Development of VIRTUAL LAB solutions through ICT on Microwave Biosensors Applications towards Early & Efficient
Diagnosis of Health Risks in Rural Zones of India.
Pilot proposal submitted toMinistry of Human Resource Development
Under the Scheme on“National Mission on Education through Information and Technology”
Dr. K. S. DayaMicrowave Physics Laboratory
Department of physics & Computer ScienceDayalbagh Educational Institute
Dayalbagh, Agra –282 110
NON-INVASIVE PLANAR MICROWAVE SENSOR for BLOOD GLUCOSE DETECTION
RAPID DETECTION MICROWAVE SENSOR FOR THE PRESENCE OF PATHOGENIC BACTERIA IN DRINKING WATER
Virtual Lab realisation on
Design objective
- Design & development of biosensors.- Developing a device by integrating the developed sensor, data analyser & the data converter.- Fusing the developed device to a communication gadget.
Present proposal aims to develop Virtual Lab solutions using devices based on simple microwave structures for effective early diagnosis of health risks.
Technology advancements in the field of healthcare and biological sciences has overwhelmingly influenced our lifestyle
and lifespan. However, advanced technologies today seem incomplete -due to the complexity of the biological systems -for its drawbacks in providing easy and fast information as it requires
# highly priced consumables,# considerable time # skilled manpower,
none of which are easily available.
Motivation
Motivation- Cont…
Hence…understanding the health risks and the health status of individuals in the rural India has not been viable till date.Over half the population of India are inhabited in rural or geographically challenging locations, thus any statistics available on the health is incomplete.
Working Principle
• Interaction between microwaves and matter • the electric field passes through the dielectric
medium, • electric field affects medium parameter called
permittivity (dielectric constant)• Measuring the dielectric properties of a material can
indirectly measure other properties that have a correlation to the material
For Eg:- Dielectric constant of blood increases with increase in glucose level in blood
• Microwave sensors are very sensitive to change in dielectric constant and most of biological substances either have high dielectric proteins or are dielectric proteins themselves.
• Microwave sensor does not require any reagents or chemical, thus an indigenous solution without interdependencies
• Unlike biological methods, results are immediate.
Advantages
• Easy to use • No technical expertise required• Can be a completely portable systems• No reagents or chemical required, thus
eliminating the need of supply chain for transporting chemicals to remote locations
• Gives autonomy to the user resulting in better health safety concern
Other Benefits
Non Invasive Blood Glucometer
Low cost, NO-PRICK and easy to use solution for continuous self monitoring of blood glucose .
Sensor Design & Development
Thus there is an immediate need for a easy and safe solution which will overcome:-
The psychological hassle to a prick.Blood related safety concerns (infections)Requirement of skilled manpower.Requirements of consumables of conventional ready to use
invasive gluco-meters.
And …
Provides with an indigenous and user friendly self monitoring systems to the under privileged and elderly
Rapid Pathogen Sensor
Sensor Design & Development
Low cost, user friendly and easy to use solution for consistent monitoring of bacterial pathogens in water.
There is an immediate need for a easy and rapid solution which will overcome:-
Cost Prolonged TAT Result related problems on consistency / repeatability & reproducibility Requirement of skilled manpower. Requirement for instruments. Requirements of consumables for conventional and test kits.
Microstrip line type sensor
Sensitivity : 8.71 mg/dl per MHz % Error : 15%
Proof of Principle
0 20 40 60 80 100 120 140 160 1800
50
100
150
200
250
300
350
400
Shift in Frequency (MHz)
Blo
od G
luco
se L
evel
(m
g/dl
)
Frequency shift and Glucose level in blood
Sample - Simulation Results
Base Architecture• Hand held device (Mobile phone) used by a patient.• Conversion of microwave data• Test Value displayed. • Data Interpretation and advice on future course of
action. (through voice, preferably in local language) • Simultaneously transmits the information to a Physician / Hospital / Repository
Realising the VIRTUAL LAB Solution
Architecture for realising Virtual Lab Non-Invasive Glucometer
(SMS)
(VOICE)
Architecture for realising Virtual Lab Rapid Bacterial Sensing
Personal information fed into the device
Calibration (automated)
Test (finger against the sensor)
Data conversion
Result interpretation
Advice to patients
Communication (SMS) to Health care personnel
Information to a
Database
Calibration (automated)
Test
Data conversion
Result interpretation
Information to a Database
Alike models
• DIAdvisor – Ongoing project titled the PERSONAL HEALTH SYSTEMS through ICT under the Seventh Framework Programme (FP7) of the European Union (EU).
• Project duration – 2008 to 2012• Project cost - €9,300,000
Timeline & Deliverables for thePILOT PHASE
Time Line Deliverable Milestones
0th month Project kick off
3rd Month Designing of resonator
6th Month Identifcation of suitable dielectric material and simulation of glucometer sensors
9th Month Spiking studies for the presence of bacteria.
1st Miles stone
12th Month Live testing of gluco sensors.
2nd Mile stone.
Non-Recurring INR 1.28 Crore
Recurring INR 0.441 Crore
Total INR 1.73 Crore
Proposed Budget forPILOT PHASE
Details of Proposed Non -Recurring Budget
S.No.
ITEM Cost in Lakhs (in INR)
1 Site Preparation 5
2 Bax DUPONT PCR based detection system 40
3 Laminar Air Flow Bench 3
4 Biosafety Cabinet 5
5 Deep Freezer 10
6 Incubators 3
7 Glass wares 5
8 Millipore filter Assembly with Vaccum pump 2
9 Analytical Balance 2.0
10 Refrigerator 1.0
11 Books & Journals 15
12 Autoclave 1.5
13 Other software 15.0
14 Microscope 10
15 Hot air oven 1.0
16 Spinner 1.0
17 Millipore water purification system 5
18 Microwave Connectors 5
19 Other equipments 7.5
Total Non Recurring Cost 128.2
Details of Recurring Budget
Thank You