Earl W. Sutherland, Jr Discovery of Cyclic AMP
Ferid MuradNitric Oxide Signaling
Alfred G. GilmanG-protein Signal Transduction
Heritage of the CWRU
Department of Pharmacology
Nobel Prize
Kris Palczewski, Chairman of
Pharmacology
First high resolution structure of a G-protein coupled receptor (GPCR)• most common target of
modern drug development
In the top five of most highly cited articles in Biology / Biochemistry
Thomas Reuters Survey
Continuing Tradition of Excellence in Pharmacology at CWRU
Membrane Structural Biology &
Pharmacology
Cellular / Molecular Biology
& Research Rotation
s
Molecular Pharmacolog
y & Cell
Regulation
Translational
Therapeutics
The MTTP provides students with outstanding training in the cellular, molecular, and physiological basis for therapeutics,
preparing them for independent careers in research and teaching in a variety of academic or industrial settings.
Molecular TherapeuticsTraining Program ( MTTP )
Cancer Therapeutics
Core and Advanced
Tracks
The NIH-funded Molecular Therapeutics Training Program (MTTP) involves faculty from six major research centers in Cleveland - CWRU, University Hospitals, Case Comprehensive Cancer Center, Cleveland Clinic Foundation, Cleveland VA Medical Center, and MetroHealth Medical Center. Students enter the Pharmacology Graduate Program directly, or via the Biomedical Sciences Training Program (BSTP) or the Medical Sciences Training Program (MSTP).
Membrane Structural Biology &
Pharmacology
Cellular / Molecular Biology
& Research Rotation
s
Molecular Pharmacolog
y & Cell
Regulation
Translational
Therapeutics
The MTTP provides students with outstanding training in the cellular, molecular, and physiological basis for therapeutics,
preparing them for independent careers in research and teaching in a variety of academic or industrial settings.
Molecular TherapeuticsTraining Program ( MTTP )
Cancer Therapeutics
Core and Advanced
Tracks
The Molecular Pharmacology and Cellular RegulationTrack promotes common research interests in molecular mechanisms of drug actions and regulatory processes that are potential targets for drug development.
• Novel role of ATP as a chemoattractant that facilitates the immune component of the anti-tumor response associated with cancer chemotherapy …
Andrea Boyd-Tressler and George Dubyak
Molecular Pharmacology and Cellular Regulation Track
Luke Bury and Shasta Sabo • Modern electrophysiology and imaging used to
discover the mechanisms by which nerve synapses are formed in the developing brain - discovering the basis for autism …
Meghana Gupta and Danny Manor • Learning how phosphorylation of tyrosine residues affects
the biochemical and physiological activities of proteins that regulate G-protein signaling – discovering anti-cancer targets …
Membrane Structural Biology &
Pharmacology
Cellular / Molecular Biology
& Research Rotation
s
Molecular Pharmacolog
y & Cell
Regulation
Translational
Therapeutics
The MTTP provides students with outstanding training in the cellular, molecular, and physiological basis for therapeutics,
preparing them for independent careers in research and teaching in a variety of academic or industrial settings.
Molecular TherapeuticsTraining Program ( MTTP )
Cancer Therapeutics
Core and Advanced
Tracks
Benefiting from the Case Comprehensive Cancer Center, the Cancer Therapeutics Track fosters common interest in the concepts of cancer biology that form the basis for specific therapeutic strategies.
Cancer Therapeutics Track
• Studies of mechanisms of regulation of lymphocyte apoptosis via the TDAG8 G protein-coupled receptor in the context of leukemia.…
Chris Ryder Clark Distelhorst
• “The role of the microenvironment in mediating breast cancer progression. Specifically I'm interested in the role of microRNAs on TGF-beta mediated-metastatic progression…”
MollyTaylor Billl Schiemann
Membrane Structural Biology &
Pharmacology
Cellular / Molecular Biology
& Research Rotation
s
Molecular Pharmacolog
y & Cell
Regulation
Translational
Therapeutics
The MTTP provides students with outstanding training in the cellular, molecular, and physiological basis for therapeutics,
preparing them for independent careers in research and teaching in a variety of academic or industrial settings.
Molecular TherapeuticsTraining Program ( MTTP )
Cancer Therapeutics
Core and Advanced
Tracks
The Translational Therapeutics Track interfaces basic science trainees with physician-scientists around a common interest in developing / improving the use of therapeutic agents in a rational and individualized manner.
• Antiplatelet therapeutics…”my project examines an agent that has ideal characteristics; it delays thrombosis but does not influence bleeding time…”
Michele Mumaw Marvin Nieman
Translational Therapeutics Track
• Structure function studies of Class A beta-lactamases. Understanding the factors that permit the successful evolution of beta-lactamases in the clinic…
Peter Levitt Robert Bonomo
• “I study the role of DNA repair in hematopoietic stem cells to understand the relationship between DNA repair, cell cycle status, and hematopoietic stem cell function.…”
Amar Desai Stan Gerson
Structural Biology & Pharmacology Track
…
Mike Mullins
Understanding the function of telomerase in
DNA replication pertaining to aging and cancer chemotherapy
Derek Taylor
Determining the structure of isolated discs from the rod cells of the eyes of
mouse models of human eye diseases
Neetu Gulati Phoebe StewartDirector, CCMSB
Chris Francy Jason Mears
Studying the molecular dynamics of Drp 1 in
mediating mitochondrial fission & fusion pertinent to
neurodegenerative diseases
Electron Microscopy NMR
X-ray generator Crystal robot
Mass spec, computational modeling, one of the 3 largest, best equipped facilities in the world!