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DIAGNOSTIC CHALLENGESPancreas FNAB
Dr. M. WeirOct 2017
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CONFLICT OF INTEREST DISCLOSURE
I have not had in the past 3 years, a financial interest, arrangement or affiliation with one or more organizations that could be perceived as a direct or indirect conflict of interest in the content of this presentation.
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OBJECTIVESAfter this session on pancreas eus fnab, should be able to:
Recognize diagnostic approaches to complex cytological problems
Expand knowledge & skills in interpretation of advanced cytology sampling techniques
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AGENDA
2 cases Pancreas eus fnabs
Photos: Hologic, PathologyOutlines, cytology.wordpress.comwww.eurocytology.eu www.joplink.net www.pubcan.org, researchgate, PathPedia.com
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Case 1
55 year old female Body of pancreas (BOP) mass Solid, 5 x 4 cm Transgastric EUS FNAB
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What is the pattern?
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What is the pattern?What is the pattern?GLANDULAR
& ACINAR
What is your diagnosis?
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What is your diagnosis?
a) Neoplastic mucinous cystb) Gastric contaminationc) Pancreatic endocrine neoplasmd) Acinar cell carcinomae) Solitary pseudopapillary neoplasm
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ApproachClinical & imaging important
- if solid – use algorithm for DDX
Microscopic approach- Adequacy
- Background- Contamination
- Diagnosis
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ALGORITHM:Solid Pancreas Mass EUS FNAB
Non-neoplastic Normal contaminant Pancreatitis
- chronic- autoimmune- acute
Infection
Neoplastic Adenocarcinoma, ductal Pancreatic endocrine
neoplasm Acinar cell carcinoma Solid pseudopapillary
neoplasm Pancreaticoblastoma Metastasis
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ALGORITHM:Acinar pattern
Non-neoplastic
Normal contaminant- pancreas
Pancreatitis
Neoplastic
Pancreatic endocrine neoplasm
Acinar cell carcinoma Solid pseudopapillary
neoplasm Pancreaticoblastoma Metastasis
Other patterns: single cells, glandular, cystic
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ADEQUACY: ROSE Define adequacy to accommodate threshold
differences in interpretation
Solid lesion:- Epithelial predominant: > 10 groups- Inflammation: may not be lesional
Purpose: triage for ancillary studiesNEED cell block!
Do cores
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Coagulative necrosis: malignantFat necrosis & pancreatitis
BACKGROUND
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BACKGROUND: Mucus/Mucin
GI luminal mucus- watery, thin, dirty, heterog- bare nuclei, food
Mucin- thick, uniform- cracked, colloid-like
BOTH + mucin stains
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CONTAMINATION
Esophagus Stomach
DuodenumBiliary duct
Pancreas
PatternsSingle cellsGlandularAcinar
Pancreas
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DIAGNOSIS: LO POWERGlandular Pattern
Mucosal Contamination
Low to high cellularity Cohesive, 2-D, flat Polarized groups Naked grooved nuclei
In mucus blobs
Adenocarcinoma
High Loosely cohesive, 3D Drunken honeycomb Single abN cells
Necrosis (coagulative)
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Mucosal contaminationPolarized, cohesive
Ductal adenocarcinomaDrunken honeycomb, atypia
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GI mucusGastric mucosal contam’n
CASE 1
What about the acinar pattern?
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DIAGNOSIS: LO POWERAcinar Pattern
Contamination(pancreas/pancreatitis)
Lo – mod cellularity Cohesive, polarized Grape-like clusters Acini, ductal, islets
Neoplasm
Variable cellularity Dyshesion Single cells Uniform cell type
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DIAGNOSIS: HI POWERAcinar Pattern
Contamination(pancreas/pancreatitis)
Lobular CB: 2-toned cytoplasm Granular cytoplasm
Lymphoid tangles CB: fibrosis, loss of acini
Neoplasm
Vascular (PEN, SPN) Nuclear clues
- salt/pepper (PEN)- grooves (SPN)- ++ nucleoli (ACC)
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Chronic pancreatitisThe worms
Normal pancreas
Lobular, two toned
Lymphoid tangles
Grapes
Fibrosis, atrophy
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PEN
SPN
ACC
Acinar Pattern
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Acinar patternSingle cells
Large polygonalSmaller finely granular
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Chief cells (purple)Parietal cells (pink)
Acinar pattern
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Non-lesionalNormal gastric oxyntic (body type) glands
CASE 1
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Remember to exclude contaminant first
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Case 2
60 year old maleDistal pancreatectomy for PEN
TOP region mass Transgastric EUS FNAB
??recurrent PEN
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What is the pattern? What is your diagnosis?
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What is your diagnosis?
a) Gastric contaminationb) Pancreatic endocrine neoplasmc) Renal cell carcinomad) Solitary pseudopapillary neoplasme) Something else?
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ApproachClinical & imaging important
- if solid – use algorithm for DDX
Microscopic approach- Adequacy
- Background- Contamination
- Diagnosis
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ALGORITHM:Acinar pattern
Non-neoplastic
Normal contaminant- pancreas- gastric oxyntic cells
Pancreatitis
Neoplastic
Pancreatic endocrine neoplasm
Acinar cell carcinoma Solid pseudopapillary
neoplasm Pancreaticoblastoma Metastasis
Other patterns: single cells, glandular, cystic
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ADEQUACY: ROSE Purpose: triage for ancillary studies
NEED cell block!Do cores
EUS toys- Shark cores
- decrease # smears- better sampling fibrosis- id invasion: stromal, perineural- material for immunomarkers
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PEN
Dyshesive, homogeneousSalt & pepperCell block: insular/acinar patternChromogranin, synaptophysin +
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The worms
SPN
VascularHeterogeneicPseudopapillaryGrooved nucleiB-catenin, CD10 +Chromo -, synapto +
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ACC
DyshesiveLoose aciniNucleoliChymotrypsin, trypsin +
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Foamy vacuolated cytoplasmBland nuclei
Cell block
Lacks salt/pepper No groovesNot vascular
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Cell block
Inhibin + Melan-A +
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ADRENAL CORTICAL CELLSOuter layer
foamy lipid rich background
single cells, clusters bland oval nuclei no or small nucleoli abundant vacuolated
cytoplasm with frayed edges
Inner Layer
smaller cells lipofuscin pigment granular eosinophilic
cytoplasm no vacuolization
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What is the pattern? What is your diagnosis?
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CASE 2
How would you report this?
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CASE 2
How would you report this?
Indeterminate Adrenal cortical sampling
May represent normal cortex or neoplasm (benign/mal)
Distinction not possible based on fnab alone
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ALGORITHM:Acinar pattern
Non-neoplastic
Normal contaminant- pancreas- gastric oxyntic cells- adrenal
Pancreatitis
Neoplastic Pancreatic endocrine
neoplasm Acinar cell carcinoma Solid pseudopapillary
neoplasm Pancreaticoblastoma Metastasis Adrenal neoplasm
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Optimization Cell Blocks
ROSE triage - once dx made, then CB #1 priority
Increase # CB & fixative types- formalin, Cytolyt, cores, pellets, Histogel
Avoid refacing CBCut H&E levels
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Remember samplingof adjacent structures
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Take home pointsUse solid, acinar algorithm for DDXRemember ABCDs
Consider - normal contaminants- adjacent structure sampling
Optimize cell block use
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Questions?