Download - DNA Rep & Protein Syn
DNA Rep & Protein Syn
1928 – Griffith Transformation Experiment
1941-Avery, McCarty, MacLeod
1952-Hershey & Chase
1952-Rosalind Franklin
1953-Watson & Crick
Chromosomes, DNA, and Genes
DNA StructureDeoxyribonucleic AcidDouble HelixMade of nucleotides
Pentose Sugar (deoxyribose)PhosphateNitrogenous Base
A-T / C-G
Nucleotide
Nitrogenous Bases
Base Pairing
DNA is AntiParallel
DNA is still AntiParallel
How?
Possible Models for DNA Replication
Step 1
Step 2
DNA Replication Animation
http://highered.mcgraw-hill.com/olcweb/cgi/pluginpop.cgi?it=swf::535::535::/sites/dl/free/0072437316/120076/micro04.swf::DNA%20Replication%20Fork
Think About ItIf your DNA has 6 billion base pairs and generally there is one mistake made for every 100,000bp that are copied during replication, how many errors should result each time you copied your DNA?How many errors result in reality?Why?
Protein Synthesis Overview
RNA StructureRibonucleic AcidSingle Strand of nucleotides
Pentose Sugar (ribose)PhosphateNitrogenous Base
A-U / C-G
RNA Nucleotide
3 Types of RNAmRNA, tRNA, rRNA
Protein Synthesis
Step 1 – Transcription
Step 2 – Translation
TranscriptionDefinitionTATA BoxRNA PolymeraseDNA Terminator5’ CapPoly – A Tail
TATA Box
Transcription Animationhttp://highered.mcgraw-hill.com/sites/0072507470/student_view0/chapter3/animation__mrna_synthesis__transcription___quiz_2_.html
mRNA Processing
http://highered.mcgraw-hill.com/sites/9834092339/student_view0/chapter16/animation_-_exon_shuffling.html
TranslationDefinition
mRNA Codons
thedogbitthecatforfun
the dog bit the cat for fun
aug uuu cgc ggg cua aga uaa
tRNA
Ribosome
Codons
Codons
Translation Animationhttp://highered.mcgraw-hill.com/sites/0072943696/student_view0/chapter3/animation__how_translation_works.html
Protein Folding
Protein Processinghttp://highered.mcgraw-hill.com/sites/0072943696/student_view0/chapter2/animation__protein_denaturation.html
Gene RegulationRepressible Operon – trp OperonInducible Operon – lac Operon
trp Operon
lac Operon
cAMP & lac Operon
lac Operon Animationhttp://highered.mcgraw-hill.com/sites/007337797x/student_view0/chapter13/animation_quiz_-_combination_of_switches__the_lac_operon.html