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APAKAH HASIL PENELITIAN TERSEBUT VALID?
A. Petunjuk Primer
1. Apakah terdapat sampel yang representatif, terdefinisi jelas, dan berada pada kondisi yang
sama dalam perjalanan penyakitnya?
The criteria for surgical resection of HCC patients inthis study were (1) patients with tumor invasion in singlelobe or tumors in both lobes involving no more than 3Healey’s segments, (2) Child-Turcotte-Pugh (CTP) class Aor B with \25% retention of indocyanine green 15 minafter injection, and (3) no main portal vein trunk involvementor distant metastasis.
Variables associated with therapeutic strategy and longtermprognosis were comprehensively selected into thepropensity score model involving 146 matched pairs ofpatients from each treatment arm (Table 3). There were nosignificant baseline differences in age, sex, etiology of liverdisease, tumor-related parameters, severity of cirrhosis,performance status, vascular invasion, and cancer stagingsystems between the 2 patient groups. A matched studypopulation was constructed to compare the long-termprognosis between these 2 groups.
2. Apakah follow-up cukup lama dan lengkap?
Comparison of long-term survival between the 2 groups
in the propensity model is shown in Fig. 3. Patients
undergoing SR had significantly better long-term survival
than patients receiving TACE (P\.001). During a mean
follow-up period of 20 ± 17 months, 44 (30%) and 68
(47%) patients undergoing SR and TACE, respectively,
died. The 1-, 3-, and 5-year survival rates of HCC patients
receiving SR and TACE were 82% vs 65%, 68% vs 29%,
and 46% vs 22%, respectively. In the univariate survival
analysis, patients receiving TACE had significantly poorer
prognosis than patients receiving SR (HR: 2.44, 95% CI:
1.65–3.59; P\.001). In the multivariate Cox model, age
C65 years (HR: 2.13, 95% CI: 1.44–3.17; P\.001),
TACE (HR: 2.56, 95% CI: 1.73–3.78; P\.001), tumor
size C7 cm (HR: 1.62, 95% CI: 1.08–2.42; P = .019) and
vascular invasion (HR: 2.13, 95% CI: 1.44–3.17; P\.001)
were identified as independent predictors of poor prognosis
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APA HASILNYA?
1. Bagaimana gambaran outcome menurut waktu?
APAKAH HASIL PENELITIAN INI DAPAT DIAPLIKASIKAN?
1. Apakah pasien dalam penelitian tersebut serupa dengan pasien saya?
YA
2. Apakah hasil tersebut membantu memilih atau menghindari terapi tertentu?
YA
Dalam jurnal penelitian ini surgical resection merupakan terapi yang dipilih untuk pasien
karsinoma hepatoseluler stadium intermediate
3. Apakah hasilnya membantu dalam memberikan konseling kepada pasien saya?
YA
Dalam jurnal penelitian ini disebutkan bahwa hasil prognosis dilakukan surgical
resection bagi pasien karsinoma hepatoseluler stadium intermediate lebih baik dibanding
dengan TACE.