EARLY NUTRITION ANDITS LATER CONSEQUENCES :NEW OPPORTUNITIE SPerinatal Programming of Adult Health -EC Supported Research
Berthold Koletzko
Peter Dodds
Hans Akerblom
Margaret Ashwell
PREFACEBerthold Koletzko, Manuel Serrano Rios xii i
WHAT IS THE EU INFANT NUTRITION CLUSTER? xv
EARLY NUTRITION AND ITS LATER CONSEQUENCES : NEW
OPPORTUNITIE S
Berthold Koletzko 1
THE DEVELOPMENTAL ORIGINS OF ADULT HEALTH AN DWELL-BEING
Alan Lucas 1 3
LONG TERM EFFECTS OF BREASTFEEDING ON THE INFAN TAND MOTHER
Lene Schack-Nielsen, Anni Larnkjaer, Kim Fleische rMichaelsen 1 6
EXPERIMENTAL EVIDENCE FOR LONG-TERM PROGRAMMIN G
EFFECTS OF EARLY DIETM.E . Symonds, H .Budge, T . Stephenson and D .S. Gardner 24
CANDIDATE GENES FOR OBESITY - HOW MIGHT THEY
INTERACT WITH ENVIRONMENT AND DIET ?I . Sadaf Faroogi 3 3
RATE OF GROWTH IN EARLY LIFE : A PREDICTOR O F
LATER HEALTH ?Marie Frangoise Rolland-Cachera 35
PROTECTIVE EFFECT OF BREAST-FEEDING AGAINS T
OBESITY IN CHILDHOO D
Stephan Arenz and Rüdiger von Kries 40
DISCUSSION FORUM : FROM INNOVATION TO IMPLEMENTATIO N
Hildegard Przyrembel, Jean Michel Antoine, O . Hernell, D . Turck,
E. Underwood and M.C. Secretin 49
CHALLENGES AND OPPORTUNITIES IN PAN-EUROPEANCOLLABORATION FOR RESEARCHERS FROM CENTRALAND EASTERN EUROPE
T. Decsi, N . Fidler Mis, S . Kolacek, I . Kon, J. Kopecky, I . Penas -Jimenez, P. Socha and H . Szajewska 54
BEST PRACTICE IN COMMUNICATING THE RESULTS O F
EUROPEAN RESEARCH TO THE PUBLI CMargaret Ashwell and Michel Claessens 60
LONGTERM EFFECTS OF PRE- AND POSTNATAL EXPOSURETO LOW AND HIGH DIETARY PROTEIN LEVELS
Cornelia C . Metges 64
PROTEIN INTAKE IN THE FIRST YEAR OF LIFE : A RISKFACTOR FOR LATER OBESITY?
Berthold Koletzko, Daniel Brasseur, Ricardo Closa, Marcell oGiovannini and Jerzy Socha 69
THE ROLE OF LONG-CHAIN POLY-UNSATURATED FATTYACIDS (LCPUFA) IN GROWTH AND DEVELOPMEN T
Mijna Hadders-Algra 8 0
EXPERIMENTAL MODELS FOR STUDYING PERINATALLIPID METABOLISM
E. Herrera, I . Lopez-Soldado, M. Limones, E. Amusquivar an dM.P. Ramos 95
EFFECT OF N-3 POLYUNSATURATED FATTY ACIDSUPPLEMENTATION IN PREGNANCY : THE NUHEAL TRIAL
Tamäs Decsi, Cristina Campoy and Berthold Koletzko 109
YOUNG RESEARCHERS' WORKSHOPI. Broekaert, E . Larque 11 4
CONSUMER NEEDS REGARDING DIETETIC PRODUCTS FORPREGNANT AND LACTATING WOMEN AND FOR BABY FOOD S
Monique Raats , Kaisa Poutanen and Maria Almeida 120
FOCUS GROUP : BREAKFAST MEETING : SMES AND THEI RCO-OPERATION WITH ACADEMI A
Jean Michel Antoine and Mats Strömgvist 127
ETHICAL ISSUES IN PERINATAL NUTRITION RESEARCHIrene Cetin, and Robin Gill, 132
EARLY PROGRAMMING OF DIABETES RISK- A NINTRODUCTIO N
H.K. Akerblom 139
EARLY NUTRITION AND LATER DIABETES RIS K
Mikael Knip and Hans K. Akerblom 142
IS TYPE 1 DIABETES A DISEASE OF THE GUT IMMUN ESYSTEM TRIGGERED BY COW'S MILK INSULIN ?
Outi Vaarala 15 1
GLUTEN-FREE DIET IN SUBJECTS AT RISK FOR TYPE 1
DIABETES: A TOOL FOR DELAYING PROGRESSION
TO CLINICAL DISEASE?Emanuele Bosi, Matteo R Pastore, Laura Molteni, Elena
Bazzigaluppi, Ezio Bonifacio and Lorenzo Piemonti 157
INSULIN LIKE GROWTH FACTOR REGULATION OFBODY MASS IN BREASTFED AND MILK FORMULA FEDINFANTS
P. Socha, R . Janas, A. Dobrzanska, B . Koletzko, I . Broekaert, D .Brasseur, A. Sengier, M. Giovannini, C . Agostoni, R. ClosaMonasterolo, G . Mendez, EU Childhood Obesity Study Team . . .15 9
INVERSE ASSOCIATION BETWEEN TRANS ISOMERI CAND LONG-CHAIN POLYUNSATURATED FATTY ACIDSIN ERYTHROCYTE MEMBRANE LIPIDS IN PREGNANTWOMEN
A. Kovacs, C . Campoy, B . Koletzko, T. Marosvölgyi, E . Szabo,M. Jimenez, H. Demmelmair, T . Decsi 164
COMPARISON OF ESSENTIAL FATTY ACID STATU SAMONG GERMAN, HUNGARIAN AND SPANISH WOMENAT MID-GESTATION
T. Marosvölgyi, C. Campoy, B. Koletzko, V. Jakobik, V . Dolz,H. Demmelmair, B. Veszpremi, T . Decsi 166
TRANS ISOMERIC FATTY ACIDS AS CONFOUNDINGVARIABLES IN STUDIES ON PERINATAL LC-PUFASUPPLY
Tamäs Decs i 168
AN EIGHT YEARS PROSPECTIVE STUDY OF IRO NDEFICIENCY ANAEMIA IN INFANC Y
Antunes H, Gonsalves S, Santos C, Costa-Pereira A, Tojo-Sierr aR, Aguiar A 170
NEW INSIGHTS IN THE POTENTIAL MECHANISM O FACTION OF NUCLEOTIDES TO MODULATE IMMUNIT Y
M. Manzano, A. Gil, R. Rueda 172
THRIVING OF MALNOURISHED BREASTFED INFANT SAFTER ADDITIONAL FORMULA MILK FEEDIN G
N. Fidler Mis, I . Hren, J. Brecelj, A . Sirca Campa, M. Sedmak,C . Kr2ignik, B. Koletzko 174
ROLE OF MAMMARY GLAND LIPOPROTEIN LIPASE INTHE AVAILABILITY OF POLYUNSATURATED FATTYACIDS FOR MILK SYNTHESIS
E. Amusquivar, I . Lopez-Soldado, H . Ortega, E . Herrera. . . .176
IS THE CRYING BEHAVIOUR IN INFANTS UP TO THEAGE OF 3 MONTHS INFLUENCED BY THE TYPE O FEARLY NUTRITION?
Sonia Schiess, Doris Oberle, Ilse Broekaert, Anna Reith,Sabine Verwied-Jorky . Berthold Koletzko 177
DIETARY GANGLIOSIDES: BENEFICIAL EFFECTS FORTHE NEONATE AND POTENTIAL MECHANISM OFACTION
E. Vazquez, A . Gil, R. Rueda 179
LEPTIN IN BREAST-FED AND FORMULA-FED INFANT SFrancesco Savino, Maria Francesca Fissore, Erica Clara
Grassino, Giuliana Eva Nanni, Roberto Oggero, GianCarlo Mussa 18 1
DIETARY FATTY ACIDS DURING PREGNANCYDETERMINES MATERNAL FATTY ACID PROFILE DURIN GLATE PREGNANCY AND THEIR AVAILABILITY TO TH EFETUS EVEN DURING FASTING CONDITION S
I. Lopez-Soldado, H . Ortega, E . Amusquivar andE. Herrera 183
EFFECT OF OIL-SUPPLEMENTED DIETS ON LIVEREXPRESSION OF PPAR ALPHA-RELATED GENES INPREGNANT RATS
C. Bocos, M . Gonzalez, I . Lopez-Soldado, and E . Herrera 185
EFFECT OF A NEW INFANT FORMULA ENRICHEDWITH PROBIOTICS, PROBIOTICS, NUCLEOTIDES AND LC -PUFA ON RECOVERY AFTER INFECTION
M. Rivero, A. Roca, R. Chifre, M. Conde, M. Rodriguez, A .Santamaria, Gemma Colome 186
DOES HABITUAL PROTEIN INTAKE IN EARLYCHILDHOOD INFLUENCE AGE AND BODY MASS INDEXAT ADIPOSITY REBOUND?
Anke L. B. Günther, Anette E. Byuken, Sebastian Hahn ,Mathilde Kersting, Anja Kroke 188
DIETARY COMPLIANCE IN DIABETES PREVENTIO NPROJECT IN FINLAND
Sonja Bärlund, Ulla Uusitalo, Päivi Kleemola, Mikael Knip ,Hans K. Akerblom, Suvi M . Virtanen 18 9
CHANGES OF PLASMA FATTY ACID PROFILE AN DANTIOXIDANT VITAMINS DURING NORMALPREGNANCY
E. Herrera, H. Ortega, G. Alvino, N. Giovannini ,E. Amusquivar, I . Cetin 190
OPTIMAL DESIGN FOR THE RECRUITMENT OFPARTICIPANTS AS A FACTOR FOR THE EFFECTIVEIMPLEMENTATION OF A CLINICAL TRIAL
B . Aschemeier BHC, C . Bittner, K . Lüpke, O . Kordonouri, T .Danne 19 1
THE EFFECT OF PONDERAL INDEX ON PLASM ACONCENTRATION OF INSULIN-LIKE GROWTH FACTOR- 1(IGF-l) IN NEONATAL PIG S
J. C . Litten, K. S . Perkins, J . Laws, A . M. Corson and L .Clarke 193
EFFECTS OF PRENATAL EXPOSURE TO LOW AN DHIGH DIETARY PROTEIN LEVELS ON MATERNAL ANDFETAL AMINO ACID METABOLISM IN RAT S
Maren Daenzer, Jeanette Günther, Klaus J . Petzke, Cornelia C .Metges, Susanne Klaus 195
COW'S MILK INTRODUCTION IN SPANISH INFANTSSantamaria-Orleans A, Miranda-Leon MT, Rivero-Urgell M,
Campoy-Folgoso C 196
LONGER TERM EFFECTS OF EARLY CHOLESTERO LINTAKE ON CHOLESTEROL BIOSYNTHESIS AND PLASM ALIPIDS : A RANDOMIZED CLINICAL TRIAL
Thea A . Demmers, Peter J.H. Jones, Yanwen Wang, SusanKrug, Vivian Creutzinger, James E . Heubi 197
PATTERNS OF GROWTH AND ENERGY UTILIZATIONOF THE DIET AFTER A PERIOD OF DIETARYRESTRICTION DURING THE WEANING PERIO D
A.P.R. Battochio; A.G. Santos ; C.A .R. Coelho 198
INFANT FORMULA FEEDING PATTERN AND WEANINGINTRODUCTION IN SPANISH INFANTS
Santamaria-Orleans A, Miranda-Leon MT, Rivero-Urgell M ,Campoy-Folgoso C 199
VISUAL EVOKED POTENTIALS IN INFANTS AFTE RDIETARY SUPPLY OF DOCOSAHEXAENOIC ACID AND 5 -METHYLTETRAHYDROFOLATE DURING PREGNANCY
I. Broekaert, C . Campoy, C . Iznaola, B . Hoffmann, W .Müller-Felber, B . Koletzko 20 1
ELECTRONIC DATA CAPTURE AND USE OF INTERNETTECHNOLOGIES IN A DOUBLE-BLIND RANDOMISEDINTERVENTION TRIA L
D . Oberle, H . Köhler, T. Richardsen, D . Brasseur ,B . Koletzko 203
BREASTFEEDING AND BABY FRIENDLY HOSPITA LINITIATIVE IN SLOVENIA
B . Bratanic, N. Fidler Mis, Z. Felc, P . Truden Dobrin 205
NUTRITIONAL STATUS IN YOUNG ADULTS WITHSCREEN-DETECTED SILENT/SUB-CLINICAL COELIA CDISEASE
M. Haapalahti, P. Kulmala, TJ . Karttunen, L . Paajanen ,K. Laurila, M . Mäki, H. Mykkänen, J . Kokkonen 207
LIPOPROTEIN LIPASE (LPL) MRNA EXPRESSION I NPLACENTAS FROM NORMAL AND IUGR (INTRAUTERINEGROWTH RESTRICTED) PREGNANCIES BY REAL-TIMEPCR
S. Tabano, G . Alvino, P. Antonazzo, V . Cozzi, F. Grati, M .Miozzo, I . Cetin 208
MATERNAL FASTING EFFECT ON NEONATAL HEALTHKavehmanesh Z. Md 21 0
THE QUALITY OF SCHOOLCHILDREN'S NUTRITION INSERBIA
Mirjana Pavlovic, Agnes Kadvan, Milija Vukotic 21 2
TENDENCY TOWARDS OBESITY IN SYDNEY SCHOO LCHILDREN
Kaye Brock, Stephen Morrell, Richard Taylor 21 4
MONITORING AND SUPERVISING A DIETARYINTERVENTION TRIAL USING MODERN DATAPROCESSING SYSTEM
M. J. Koski, J . P. Krischer 21 6
ANALYSIS OF DROP-OUTS IN A LONGITUDINA LSTUDY
G. Mendez, V . Luque, F . Capdevila, J . Marine, R . Closa, J.Escribano 21 7
RECRUITMENT STRATEGIES OF THE SPANISH GROUPIN THE "EU CHILDHOOD OBESITY : PROGRAMMING B YINFANT NUTRITION"
V. Luque, G. Mendez, F . Capdevila, J . Marine, R . Closa, J .Escribano 218
DIET AND NUTRITIONAL RISK FACTORS I NSCHOOLCHILDREN
Mirjana Pavlovic, Agnes Kadvan, Draginja Rapic 21 9
INFLUENCE OF TWO FORMS O FCASEINOPHOSPHOPEPTIDE ON IRON BIO AVAILABILITY
I .B . Kibangou, S . Bouhallab, F . Bureau, P . Guerin, S . Allouche ,P. Arhan, D. Bougie 22 1
MODEL OF CHILDHOOD OBESITY PRIMARYPREVENTION PROGRAMME
Mirjana Pavlovic 223
PROBLEMS RELATED TO RECRUITMENT O FPARTICIPANTS FOR THE TRIGER PROJECT
Aleksandra G6rska 225
VITAMIN D STATUS AT BIRTH IN BRUSSELS -PRELIMINARY RESULT S
F. Petry, L. Gianquinto, H. Cheblal, N . Hennebert, J . Vanderpas ,J .L. Wayenberg, 226
OBESITY AMONG YOUNG ADOLESCENT KUWAITI SAbdulwahab Naser Al-Isa 228
DYNAMIC CHANGES IN ADIPOSITY FROM FETAL T OPOSTNATAL LIFE ARE INVOLVED IN THE ADULTMETABOLIC SYNDROME ASSOCIATED WITH REDUCEDFETAL GROWTH
D. Jaquet MD, PhD, S . Deghmoun, D . Cheyenne PhD, D. CollinMD, P . Czernichow MD, C . Levy-Marchal MD 229
EXCESS FETAL ADIPOSITY IS ASSOCIATED WITHPROGRAMMING OF PLACENTAL LIPID GENE S
Tatjana Radaelli, Ali Varastehpour, Patrick Catalano, SylvieHauguel-de Mouzon 23 1
APPETITE CONTROL IN BREASTFED AND FORMULAFED INFANTS
D. Gruszfeld ; R . Janas ; J . Socha; B. Koletzko; I . Broekaert; D .Brasseur; A. Sengier; M. Giovannini ; C . Agostoni ; R. ClosaMonasterolo ; V. Luque ; EU Childhood Obesity Study Team 23 3
WHAT ARE THE DANONE INSTITUTES 235