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Daily fMRI PracticeJohn Li MD
9/27/2012
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When you preparing a fMRI study, you need to
Read and understand the fMRI requirements.
Design and choose proper paradigms.
Choose the right coil, right gradient and sequences to acquire fMRI data.
Choose proper methods to minimize motion.
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Daily fMRI Practice Mainly Involve Follow Modules
Data Acquisition
Paradigm
Post Processing
Result Interpretatio
n
Experiment Design
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Designs for fMRI Data Acquisition
Block Design
Event Related Design
Resting State
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Paradigms
Good Design
Careful Selection
Proper Delivery
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Good Paradigm Performance Needs
Good instruction, correct understanding of paradigm, good performance of paradigm.
Close observation of subject performing paradigm.
Properly reminding the subjects about the coming steps
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Checkerboard is one Well-Known Paradigm
Visual Stimulus Block Design
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Baboon’s Visual and Motor Activation Results
Wey HY, Li J, Szabo CA, Fox PT, Leland MM, Jones L, Duong TQ. Neuroimage. 2010 Oct 1;52(4):1420-7
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Different Frequency Will Stimulate Visual Cortex Differently
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Different Frequency Will Stimulate Visual Cortex Differently
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The Visual Cortex Activation Area will be Different with Different Designs of Checkerboards
Targeting Different Parts of Visual Field
Full Visual Field
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Human Bilateral Finger Tapping Sequence fMRI Result
Thanks to Crystal Franklin for the picture.
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Flashing Light and Tactile Stimulator
On
Vibration
Off
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Example:Multi-surface Wooden Ball and Multi-grades Sand Paper Stimulus and Design
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Example Results
Gao JH, Parsons LM, Bower JM, Xiong JH, Li JQ, Fox PT (1996): Cerebellum implicated in sensory acquisition and discrimination rather than motor control. Science 272:545-547
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Psychological Paradigms
N-back, Gambling, Shape-Matching, Face-Matching, Stroop…
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Visual Cue for Subject to Adjust the Squeeze Force
Rest RestSqueeze
3 min 3 min 3 min
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Adjustable Weight LoadPressured Air for Removing
Weight Load Stopper
20°
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Eccentric vs. Concentric Muscle Contraction in First Dorsal Interosseus
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Coil SelectionAny coil can be used in fMRI studies. When using
GRAPPA or mSENSE, phased array coils are required.
T/R Head Coil
12 Channel Phased Array Coil
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With Insert Gradient,
High Resolution fMRI
And Shorter TE
Will be Possible
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TSE
Segmented EPI
Conventional GRE
Single Shot EPI
Comparison of Different Pulse Sequences Used in fMRI
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Reducing Motion is One of the Keys for a Successful fMRI
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Reducing Motion is One of the Keys to fMRI Success
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Reducing Motion is One of the Keys to fMRI Success
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Reducing Motion is One of the Keys to fMRI Success
Baboon Head Holder
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Activation pattern in ASL with 2x2x5
300ml TRUTOL 75 (Glucose Tolerance Beverage)
300ml Water
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HypothalamusMotion related areas
Motion artifact shares similar activation pattern
Thanks Claudia Huerta for Data Analysis
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Adjusting Scan Parameters
TR, TE & flip angle Field of view, resolution & matrix sizeSlice thickness & gap between slicesNumber of slices & slice acquisition orderReceiver bandwidth & echo train space
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GRAPPA and mSENSEWhen you choose parallel imaging technique GRAPPA or
mSENSE, you can get more slices for a given TR.
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Auto Generation of fMRI Results
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5% MVC
30% MVC
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Interpretation of fMRI ResultsHypothalamus shows decreased activation after glucose ingestion.
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Using Data Base to Track MRI Scans
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Using Data Base to Track MRI Scans
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Using Data Base to Track MRI Scans
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Supplementing MRA with fMRI
MR Angiography Demonstrates an AVM (Arteriovenous Malformation)
Yellow Arrow: Supply Artery
Blue Arrow: AVM
Red Arrow: Drain Vein
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Interpretation of fMRI ResultsT2 Axial Images T1 Axial ImagesAVM
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Interpretation of fMRI Results
Verb Generation from Noun
Verb Generation from Picture
Language Center Is Dominant in the Left Hemisphere
Thank to Crystal Franklin for the pictures.
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Thanks!