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Enzymes for Biocatalysis
By Dr. Bhalchandra Vaidya
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Introduction
• Enzymes are catalytic proteins from biological
sources.
• Enzymes accelerate the rate of reaction by
lowering the energy of activation.
• Enzymes can be obtained from plants, animals or
micro-organisms
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Enzyme Technology
• An emerging field of biotechnology that utilizes
enzymes for several commercial applications.
– Pharmaceuticals
– Fine chemicals
– Foods and beverages
– Cosmetics
– Textile
– Paper
– Leather
– Animal Feed
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Goals of Enzyme technology
• Integration of biology, chemistry and engineering
• To develop of novel alternative routes, processes
and services
• To design innovative products and processes that
are not only competitive but also meet criteria of
sustainability
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Advantages of enzymes
• Efficient catalysis
• Selective (Enantio- and regio-selectivity)
• Specific in action (Less byproducts)
• Environmentally benign catalysis
– Non Toxic, Non- flammable,
– Completely biodegradable,
– Sustainable,
– Requires mild reaction conditions
• Recycled and reused when immobilized
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Misconceptions and myths
• Enzymes are highly unstable
• Enzymes act only on natural substrates
• Enzymes are too expensive
• Productivity of Enzymes are too low
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Enzymes in Pharma Industry
• Chirality plays a major role in design,
development, marketing and patenting of APIs.
• Being stereo-selective, enzymes offer specific
solutions to introduce chirality in APIs.
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Classification of enzymes
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Classification of enzymes
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Hydrolases
• Hydrolysis of C-O, C-N, C-C bonds
• Favorite class of Enzymes for organic chemistry
– No need of co-factor
– Reversible in action
– Wide substrate specificity and catalytic versatality
– Relatively higher stability in non-natural conditions
• Large number of hydrolases are commercially
available
• Extensively employed for industrial processes
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Enzymes (hydrolases) for
Biocatalysis by Advanced Enzymes
• Lipases
– CAL-A (Candida antarctica lipase-A)
– CAL-B (Candida antarctica lipase-A)
– TLL (Thermomyces lanuginosa Lipase)
– RDL (Rhizopus delemar lipase)
– ANL (Aspergillus niger lipase)
• Esterases
• Proteases
• Amylase and other carbohydratases
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Lipase
A Versatile biocatalyst
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Lipase
A Versatile biocatalyst
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Lipases are used for:
• Resolution of carboxylic acids
• Resolution of alcohols
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Lipases are used for:
• Synthesis of enantiopure amides:
• Desymmetrization reactions:
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Lipases are used for
• Synthesis of enantiopure epoxides
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What we offer…
• We at Advanced Enzymes are manufacturing,
marketing and exporting enzymes for the various
applications over the last 50 years.
• Our technical and application labs are well
equipped to develop enzymatic processes and to
provide technical solutions.
• Talk to us for the new development and support.
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Concluding remarks
• Sustainability is development that meets the needs
of the present without compromising the ability of
future generations to meet their own needs.
• Enzymes technology is an invaluable tool for organic
chemists to create the future in balance between
economy, cleaner environment and better lives
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Thank You
“Think of Life …
Think of enzymes…
Think of Advanced Enzymes”
Where Enzyme is life