YIANNIS S. CHATZIZISIS – CV – 2018-09-30
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CURRICULUM VITAE
YIANNIS S. CHATZIZISIS, MD, PhD, FACC, FAHA, FESC
Work address: Cardiovascular Division, University of Nebraska Medical Center, 982265
Nebraska Medical Center, Omaha, NE 68198
Cell: 857 234 2604
E-mail: [email protected]; [email protected]
EDUCATION
1994-2000 MD, Aristotle University Medical School, Thessaloniki, Greece
2002-2004 MSc, Medical Research and Technology, Aristotle University Medical
School, Thessaloniki, Greece
2004-2009 PhD, Aristotle University Medical School, Thessaloniki, Greece
POST DEGREE TRAINING
09/2005-08/2008 Postdoctoral Research Fellowship, Cardiovascular Medicine, Brigham and
Women's Hospital, Harvard Medical School, Boston, MA
06/2006-08/2008 Postdoctoral Research Fellow, Harvard-MIT Division of Health Science
and Technology, Massachusetts Institute of Technology, Cambridge, MA
05/2008-01/2012 Clinical Fellowship, Cardiovascular Medicine, AHEPA University
Hospital, Aristotle University Medical School, Thessaloniki, Greece
02/2012-05/2012 Clinical Fellowship, Cardiovascular Medicine, Brigham and Women's
Hospital, Harvard Medical School, Boston, MA
05/2012-01/2014 Clinical Fellowship, Advanced Non-Invasive Cardiovascular Imaging,
Cardiovascular Division, Brigham and Women's Hospital, Harvard
Medical School, Boston, MA
02/2014-07/2015 Clinical Fellowship, Interventional Cardiology, Cardiovascular Division,
Brigham and Women's Hospital, Harvard Medical School, Boston, MA
ACADEMIC APPOINTMENTS
2015-Present Associate Professor, Internal Medicine, Cardiovascular Division,
University of Nebraska Medical Center (UNMC), Omaha, NE
YIANNIS S. CHATZIZISIS – CV – 2018-09-30
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CLINICAL APPOINTMENTS
2015-Present Attending Cardiologist, Cardiac Catheterization Laboratories,
Cardiovascular Division, University of Nebraska Medical Center, Omaha,
NE
2015-Present Attending Cardiologist, Cardiac CT/MRI Program, Cardiovascular
Division, University of Nebraska Medical Center, Omaha, NE
ADMINISTRATIVE APPOINTMENTS
2017-Present Director, Heart and Vascular Unit
2015-Present Director, Cardiovascular Biology and Biomechanics Laboratory
CERTIFICATIONS AND LICENSES
2015-Present Medical License Nebraska, 28658
2012-2015 Medical License Massachusetts, 250132
2013 Echocardiography (Level III), American Society of Echocardiography
2013 Cardiac CT (Level III), Society of Cardiac Computed Tomography
2013 Nuclear cardiology (Level II), American Society of Nuclear Cardiology
GRANTS AND CONTRACT SUPPORT
Completed
Title: Development and applications of quantifiable sympathetic vasomotion
Funding Agency: Nebraska Research Initiative
Project Period: 2016-2017
Total Dollars: $150,000
Role: Co-Principal Investigator
Ongoing
Title: Startup funding
Funding Agency: University of Nebraska Medical Center
Project Period: 2015-2020
Total Dollars: $1,000,000
Role: Principal Investigator
Title: Novel Targeted treatments of high risk atherosclerotic plaque via catheter-
YIANNIS S. CHATZIZISIS – CV – 2018-09-30
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directed local treatment of high risk plaque using anti-inflammatory
nanoparticles
Funding Agency: UNL and UNMC Sciences, Engineering and Medicine Initiative
Project Period: 2016-2018
Total Dollars: $100,000
Role: Principal Investigator
Title: Microscale Investigation of Mechanobiology of Atherosclerosis Using
Novel Microfluidic Biochambers
Funding Agency: University of Nebraska, Collaboration Initiative Seed Grant
Project Period: 2017-2019
Total Dollars: $150,000
Role: Co-Principal Investigator
Title: Morphologic comparison of HD IVUS vs. OCT
Funding Agency: Boston Scientific
Project Period: 2018
Role: Principal Investigator
Pending
Title: Patient-specific simulations to guide coronary bifurcation stenting
Funding Agency: NHLBI
ID Number: 1R01HL144690-01 Application scored 7th percentile
Project Period: 2019-2024
Total Dollars: $2,500,000
Role: Principal Investigator
Title: In-vitro Experimental and Computational Models for Multiscale
Investigation of Mechanobiology of Atherosclerosis
Funding Agency: AHA
ID Number: 18TPA34230014
Project Period: 2018-2021
Total Dollars: $300,000
Role: Co-Principal Investigator
OUTSIDE GRANTS
Completed
Title: Prediction of acute coronary events using non-invasive assessment of
endothelial shear stress with coronary CT angiography.
Funding Agency: Behrakis Foundation, Boston, MA
Institution: Brigham and Women's Hospital, Harvard Medical School
Project Period: 2012-2015
YIANNIS S. CHATZIZISIS – CV – 2018-09-30
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Total Dollars: $200,000
Role: Principal Investigator
Title: Combination of shear stress and molecular imaging of inflammation to
predict high-risk atherosclerotic plaque.
ID Number: FP7-PEOPLE-2009-RG/249303
Funding Agency: EU Marie Curie International Reintegration Grant
Institution: Aristotle University Medical School
Project Period: 2010-2014
Total Dollars: $120,000
Role: Principal Investigator
Title: Automatic segmentation of intracoronary ultrasound
Funding Agency: Boston Scientific
Institution: Brigham and Women's Hospital, Harvard Medical School
Project Period: 2007
Total Dollars: $10,000
Role: Principal Investigator
Title: Role of shear stress in the natural history of atherosclerosis
Funding Agency: Behrakis Foundation, Boston USA
Institution: Brigham and Women's Hospital, Harvard Medical School
Project Period: 2007-2015
Total Dollars: $1,000,000
Role: Principal Investigator
Title: Prediction of progression of coronary artery disease and clinical outcome
using vascular profiling of shear stress and wall morphology
Funding Agency: Boston Scientific Inc.
Institution: Brigham and Women's Hospital, Harvard Medical School
Project Period: 2006-2012
Total Dollars: $6,000,000
Role: Co-Investigator
Title: The effects of valsartan alone and valsartan plus simvastatin on the
progression of coronary atherosclerosis in a diabetic porcine model
ID Number: CVAL489AUS59
Funding Agency: Novartis Pharmaceuticals Inc.
Institution: Brigham and Women's Hospital, Harvard Medical School
Project Period: 2005-2008
Total Dollars: $400,000
Role: Co-Investigator
CLINICAL TRIALS
YIANNIS S. CHATZIZISIS – CV – 2018-09-30
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Title: Effect of Local Biomechanical Factors on Bifurcation Stent Restenosis
and Thrombosis (Flow ISR Study)
Funding Agency: Medtronic
Institution: University of Nebraska Medical Center
Project Period: 2016-2019
Role: Principal Investigator
Title: Study of access site for enhancing PCI in STEMI for seniors (SAFE
STEMI for Seniors)
Funding Agency: Medtronic/Volcano/Terumo
Institution: Duke University Medical Center
Project Period: 2017-2021
Role: Site Principal Investigator
OTHER APPOINTMENTS AND POSITIONS
2000 - 2002 Internship, Internal Medicine, General Hospital of Trikala, Trikala, Greece
2002 - 2004 Obligatory Military Service, Primary care physician in Hellenic Air Force
2004 - 2005 Residency, Internal Medicine, Aristotle University Medical School,
Thessaloniki, Greece
HONORS AND AWARDS
International
2007 Norman Alpert Visiting Scientist Award, ESC
2008 Travel Award, ESC Congress, Munich, Germany
2008 Young Investigators Award (Finalist), ESC Congress, Munich, Germany
2009 Young Investigator Award, ESC Congress, Barcelona, Spain
2009 Travel Award, ESC Congress, Barcelona, Spain
2010 Young Investigator Award, European Atherosclerosis Society Congress,
Gothenburg, Sweden
2010 Young Investigator Award, ESC Congress, Stockholm, Sweden
2011 Young Investigator Award, ESC Congress, Paris, France
2011 Bernard and Joan Marshall Young Investigators Award, British Society of
Cardiovascular Research, London, UK
2012 Best Poster, ESC Congress, Munich, Germany
National
2006 Young Investigator Merit Award, AHA Scientific Sessions, Chicago, IL,
USA
2008 ATVB Merit Award for Young Investigators, ATVB Annual Conference,
YIANNIS S. CHATZIZISIS – CV – 2018-09-30
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Atlanta, GA, USA
2009 Young Investigator Award, XV International Symposium on
Atherosclerosis, Boston, MA, USA
2014 Young Investigators Award, Society of Cardiovascular Computed
Tomography Annual Scientific Meeting, San Diego, CA, USA
Regional
2006 Michael Mulinos Postgraduate Award, Hellenic Medical Society of New
York, New York, New York, USA
2013 1st Award, George D. Behrakis Cardiovascular Symposium in Vascular
Biology, Boston, MA, USA
Local
2016 Best Teacher Award
2016 UNMC Faculty Mentoring Recognition Luncheon
Hellenic
2000 Greek State Scholarships Foundation, Athens, Greece
2003-2006 PhD Scholarship, Greek State Scholarships Foundation, Athens, Greece
2005-2006 PhD Scholarship, Aristotle University of Thessaloniki Research
Committee, Thessaloniki, Greece
2005-2006 Research Grant, Hellenic Harvard Foundation, Athens, Greece
2006-2008 Research Grant, Propondis Foundation, Athens, Greece
2006-2007 Research Grant, Hellenic Harvard Foundation, Athens, Greece
2006 Dr Frederick Valegrakis Research Grant, Hellenic University Club of
New York, New York City, NY
2007-2008 Research Grant, Hellenic Harvard Foundation, Athens, Greece
2007-2008 Research Grant, Alexander S. Onassis Public Benefit Foundation, Athens,
Greece
2007-2008 Research Grant, AG Leventis Foundation, Paris, France
2007-2008 Research Grant, Hellenic Atherosclerosis Society, Athens, Greece
2007-2008 Research Grant, Hellenic Heart Foundation, Athens, Greece
2007-2008 Research Grant, George D. Behrakis Research Fellowship, Boston, MA,
MEMBERSHIPS AND OFFICES IN PROFESSIONAL SOCIETIES
2006-Present Member, International Atherosclerosis Society
2007-Present Member, European Atherosclerosis Society
2008-Present Member, European Bifurcation Club
2010-Present Fellow, American Heart Association (FAHA)
2010-Present Fellow, European Society of Cardiology (FESC)
2010-2012 Member, International Society for Heart Research, International Society
YIANNIS S. CHATZIZISIS – CV – 2018-09-30
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for Heart Research
2010-Present Member, ESC Working Group 06 - Coronary Pathophysiology and
Microcirculation, ESC Working Group
2010-2012 Member, British Society for Cardiovascular Research, British Society for
Cardiovascular Research
2011-Present Fellow, American College of Cardiology (FACC)
2011-Present Member, European Association of Percutaneous Coronary Interventions
2012-Present Member, American Society of Echocardiography
2013-Present Member, American Society of Nuclear Cardiology
2014 Conference organizer committee member, George D. Behrakis
Cardiovascular Symposium on Vascular Biology, Harvard Medical School
2012-2014 Vice president, Hellenic Cardiological Society, Working Group on Basic
2013-Present Member, American Society of Nuclear Cardiology
2016-Present Board Member, European Bifurcation Club
PATENTS
2017 Three-dimensional co-cultures as in-vitro models of atherosclerosis
(#17056)
2017 Drug delivery catheter for atherosclerosis disease (#18003P)
2017 Stitching device for trans-catheter vascular anastomosis (#18040P)
2018 Time-varying quantification of capacitive and resistive arterial blood flow
(#25714-00010P01)
LECTURES
Invited International Lectures
2007
Role of shear stress in the natural history of atherosclerosis. 3rd Scientific Conference of the
Atherosclerosis Association of Northern Greece, March 15-17, 2007, Thessaloniki, Greece
Role of low endothelial shear stress in the development of inflamed high-risk coronary
atherosclerotic plaques. Cardiovascular, Diabetes, and Metabolic Disorders Research Center
Weekly Seminar Series, BWH Biomedical Research Institute, Brigham and Women’s
Hospital, Harvard Medical School, December 05, 2007, Boston, MA, USA
A strategy for the prediction of vulnerable plaque. 4th Scientific Conference of the
Atherosclerosis Association of Northern Greece, February 21-24, 2008, Thessaloniki, Greece
2008
YIANNIS S. CHATZIZISIS – CV – 2018-09-30
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In-vivo assessment of endothelial shear stress to predict development of high-risk plaque. 3rd
International Symposium on Biomechanics in Vascular Biology and Cardiovascular Disease,
April 24-25, 2008, Thoraxcenter, Rotterdam, Netherlands
Role of endothelial shear stress in the natural history of coronary atherosclerosis and
remodeling. European Bifurcation Club Meeting, September 26-27, 2008, Prague, Czech
Republic
2009
Role of elevated heart on coronary artery disease. 5th Scientific Conference of the
Atherosclerosis Association of Northern Greece, March 23-25, 2009, Thessaloniki, Greece
Role of Valsartan alone or in combination with Simvastatin in the development of coronary
atheromata with thin fibrous cap. 4th International Symposium on Biomechanics in Vascular
Biology and Cardiovascular Disease, April 16-18, 2009, Thoraxcenter, Rotterdam,
Netherlands
Pathophysiology of Vulnerable Plaque. 24th International Meeting on Clinical Cardiology,
Hellenic Heart Foundation April 23-25, 2009, Athens, Greece
Stent thrombosis and bifurcation stenting. Reasons for increased risk: Flow? 5th European
Bifurcation Club Meeting, October 16-17, 2009, Berlin, Germany
2010
Shear stress: From atherogenesis to vulnerable plaque formation and rupture. Guest Lecture –
January 23, 2010. Department of Radiology, Addenbrooke’s Hospital, University of
Cambridge, Cambridge, UK
Flow dynamic factors and vectors of neo intimal hyperplasia. 6th European Bifurcation Club
Meeting, October 22-23, 2010, Budapest, Hungary
Augmented expression and activity of extracellular matrix–degrading enzymes in regions of
low endothelial shear stress co-localize with coronary atheromata with thin fibrous caps in
pigs. 79th European Atherosclerosis Society Congress, June 24-28, 2010, Gothenburg,
Sweden
2011
Role of shear stress in matrix-degrading enzymes and vulnerable plaque development. British
Society of Cardiovascular Research, Autumn Meeting, September 5-6, 2011, London, UK
Shear Stress: From atherogenesis to vulnerable plaque. Midwest Atherosclerosis Prevention
Society, November Meeting, November 10, 2011, Kansas City, Missouri, USA
YIANNIS S. CHATZIZISIS – CV – 2018-09-30
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2012
Bench testing and simulation to improve bifurcations stenting. 8th European Bifurcation Club
Meeting, October 12-13, 2012, Barcelona, Spain
2013
New Insights into the role of hemodyamics in plaque instability (keynote presentation). 81st
European Atherosclerosis Society Congress. June 2-5, 2013, Lyon, France
Patient-Specific Bifurcation Stenting Modeling. What for? To Predict Outcomes. 9th
European Bifurcation Club Meeting, October 18-19, 2013, London, UK
2014
Flow Modeling Based on 3D OCT Reconstructions. 10th European Bifurcation Club Meeting,
October 17-18, 2014, Bordeaux, France
2015
Multicenter Clinical Trial on the Impact of Biomechanical Factors on Bifurcation Stent
Restenosis and Thrombosis. 11th European Bifurcation Club Meeting, September 25-26,
2015, Athens, Greece
2016
Why, When and How I Should Manage a Patient with Bifurcation Lesion: Ten Steps. C3
Complex Cardiovascular Catheter Therapeutics June 28 - July 1, 2016, Orlando, Florida
Impact of Biomechanical Factors on Bifurcation Stent Restenosis and Thrombosis. C3
Complex Cardiovascular Catheter Therapeutics June 28 - July 1, 2016, Orlando, Florida
Mechanical and Flow Factors of In-Stent Hyperplasia: Introduction to Flow ISR Study. 12th
European Bifurcation Club Meeting, October 14-15, 2016, Rotterdam, Netherlands
2017
Wall Shear Stress and Stents. EPIC-SEC, April 20-22, 2017, Atlanta, Georgia
Patient-specific bifurcation stenting simulations. 13th European Bifurcation Club Meeting,
October 13-14, 2017, Porto, Portugal
Shear stress and vulnerability of atherosclerotic plaques. AHA Scientific Sessions, November
11-15, 2017, Anaheim, California
YIANNIS S. CHATZIZISIS – CV – 2018-09-30
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2018
Cardiovascular simulations: Clinical perspectives and research opportunities. Emory Heart
and Vascular Grand Rounds, April 2, 2018, Atlanta
Local Lectures
Interventional Cardiology: Moderator of Cath Lab Conference (2015-present, weekly)
Non-invasive Cardiovascular Imaging: Moderator of Advanced Non-invasive Cardiovascular
Imaging Conference (2016-present, weekly)
2015
Cardiothoracic Surgery Journal Club, UNMC: What is complete surgical revascularization?
Is FFR a game-changer?
Cardiovascular Division Interventional Conference, UNMC: Vascular Biology of
Atherosclerosis and Stent Restenosis/Thrombosis
Cardiology Grand Rounds, UNMC: New Interventional Strategies
Internal Medicine Grand Rounds, UNMC: Computational Simulations and Cardiovascular
Disease
2016
Physiology Seminars, UNMC: Simulations of Flow Physiology and Atherosclerosis
DEM Research Conference, UNMC: Local Hemodynamics and atherosclerosis
Cardiology Grand Rounds, UNMC: Cardiac CT: Clinical Applications
Cardiovascular Division Interventional Conference, UNMC: Vascular Biology of
Atherosclerosis and Stent Restenosis/Thrombosis
Cardiovascular Division Interventional Conference, UNMC: Coronary artery vasculitis
2017
Cardiology Grand Rounds, UNMC: Myocardial Ischemia and Viability
Cardiovascular Division Interventional Conference, UNMC: Vascular Biology of
Atherosclerosis and Stent Restenosis/Thrombosis
Cardiovascular Division Interventional Conference, UNMC: Coronary artery vasculitis
Cardiovascular Division Interventional Conference, UNMC: Angiographic projections
Cardiovascular Division Interventional Conference, UNMC: OCT in Cardiology
Internal Medicine Residents Noon Conference, UNMC: Pericardial disease
Cardiology Grand Rounds, UNMC: Cardiovascular simulations
YIANNIS S. CHATZIZISIS – CV – 2018-09-30
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EDITORIAL BOARDS
2008-2014 The Open Cardiovascular Medicine Journal
2009-2013 World Journal of Cardiology (Editorial board member)
2009-Present Vascular Health and Risk Management (Editorial board member)
2010-Present Expert Reviews on Cardiovascular Therapy (Editorial board member)
2010-Present Pharmacology and Therapeutics (Associate editor)
2013-Present Atherosclerosis (Associate editor)
SCIENTIFIC MANUSCRIPT REVIEWER
2005-Present International Journal of Cardiology
2006-Present American Journal of Cardiology
2007-Present Medical Engineering and Physics
2007-Present Journal of Cardiac Failure
2007-Present Canadian Journal of Cardiology
2007-Present European Journal of Clinical Investigation
2008-Present Current Medicinal Chemistry
2008-Present Annals of Noninvasive Electrocardiology
2008-Present Clinical Endocrinology
2008-Present Heart
2008-Present Atherosclerosis
2008-Present The Open Cardiovascular Medicine Journal
2008-Present British Journal of Nutrition
2009-Present Antiviral Therapy
2009-Present Circulation
2009-Present Circulation Research
2010-Present Circulation Cardiovascular Imaging
2015-Present Circulation Cardiovascular Interventions
2015-Present JACC Cardiovascular Imaging
2017-Present JACC Cardiovascular Interventions
2017-Present JACC
GRANT REVIEWER
2010-Present Technology Foundation STW, The Netherlands,
2014-Present Wellcome Trust Foundation, Great Britain
YIANNIS S. CHATZIZISIS – CV – 2018-09-30
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PUBLICATIONS
A. ARTICLES PUBLISHED IN SCHOLARLY JOURNALS
1. Baibhav B, Gedela M, Moutlon M, Pavlides G, Pompili V, Rab T, Dangas G, Bhatt D,
Siddique A, Chatzizisis YS. Role of Invasive Functional Assessment in Surgical
Revascularization of Coronary Artery Disease. Circulation. 2018, In press.
2. Gutiérrez-Chico, JL, Zhao S, Chatzizisis YS. Vorticity: At the Crossroads of Coronary
Biomechanics and Physiology. Atherosclerosis 2018, In press.
3. Karagiannis AD, Liu M, Toth PP, Zhao S, Agrawal DK, Libby P, Chatzizisis YS.
Pleiotropic Anti-atherosclerotic Effects of PCSK9 InhibitorsFrom Molecular Biology to
Clinical Translation. Curr Atheroscler Rep. 2018, In press.
4. Giannopoulos AA, Zhao S, Chatzizisis YS. Rupture of a stenotic thin-cap fibroatheroma in
an area of low endothelial shear stress: Implication for mechanism of acute coronary
syndromes. Eur Heart J Cardiovasc Imaging. 2018, In press.
5. Chatzizisis YS, Stefanadis C. Clash of Oral P2Y(12) Receptor Inhibitors in Acute Coronary
Syndromes. J Am Coll Cardiol. 2018;71:382-385
6. Asawaeer M, Sayyed S, Chatzizisis YS. A rare case of granulomatosis with polyangiitis-
induced burnout cardiomyopathy: role of combined viability and metabolic imaging. Eur
Heart J Cardiovasc Imaging. 2018, In press
7. Malik SA, Brilakis ES, Pompili V, Chatzizisis YS. Lost and found: Coronary stent retrieval
and review of literature. Catheter Cardiovasc Interv. 2018, In press.
8. Giannopoulos AA, Giannoglou GD, Chatzizisis YS. Predicting Coronary Atherosclerotic
Plaque Burden From Clinical Parameters: Bringing Old Knowledge in the Game. Angiology.
2018, In press.
9. Ormiston JA, Kassab G, Finet G, Chatzizisis YS, Foin N, Mickley TJ, Chiastra C, Murasato
Y, Hikichi Y, Wentzel JJ, Darremont O, Iwasaki K, Lefèvre T, Louvard Y, Beier S,
Hojeibane H, Netravali A, Wooton J, Cowan B, Webster MW, Medrano-Gracia P, Stankovic
G. Bench Testing and Coronary Artery Bifurcations: A Consensus Document from the
European Bifurcation Club. EuroIntervention. 2018;13:e1794-1803.
10. Kishi S, Giannopoulos AA, Tang A, Kato N, Chatzizisis YS, Dennie C, Horiuchi Y, Tanabe
K, Lima JAC, Rybicki FJ, Mitsouras D. Fractional Flow Reserve Estimated at Coronary CT
Angiography in Intermediate Lesions: Comparison of Diagnostic Accuracy of Different
Methods to Determine Coronary Flow Distribution. Radiology. 2018;287:76-84.
YIANNIS S. CHATZIZISIS – CV – 2018-09-30
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11. Selim A, Zolty R, Chatzizisis YS. The evolution of heart failure with reduced ejection
fraction pharmacotherapy: What do we have and where are we going? Pharmacol Ther.
2017;178:67-82.
12. Shah NR, Cheezum MK, Motoyama S, Chatzizisis YS. Do we really need another individual
coronary plaque characterization measurement? Atherosclerosis. 2017;261:160-162.
13. Selim A, Zolty R, Chatzizisis YS. New heart failure pharmacotherapy in clinical trials: a
hope in progress. Expert Rev Cardiovasc Ther. 2017;15:649-651.
14. Cheimariotis GA, Chatzizisis YS, Koutkias VG, Toutouzas K, Giannopoulos A, Riga M,
Chouvarda I, Antoniadis AP, Doulaverakis C, Tsamboulatidis I, Kompatsiaris I, Giannoglou
GD, Maglaveras N. ARCOCT: Automatic detection of lumen border in intravascular OCT
images. Comput Methods Programs Biomed. 2017;151:21-32.
15. Malik SA, Porter TT, Pavlides G, Chatzizisis Y. Vasospastic Angina Presenting With
Syncope and Chest Pain: A Case Report and Brief Literature Review. S D Med.
2017;70:498-502.
16. Franck G, Mawson T, Sausen G, Salinas M, Santos Masson G, Cole AP, Beltrami Moreira
M, Chatzizisis Y, Quillard T, Tesmenitsky Y, Shvartz E, Sukhova GK, Swirski FK,
Nahrendorf M, Aikawa E, Croce K, Libby P. Flow Perturbation Mediates Neutrophil
Recruitment and Potentiates Endothelial Injury via TLR2 in Mice: Implications for
Superficial Erosion. Circ Res. 2017;121:31-42.
17. Giannopoulos AA, Mitsouras D, Yoo SJ, Liu PP, Chatzizisis YS, Rybicki FJ. Applications
of 3D printing in cardiovascular diseases. Nat Rev Cardiol. 2016;13:701-718.
18. Huang D, Muramatsu T, Li Y, Yang W, Nagahara Y, Chu M, Kitslaar P, Sarai M, Ozaki Y,
Chatzizisis YS, Yan F, Reiber JH, Wu R, Pu J, Tu S. Assessment of endothelial shear stress
in patients with mild or intermediate coronary stenoses using coronary computed tomography
angiography: comparison with invasive coronary angiography. Int J Cardiovasc Imaging.
2017;33:1101-1110
19. Antoniadis AP, Papafaklis MI, Takahashi S, Shishido K, Andreou I, Chatzizisis YS, Tsuda
M, Mizuno S, Makita Y, Domei T, Ikemoto T, Coskun AU, Honye J, Nakamura S, Saito S,
Edelman ER, Feldman CL, Stone PH. Arterial Remodeling and Endothelial Shear Stress
Exhibit Significant Longitudinal Heterogeneity Along the Length of Coronary Plaques.
JACC Cardiovasc Imaging. 2016;9:1007-9
20. Chatzizisis YS, Toutouzas K, Giannopoulos AA, Riga M, Antoniadis AP, Fujinom Y,
Mitsouras D, Koutkias VG, Cheimariotis G, Doulaverakis C, Tsampoulatidis I, Chouvarda I,
Kompatsiaris I, Nakamura S, Rybicki FJ, Maglaveras N, Tousoulis D, Giannoglou GD.
Association of global and local low endothelial shear stress with high-risk plaque using
intracoronary 3D optical coherence tomography: Introduction of 'shear stress score'. Eur
Heart J Cardiovasc Imaging. 2017;18:888-897
YIANNIS S. CHATZIZISIS – CV – 2018-09-30
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21. Gitsioudis G*, Chatzizisis YS*, Wolf P, Missiou A, Antoniadis AP, Mitsouras D, Bartling
S, Arica Z, Stuber M, Rybicki FJ, Nunninger M, Erbel C, Libby P, Giannoglou GD, Katus
HA, Korosoglou G. Combined non-invasive assessment of endothelial shear stress and
molecular imaging of inflammation for the prediction of inflamed plaque in hyperlipidaemic
rabbit aortas. Eur Heart J Cardiovasc Imaging. 2017;187:19-30
22. Giannoglou GD, Giannopoulos AA, Chatzizisis YS. Lowering Heart Rate Post
Revascularization: Angina and Quality of Life Improvement. Angiology. 2017;68:5-7
23. Tsigkas N, Kidambi S, Tawakol A, Chatzizisis YS. Drug-loaded particles: "Trojan horses"
in the therapy of atherosclerosis. Atherosclerosis. 2016;251:528-30.
24. Giannopoulos AA, Chatzizisis YS, Maurovich-Horvat P, Antoniadis AP, Hoffmann U,
Steigner ML, Rybicki FJ, Mitsouras D. Quantifying the effect of side branches in endothelial
shear stress estimates. Atherosclerosis. 2016;251:213-8.
25. Carreras ET, Chatzizisis YS, Mauri L, MacRae C. Acute Coronary Syndrome in a 52-Year-
Old Woman With Scleroderma. Circulation. 2016;133:2576-82.
26. Giannopoulos AA, Giannoglou GD, Chatzizisis YS. Refractory angina: new drugs on the
block. Expert Rev Cardiovasc Ther. 2016;14:881-3.
27. Giannopoulos AA, Antoniadis AP, Croce K, Chatzizisis YS. Erosion of Thin-Cap
Fibroatheroma in an Area of Low Endothelial Shear Stress: Anatomy and Local
Hemodynamic Environment Dictate Outcomes. JACC Cardiovasc Interv. 2016;9:e77-8.
28. Giannopoulos AA, Giannoglou GD, Chatzizisis YS. Pharmacological approaches of
refractory angina. Pharmacol Ther. 2016;163:118-31.
29. George E, Giannopoulos AA, Aghayev A, Rohatgi S, Imanzadeh A, Antoniadis AP,
Kumamaru KK, Chatzizisis YS, Dunne R, Steigner M, Hanley M, Gravereaux EC, Rybicki
FJ, Mitsouras D. Contrast inhomogeneity in CT angiography of the abdominal aortic
aneurysm. J Cardiovasc Comput Tomogr. 2016;10:179-83.
30. Antoniadis AP, Stone PH, Chatzizisis YS. Foretelling plaque disruption: Is the journey to
Ithaca reaching destination? Atherosclerosis. 2016;244:147-8.
31. Vergallo R, Aguirre AD, Abtahian F, Minami Y, Soeda T, Chatzizisis YS, Croce K, Jang
IK. Recurrent myocardial infarctions and premature coronary atherosclerosis in a 23-year-old
man with antiphospholipid syndrome. Thromb Haemost. 2016;115:237-9.
32. Antoniadis AP, Papafaklis MI, Takahashi S, Shishido K, Andreou I, Chatzizisis YS, Tsuda
M, Mizuno S, Makita Y, Domei T, Ikemoto T, Coskun AU, Honye J, Nakamura S, Saito S,
Edelman ER, Feldman CL, Stone PH. The Longitudinal Heterogeneity of Remodeling and
YIANNIS S. CHATZIZISIS – CV – 2018-09-30
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Endothelial Shear Stress along the Length of Plaque Determines the Topography and Natural
History of Coronary Artery Disease in Humans. JACC Cardiovasc Imaging 2016;9:1007-9.
33. Toutouzas K, Benetos G, Karanasos A, Chatzizisis YS, Giannopoulos AA, Tousoulis D.
Vulnerable plaque imaging: updates on new pathobiological mechanisms. Eur Heart J.
2015;36:3147-54.
34. Antoniadis AP, Mortier P, Kassab G, Dubini G, Foin N, Murasato Y, Giannopoulos AA, Tu
S, Iwasaki K, Hikichi Y, Migliavacca F, Chiastra C, Wentzel JJ, Gijsen F, Reiber JH, Barlis
P, Serruys PW, Bhatt DL, Stankovic G, Edelman ER, Giannoglou GD, Louvard Y,
Chatzizisis YS. Biomechanical Modeling to Improve Coronary Artery Bifurcation Stenting:
Expert Review Document on Techniques and Clinical Implementation. JACC Cardiovasc
Interv. 2015;8:1281-96.
35. Dakos G, Konstantinou D, Chatzizisis YS, Chouvarda I, Filos D, Paraskevaidis S, Mantziari
L, Maglaveras N, Karvounis H, Vassilikos V. P wave analysis with wavelets identifies
hypertensive patients at risk of recurrence of atrial fibrillation: A case-control study and
1year follow-up. J Electrocardiol. 2015;48:845-52.
36. Mavrakanas TA, Chatzizisis YS. Bivalirudin in ST-segment-elevation myocardial infarction:
for better or worse? Expert Rev Cardiovasc Ther. 2015;13:893-5.
37. Ferencik M, Chatzizisis YS. Statins and the coronary plaque calcium "paradox": Insights
from non-invasive and invasive imaging. Atherosclerosis. 2015;241:783-5.
38. Migliavacca F, Chiastra C, Chatzizisis YS, Dubini G. Virtual bench testing to study
coronary bifurcation stenting. EuroIntervention. 2015;11 Suppl V:V31-4.
39. Antoniadis AP, Giannopoulos AA, Wentzel JJ, Joner M, Giannoglou GD, Virmani R,
Chatzizisis YS. Impact of local flow haemodynamics on atherosclerosis in coronary artery
bifurcations. EuroIntervention. 2015 May;11 Suppl V:V18-22.
40. Giannopoulos AA, Antoniadis AP, Croce KJ, Chatzizisis YS. Advanced anatomical and
functional imaging guides management of coronary artery ulcerated plaque. Eur Heart J
Cardiovasc Imaging. 2015;16:1042.
41. Toutouzas K, Chatzizisis YS, Riga M, Giannopoulos A, Antoniadis AP, Tu S, Fujino Y,
Mitsouras D, Doulaverakis C, Tsampoulatidis I, Koutkias VG, Bouki K, Li Y, Chouvarda I,
Cheimariotis G, Maglaveras N, Kompatsiaris I, Nakamura S, Reiber JH, Rybicki F,
Karvounis H, Stefanadis C, Tousoulis D, Giannoglou GD. Accurate and reproducible
reconstruction of coronary arteries and endothelial shear stress calculation using 3D OCT:
comparative study to 3D IVUS and 3D QCA. Atherosclerosis. 2015;240:510-9.
42. Saboo SS, Abbara S, Rybicki FJ, Chatzizisis YS. Quantification of aortic calcification - how
and why should we do it? Atherosclerosis. 2015;240:469-71.
YIANNIS S. CHATZIZISIS – CV – 2018-09-30
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43. Mavrakanas TA, Chatzizisis YS. Bivalirudin in stable angina and acute coronary syndromes.
Pharmacol Ther. 2015;152:1-10.
44. Juan YH, Chatzizisis YS, Saboo SS, Rocha T, Steigner ML. Tumor encasement of the right
coronary artery: role of anatomic and functional imaging in diagnosis and therapeutic
management. Open Cardiovasc Med J. 2014;8:110-2.
45. Andreou I, Antoniadis AP, Shishido K, Papafaklis MI, Koskinas KC, Chatzizisis YS,
Coskun AU, Edelman ER, Feldman CL, Stone PH. How do we prevent the vulnerable
atherosclerotic plaque from rupturing? Insights from in vivo assessments of plaque, vascular
remodeling, and local endothelial shear stress. J Cardiovasc Pharmacol Ther.
2015;20:261-75.
46. Hucker WJ, Chatzizisis YS, Steigner ML, Winters GL, Kirshenbaum JM. Myocardial
catastrophe: a case of sudden, severe myocardial dysfunction. Circulation. 2014;130:854-
62.
47. Chatzizisis YS, Antoniadis AP, Wentzel JJ, Giannoglou GD. Vulnerable plaque: the
biomechanics of matter. Atherosclerosis. 2014;236:351-2.
48. Chatzizisis YS, George E, Cai T, Fulwadhva UP, Kumamaru KK, Schultz K, Fujisawa Y,
Rassi C, Steigner M, Mather RT, Blankstein R, Rybicki FJ, Mitsouras D. Accuracy and
reproducibility of automated, standardized coronary transluminal attenuation gradient
measurements. Int J Cardiovasc Imaging. 2014;30:1181-9.
49. Giannoglou GD, Chatzizisis YS. Heart rate lowering reduces cardiovascular disease burden.
Curr Med Res Opin. 2014;30:1757.
50. Chatzizisis YS, Blankstein R, Libby P. Inflammation goes with the flow: Implications for
non-invasive identification of high-risk plaque. Atherosclerosis. 2014;234:476-8.
51. Dakos G*, Chatzizisis YS*, Konstantinou D, Chouvarda I, Filos D, Paraskevaidis S,
Mantziari L, Maglaveras N, Karvounis H, Styliadis I, Vassilikos V. Wavelet-based analysis
of P waves identifies patients with lone atrial fibrillation: A cross-sectional pilot study. Int J
Cardiol. 2014;174:389-92.
52. Chatzizisis YS, Koutkias VG, Toutouzas K, Giannopoulos A, Chouvarda I, Riga M,
Antoniadis AP, Cheimariotis G, Doulaverakis C, Tsampoulatidis I, Bouki K, Kompatsiaris I,
Stefanadis C, Maglaveras N, Giannoglou GD. Clinical validation of an algorithm for rapid
and accurate automated segmentation of intracoronary optical coherence tomography images.
Int J Cardiol. 2014;172:568-80.
53. Juan YH, Chatzizisis YS, Saboo SS, Newburger JW, Steigner ML. Hypoplastic left coronary
artery with large collateral vessels from an ectatic right coronary artery: Multimodality
imaging-based diagnostic work-up. Int J Cardiol. 2014;15:185-7
YIANNIS S. CHATZIZISIS – CV – 2018-09-30
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54. Waller AH, Chatzizisis YS, Moslehi JJ, Chen FY, Mangion JR. Real-time three-dimensional
transoesophageal echocardiography enables preoperative pulmonary valvulopathy
assessment. Eur Heart J Cardiovasc Imaging 2014;15:713.
55. Ghosh N, Waller AH, Rinehart E, Lakdawala NK, Chatzizisis YS, Padera R, Couper G,
Mangion J, Steigner M. Multimodality imaging for the assessment of total artificial heart
function: complementary utility of 2- and 3-dimensional transesophageal echocardiography
and computed tomography. J Am Coll Cardiol. 2014;63:e7.
56. Doulaverakis C, Tsampoulatidis I, Antoniadis AP, Chatzizisis YS, Giannopoulos A,
Kompatsiaris I, Giannoglou GD. IVUSAngio tool: a publicly available software for fast and
accurate 3D reconstruction of coronary arteries. Comput Biol Med. 2013;43:1793-803.
57. Koskinas KC*, Chatzizisis YS*, Papafaklis MI, Coskun AU, Baker AB, Jarolim P,
Antoniadis A, Edelman ER, Stone PH, Feldman CL. Synergistic effect of local endothelial
shear stress and systemic hypercholesterolemia on coronary atherosclerotic plaque
progression and composition in pigs. Int J Cardiol. 2013;169:394-401.
58. Gutierrez A, Chatzizisis YS, Rao SV. Progression of radial approach to PCI in the USA:
from niche procedure to default approach. Expert Rev Cardiovasc Ther. 2013;11:1271-3.
59. Paraskevaidis S, Theofilogiannakos EK, Kamperidis V, Chatzizisis YS, Tsilonis K,
Vassilikos VP, Dakos G, Stavropoulos G, Ziakas A, Hadjimiltiades S, Styliadis IH.
Quinidine: an "endangered species" drug appropriate for management of electrical storm in
brugada syndrome. Indian Pacing Electrophysiol J. 2013;13:178-80.
60. Chatzizisis YS, Murthy VL, Solomon SD. Echocardiographic evaluation of coronary artery
disease. Coron Artery Dis. 2013;24:613-23.
61. Vassilikos VP, Mantziari L, Dakos G, Kamperidis V, Chouvarda I, Chatzizisis YS, Kalpidis
P, Theofilogiannakos E, Paraskevaidis S, Karvounis H, Mochlas S, Maglaveras N, Styliadis
IH. QRS analysis using wavelet transformation for the prediction of response to cardiac
resynchronization therapy: a prospective pilot
study. J Electrocardiol. 2014;47:59-65.
62. Katranas SA, Kelekis AL, Antoniadis AP, Chatzizisis YS, Giannoglou GD. Association of
Remodeling With Endothelial Shear Stress, Plaque Elasticity, and Volume in Coronary
Arteries: A Pilot Coronary Computed Tomography Angiography Study. Angiology.
2014;65:413-9
63. Chatzizisis YS, Ziakas A, Feloukidis C, Paramythiotis D, Hadjimiltiades S, Iliadis A,
Basdanis G, Styliadis I. Pheochromocytoma crisis presenting with cardiogenic shock. Herz.
2014;39:156-60
YIANNIS S. CHATZIZISIS – CV – 2018-09-30
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64. Saboo SS, Chatzizisis YS, Khandelwal A, Blankstein R. Acute coronary syndrome
unmasking a puzzling coronary anatomy: role of multimodality anatomic and functional
imaging. Eur Heart J. 2013;34:3089.
65. Koskinas KC*, Sukhova GK*, Baker AB*, Papafaklis MI*, Chatzizisis YS*, Coskun AU,
Quillard T, Jonas M, Maynard C, Antoniadis AP, Shi GP, Libby P, Edelman ER, Feldman
CL, Stone PH. Thin-Capped Atheromata With Reduced Collagen Content in Pigs Develop in
Coronary Arterial Regions Exposed to Persistently Low Endothelial Shear Stress.
Arterioscler Thromb Vasc Biol. 2013;33:1494-1504.
66. Koskinas KC*, Chatzizisis YS*, Antoniadis A, Giannoglou GD. Role of Endothelial shear
stress in stent restenosis and thrombosis. Pathophysiologic mechanisms and implications for
clinical translation. J Am Coll Cardiol 2012;59:1337-49.
67. Chatzizisis YS, Baker A, Sukhova GK, Koskinas K, Papafaklis M, Beigel R, Jonas M,
Coskun AU, Stone BV, Maynard C, Shi GP, Libby P, Edelman ER, Feldman CL, Stone PH.
Augmented expression and activity of extracellular matrix–degrading enzymes in regions of
low endothelial shear stress co-localize with coronary atheromata with thin fibrous caps in
pigs. Circulation 2011;123:621-30.
68. Koskinas KC, Feldman CL, Chatzizisis YS, Coskun AU, Jonas M, Maynard C, Baker A,
Papafaklis M, Edelman ER, Stone PH. Natural history of experimental coronary
atherosclerosis and vascular remodeling in relation to endothelial shear stress: A serial, in-
vivo intravascular ultrasound study. Circulation 2010;121:2092-101.
69. Chatzizisis YS, Jonas M, Coskun AU, Beigel R, Stone BV, Maynard C, Gerrity RG, Daley
W, Rogers C, Edelman ER, Feldman CL, Stone PH. Prediction of the localization of high-
risk coronary atherosclerotic plaques on the basis of low endothelial shear stress: an
intravascular ultrasound and histopathology natural history study. Circulation.
2008;117:993-1002.
70. Nelson KH, Chatzizisis YS, Steigner ML, Mitchell RN, Blankstein R, Givertz MM. Cardiac
Allograft Involvement by Post-transplant Lymphoproliferative Disorder. J Am Coll Cardiol
2013;62:937.
71. Konstantinou DM, Chatzizisis YS, Giannoglou GD. Heart failure with preserved ejection
fraction: future directions in medical treatment. Expert Rev Cardiovasc Ther.
2013;11:1085-7.
72. Konstantinou DM, Chatzizisis YS, Giannoglou GD. Pathophysiology-based novel
pharmacotherapy for heart failure with preserved ejection fraction. Pharmacol Ther.
2013;140:156-66.
73. Saboo SS, Chatzizisis YS, Khandelwal A, Bolman RM 3rd, Steigner M. Multimodality
imaging of aortic valve fibroelastoma. Eur Heart J Cardiovasc Imaging. 2013;14:834.
YIANNIS S. CHATZIZISIS – CV – 2018-09-30
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74. Papafaklis MI, Chatzizisis YS, Naka KK, Giannoglou GD, Michalis LK. Drug-eluting stent
restenosis: Effect of drug type, release kinetics, hemodynamics and coating strategy.
Pharmacol Ther. 2012;134:43-53.
75. Wentzel JJ, Chatzizisis YS, Gijsen FJ, Giannoglou GD, Feldman CL, Stone PH. Endothelial
shear stress in the evolution of coronary atherosclerotic plaque and vascular remodelling:
current understanding and remaining questions. Cardiovasc Res. 2012;96:234-43.
76. Giannopoulos A, Chatzizisis YS, Giannoglou GD. Optical coherence tomography: an arrow
in our quiver. Expert Rev Cardiovasc Ther. 2012;10:539-41.
77. Giannoglou GD, Chatzizisis YS. Atherosclerosis: what are we looking for? Angiology.
2012;63:397-9.
78. Chatzizisis YS, Giannoglou GD. Importance of local hemodynamic conditions in the
atherosclerotic effect of increased heart rate. J Am Coll Cardiol. 2011;57:2206.
79. Katranas SA, Kelekis AL, Antoniadis AP, Chatzizisis YS, Theodoridis TF, Tzanis AP,
Giannoglou GD. Non-invasive assessment of endothelial shear stress and coronary stiffness
using multislice computed tomography. Int J Cardiol. 2011;20;152:281-4.
80. Vaklavas C, Chatzizisis YS, Tsimberidou AM. Common cardiovascular medications in
cancer therapeutics. Pharmacol Ther. 2011;130:177-90.
81. Vasilikos V, Dakos G, Chatzizisis YS, Chouvarda I, Karvounis C, Maynard C, Maglaveras
N, Styliadis, Paraskevaidis S, Mochlas S, Styliadis I. Novel non-invasive P wave analysis for
the prediction of paroxysmal atrial fibrillation recurrences in patients without heart disease:
A prospective pilot study. Int J Cardiol 2011;153:165-72.
82. Mantziari AA, Vassilikos VP, Chatzizisis YS, Dakos G, Stavropoulos G, Paraskevaidis S,
Styliadis IH. Cardiac arrest caused by torsades de pointes tachycardia after successful atrial
flutter radiofrequency catheter ablation. Open Cardiovasc Med J. 2011;5:1-3.
83. Konstantinou DM, Chatzizisis YS, Farmakis G, Styliadis I, Giannoglou GD. Cholesterol
embolization syndrome following thrombolysis during acute myocardial infarction. Herz.
2011;37:231-3.
84. Vaklavas C, Chatzizisis YS. The changing perspective of cardiology in cancer care. Expert
Rev Cardiovasc Ther 2011;9:1-3.
85. Paraskevaidis S, Kamperidis V, Theofilogiannakos E, Chatzizisis YS, Stavropoulos G,
Vassilikos V, Dakos G, Gavrielidis S, Styliadis I. Brugada syndrome associated with
supraventricular tachycardia: Diagnostic and therapeutic strategy. Herz 2011;36:724-7.
YIANNIS S. CHATZIZISIS – CV – 2018-09-30
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86. Koskinas KC, Chatzizisis YS, Kamperidis V, Anastasiadis Κ, Zioga C, Hadjimiltiades S,
Giannoglou GD. Extremely rare case of primary cardiac chondroma in a patient presenting
with acute pulmonary edema. Cardiovasc Pathol 2011;20:374-6.
87. Giannoglou GD, Antoniadis AP, Koskinas KC, Chatzizisis YS. Flow and atherosclerosis in
coronary bifurcations. EuroIntervention. 2010;6 Suppl J:J16-23.
88. Papafaklis MI, Koskinas KC, Chatzizisis YS, Stone PH, Feldman CL. In vivo assessment of
the natural history of coronary atherosclerosis: vascular remodeling and endothelial shear
stress determine the complexity of atherosclerotic disease progression. Curr Opin Cardiol
2010;25:627-38
89. Baker AB*, Chatzizisis YS*, Beigel R, Jonas M, Stone BV, Coskun AU, Maynard C,
Campbell R, Feldman CL, Stone PH, Edelman ER. Regulation of heparanase expression in
coronary artery disease in diabetic hyperlipidemic swine. Atherosclerosis 2010;213:436-42
90. Chatzizisis YS, Jonas M, Beigel R, Coskun AU, Baker AB, Stone BV, Maynard C, Gerrity
RG, Daley W, Edelman ER, Feldman CL, Stone PH. Attenuation of inflammation and
expansive remodeling by Valsartan alone or in combination with Simvastatin in high-risk
coronary atherosclerotic plaques. Atherosclerosis. 2009;203:387-94.
91. Koskinas KC, Chatzizisis YS, Baker AB, Edelman ER, Stone PH, Feldman CL. The role of
low endothelial shear stress in the conversion of atherosclerotic lesions from stable to
unstable plaque. Curr Opin Cardiol. 2009;24:580-90.
92. Chatzizisis YS, Coskun AU, Jonas M, Edelman ER, Stone PH, Feldman CL. Risk
stratification of individual coronary lesions using local endothelial shear stress: a new
paradigm for managing coronary artery disease. Curr Opin Cardiol. 2007;22:552-64.
93. Giannoglou GD, Antoniadis AP, Chatzizisis YS, Louridas GE. Difference in the topography
of atherosclerosis in the left versus right coronary artery in patients referred for coronary
angiography. BMC Cardiovasc Disord 2010;10:26.
94. Chatzizisis YS, Giannoglou GD. Shear Stress and Inflammation: Are we getting closer to the
prediction of vulnerable plaque? Expert Rev Cardiovasc Ther 2010;8:1351-3.
95. Kontantinou DM, Chatzizisis YS, Louridas GE, Parcharidis GE, Giannoglou GD. Non-
diabetic hyperglycemia correlates with angiographic coronary artery disease prevalence and
severity. Diabetes Metab 2010;36:402-8.
96. Chatzizisis YS, Koskinas K, Misirli G, Vaklavas C, Hatzitolios A, Giannoglou G. Risk
factors and drug interactions predisposing to statin-induced myopathy: Implications for risk
assessment, prevention and treatment. Drug Saf 2010;32:1-17.
97. Katsiki N, Tziomalos K, Chatzizisis Y, Elisaf M, Hatzitolios AI. Effect of HMG-CoA
reductase inhibitors on vascular cell apoptosis: Beneficial or detrimental? Atherosclerosis
YIANNIS S. CHATZIZISIS – CV – 2018-09-30
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2010;211:9-14.
98. Giannoglou GD, Konstantinou DM, Kovatsi L, Chatzizisis YS, Louridas GD. Association of
reduced zinc status with angiographically severe coronary atherosclerosis. A pilot study.
Angiology 2010;61:449-55.
99. Konstantinou DM, Chatzizisis YS, Louridas GE, Giannoglou GD. Metabolic syndrome and
angiographic coronary artery disease prevalence in association with Framingham risk score.
Metab Syndr Relat Disord 2010;8:201-8.
100. Chatzizisis YS, Saravakos P, Boufidou A, Parharidou D, Styliadis I. Acute myocardial
infarction manifested with headache. Open Cardiovasc Med J 2010;4;148-150.
101. Paraskevaidis S, Theofilogiannakos EK, Chatzizisis YS, Mantziari A, Economou F, Ziakas
A, Hadjimiltiades S, Styliadis IH. Spontaneous dissection of a right coronary artery
manifested with acute myocardial infarction. Open Cardiovasc Med J 2010;4:178-80.
102. Giannoglou GD, Antoniadis AP, Chatzizisis YS, Louridas GE. Adult congenital heart
disease investigated with cardiac catheterization over a 20-year period. Open Cardiovasc
Med J. 2009;3:124-7.
103. Vaklavas C, Chatzizisis YS, Ziakas A, Zamboulis C, Giannoglou GD. Molecular basis of
statin-associated myopathy. Atherosclerosis. 2009;202:18-28.
104. Paraskevaidis S, Stavropoulos G, Vassilikos V, Chatzizisis YS, Polymeropoulos K, Ziakas
A, Dakos G, Parcharidis GE. Idiopathic left ventricular aneurysm causing ventricular
tachycardia with 1:1 ventriculoatrial conduction and intermittent wenckebach block. Open
Cardiovasc Med J. 2009;3:105-9.
105. Chatzizisis YS, Giannoglou GD. Myocardial bridges spared from atherosclerosis: overview
of the underlying mechanisms. Can J Cardiol. 2009;25:219-22.
106. Chatzizisis YS, Vaklavas C, Giannoglou GD. Coenzyme Q10 depletion: etiopathogenic or
predisposing factor in statin associated myopathy? Am J Cardiol. 2008;101:1071.
107. Chatzizisis YS, Misirli G, Hatzitolios AI, Giannoglou GD. The syndrome of
rhabdomyolysis: complications and treatment. Eur J Intern Med. 2008;19:568-74.
108. Antoniadis AP, Chatzizisis YS, Giannoglou GD. Pathogenetic mechanisms of coronary
ectasia. Int J Cardiol. 2008;130:335-43.
109. Papadogiorgaki M, Mezaris V, Chatzizisis YS, Giannoglou GD, Kompatsiaris I. Image
analysis techniques for automated IVUS contour detection. Ultrasound Med Biol.
2008;34:1482-98.
110. Giannoglou GD, Antoniadis AP, Chatzizisis YS, Damvopoulou E, Parcharidis GE, Louridas
YIANNIS S. CHATZIZISIS – CV – 2018-09-30
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GE. Sex-related differences in the angiographic results of 14,500 cases referred for suspected
coronary artery disease. Coron Artery Dis. 2008;19:9-14.
111. Chatzizisis YS, Giannoglou GD, Sianos G, Ziakas A, Tsikaderis D, Dardas P, Matakos A,
Basdekidou C, Misirli G, Zamboulis C, Louridas GE, Parcharidis GE. In vivo comparative
study of linear versus geometrically correct three-dimensional reconstruction of coronary
arteries. Am J Cardiol. 2008;101:263-7.
112. Giannoglou GD, Chatzizisis YS, Zamboulis C, Parcharidis GE, Mikhailidis DP, Louridas
GE. Elevated heart rate and atherosclerosis: an overview of the pathogenetic mechanisms. Int
J Cardiol. 2008;126:302-12.
113. Soulis JV, Giannoglou GD, Chatzizisis YS, Seralidou KV, Parcharidis GE, Louridas GE.
Non-Newtonian models for molecular viscosity and wall shear stress in a 3D reconstructed
human left coronary artery. Med Eng Phys. 2008;30:9-19.
114. Chatzizisis Y. Ask the doctor. Why don't you ever tell your readers that everyone who takes
a statin to lower cholesterol should be taking coenzyme Q(10) too? Harv Heart Lett.
2008;19:8.
115. Chatzizisis YS, Coskun AU, Jonas M, Edelman ER, Feldman CL, Stone PH. Role of
endothelial shear stress in the natural history of coronary atherosclerosis and vascular
remodeling: molecular, cellular, and vascular behavior. J Am Coll Cardiol. 2007;49:2379-
93.
116. Chatzizisis YS, Giannoglou GD, Parcharidis GE, Louridas GE. Is left coronary system more
susceptible to atherosclerosis than right? A pathophysiological insight. Int J Cardiol.
2007;116:7-13
117. Chatzizisis YS, Giannoglou GD. Coronary hemodynamics and atherosclerotic wall stiffness:
a vicious cycle. Med Hypotheses. 2007;69:349-55.
118. Giannoglou GD, Chatzizisis YS, Misirli G. The syndrome of rhabdomyolysis:
Pathophysiology and diagnosis. Eur J Intern Med. 2007;18:90-100.
119. Giannoglou GD, Chatzizisis YS, Koutkias V, Kompatsiaris I, Papadogiorgaki M, Mezaris V,
Parissi E, Diamantopoulos P, Strintzis MG, Maglaveras N, Parcharidis GE, Louridas GE. A
novel active contour model for fully automated segmentation of intravascular ultrasound
images: in vivo validation in human coronary arteries. Comput Biol Med. 2007;37:1292-
302.
120. Chatzizisis Y, Coskun AU, Jonas M, Edelman ER, Feldman CL, Stone PH. Reply to the
letter to the Editor by H. Kaneda. J Am Coll Cardiol 2007;50:2171-2.
121. Giannoglou GD, Chatzizisis YS, Sianos G, Tsikaderis D, Matakos A, Koutkias V,
Diamantopoulos P, Maglaveras N, Parcharidis GE, Louridas GE. Integration of multi-
YIANNIS S. CHATZIZISIS – CV – 2018-09-30
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modality imaging for accurate 3D reconstruction of human coronary arteries in vivo. Nucl
Instr Meth Phys Res A. 2006;569:310-3.
122. Papadogiorgaki M, Mezaris V, Chatzizisis YS, Giannoglou GD, Kompatsiaris I. Texture
Analysis and Radial Basis Function Approximation for IVUS Image Segmentation. Open
Biomed Eng J. 2007;1:53-9.
123. Giannoglou GD, Antoniadis AP, Chatzizisis YS, Damvopoulou E, Parcharidis GE, Louridas
GE. Prevalence of narrowing >or=50% of the left main coronary artery among 17,300
patients having coronary angiography. Am J Cardiol. 2006;98:1202-5.
124. Giannoglou G, Giannakoulas G, Soulis J, Chatzizisis Y, Perdikides T, Melas N, Parcharidis
G, Louridas G. Predicting the risk of rupture of abdominal aortic aneurysms by utilizing
various geometrical parameters: revisiting the diameter criterion. Angiology. 2006;57:487-
94.
125. Chatzizisis YS, Giannoglou GD, Matakos A, Basdekidou C, Sianos G, Panagiotou A,
Dimakis C, Parcharidis GE, Louridas GE. In-vivo accuracy of geometrically correct three-
dimensional reconstruction of human coronary arteries: is it influenced by certain
parameters? Coron Artery Dis. 2006;17:545-51.
126. Giannoglou GD, Chatzizisis YS, Sianos G, Tsikaderis D, Matakos A, Koutkias V,
Diamantopoulos P, Maglaveras N, Parcharidis GE, Louridas GE. In-vivo validation of
spatially correct three-dimensional reconstruction of human coronary arteries by integrating
intravascular ultrasound and biplane angiography. Coron Artery Dis. 2006;17:533-43.
127. Giannoglou GD, Antoniadis AP, Chatzizisis YS, Damvopoulou E, Parcharidis GE, Louridas
GE. Prevalence of ectasia in human coronary arteries in patients in northern Greece referred
for coronary angiography. Am J Cardiol. 2006;98:314-8.
128. Soulis JV, Giannoglou GD, Chatzizisis YS, Farmakis TM, Giannakoulas GA, Parcharidis
GE, Louridas GE. Spatial and phasic oscillation of non-Newtonian wall shear stress in human
left coronary artery bifurcation: an insight to atherogenesis. Coron Artery Dis. 2006;17:351-
8.
129. Chatzizisis YS, Giannoglou GD. Pulsatile flow: a critical modulator of the natural history of
atherosclerosis. Med Hypotheses. 2006;67:338-40.
130. Tzavella K, Chatzizisis YS, Vakali A, Mandraveli K, Zioutas D,Alexiou-Daniel S. Severe
case of Mediterranean spotted fever in Greece with predominantly neurological features. J
Med Microbiol. 2006;55:341-3.
131. Soulis JV, Farmakis TM, Giannoglou GD, Chatzizisis YS, Giannakoulas GA, Parcharidis
GE, Louridas GE. Molecular viscosity in the normal left coronary arterial tree. Is it related to
atherosclerosis? Angiology. 2006;57:33-40.
YIANNIS S. CHATZIZISIS – CV – 2018-09-30
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C. ARTICLES SUBMITTED FOR PUBLICATION IN SCHOLARLY JOURNALS
1. Chatzizisis YS, Watanabe Y, Murasato Y, Karagiannis A, Asawaeer M, Zhao S, Shinke T,
Wooten S, Lefevre T, Nagoshi R, Nozaki Y, Masuda N, Okamura, T, Numasawa, Y, Takagi
K, Chiastra C, Dubini G, Burzotta F, Samady H, Stankovic G, Kozuma K, Louvard Y,
Kassab G. Effect of Local Biomechanical Factors on Bifurcation Stent Restenosis and
Thrombosis: Rationale and Design of a multi-center, prospective, randomized Flow ISR
Study. Submitted, BMJ Open.
2. Mavrakanas TA, Chatzizisis YS, Gariani K, Kereiakes DJ, Gargiulo G, Helft G, Gilard M,
Morice MC, Georges JL, Valgimigli M, Bhatt DL, Mauri L, Charytan DM. Duration of dual
antiplatelet therapy in patients with chronic kidney disease and drug-eluting stents: a meta-
analysis. Submitted, J Am Soc Nephrol.
D. CHAPTERS IN BOOKS
1. Parissi, E, Kompatsiaris, Y, Chatzizisis YS, Koutkias V, Magalveras N, Strintzis MG,
Giannoglou GD. Lecture Notes in Bioinformatics. Berlin Heidelberg, Germany: Springer-
Verlag; 2006. An automated model for rapid and reliable segmentation of intravascular
ultrasound images; 368-377.
2. Chatzizisis YS, Papadogiorgaki M, Mezaris, V, Giannoglou GD, Kompatsiaris I.
Encyclopedia of Information Science and Technology. 2nd. VIII. IGI Global; 2008. Visual
Medical Information Analysis; 4034-40.
3. Feldman CL, Chatzizisis YS, Coskun AU, Koskinas KC, Naghavi M, Stone PH. Vulnerable
Anatomy: The Role of Coronary Anatomy and Endothelial Shear Stress in the Progression
and Vulnerability of Coronary Artery Lesions: Is Anatomy Destiny? Humana Press; 2010.
Asymptomatic Atherosclerosis: Pathophysiology, Detection and treatment.
4. Giannoglou, GD, Chatzizisis YS. Future Trends in Intravascular Imaging. IGI Global; 2011.
Intravascular Imaging: Current Applications and Research Developments; 350-354.
COMMITTEES
Local
1. Member, Cardiac arrest subcommittee, UNMC
2. Member, Mortality review committee, UNMC
International
Conference organizing
committee member
George D. Behrakis Cardiovascular Symposium on Vascular Biology
November 2014, Brigham and Women’s Hospital, Harvard Medical
School, Boston, USA
YIANNIS S. CHATZIZISIS – CV – 2018-09-30
Page 25 of 25
Round table chair Session: How to evaluate stents and techniques for bifurcation
stenting? 8th European Bifurcation Club Meeting, October 12-13,
2012, Barcelona, Spain
Poster moderator Poster Group 1: Endothelium and atherothrombosis
81st European Atherosclerosis Society Congress. June 2-5, 2013,
Lyon, France
COMPUTER SKILLS
Microsoft Windows 8.0
OSX 10.9 (Mac)
Microsoft Office (Word, Excel, PowerPoint, Outlook, Access)
iWorks (Pages, Numbers, Keynote)
Statistical software: SPSS, GraphPad Prism, STATA, MedCalc
Computer-aided design software: Rhinoceros, MIMICS, CorelDraw, iDraw
Mathematical software: Matlab
Computational fluid dynamics (CFD) software: ANSYS, Fluent
LANGUAGES
Fluent in English
Fluent in Greek
HOBBIES AND INTERESTS
Soccer
Formula 1
Photography
Ancient Greek Literature