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DRAFT BHIVA DRAFT BHIVA GUIDELINESGUIDELINES
Routine monitoring of Routine monitoring of HIVHIV
UK-CAB 31 July 2009
Matt Williams writing committee community rep
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DRAFT BHIVA GUIDELINESDRAFT BHIVA GUIDELINESRoutine monitoring of HIVRoutine monitoring of HIV
First guideline of this kindStatus: (soon-to-be published) draft for
consultation Headlines:• Long• Confirms much current practice• Some important new points
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DRAFT BHIVA GUIDELINESDRAFT BHIVA GUIDELINESRoutine monitoring of HIVRoutine monitoring of HIV
NEW!
Diagnosis recommended confirmed using 4th generation tests (therefore all clinics should have access to 4th generation tests)
Window period: gone…
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DRAFT BHIVA GUIDELINESDRAFT BHIVA GUIDELINESRoutine monitoring of HIVRoutine monitoring of HIV
NEW!
4th generation tests can detect HIV before seroconversion
6 week negative results for HIV antibody and antigen with no symptoms = does not have HIV
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DRAFT BHIVA GUIDELINESDRAFT BHIVA GUIDELINESRoutine monitoring of HIVRoutine monitoring of HIV
NEW!
Viral load cut-off: clinics must decide lower level for reporting “detectable” result
Is it to be >40 copies/mL? >50? >100? Importance of viral load <50 v >50 notedVL in compartments not generally useful
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DRAFT BHIVA GUIDELINESDRAFT BHIVA GUIDELINESRoutine monitoring of HIVRoutine monitoring of HIV
NEW!
Viral load cut-off: some tests are very sensitive and report “mini-spikes” – in the 100s sometimes
No firm recommendation on cut-offClinics need to be aware of nature of, and
ideally choose, viral load tests they usePaper forthcoming…
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DRAFT BHIVA GUIDELINESDRAFT BHIVA GUIDELINESRoutine monitoring of HIVRoutine monitoring of HIV
CURRENT
CD4 (CD4%) and viral load every 3-4 months generally
Every 6 months sometimesMore often when starting/just started
ARVs or otherwise neededFrequency by mutual agreement
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DRAFT BHIVA GUIDELINESDRAFT BHIVA GUIDELINESRoutine monitoring of HIVRoutine monitoring of HIV
NEW!
CD4 – 2 baseline tests (diagnosis and first follow-up visit)?
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DRAFT BHIVA GUIDELINESDRAFT BHIVA GUIDELINESRoutine monitoring of HIVRoutine monitoring of HIV
CURRENT
Resistance tests as soon as practical after diagnosis (genotype)
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DRAFT BHIVA GUIDELINESDRAFT BHIVA GUIDELINESRoutine monitoring of HIVRoutine monitoring of HIV
NEW!
Resistance tests at any viral loadComment on effectiveness of current
assays at viral load <500 copies/mL (often works)
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DRAFT BHIVA GUIDELINESDRAFT BHIVA GUIDELINESRoutine monitoring of HIVRoutine monitoring of HIV
NEW!
Formalised comprehensive history at first visit, annual review
Includes asking about mood and cognitionShort form (2 question) format as per
NICE guidelinesQ: should mood and cognition be included
at every clinic visit?
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DRAFT BHIVA GUIDELINESDRAFT BHIVA GUIDELINESRoutine monitoring of HIVRoutine monitoring of HIV
NEW!
Baseline assessment includes extensive screening for tropical diseases, including worms, TB, malaria and other infectious/parasitic agents
Debate over measles immunity (current preference not to comment)
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DRAFT BHIVA GUIDELINESDRAFT BHIVA GUIDELINESRoutine monitoring of HIVRoutine monitoring of HIV
CURRENT
STI screen: baseline and regularly
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DRAFT BHIVA GUIDELINESDRAFT BHIVA GUIDELINESRoutine monitoring of HIVRoutine monitoring of HIV
CURRENT
Cholesterol and cardiovascular risk assessment: baseline and annual check
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DRAFT BHIVA GUIDELINESDRAFT BHIVA GUIDELINESRoutine monitoring of HIVRoutine monitoring of HIV
CURRENT
Bone: baseline and annual metabolites (more often if over 50? smoker? on tenofovir)
Vitamin D: noted (no recommendations on value of having a measure of deficiency)
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DRAFT BHIVA GUIDELINESDRAFT BHIVA GUIDELINESRoutine monitoring of HIVRoutine monitoring of HIV
NEW!
Bone: DEXA scan as per osteoporosis guidelines for general population at risk
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DRAFT BHIVA GUIDELINESDRAFT BHIVA GUIDELINESRoutine monitoring of HIVRoutine monitoring of HIV
CURRENT
Liver enzymes: at every visit
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DRAFT BHIVA GUIDELINESDRAFT BHIVA GUIDELINESRoutine monitoring of HIVRoutine monitoring of HIV
CURRENT
Hepatitis: baseline and annual check (A, B, C)
Hepatitis A and B vaccination: recommended (check immunity)
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DRAFT BHIVA GUIDELINESDRAFT BHIVA GUIDELINESRoutine monitoring of HIVRoutine monitoring of HIV
CURRENT
Urine protein: recommended (when?)Blood glucose: recommended (when?
alternatives?)Full blood count: annual or more frequentAlbumin: every visitTDM: as required
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DRAFT BHIVA GUIDELINESDRAFT BHIVA GUIDELINESRoutine monitoring of HIVRoutine monitoring of HIV
NEW!
Lipdystrophy, lipoatropy, metabolic syndrome, peripheral neuropathy: little comment, refer to (forthcoming) side effects and toxicity guidelines/other treatment guidelines
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DRAFT BHIVA GUIDELINESDRAFT BHIVA GUIDELINESRoutine monitoring of HIVRoutine monitoring of HIV
NEW!
Age: wrap-up comment on cardiovascular health, bone density and cognition (no special recommendations since no-one quite knows what to do)
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DRAFT BHIVA GUIDELINESDRAFT BHIVA GUIDELINESRoutine monitoring of HIVRoutine monitoring of HIV
NEW!
Phylogenetic testing: comment and overview of science
Recommendation: no routine clinical use
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DRAFT BHIVA GUIDELINESDRAFT BHIVA GUIDELINESRoutine monitoring of HIVRoutine monitoring of HIV
NEW!
Phylogenetic testing is a research test used to show infection A relates genetically to infection B (as per criminal cases)
What do people think?
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DRAFT BHIVA GUIDELINESDRAFT BHIVA GUIDELINESRoutine monitoring of HIVRoutine monitoring of HIV
NEW!
STARHS (detecting recent infection): recommended as routine
What do people think?
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DRAFT BHIVA GUIDELINESDRAFT BHIVA GUIDELINESRoutine monitoring of HIVRoutine monitoring of HIV
NEW!
Superinfection (reinfection): comment and overview of science
If this occurs, not a useful indicator of a person’s sexual life (ie putting others at risk)
What do people think?
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DRAFT BHIVA GUIDELINESDRAFT BHIVA GUIDELINESRoutine monitoring of HIVRoutine monitoring of HIV
UNSETTLED
Pregnancy testing for women who may start/are on ARVs: offer?
GP/HCW communicationSome aspects of initial work-upExtra points for late diagnosisAdherence
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DRAFT BHIVA GUIDELINESDRAFT BHIVA GUIDELINESRoutine monitoring of HIVRoutine monitoring of HIV
NOT COVERED
Patient communicationPeople lost to follow-upConsentPainCancer screening (but no to routine HPV
screening for men)What do people think?
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DRAFT BHIVA GUIDELINESDRAFT BHIVA GUIDELINESRoutine monitoring of HIVRoutine monitoring of HIV
ROADMAP
Draft imminent3 weeks BHIVA/UK-CAB advance
consultation3 weeks general consultationFinal editPublish in time for BHIVA autumn
conference….