15/05 / 06/16/05Species/Strain: RATS/F 344/N Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 26
![Page 27: Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC ...TDMSE Version: 3.0.2.0_001 PWG Approval Date: 11/26/2007 Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL](https://reader034.vdocuments.us/reader034/viewer/2022051823/5fed56a1c69d0e2eda06e943/html5/thumbnails/27.jpg)
DAY ON TEST
FISCHER 344 RATS FEMALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
UNTREATEDANIMAL ID
00271
00272
00273
00274
00275
00276
00277
00278
00279
00280 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + 10
Intestine Large, Cecum + + + + + + + + + + 10
Intestine Large, Colon + + + + + + + + + + 10
Intestine Large, Rectum + + + + + + + + + + 10
Intestine Small, Duodenum + + + + + + + + + + 10
Intestine Small, Ileum + + + + + + + + + + 10
Intestine Small, Jejunum + + + + + + + + + + 10
Liver + + + + + + + + + + 10Hematopoietic Cell Proliferation 1 1 2 1.0Hepatodiaphragmatic Nodule X X 2Inflammation 1 1 1 1 1 1 1 1 1 1 10 1.0
Pancreas + + + + + + + + + + 10Infiltration Cellular, Mononuclear Cell 1 1 1 2 2 1 1 7 1.3
Salivary Glands + + + + + + + + + + 10Submandibular Gland, Vacuolization
Cytoplasmic1 1 1 3 1.0
Stomach, Forestomach + + + + + + + + + + 10
Stomach, Glandular + + + + + + + + + + 10
Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:13:55
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/15/05 / 06/16/05Species/Strain: RATS/F 344/N Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 27
![Page 28: Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC ...TDMSE Version: 3.0.2.0_001 PWG Approval Date: 11/26/2007 Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL](https://reader034.vdocuments.us/reader034/viewer/2022051823/5fed56a1c69d0e2eda06e943/html5/thumbnails/28.jpg)
DAY ON TEST
FISCHER 344 RATS FEMALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
UNTREATEDANIMAL ID
00271
00272
00273
00274
00275
00276
00277
00278
00279
00280 * TOTALS
CARDIOVASCULAR SYSTEM
Blood Vessel + + + + + + + + + + 10
Heart + + + + + + + + + + 10Cardiomyopathy 1 1 1 1 1 1 1 1 1 1 10 1.0Inflammation, Chronic Active 2 1 2.0
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + 10Infiltration Cellular 1 1 1.0
Adrenal Medulla + + + + + + + + + + 10
Islets, Pancreatic + + + + + + + + + + 10
Parathyroid Gland + + + + + + + + + M 9
Pituitary Gland + + + + + + + + + + 10Cyst 1 1 2 1.0
Thyroid Gland + + + + + + + + + + 10
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Clitoral Gland + + + + + + + + + + 10
Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:13:55
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/15/05 / 06/16/05Species/Strain: RATS/F 344/N Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 28
![Page 29: Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC ...TDMSE Version: 3.0.2.0_001 PWG Approval Date: 11/26/2007 Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL](https://reader034.vdocuments.us/reader034/viewer/2022051823/5fed56a1c69d0e2eda06e943/html5/thumbnails/29.jpg)
DAY ON TEST
FISCHER 344 RATS FEMALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
UNTREATEDANIMAL ID
00271
00272
00273
00274
00275
00276
00277
00278
00279
00280 * TOTALS
Infiltration Cellular, Mononuclear Cell 2 1 2.0Inflammation, Focal, Chronic Active 2 1 2.0Inflammation, Chronic Active 2 1 2.0
Ovary + + + + + + + + + + 10Left, Cyst 3 1 3.0
Uterus + + + + + + + + + + 10
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10
Lymph Node, Mandibular M M M M M M M M M M 0
Lymph Node, Mesenteric + + + + + + + + + + 10
Spleen + + + + + + + + + + 10
Thymus + + + + + + + + + + 10
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + 10
Skin + + + + + + + + + + 10
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + 10
Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:13:55
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/15/05 / 06/16/05Species/Strain: RATS/F 344/N Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 29
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DAY ON TEST
FISCHER 344 RATS FEMALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
UNTREATEDANIMAL ID
00271
00272
00273
00274
00275
00276
00277
00278
00279
00280 * TOTALS
NERVOUS SYSTEM
Brain + + + + + + + + + + 10
RESPIRATORY SYSTEM
Lung + + + + + + + + + + 10Inflammation 1 1 1 3 1.0Metaplasia, Osseous 1 1 1.0
Nose + + + + + + + + + + 10
Trachea + + + + + + + + + + 10Infiltration Cellular, Mononuclear Cell 1 1 1.0
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + 10
Harderian Gland + + + + + + + + + + 10
URINARY SYSTEM
Kidney + + + + + + + + + + 10Infarct, Focal, Chronic X 1Mineralization 1 1 1 1 1 5 1.0
Urinary Bladder + + + + + + + + + + 10Infiltration Cellular, Mononuclear Cell 1 1 1 1 1 5 1.0
Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:13:55
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/15/05 / 06/16/05Species/Strain: RATS/F 344/N Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 30
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DAY ON TEST
FISCHER 344 RATS FEMALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
0 %ANIMAL ID
00281
00282
00283
00284
00285
00286
00287
00288
00289
00290 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + 10
Intestine Large, Cecum + + + + + + + + + + 10
Intestine Large, Colon + + + + + + + + + + 10
Intestine Large, Rectum + + + + + + + + + + 10Parasite Metazoan 1 1 1.0
Intestine Small, Duodenum + + + + + + + + + + 10
Intestine Small, Ileum + + + + + + + + + + 10
Intestine Small, Jejunum + + + + + + + + + + 10
Liver + + + + + + + + + + 10Hepatodiaphragmatic Nodule X 1Inflammation 1 1 1 1 1 2 1 1 1 9 1.1
Pancreas + + + + + + + + + + 10Infiltration Cellular, Mononuclear Cell 1 1 1 1 4 1.0
Salivary Glands + + + + + + + + + + 10Submandibular Gland, Vacuolization
Cytoplasmic2 1 2 1 4 1.5
Stomach, Forestomach + + + + + + + + + + 10
Stomach, Glandular + + + + + + + + + + 10
Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:13:55
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/15/05 / 06/16/05Species/Strain: RATS/F 344/N Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 31
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DAY ON TEST
FISCHER 344 RATS FEMALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
0 %ANIMAL ID
00281
00282
00283
00284
00285
00286
00287
00288
00289
00290 * TOTALS
CARDIOVASCULAR SYSTEM
Blood Vessel + + + + + + + + + + 10
Heart + + + + + + + + + + 10Cardiomyopathy 1 1 1 1 1 1 1 1 1 9 1.0
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + 10Infiltration Cellular, Mononuclear Cell 1 1 1.0Mineralization 2 1 2.0
Adrenal Medulla + + + + + + + + + + 10
Islets, Pancreatic + + + + + + + + + + 10
Parathyroid Gland + + + + + + + + M + 9
Pituitary Gland + + + + + + + + + + 10Cyst 1 1 2 1.0
Thyroid Gland + + + + + + + + + + 10Infiltration Cellular, Mononuclear Cell 1 2 2 1.5Ultimobranchial Cyst X X X 3
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:13:55
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/15/05 / 06/16/05Species/Strain: RATS/F 344/N Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 32
![Page 33: Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC ...TDMSE Version: 3.0.2.0_001 PWG Approval Date: 11/26/2007 Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL](https://reader034.vdocuments.us/reader034/viewer/2022051823/5fed56a1c69d0e2eda06e943/html5/thumbnails/33.jpg)
DAY ON TEST
FISCHER 344 RATS FEMALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
0 %ANIMAL ID
00281
00282
00283
00284
00285
00286
00287
00288
00289
00290 * TOTALS
Clitoral Gland + + + + + + + + + + 10
Ovary + + + + + + + + + + 10
Uterus + + + + + + + + + + 10
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10
Lymph Node, Mandibular M M M M M M M M M M 0
Lymph Node, Mesenteric + + + + + + + + + + 10
Spleen + + + + + + + + + + 10
Thymus + + + + + + + + + + 10
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + 10
Skin + + + + + + + + + + 10
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + 10
NERVOUS SYSTEM
Brain + + + + + + + + + + 10
Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:13:55
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/15/05 / 06/16/05Species/Strain: RATS/F 344/N Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 33
![Page 34: Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC ...TDMSE Version: 3.0.2.0_001 PWG Approval Date: 11/26/2007 Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL](https://reader034.vdocuments.us/reader034/viewer/2022051823/5fed56a1c69d0e2eda06e943/html5/thumbnails/34.jpg)
DAY ON TEST
FISCHER 344 RATS FEMALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
0 %ANIMAL ID
00281
00282
00283
00284
00285
00286
00287
00288
00289
00290 * TOTALS
RESPIRATORY SYSTEM
Lung + + + + + + + + + + 10Infiltration Cellular, Histiocyte 1 1 1.0Inflammation 1 1 2 1.0Metaplasia, Osseous 1 1 1.0
Nose + + + + + + + + + + 10Vacuolization Cytoplasmic 3 1 3.0
Trachea + + + + + + + + + + 10
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + 10
Harderian Gland + + + + + + + + + + 10
URINARY SYSTEM
Kidney + + + + + + + + + + 10Mineralization 1 1 1 1 1 5 1.0Nephropathy 1 1 1.0
Urinary Bladder + + + + + + + + + + 10Infiltration Cellular, Mononuclear Cell 2 1 2 1.5
Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:13:55
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/15/05 / 06/16/05Species/Strain: RATS/F 344/N Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 34
![Page 35: Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC ...TDMSE Version: 3.0.2.0_001 PWG Approval Date: 11/26/2007 Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL](https://reader034.vdocuments.us/reader034/viewer/2022051823/5fed56a1c69d0e2eda06e943/html5/thumbnails/35.jpg)
DAY ON TEST
FISCHER 344 RATS FEMALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
6.25 %ANIMAL ID
00291
00292
00293
00294
00295
00296
00297
00298
00299
00300 * TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + 10Inflammation 1 1 1 1 1 1 1 2 1 1 10 1.1
Mesentery + 1Mineralization 2 1 2.0Necrosis 3 1 3.0Fat, Inflammation, Granulomatous, Chronic
Active3 1 3.0
CARDIOVASCULAR SYSTEM
NONE
ENDOCRINE SYSTEM
Thyroid Gland + + + + + + + + + + 10Ultimobranchial Cyst X X 2
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
NONE
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + 9
Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:13:55
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/15/05 / 06/16/05Species/Strain: RATS/F 344/N Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 35
![Page 36: Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC ...TDMSE Version: 3.0.2.0_001 PWG Approval Date: 11/26/2007 Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL](https://reader034.vdocuments.us/reader034/viewer/2022051823/5fed56a1c69d0e2eda06e943/html5/thumbnails/36.jpg)
DAY ON TEST
FISCHER 344 RATS FEMALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
6.25 %ANIMAL ID
00291
00292
00293
00294
00295
00296
00297
00298
00299
00300 * TOTALS
INTEGUMENTARY SYSTEM
Skin + + + + + + + + + + 10Site Of Application - Epidermis, Hyperkeratosis 1 1 1.0Site Of Application - Epidermis, Hyperplasia 1 1 1 1 4 1.0
MUSCULOSKELETAL SYSTEM
NONE
NERVOUS SYSTEM
NONE
RESPIRATORY SYSTEM
NONE
SPECIAL SENSES SYSTEM
NONE
URINARY SYSTEM
NONE
Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:13:55
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/15/05 / 06/16/05Species/Strain: RATS/F 344/N Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 36
![Page 37: Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC ...TDMSE Version: 3.0.2.0_001 PWG Approval Date: 11/26/2007 Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL](https://reader034.vdocuments.us/reader034/viewer/2022051823/5fed56a1c69d0e2eda06e943/html5/thumbnails/37.jpg)
DAY ON TEST
FISCHER 344 RATS FEMALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
12.5 %ANIMAL ID
00301
00302
00303
00304
00305
00306
00307
00308
00309
00310 * TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + 10Inflammation 1 1 1 1 1 1 1 1 1 9 1.0
CARDIOVASCULAR SYSTEM
NONE
ENDOCRINE SYSTEM
Thyroid Gland + + + + + + + + + + 10
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
NONE
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10
INTEGUMENTARY SYSTEM
Skin + + + + + + + + + + 10Hair Follicle, Site Of Application, Hyperplasia 1 1 1.0Sebaceous Gland, Site Of Application,
Hyperplasia1 1 1 1 4 1.0
Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:13:55
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/15/05 / 06/16/05Species/Strain: RATS/F 344/N Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 37
![Page 38: Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC ...TDMSE Version: 3.0.2.0_001 PWG Approval Date: 11/26/2007 Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL](https://reader034.vdocuments.us/reader034/viewer/2022051823/5fed56a1c69d0e2eda06e943/html5/thumbnails/38.jpg)
DAY ON TEST
FISCHER 344 RATS FEMALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
12.5 %ANIMAL ID
00301
00302
00303
00304
00305
00306
00307
00308
00309
00310 * TOTALS
Site Of Application, Inflammation, ChronicActive
1 1 1 1 1 1 1 7 1.0
Site Of Application - Dermis, Fibrosis 1 1 1.0Site Of Application - Epidermis, Hyperkeratosis 1 1 1 1 1 5 1.0Site Of Application - Epidermis, Hyperplasia 1 2 2 2 2 1 2 7 1.7Site Of Application - Epidermis, Ulcer 2 1 2.0
MUSCULOSKELETAL SYSTEM
NONE
NERVOUS SYSTEM
NONE
RESPIRATORY SYSTEM
NONE
SPECIAL SENSES SYSTEM
NONE
URINARY SYSTEM
NONE
Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:13:55
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/15/05 / 06/16/05Species/Strain: RATS/F 344/N Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 38
![Page 39: Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC ...TDMSE Version: 3.0.2.0_001 PWG Approval Date: 11/26/2007 Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL](https://reader034.vdocuments.us/reader034/viewer/2022051823/5fed56a1c69d0e2eda06e943/html5/thumbnails/39.jpg)
DAY ON TEST
FISCHER 344 RATS FEMALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
25 %ANIMAL ID
00311
00312
00313
00314
00315
00316
00317
00318
00319
00320 * TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + 10Inflammation 1 1 1 1 1 1 1 1 8 1.0
Salivary Glands + + + + + + + + + + 10
CARDIOVASCULAR SYSTEM
NONE
ENDOCRINE SYSTEM
Thyroid Gland + + + + + + + + + + 10Ultimobranchial Cyst X X X 3
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
NONE
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10Hyperplasia 1 1 2 1.0
INTEGUMENTARY SYSTEM
Skin + + + + + + + + + + 10
Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:13:55
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/15/05 / 06/16/05Species/Strain: RATS/F 344/N Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 39
![Page 40: Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC ...TDMSE Version: 3.0.2.0_001 PWG Approval Date: 11/26/2007 Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL](https://reader034.vdocuments.us/reader034/viewer/2022051823/5fed56a1c69d0e2eda06e943/html5/thumbnails/40.jpg)
DAY ON TEST
FISCHER 344 RATS FEMALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
25 %ANIMAL ID
00311
00312
00313
00314
00315
00316
00317
00318
00319
00320 * TOTALS
Hair Follicle, Site Of Application, Hyperplasia 2 1 2 2 1 2 2 2 1 9 1.7Sebaceous Gland, Site Of Application,
Hyperplasia2 1 2 2 2 1 2 2 2 9 1.8
Site Of Application, Inflammation, ChronicActive
2 1 1 1 2 1 1 1 1 1 10 1.2
Site Of Application - Dermis, Fibrosis 2 1 1 1 1 1 1 7 1.1Site Of Application - Epidermis, Hyperkeratosis 1 1 2 1 1 1 1 2 1 1 10 1.2Site Of Application - Epidermis, Hyperplasia 2 2 3 2 2 1 2 3 2 2 10 2.1Site Of Application - Epidermis, Ulcer 3 1 3.0
MUSCULOSKELETAL SYSTEM
NONE
NERVOUS SYSTEM
NONE
RESPIRATORY SYSTEM
NONE
SPECIAL SENSES SYSTEM
NONE
URINARY SYSTEM
NONE
Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:13:55
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/15/05 / 06/16/05Species/Strain: RATS/F 344/N Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 40
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DAY ON TEST
FISCHER 344 RATS FEMALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
50 %ANIMAL ID
00321
00322
00323
00324
00325
00326
00327
00328
00329
00330 * TOTALS
ALIMENTARY SYSTEM
Liver + + + + + + + + + + 10Inflammation 1 1 1 1 1 5 1.0
Salivary Glands + + + + + + + + + + 10
CARDIOVASCULAR SYSTEM
NONE
ENDOCRINE SYSTEM
Thyroid Gland + + + + + + + + + + 10Ultimobranchial Cyst X X X 3
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
NONE
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10Hyperplasia 1 1 2 1.0
INTEGUMENTARY SYSTEM
Skin + + + + + + + + + + 10
Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:13:55
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/15/05 / 06/16/05Species/Strain: RATS/F 344/N Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 41
![Page 42: Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC ...TDMSE Version: 3.0.2.0_001 PWG Approval Date: 11/26/2007 Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL](https://reader034.vdocuments.us/reader034/viewer/2022051823/5fed56a1c69d0e2eda06e943/html5/thumbnails/42.jpg)
DAY ON TEST
FISCHER 344 RATS FEMALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
50 %ANIMAL ID
00321
00322
00323
00324
00325
00326
00327
00328
00329
00330 * TOTALS
Hair Follicle, Site Of Application, Hyperplasia 3 2 3 1 2 3 3 4 4 3 10 2.8Sebaceous Gland, Site Of Application,
Hyperplasia3 3 3 3 3 3 2 3 3 3 10 2.9
Site Of Application, Inflammation, ChronicActive
3 2 3 2 3 2 2 3 1 3 10 2.4
Site Of Application - Dermis, Fibrosis 2 2 2 2 1 1 2 2 8 1.8Site Of Application - Epidermis, Hyperkeratosis 3 3 2 3 2 2 2 3 2 3 10 2.5Site Of Application - Epidermis, Hyperplasia 3 3 3 3 3 2 3 3 2 3 10 2.8Site Of Application - Epidermis, Ulcer 2 2 3 2 4 2.3
MUSCULOSKELETAL SYSTEM
NONE
NERVOUS SYSTEM
NONE
RESPIRATORY SYSTEM
NONE
SPECIAL SENSES SYSTEM
NONE
URINARY SYSTEM
NONE
Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:13:55
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/15/05 / 06/16/05Species/Strain: RATS/F 344/N Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 42
![Page 43: Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC ...TDMSE Version: 3.0.2.0_001 PWG Approval Date: 11/26/2007 Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL](https://reader034.vdocuments.us/reader034/viewer/2022051823/5fed56a1c69d0e2eda06e943/html5/thumbnails/43.jpg)
DAY ON TEST
FISCHER 344 RATS FEMALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
100 %ANIMAL ID
00331
00332
00333
00334
00335
00336
00337
00338
00339
00340 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + 10
Intestine Large, Cecum + + + + + + + + + + 10
Intestine Large, Colon + + + + + + + + + + 10
Intestine Large, Rectum + + + + + + + + + + 10
Intestine Small, Duodenum + + + + + + + + + + 10
Intestine Small, Ileum + + + + + + + + + + 10
Intestine Small, Jejunum + + + + + + + + + + 10
Liver + + + + + + + + + + 10Inflammation 1 1 1 1 1 1 1 7 1.0
Pancreas + + + + + + + + + + 10Atrophy 1 1 1.0Infiltration Cellular, Mononuclear Cell 1 1 1 3 1.0
Salivary Glands + + + + + + + + + + 10Sublingual Gland, Ectopic Tissue 1 1 1.0Submandibular Gland, Ectopic Tissue 1 1 1.0Submandibular Gland, Vacuolization
Cytoplasmic2 1 2.0
Stomach, Forestomach + + + + + + + + + + 10
Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:13:55
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/15/05 / 06/16/05Species/Strain: RATS/F 344/N Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 43
![Page 44: Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC ...TDMSE Version: 3.0.2.0_001 PWG Approval Date: 11/26/2007 Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL](https://reader034.vdocuments.us/reader034/viewer/2022051823/5fed56a1c69d0e2eda06e943/html5/thumbnails/44.jpg)
DAY ON TEST
FISCHER 344 RATS FEMALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
100 %ANIMAL ID
00331
00332
00333
00334
00335
00336
00337
00338
00339
00340 * TOTALS
Stomach, Glandular + + + + + + + + + + 10
CARDIOVASCULAR SYSTEM
Blood Vessel + + + + + + + + + + 10
Heart + + + + + + + + + + 10Cardiomyopathy 1 1 1 1 1 1 1 1 1 1 10 1.0
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + 10
Adrenal Medulla + + + + + + + + + + 10
Islets, Pancreatic + + + + + + + + + + 10
Parathyroid Gland + + + + + + + + + + 10
Pituitary Gland + + + + + + + + + + 10Cyst 1 1 1.0
Thyroid Gland + + + + + + + + + + 10Infiltration Cellular, Mononuclear Cell 2 1 2.0Ultimobranchial Cyst X X 2
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:13:55
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/15/05 / 06/16/05Species/Strain: RATS/F 344/N Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 44
![Page 45: Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC ...TDMSE Version: 3.0.2.0_001 PWG Approval Date: 11/26/2007 Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL](https://reader034.vdocuments.us/reader034/viewer/2022051823/5fed56a1c69d0e2eda06e943/html5/thumbnails/45.jpg)
DAY ON TEST
FISCHER 344 RATS FEMALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
100 %ANIMAL ID
00331
00332
00333
00334
00335
00336
00337
00338
00339
00340 * TOTALS
Clitoral Gland + + + + + + + + + + 10
Ovary + + + + + + + + + + 10
Uterus + + + + + + + + + + 10
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + 10Hyperplasia 1 1 1 1 1 1 1 7 1.0
Lymph Node, Mandibular M M M M M M M M M M 0
Lymph Node, Mesenteric + + + + + + + + + + 10
Spleen + + + + + + + + + + 10
Thymus + + + + + + + + + + 10
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + 10
Skin + + + + + + + + + + 10Hair Follicle, Site Of Application, Hyperplasia 4 4 4 4 3 2 4 4 3 4 10 3.6Sebaceous Gland, Site Of Application,
Hyperplasia3 3 3 3 3 3 3 3 3 3 10 3.0
Site Of Application, Inflammation, ChronicActive
2 2 2 3 2 3 2 2 3 3 10 2.4
Site Of Application - Dermis, Fibrosis 2 2 2 2 2 3 2 2 2 2 10 2.1Site Of Application - Epidermis, Hyperkeratosis 3 3 3 3 3 3 3 3 3 3 10 3.0
Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:13:55
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/15/05 / 06/16/05Species/Strain: RATS/F 344/N Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 45
![Page 46: Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC ...TDMSE Version: 3.0.2.0_001 PWG Approval Date: 11/26/2007 Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL](https://reader034.vdocuments.us/reader034/viewer/2022051823/5fed56a1c69d0e2eda06e943/html5/thumbnails/46.jpg)
DAY ON TEST
FISCHER 344 RATS FEMALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
100 %ANIMAL ID
00331
00332
00333
00334
00335
00336
00337
00338
00339
00340 * TOTALS
Site Of Application - Epidermis, Hyperplasia 3 3 3 3 3 3 3 3 3 3 10 3.0Site Of Application - Epidermis, Ulcer 3 3 3 3 3 4 3 3 3 3 10 3.1
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + 10
NERVOUS SYSTEM
Brain + + + + + + + + + + 10
RESPIRATORY SYSTEM
Lung + + + + + + + + + + 10Infiltration Cellular, Histiocyte 1 1 1.0Inflammation 1 1 2 1.0
Nose + + + + + + + + + + 10Inflammation, Chronic Active 2 1 2.0
Trachea + + + + + + + + + + 10
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + 10
Harderian Gland + + + + + + + + + + 10Infiltration Cellular 1 1 1.0
URINARY SYSTEM
Kidney + + + + + + + + + + 10
Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:13:55
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/15/05 / 06/16/05Species/Strain: RATS/F 344/N Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 46
![Page 47: Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC ...TDMSE Version: 3.0.2.0_001 PWG Approval Date: 11/26/2007 Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL](https://reader034.vdocuments.us/reader034/viewer/2022051823/5fed56a1c69d0e2eda06e943/html5/thumbnails/47.jpg)
DAY ON TEST
FISCHER 344 RATS FEMALE
0093
0093
0093
0093
0093
0093
0093
0093
0093
0093
100 %ANIMAL ID
00331
00332
00333
00334
00335
00336
00337
00338
00339
00340 * TOTALS
Mineralization 1 1 1 1 1 1 6 1.0Nephropathy 1 1 1.0
Urinary Bladder + + + + + + + + + + 10
*** END OF REPORT ***
Experiment Number: 20316 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 02/03/2014Test Type: 90-DAY Cedarwood oil Time Report Requested: 08:13:55
Route: SKIN APPLICATION CAS Number: 8000-27-9 First Dose M/F: 06/15/05 / 06/16/05Species/Strain: RATS/F 344/N Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 47