CURRICULUM VITAE
NAME: Robert A. Levine, Ph.D., C.Ht.
BIRTHDATE: July 25, 1954
BIRTHPLACE: Waltham, Massachusetts
MARITAL STATUS: Married to Charlene with 3 sons
RESIDENCE: 6070 Oak Trail
West Bloomfield, MI 48322
(248) 615-1010
(206) 666-2803 (Fax)
(248) 342-7555 (Cell)
OFFICE ADDRESS: Corporate Wellness Resources, LLC
16250 Northland Drive, Suite 160
Southfield, MI 4807
(248) 850-4297
(206) 666-2803 (FAX)
Email: [email protected] or [email protected]
http://www.CWRnow.com or
http://www.corporatewellnessresources.com
CURRENT POSITIONS: Vice President, Wellness and High-Performance Strategies
Corporate Wellness Resources, LLC
Southfield, MI
(see page 22 for summary of Integrative Medicine activities)
Clinical Professor of Wellness, Health Promotion, and
Injury Prevention
School of Health Sciences, Oakland University
Adjunct Professor of Pharmaceutical Sciences
Wayne State University
Robert A. Levine, Ph.D., C.Ht.
2
EDUCATION:
January 2002 - April 2002 Hypnotherapy Certification (C.Ht.)
Infinity Institute, Royal Oak, MI
Basic and advanced hypnosis, regression analysis, guided
imagery, holistic hypnoanalysis
September 2000 - May 2001 Medical Acupuncture for Physicians Program (Dr. Joe Helms)
UCLA School of Medicine, Los Angeles, CA
300 CME credits received
Fall 1996 - Spring 2001 Trained in St. John Neuromuscular Therapy (NMT); now
referred to as Neurosomatic Therapy
(www.neurosomaticeducators.com)
Attended the following seminars: NMT1, NMT2, NMT3,
NMT5, NMT6, NMT7 offered by the St. John Neuromuscular
Pain Relief Institute, Largo, FL
September 1977 - July 1982 George Washington University Major: Pharmacology
Washington, D.C. DEGREE: Ph.D.
Ph.D. coursework included taking the first 2 years of medical
school coursework with medical students (e.g. medical
biochemistry, physiology, pharmacology, pathology,
neuromuscular anatomy, etc.) before taking specialized
pharmacology classes, research electives, and conducting
graduate level teaching and thesis research.
September 1976 - May 1977 George Washington University Graduate level courses
Washington, D.C.
September 1972 - June 1976 University of Massachusetts Major: Zoology
Amherst, MA DEGREE: B.S.
PREDOCTORAL TRAINING:
September 1977 - June 1983 Pharmacologist research appointment
Section on Biochemical Pharmacology
National Heart, Lung, and Blood Institute, NIH
Bethesda, MD
June 1977 - August 1977 Summer research appointment
Section of Biochemical Pharmacology
National Heart, Lung, and Blood Institute, NIH
Bethesda, MD (salary paid by University of Vermont)
Robert A. Levine, Ph.D., C.Ht.
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PREDOCTORAL TRAINING (continued):
June 1976 - May 1977 Part-time graduate student research appointment
Laboratory of Chemical Pharmacology
National Heart, Lung, and Blood Institute, NIH
Bethesda, MD
June 1975 - August 1975 Summer research appointment
Laboratory of Chemical Pharmacology
National Heart, Lung, and Blood Institute, NIH
Bethesda, MD
POSTDOCTORAL TRAINING:
July 1983 - August 1985 Visiting Scientist
Children’s Hospital of Zurich (intermittent collaborative
research trips; Professor Hans-Christoph Curtius, sponsor)
Zurich, Switzerland
July 1983 - August 1985 Pharmacology Research Associates Training Program Fellow
National Institute of General Medical Sciences, and
Laboratory of Cell Biology and Genetics, NIADDK, NIH
Bethesda, MD
July 1982 - June 1983 Postdoctoral fellow
Section on Biochemical Pharmacology
National Heart, Lung, and Blood Institute, NIH
Bethesda, MD
EMPLOYMENT:
July 2012 – present Vice President, Wellness and High-Performance Strategies
Corporate Wellness Resources, LLC
Southfield, MI
April 2008 – July 2012 Director, Center for Integrative Wellness
Director, Integrative Wellness Research
Henry Ford Health System
Detroit, MI
Sept. 2000 - December 2008 Co-director, Henry Ford Center for Integrative Medicine
Director, Integrative Medicine Research
Henry Ford Health System
Detroit, MI
Robert A. Levine, Ph.D., C.Ht.
4
EMPLOYMENT (continued):
January 1993 - March 2007 Director, William T. Gossett Neurology Laboratories
Henry Ford Health System, Detroit, MI
March 1992 – December 2006 Research Pharmacologist
Detroit Veterans Administration Medical Center
August 1985 - December 1992 Director, Laboratory of Molecular Neurobiology
Director, Clinical Chemistry Laboratory
Lafayette Clinic
Detroit, MI
ACADEMIC APPOINTMENTS:
September 2005 - Present Clinical Professor of Wellness, Health Promotion, and
Injury Prevention
School of Health Sciences, Oakland University
March 1997 - Present Adjunct Professor
Department of Pharmaceutical Sciences
Wayne State University
Detroit, MI
December 2000 - 2002 Adjunct Professor of Energy Medicine
Greenwich University
Norfolk Island, Australia
January 1993 - March 1997 Adjunct Associate Professor
Department of Psychiatry and Behavioral Neurosciences
Wayne State University
Detroit, MI
January 1988 - December 1992 Associate Professor
Department of Psychiatry and Behavioral Neurosciences
Wayne State University
Detroit, MI
August 1985 - December 1987 Assistant Professor
Department of Psychiatry and Behavioral Neurosciences
Wayne State University
Detroit, MI
Robert A. Levine, Ph.D., C.Ht.
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PROFESSIONAL AFFILIATIONS:
International Medical and Dental Hypnotherapy Association
International Association of Counselors and Therapists
AWARDS AND HONORS:
2011 Detroit Crain’s Healthcare Heroes 2011
Dr. Levine was the recipient of the Corporate Achievement
Award for group programs offered to large self-funding
corporations to provide relief of chronic pain, stress, and
symptoms of stress-related conditions. Levine operates on the
principle that the main way of reducing national healthcare
costs in the long-run is to produce sustained health
improvement. The group programs have demonstrated
improved health that is sustained for up to 16 months after
programs end. See online:
http://www.crainsdetroit.com/article/20110911/AWARDS05/30
9119983/wellness-programs-go-on-the-road
2010 Henry Ford Health System Quality and Safety Expo
Competition Winner for “Stress and Pain Free Living”
programs offered at Chrysler & HFHS employees
Henry Ford Health System recognized the further innovations
brought to the group wellness programs offered by the Center
for Integrative Wellness. New for 2010 were programs offered
at Dow Chemical, Midland and the community program at New
Hope Missionary Baptist Church. The results of these
independent programs were equivalent and equal to the positive
outcomes produced in earlier years (see description below).
This project demonstrated that programs could be effective
when offered outside the Detroit Metro area (Midland) and
when delivered to an African American population in the faith-
based community.
2010 International Medical and Dental Hypnotherapy Association
Outstanding Research Award in the Mind-Body Medicine
Award Presented at the International Medical and Dental
Hypnotherapy Association annual international meeting.
2009 Henry Ford Health System Quality and Safety Expo
Competition Winner for “Stress and Pain Free Living”
programs offered at Chrysler & HFHS employees
Henry Ford Health System recognized the further innovations
brought to the group wellness programs offered by the Center
Robert A. Levine, Ph.D., C.Ht.
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AWARDS AND HONORS (continued):
for Integrative Wellness. New for 2009 was the tracking of
stress elimination in Chrysler and HFHS employees. Stress
elimination, defined as a score of 0 average stress in the last
week on a 0-10 scale (score of 0 is when more than 95% of the
time is spent free of unhealthy stress reactions), was reported by
14% of participants. Programs were reduced from 24 to 18
contact hours; elimination of chronic pain conditions was
sustained at 45%, and other validated measures were favorably
impacted (disability, stress, and depression were significantly
reduced; sleep quality was significantly improved).
2008 Detroit Crain’s Healthcare Heroes 2008
One of eight awardees in the Southeast Michigan area. Dr.
Levine was the recipient of a Corporate Achievement Award for
the Chrysler “We’ve Got Your Back” program. Chrysler
employees were treated in the workplace in groups of up to 48
people at a time with a hands-off complementary and alternative
medicine approach. After 24 contact hours over 6 months, 55%
of reporting employees eliminated back pain compared with 0%
of untreated, randomized controls. There were also significant
reductions in stress, disability, and depression symptoms, as
well as improvements in sleep quality. See online:
http://www.crainsdetroit.com/article/20080810/AWARDS/8081
10320/-1
2008 HFHS Quality and Safety Expo Competition Winner for
Chrysler & HFHS Pain Alleviation Program
Henry Ford Health System recognized the quality of the group
pain alleviation programs offered by the Center for Integrative
Wellness. The programs offered under the umbrella of “Pain
Free in 2008” received the award for the positive health
outcomes achieved with employees of Chrysler (“Pain
Free Zone”) and HFHS (“Living a Pain Free Life”). All
musculoskeletal pain conditions were included in the same
group and employees received 24 contact hours over about 7
months; 35% of all chronic pain conditions were eliminated.
There were also significant reductions in stress, disability, and
depression symptoms, as well as improvements in sleep quality.
Robert A. Levine, Ph.D., C.Ht.
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AWARDS AND HONORS (continued):
2007 Focus on People 2007 Award for Chrysler Back Pain Program
Presented by the Board of Trustees of Henry Ford Health
System to Dr. Levine and his team for creating and delivering
the “We’ve Got Your Back” program to Chrysler employees
(results described above).
2007 Henry Ford Health System Quality and Safety Expo
Competition Winner for Chrysler Back Pain Program
Henry Ford Health System recognized the achievement in
enhancing quality for a major System employer group through
offering the “We’ve Got Your Back” program to Chrysler
employees (results described above).
2005 Focus on People 2005 Award
Presented by the Board of Trustees of Henry Ford Health
System for participation in the “Journey to Wellness” Program,
an educational and intervention program designed to support the
health and wellness of members of city of Detroit churches.
2004 Distinguished Researcher in Hypnotherapy Award Presented at the International Medical and Dental Hypnotherapy
Association annual international meeting.
2002 Deputy Director for National Center for Complementary and
Alternative Medicine at NIH- Interviewee
One of 3 individuals selected from several hundred applicants to
interview for the position of Deputy Director reporting to
Steven Straus, then the Director of NCCAM. Although not
selected, this was recognition of Dr. Levine’s broad expertise in
conventional basic and clinical research, experience and
productivity in NIH grant-funded research and peer-review
publications, being a practitioner of integrative medicine
therapies, and having expertise in integrative medicine basic
and clinical research.
June 1996 - May 1997 Exceptional Performance Award
Detroit VA Medical Center
June 1995 - May 1996 Outstanding Rating Certificate
Detroit VA Medical Center
Robert A. Levine, Ph.D., C.Ht.
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FELLOWSHIPS:
July 1983 - August 1985 Pharmacology Research Associate Training Program
Fellowship
National Institutes of General Medical Sciences
National Institutes of Health
Bethesda, MD
July 1982 - July 1983 Postdoctoral fellowship
Section on Biochemical Pharmacology
National Heart, Lung, and Blood Institute, NIH
Bethesda, MD
March 1983 Outstanding Young Investigator in Neurochemistry
Awarded by Vector Labs, Inc.
July 1982 - September 1982 Roche Research Foundation (Basel) Senior Scientist Award
To support collaborative work in Department of Pediatrics
Children’s Hospital of Zurich, Switzerland
CONSULTING:
January 1988 - Dec 2000 Ronald L. Hofer of Harness, Dickey, and Pierce Patent Firm
Consulted on intellectual property and patents related to
biotechnology
October 1990 - June 1992 Suntory Limited, Pharmaceutical Division
Consultant on clinical trials with tetrahydrobiopterin therapy in
Alzheimer's disease, familial dystonia, and infantile autism
May 1980 - August 1984 Fund for Integrative Biomedical Research (FIBER).
Consulted for Scientific Director on scientific merit and
economic feasibility of proposals on neuropsychiatry and aging
JOURNAL/EDITORIAL ACTIVITY:
Books Edited: Pteridines and Related Biogenic Amines and Folates-1992. N. Blau, H.-Ch.
Curtius, R.A. Levine, and J. Yim (eds.), Hanrim Publishing Co., Seoul 100-
230, Korea, 1992
Pterins and Biogenic Amines in Neurology, Pediatrics, and Immunology. N.
Blau, H.-Ch. Curtius, R.A. Levine, and R.G.H. Cotton (eds.), Lakeshore
Publishing, MI, 1991
Robert A. Levine, Ph.D., C.Ht.
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JOURNAL/EDITORIAL ACTIVITY (continued):
Pteridines and Biogenic Amines in Neuropsychiatry, Pediatrics, and
Immunology. R.A. Levine, S. Milstien, and H.-Ch. Curtius (eds), Lakeshore
Publishing, MI, 1989
Unconjugated Pterins and Related Biogenic Amines. H.-Ch. Curtius, N. Blau,
and R.A. Levine (eds.) Walter de Gruyter, Berlin, New York, 1987
Unconjugated Pterins in Neurobiology: Basic and Clinical Aspects. W.
Lovenberg and R.A. Levine (eds.), Taylor and Francis, London, New York,
1987.
Memberships on Editorial Boards:
Pteridines
Journal of Neural Transmission
The American Journal of Chinese Medicine
Journal Reviewer: Analytical Biochemistry
Annals of New York Academy of Sciences
Archives of General Psychiatry
Biological Psychiatry
Brain Research
European Journal of Biochemistry
Journal of Neural Transmission
Journal of Neurochemistry
Journal of Pharmacology and Experimental Therapeutics
Molecular Neurobiology
Neurobiology of Aging
Neurochemistry International
Journal of Neural Transmission
Journal of Neurological Sciences
Journal of Neuroscience
Proceedings of the National Academy of Sciences
Proceedings of the Society for Experimental Biology and Medicine
Pteridines
Science
The American Journal of Chinese Medicine
Robert A. Levine, Ph.D., C.Ht.
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MEETINGS ORGANIZED:
May 2006 Conference on Complementary and Alternative Medicine and End-of-Life Care
Principal organizer and principal investigator funded by the Agency for
Healthcare Research and Quality (AHRQ) through the Small Grant Program
for Conference Support (PAR-00-141); amount of funding: $25,000.
April 2003 Thirteenth International Conference on Pteridines and Related Biogenic
Amines
Member of international organizing committee
Maui, Hawaii, USA
June 2001 Twelfth International Symposium on Pteridines and Folates
Member of international organizing committee
National Institutes of Health, Bethesda, MD, USA
March 2000 Twelfth International Conference on Pteridines and Related Biogenic Amines.
Member of international organizing committee
St. Moritz, Switzerland
March 1999 Eighteenth International Winter Workshop on Chemical, Biochemical, and
Clinical Aspects of Pteridines and Eleventh International Conference on
Pteridines and Related Biogenic Amines (combined meeting).
Member of international organizing committee
St. Christoph/Arlberg, Austria
April 1998 Tenth International Conference on Pteridines and Related Biogenic Amines
Principal Organizer
Salt Lake City, UT, USA
June 1997 Eleventh International Symposium on Chemistry and Biology of Pteridines and
Folates. Member of international organizing committee
Berchtesgaden, Germany
May 1996 Ninth International Conference on Pteridines and Related Biogenic Amines
Member of international organizing committee
Cairns, Queensland, Australia
March 1995 Eighth International Conference on Pteridines and Related Biogenic Amines
Member of international organizing committee
St. Moritz, Switzerland
Robert A. Levine, Ph.D., C.Ht.
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MEETINGS ORGANIZED (continued):
February 1994 Seventh International Conference on Pteridines and Related Biogenic Amines
Co-sponsored with Dr. Watanabe. Abstracts published in the journal,
Pteridines.
Hokkaido, Japan
March 1993 Tenth International Symposium on Chemistry and Biology of Pteridines and
Folates. Member of international organizing committee
Proceedings published (see books edited above)
Orange Beach, AL
June 1992 Sixth International Conference on Pteridines and Related Biogenic Amines and
Folates. Co-organized with Drs. Jeongbin Yim and Nenad Blau
Proceedings published (see books edited above)
Seoul, Korea
November 1991 Fifth International Conference on Pteridines and Related Biogenic Amines and
Folates. Co-organized with Drs. Richard Cotton and Nenad Blau
Cairns, Queensland, Australia
March 1990 Fourth International Conference on Pteridines and Biogenic Amines
Co-organized with Dr. Nenad Blau, Proceedings published (see books edited
above)
St. Moritz, Switzerland
September 1989 Ninth International Symposium on Pteridines and Folic Acid Derivatives:
Chemical, Biological, and Clinical Aspects
Member of international organizing committee
Zurich, Switzerland
March 1989 Third International Conference on Pteridines and Related Biogenic Amines
Principal Organizer
Salt Lake City, UT
March 1988 Second International Conference on Pteridines and Related Biogenic Amines
Principal Organizer. Proceedings published (see books edited above)
Salt Lake City, UT
February 1987 First International Conference on Pteridines and Related Biogenic Amines
Co-organized with Professor H.-Ch. Curtius and Dr. N.Blau, Kinderspital
Zurich
Proceedings published (see books edited above)
Flims, Switzerland
Robert A. Levine, Ph.D., C.Ht.
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MEETINGS ORGANIZED (continued):
June 1986 Tetrahydrobiopterin: Neural Function and Neuropsychiatric Disease
Co-organized with Dr. Gregory Kapatos, Sinai Research Institute
Detroit, MI
SUPERVISION OF PERSONNEL:
July 2012 – Present Corporate Wellness Resources, LLC
Responsible for developing content for in-person and online
group programs, including accelerated learning strategies,
automatic pattern interruption© technology, and Effective
Muscle Release© movement routines (see www.cwrnow.com)
April 2008 – July 2012 Henry Ford Health System, Center for Integrative Wellness
Directing all activities of the award-winning group pain and
stress alleviation programs (see awards and honors) offered
onsite to self-insuring corporations.
June 2002 - April 2008 Henry Ford Health System, Center for Integrative Medicine
Direct the activities of personnel at the Center, including 1
administrative manager, 3 customer service representatives, 2
acupuncturists, 2 mind-body therapists, 2 neuromuscular
therapists, 3 massage therapists, 2 holistic nutritionists, 1
chiropractor, 1 Feldenkrais practitioner, 4 research staff
members, and 1 counseling student clinical intern.
January 1999 - December 2006 Henry Ford Health System
Clinical trial supervision in complementary and integrative
medicine, serving as PI on several randomized, control clinical
trials including: 1) St. John Neuromuscular Therapy vs. control
relaxation massage for alleviating chronic, intractable migraine
and cervicogenic headaches; 2) complementary and integrative
medicine therapies vs. conventional physical therapy for
alleviating chronic low back pain; 3) acupuncture vs.
venlafaxine (Effexor) for alleviating hot flashes and other
vasomotor symptoms in breast cancer patients receiving
hormone therapy; 4) Hands-off group complementary treatment
of chronic musculoskeletal pain in the workplace at Chrysler
and Henry Ford Health System. These trials involve overseeing
the activities of approximately 20 people including many
complementary medicine practitioners, integrative medicine
research fellows, research study coordinators, data managers,
and interfacing with biostatistics personnel.
Robert A. Levine, Ph.D., C.Ht.
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SUPERVISION OF PERSONNEL (continued):
January 1993 - March 2007 Henry Ford Health System
Direct the basic research activities as the Director of the
William T. Gossett Neurology laboratories, employing
postdoctoral fellows, research assistants, post-undergraduates,
college and high school students, and an administrative
assistant.
April 1992 - September 2002 Detroit Veterans Administration
Directed research laboratory that employed postdoctoral fellows
and research assistants.
October 1985 - December 1992 Director, Laboratory of Molecular Neurobiology, Lafayette
Clinic
Directed research laboratory that employed 1-2 postdoctoral
fellows, 2-3 technicians; mentored 1 medical student's research
project, and 1 graduate student's Ph.D. dissertation project.
Director, Clinical Chemistry Laboratory, Lafayette Clinic
3 medical laboratory technicians
Radiation Safety Officer, Lafayette Clinic (1990-1992)
Directed radiation usage activities of more than 50 employees
July 1982 - June 1985 Department of Pediatrics, Kinderspital Zurich (periodic visits)
3 technicians who worked on testing the ability of synthetic
analogues of tetrahydrobiopterin to penetrate the blood-brain
barrier and influence hydroxylase enzyme activity and biogenic
amine metabolism
UNIVERSITY/INSTITUTIONAL COMMITTEES:
January 2009 – July 2012 HFHS Wellness Ambassador Team member
Jan 2005 - December 2005 HFHS planning committee for “Your Journey to Wellness”
Program, offered to Detroit area churches
June 1999 - June 2002 Member, Complementary/Alternative Medicine Task Force
Henry Ford Hospital, Detroit, MI
May 1999 - October 2003 Member, Pain Management Strategy Committee
Veterans Administration VISN 11 (midwest VAs)
Robert A. Levine, Ph.D., C.Ht.
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UNIVERSITY/INSTITUTIONAL COMMITTEES (continued):
September 1999 - October 2003 Member, Committee on Complementary and Alternative
Medicine
Veterans Administration VISN 11 (midwest VAs)
March 1997 - December 2001 Member, Task Force on Bioscientific Staff Development
Henry Ford Hospital, Detroit, MI
October 1998 - December 2001 Member, Grant Development Committee
Henry Ford Hospital, Detroit, MI
August 1977 - December 1998 Member, Task Force on Case Western Reserve University-
Henry Ford Health System Basic Science Curriculum
Henry Ford Hospital, Detroit, MI
January 1997 - September 1998 Member, Small Projects Funding Committee
Henry Ford Hospital, Detroit, MI
January 1994 - December 1997 Member, Finance committee, Department of Neurology
Henry Ford Hospital, Detroit, MI
January 1995 - May 1996 Member, Research Purchasing Task Force
Henry Ford Hospital, Detroit, MI
January 1996 - July 1999 Chairman, Research and Development Committee
John D. Dingle Veterans Administration, Detroit, MI
January 1993 - December 2001 Member, Research and Development Committee
John D. Dingle Veterans Administration, Detroit, MI
October 1986 - September 1988 Member, Curriculum Development Committee,
Cellular and Clinical Neurobiology Ph.D. Program
Dept. of Psychiatry and Behavioral Neurosciences
Wayne State University
TEACHING ACTIVITIES:
Course coordination and lecture activity:
January 1997 - Present Lecturer, Neurology Pharmacotherapeutics, undergraduate
Department of Pharmaceutical Sciences
Wayne State University, Detroit, MI
Robert A. Levine, Ph.D., C.Ht.
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TEACHING ACTIVITIES (continued):
September 1993 - August 1995 Course coordinator and lecturer, Basic Neurobiology
Department of Psychiatry and Behavioral Neurosciences
Wayne State University
Fall 1993 Lecturer, Topics in Neurobiology
Department of Psychiatry Medical Residents
Henry Ford Hospital
October 1986 - March 1997 Member, Cellular and Clinical Neurobiology Program
Duties: lecturing and graduate student training
Department of Psychiatry and Behavioral Neurosciences
Wayne State University
Spring 1981 Lecturer, General Neurochemistry
George Washington University, Washington, D.C.
Fall 1978 - Spring 1981 Lecturer, Advanced Topics in Pharmacology:
George Washington University
Fellows (Ph.D & M.D.) trained: Panagiotis Anastasiadis, Ph.D.
(*including sabbaticals) Krishnamoorthy Sankaran, Ph.D.
Randy Shoemaker, Ph.D.
Torbjoern Nygaard, M.D.*
Laurent Bezin, Ph.D.
Min Zhu, M.D.
Jane Foster, Ph.D.
Hao Jiang, Ph.D.
David Koubi, Ph.D.
Alba Rodriguez, Ph.D. (integrative medicine)
Dissertations directed:
May 2005 - December 2005 Hosted Maria Angoa Perez for Ph.D. thesis research
Ph.D. Degree to be granted by:
National University of Mexico, Mexico City, Mexico
January 1998 - December 2001 Co-supervisor for thesis of Laurent Groc (working in U.S.)
Ph.D. Degree granted by:
Laboratoire de Neuropharmacoligie Moleculaire
CNRS- UCBL UMR 5542
Lyon, France
Robert A. Levine, Ph.D., C.Ht.
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TEACHING ACTIVITIES (continued):
January 1989 - March 1993 Supervised Ph.D. thesis of Panagiotis Anastasiadis
Cellular and Clinical Neurobiology Program
Department of Psychiatry and Behavioral Sciences
Wayne State University, Detroit, MI
Post-undergraduates mentored: Bruce Imerman (Wayne State University Medical School)
(subsequent career path listed) Jennifer Blitz (University of PA Medical School),
Martin Berent (Wayne State University Medical School)
Michael Flam (Arizona College of Osteopathic Medicine)
Ryan Stearn (Wayne State University Law School)
Undergraduates trained: James Neville (University of Michigan)
(university attended) Arthur Nugent (University of Michigan)
Kevin Kuzia (University of Michigan)
Claudia Reich (Oakland University)
Minority High School Students trained:
(subsequent university attended) Melisa Louie (University of Michigan)
Alfred Valrie (Dartmouth College)
Letteice Jones
Janea Lowe
Curriculum development:
January 1986 - September 1988 Member, Curriculum Development Committee
Ph.D. program in Cellular and Clinical Neurobiology
Department of Psychiatry and Behavioral Sciences
Wayne State University
GRANT REVIEW COMMITTEES:
December 2003 - March 2007 National Institutes of Health, NINDS
Member, Special Review Panel
Reviewing applications for Morris K. Udall Parkinson's Disease
Research Centers of Excellence
March 2002 - Present Alzheimer’s Disease and Related Disorders Association
Ad-hoc reviewer
December 1999 - March 2000 National Institutes of Health
Member, Special Review Panel
National Center for Complementary and Alternative Medicine
Robert A. Levine, Ph.D., C.Ht.
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GRANT REVIEW COMMITTEES (continued):
March 1995 - February 2002 Veterans Administration
Member, National Review Committee
“Research training initiative for historically black colleges and
universities and Hispanic-serving institutions”
September 1995 - October 1999 Veterans Administration
Chairman, National Review Committee
“Research training initiative for historically black colleges and
universities and Hispanic-serving institutions”
February 1987 National Institutes of Health
Ad-hoc reviewer for National Institute on Drug Abuse
GRANT SUPPORT:
Mar 2011 - Feb 2012 Blue Cross Blue Shield Michigan
“Group programs for stress and pain relief offered through
mainstream physician organizations”
P.I. - Robert A. Levine, Ph.D.
$380,000/1yr total costs
June 2004 - December 2007 Health Alliance Plan Quantum Leaps in Quality
“Improving Quality and Reducing Cost of Care in Patients with
Chronic Back Pain Using Integrative Medicine Approaches”
P.I. - Robert A. Levine, Ph.D.
$1,000,000/3yr direct costs
June 2004 - May 2007 Susan Komen Breast Cancer Foundation
“Acupuncture for the Treatment of Vasomotor Symptoms in
Breast Cancer Patients Receiving Hormonal Therapy”
P.I. – Eleanor Walker, M.D. (Co-I: Robert A. Levine, Ph.D.)
$250,000/2yr direct costs
Sep 2005 - Aug 2006 National Institutes of Health- Agency for Healthcare Research
and Quality (AHRQ)
Small Grant Program for Conference Support (PAR-00-141)
“Conference on Complementary and Alternative Medicine and
End-of-Life Care”
P.I. - Robert A. Levine, Ph.D.
$25,000/1 yr direct costs
Robert A. Levine, Ph.D., C.Ht.
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GRANT SUPPORT (continued):
June 2000 - March 2004 National Institutes of Health (R01)
"Biopterin, Catecholamines, & NO in Regulating Apoptosis"
P.I. - Robert A. Levine, Ph.D.
Total direct costs: $600,000
January 1999 - December 2001 Henry Ford Health System
“St. John Neuromuscular Therapy for Intractable Headaches”
P.I. - Robert A. Levine, Ph.D.
Total direct costs: $150,000 (funding provided by Gail Warden,
CEO, and Dr. Tom Royer, CMO)
October 1996 - September 2002 Veterans Administration, National Peer Review Merit Award
(2nd
funded competitive renewal) "Regulation of Nitric Oxide and Tetrahydrobiopterin-related
Gene Expression"
P.I. - Robert A. Levine, Ph.D.
Total direct costs: $735,000
August 1992 - May 1997 National Institutes of Health, NINDS, 1 R01 NS28800
"Biopterin & Catecholamines in Aging and Neurodegeneration"
P.I. - Robert A. Levine, Ph.D.
Total direct costs: $384,000
April 1995 - March 1997 Dystonia Medical Research Foundation
“GTP Cyclohydrolase I as a Marker for Dopa-responsive
Dystonia”
P.I. - Robert A. Levine, Ph.D.
Total direct costs: $50,000
October 1993 - September 1996 Veterans Administration, National Peer Review Merit Award
(1st funded competitive renewal) "Regulation of Nitric Oxide and Tetrahydrobiopterin-related
Gene Expression"
P.I. - Robert A. Levine, Ph.D.
April 1992 - March 1995* Veterans Administration, National Peer Review Merit Award
"Regulation of Biopterin and Catecholamine-related Gene
Expression "
P.I. - Robert A. Levine, Ph.D.
Total direct costs: $366,000
*returned to central office (8/1/92) due to overlap with
NS28800.
Competitive renewal submitted (please see above)
Robert A. Levine, Ph.D., C.Ht.
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GRANT SUPPORT (continued):
September 1992 - May 1995 National Institutes of Health, NIA, 1 R01 AG10687
"Biopterin/Catecholamine Metabolism in Alzheimer's & Aging"
P.I. - Robert A. Levine, Ph.D.
Total direct costs: $275,000
INVITED PRESENTATIONS (selected events):
(For presentations related to Complementary and Integrative Medicine, see pages 21-38)
June 2005 Fourth Stromboli Conference on Neuroimmunology, Aging, and Cancer: The
Reversal of Aging, Myth and Reality
Stromboli, Italy
April 2003 13th
International Conference on Pteridines and Related Biogenic Amines and
Folates
Maui, Hawaii
June 2001 11th
International Symposium on Chemistry and Biology of Pteridines and
Folates
NIH, Bethesda, MD
March 1999 18th
International Winter Workshop on Chemical, Biochemical, and Clinical
Aspects of Pteridines and 11th International Conference on Pteridines and
Related Biogenic Amines (joint meeting).
St. Christoph, Arlberg, Austria
April 1998 10th
International Conference on Pteridines and Related Biogenic Amines and
Folates
Salt Lake City, UT
June 1997 11th
International Symposium on Chemistry and Biology of Pteridines and
Folates
Berchtesgaden, Germany
October 1996 3rd
International Dystonia Symposium
Miami, FL
May 1996 9th
International Conference on Pteridines and Related Biogenic Amines and
Folates
Port Douglas, North Queensland, Australia
March 1995 8th
International Conference on Pteridines and Related Biogenic Amines
St. Moritz, Switzerland
Robert A. Levine, Ph.D., C.Ht.
20
INVITED PRESENTATIONS (continued):
February 1994 7th
International Conference on Pteridines and Related Biogenic Amines
Hokkaido, Japan
March 1993 10th
International Symposium on Chemistry and Biology of Pteridines and
Folates
Mobile, AL
June 1992 6th
International Conference on Pteridines and Related Biogenic Amines and
Folates
Soeul, Korea
June 1992 Osaka Bioscience Institute
Osaka, Japan
November 1991 9th
International Conference on Pteridines and Related Biogenic Amines and
Folates
Cairns, Queensland, Australia
September 1989 9th
International Symposium on Pteridines and Folic Acid Derivatives:
Chemical, Biological, and Clinical Aspects
Zurich, Switzerland
November 1988 Department of Psychiatry, Hillside Hospital, Long Island Jewish Medical
Center
Glen Oaks, NY
March 1988 Department of Pharmacology, University of Utah
Salt Lake City, Utah
June 1987 First International Conference on Neuroimmunomodulation, Aging, and
Cancer
Stromboli, Italy
April 1984 Department of Pharmaceutics, S.U.N.Y. at Buffalo
Amherst, NY
June 1983 Schering Pharmaceutical Company
West Berlin, Germany
December 1982 Neurobiology Colloquium, Psychiatric Hospital, University of Zurich
Zurich, Switzerland
Robert A. Levine, Ph.D., C.Ht.
21
INVITED PRESENTATIONS (continued):
July 1981 Department of Pharmacology, Kyushu University
Fukuoka, Japan
July 1981 Department of Biochemistry, Bombay Atomic Research Council
Bombay, India
Robert A. Levine, Ph.D., C.Ht.
22
Complementary and Integrative Medicine (CIM) Activities (Summary)
EMPLOYMENT:
July 2012 – Present Vice President, Wellness and High-Performance Strategies
Corporate Wellness Resources, LLC, Southfield, MI
http://www.CWRnow.com
April 2008 – July 2012 Director, Center for Integrative Wellness
Director, Integrative Wellness Research
Henry Ford Health System, Detroit, MI
Sept. 2000 - April 2008 Co-director, Henry Ford Center for Integrative Medicine
Director, Integrative Medicine Research
Henry Ford Health System, Detroit, MI
AWARDS AND HONORS:
2011 Detroit Crain’s Healthcare Heroes 2011
Dr. Levine was the recipient of the Corporate Achievement
Award for group programs offered to large self-funding
corporations to provide relief of chronic pain, stress, and
symptoms of stress-related conditions. Levine operates on the
principle that the main way of reducing national healthcare
costs in the long-run is to produce sustained health
improvement. The group programs have demonstrated
improved health that is sustained for up to 16 months after
programs end. See online:
http://www.crainsdetroit.com/article/20110911/AWARDS05/30
9119983/wellness-programs-go-on-the-road
2010 Henry Ford Health System Quality and Safety Expo
Competition Winner for “Stress and Pain Free Living”
programs offered at Chrysler & HFHS employees
Henry Ford Health System recognized the further innovations
brought to the group wellness programs offered by the Center
for Integrative Wellness. New for 2010 were programs offered
at Dow Chemical, Midland and the community program at New
Hope Missionary Baptist Church. The results of these
independent programs were equivalent and equal to the positive
outcomes produced in earlier years (see description below).
This project demonstrated that programs could be effective
when offered outside the Detroit Metro area (Midland) and
when delivered to an African American population in the faith-
based community.
Robert A. Levine, Ph.D., C.Ht.
23
CIM Activities Summary (continued):
AWARDS AND HONORS (continued):
2010 International Medical and Dental Hypnotherapy Association
Outstanding Research Award in the Mind-Body Medicine
Award. Presented at the annual meeting of the International
Medical and Dental Hypnotherapy Association and the
International Association of Counselors and Therapists.
2009 Henry Ford Health System Quality and Safety Expo
Competition Winner for “Stress and Pain Free Living”
programs offered at Chrysler & HFHS employees
Henry Ford Health System recognized the further innovations
brought to the group wellness programs offered by the Center
for Integrative Wellness. New for 2009 was the tracking of
stress elimination in Chrysler and HFHS employees. Stress
elimination, defined as a score of 0 average stress in the last
week on a 0-10 scale (score of 0 is when more than 95% of the
time is spent free of unhealthy stress reactions), was reported by
14% of participants. Programs were reduced from 24 to 18
contact hours with no loss of results; elimination of chronic pain
conditions was 45%, and other validated measures were also
favorably impacted (disability, stress, and depression were
significantly reduced; sleep quality was significantly improved).
2008 Detroit Crain’s Healthcare Heroes 2008
One of eight awardees in the Southeast Michigan area. Dr.
Levine was the recipient of a Corporate Achievement Award for
the Chrysler “We’ve Got Your Back” program. Chrysler
employees were treated in the workplace in groups of up to 48
people at a time with a hands-off complementary and alternative
medicine approach. After 24 contact hours over 6 months, 55%
of reporting employees eliminated back pain compared with 0%
of untreated, randomized controls. There were also significant
reductions in stress, disability, and depression symptoms, as
well as improvements in sleep quality.
Robert A. Levine, Ph.D., C.Ht.
24
CIM Activities Summary (continued):
AWARDS AND HONORS (continued):
2008 Henry Ford Health System Quality and Safety Expo
Competition Winner for Chrysler & HFHS Pain Alleviation
Program
Henry Ford Health System recognized the quality of the group
pain alleviation programs offered by the Center for Integrative
Wellness. The programs offered under the umbrella of “Pain
Free in 2008” received the award for the positive health
outcomes achieved with employees of Chrysler (“Pain Free
Zone”) and HFHS ( “Living a Pain Free Life”). All
musculoskeletal pain conditions were included in the same
group and employees received 24 contact hours over about 7
months; 35% of all chronic pain conditions were eliminated.
There were also significant reductions in stress, disability, and
depression symptoms, as well as improvements in sleep quality.
2007 Focus on People 2007 Award for Chrysler Back Pain Program
Presented by the Board of Trustees of Henry Ford Health
System to Dr. Levine and his team for creating and delivering
the “We’ve Got Your Back” program to Chrysler employees
(results described above).
2007 Henry Ford Health System Quality and Safety Expo
Competition Winner for Chrysler Back Pain Program
Henry Ford Health System recognized the achievement in
enhancing quality for a major System employer group through
offering the “We’ve Got Your Back” program to Chrysler
employees (results described above).
2005 Focus on People 2005 Award
Presented by the Board of Trustees of Henry Ford Health
System for participation in the Journey to Wellness Program, an
educational and intervention program designed to support the
health and wellness of members of city of Detroit churches.
2004 Distinguished Researcher in Hypnotherapy Award Presented at the International Medical and Dental Hypnotherapy
Association annual international meeting.
Robert A. Levine, Ph.D., C.Ht.
25
CIM Activities Summary (continued):
AWARDS AND HONORS (continued):
2002 Deputy Director for National Center for Complementary and
Alternative Medicine at NIH- Interviewee
One of 3 individuals selected from several hundred applicants to
interview for the position of Deputy Director reporting to
Steven Straus, then the Director of NCCAM. Although not
selected, this was recognition of Dr. Levine’s broad expertise in
conventional basic and clinical research, experience and
productivity in NIH grant-funded research and peer-review
publications, being a practitioner of integrative medicine
therapies, and having expertise in integrative medicine basic
and clinical research.
EDUCATION AND CERTIFICATIONS:
January 2002 - April 2002 Hypnotherapy Certification (C.Ht.)
Infinity Institute, Royal Oak, MI
Basic and advanced hypnosis, regression analysis, guided
imagery, holistic hypnoanalysis
March 2002 - March 2007 Advisory Board Member, International Medical and Dental
Hypnotherapy Association
September 2000 - May 2001 Medical Acupuncture for Physicians (Dr. Joe Helms)
UCLA School of Medicine, Los Angeles, CA
300 CME credits received
Fall 1996 - Spring 2001 St. John Neuromuscular Therapy (NMT) training through
attending the following seminars: NMT1, NMT2, NMT3,
NMT5, NMT6, NMT7 offered by the St. John Neuromuscular
Pain Relief Institute, Tampa, FL. (NMT, developed by Paul St.
John, is now called Neurosomatic Therapy)
Robert A. Levine, Ph.D., C.Ht.
26
CIM Activities Summary (continued):
UNIVERSITY/INSTITUTIONAL COMMITTEES:
January 2009 – July 2012 HFHS Wellness Ambassador Team member
January 2007 – July 2012 Member, Advisory Committee for wellness activities and
Research Committee member at the new West Bloomfield
Wellness Hospital
June 1999 - June 2002 Member, Complementary/Alternative Medicine Task Force
Henry Ford Hospital, Detroit, MI
September 1999 - October 2003 Member, Committee on Complementary and Alternative
Medicine
Veterans Administration VISN 11 (midwest VAs)
SUPERVISION OF PERSONNEL:
July 2012 – Present Corporate Wellness Resources, LLC
Responsible for developing content for in-person and online
group programs, including accelerated learning strategies,
automatic pattern interruption© technology, and Effective
Muscle Release© movement routines (see www.cwrnow.com)
April 2008 – July 2012 Henry Ford Health System, Center for Integrative Wellness
Directing all activities of the award-winning group pain and
stress alleviation programs (see awards and honors) offered
onsite to self-insuring corporations.
June 2002 - April 2008 Henry Ford Health System, Center for Integrative Medicine
Direct the activities of personnel at the Center, including 1
administrative manager, 3 customer service representatives, 2
acupuncturists, 2 mind-body therapists, 2 neuromuscular
therapists, 3 massage therapists, 2 holistic nutritionists, 1
chiropractor, 1 Feldenkrais practitioner, 4 research staff
members, and 1 counseling student clinical intern.
January 1999 - December 2006 Henry Ford Health System
Clinical trial supervision using CIM modalities, serving as PI or
co-I on randomized, control clinical trials including:
1) Neurosomatic Therapy vs. relaxation massage for relieving
chronic migraine and cervicogenic headaches; (con’d below)
Robert A. Levine, Ph.D., C.Ht.
27
CIM Activities Summary (continued):
SUPERVISION OF PERSONNEL (continued):
2) CIM modalities vs. conventional physical therapy for
alleviating chronic low back pain in HFHS patients. These trials
involve overseeing the activities of approximately 20 people
including many complementary medicine practitioners,
integrative medicine research fellows, research study
coordinators, data managers, and interfacing with biostatistics
personnel.
3) acupuncture vs. venlafaxine (Effexor) for alleviating hot
flashes and other vasomotor symptoms in breast cancer patients
receiving hormone therapy.
4) in-person group programs for relief of chronic back pain at
Chrysler.
5) in-person group programs for relief of chronic all
neuromuscular pain condition, stress, and symptoms of stress-
related conditions (employees at Chrysler, HFHS, Dow
Chemical, and patients at MI BCBS).
MENTORING OF PERSONNEL:
June 2002 - November 2008 Mentorship of CIM practitioners in research and developing
multimodal protocols at the Center for Integrative Medicine:
includes 12 practitioners of many disciplines, including
acupuncture/TCM, mind-body therapies, holistic nutrition,
massage therapy, St. John Neuromuscular Therapy,
chiropractic, Feldenkrais movement reeducation, among others
November 1999 – July 2012 Alba Rodriguez, Ph.D.
August 1998 - March 2001 Elizabeth Eckert, Ph.D.: Mentored dissertation research for
Ph.D. degree from Greenwich University
GRANT SUPPORT:
Mar 2011 - Feb 2012 Blue Cross Blue Shield Michigan
“Group programs for stress and pain relief offered through
mainstream physician organizations”
P.I. - Robert A. Levine, Ph.D.
$380,000/1yr total costs
Robert A. Levine, Ph.D., C.Ht.
28
CIM Activities Summary (continued):
GRANT SUPPORT (continued):
June 2004 - May 2007 Health Alliance Plan Quantum Leaps in Quality
“Improving Quality and Reducing Cost of Care in Patients with
Chronic Back Pain Using Integrative Medicine Approaches”
P.I. - Robert A. Levine, Ph.D.
$1,000,000/3yr direct costs
June 2004 - May 2007 Susan Komen Breast Cancer Foundation
“Acupuncture for the Treatment of Vasomotor Symptoms in
Breast Cancer Patients Receiving Hormonal Therapy”
P.I. – Eleanor Walker, M.D. (Co-I: Robert A. Levine, Ph.D.)
$250,000/3yr direct costs
Sep 2006 - Aug 2006 National Institutes of Health- Agency for Healthcare Research
and Quality
“Conference on Complementary and Alternative Medicine and
End-of-Life Care”
P.I. – Robert A. Levine, Ph.D.
$25,000/1 yr direct costs
January 1999 - December 2001 Henry Ford Health System
“St. John Neuromuscular Therapy for Intractable Headaches”
P.I. - Robert A. Levine, Ph.D.
Total direct costs: $150,000
GROUP TREATMENT PROGRAMS:
1) Corporate Wellness Resources (2012-2013). Offering community-based group programs
entitled, “Ultimate Stress and Pain Free Living” in the southeast MI region.
2) Blue Cross Blue Shield Michigan (2011-2012). Contracted by the PGIP (Physician Group
Incentive Program) to treat 600 BCBSM patients for chronic pain and stress relief, recruited
through the Henry Ford Medical Group (Henry Ford Health System physician group with
over 1,200 physicians). Served as a model for recruitment of patients to group programs for
chronic pain and stress relief using other physician groups in MI.
3) Henry Ford Health System, “Stress and Pain Free Living” (2010). Team leader in hands-off
group treatment program using CAM modalities to alleviate stress and chronic
musculoskeletal pain for HFHS employees and eligible family members. Other stress-related
diseases were monitored for changes in health outcomes, including diabetes, heart disease and
high blood pressure, obesity, depression, and asthma, among others.
Robert A. Levine, Ph.D., C.Ht.
29
CIM Activities Summary (continued):
GROUP TREATMENT PROGRAMS (continued):
4) Dow Chemical, Midland, MI, “Pain Free Living” (2010). Team leader in hands-off group
treatment program using CAM modalities to reduce and eliminate pain in all musculoskeletal
pain conditions. Offered to eligible Dow employees, retirees, and family members.
5) Henry Ford Health System, “Stress and Pain Free Living” (2009). Same description as 2010.
6) Chrysler LLC, “StressLess” (started summer of 2008). Team leader in hands-off group
treatment program for Chrysler employees using CAM modalities to reduce stress and
monitor other health outcomes in employees with diabetes, heart disease and high blood
pressure, obesity, depression, and asthma, among others.
7) Chrysler LLC, “Pain Free Zone” (2008). Team leader in hands-off group treatment program
using CAM modalities to reduce and eliminate pain in all musculoskeletal pain conditions.
8) Henry Ford Health System, “Living the Pain-Free Life” (2008). Team leader in hands-off
group treatment program using CAM modalities to reduce and eliminate pain in all
musculoskeletal pain conditions.
9) DaimlerChrysler (DCC; now Chrysler, LLC), “We’ve Got Your Back” Program (2007).
Team leader of group treatment program using CAM modalities of 96 employees at the DCC
World Headquarters in Auburn Hills. Treatment started in January 2007 and was completed in
June 2007. At the end of the treatment phase, 55% of employees had eliminated their pain
compared to 0% in the untreated randomized controls. 8 months after the end of the program,
46% reported being pain free (a drop of 9%)
10) HFHS “Journey to Wellness” Program (2004-5). Participated on the planning committee for
the Journey to Wellness Program offered to Detroit churches. This multi-module program
involves providing education to church members on many health topics from cardiovascular
and heart disease to cancer and stress. Presenting to church members lectures on stress
alleviation and delivering group intervention to facilitate recognition and dissipation of stress
using mind-body therapy.
11) City of Livonia Police Department (Fall 2003). Stress alleviation program delivered using
multimodal integrative protocol. Program was delivered to 20 police officers (2 contact hours
per week for 6 weeks). Program including group lectures on nutrition/lifestyle, group
acupuncture, group somatic movement reeducation, and group hypnotherapy. Data collection
demonstrated positive benefits directly after program and at the 8 month follow-up evaluation.
Robert A. Levine, Ph.D., C.Ht.
30
MEMBERSHIPS ON EDITORIAL BOARDS:
The American Journal of Chinese Medicine
ABSTRACTS AND PUBLICATIONS:
1. Rodriguez AI, St. John P, Mitsias P, Eckert E, Rau BJA, Tashman S, Peterson E and Levine, RA.
Treatment of intractable headaches via complementary & alternative medicine using St. John
neuromuscular therapy. Society for Neuroscience Abstracts, San Diego, CA, November, 2001.
2. Rodriguez AI, St. John P, Mitsias P, Eckert E, Rau BJA, Conrad K, Tashman S, and Levine RA.
Quantitative Assessment of 3D Postural Distortion As A Tool In Alleviating Chronic Pain.
Society for Neuroscience Abstracts, Orlando, FL, November, 2002.
3. Rodriguez AI, Jiang H, Kuo K, Kuo J, Jackson Hunter T, Gautam SC, Corcoran GB, Seidman
MD, and Levine RA. Resveratrol-induced apoptotic death in cultured human U251 glioma:
Involvement of cell cycle-related proteins and nitric oxide. 1st Annual International Conference
on Cancer and Integrative Medicine, Chicago, IL, October, 2002.
4. Levine RA, Zhang L , Kuo J, Kuo K, Gautam SC, Groc L, Rodriguez AI, Koubi D, Jackson
Hunter T, Corcoran GB, Seidman MD, and Jiang H. Resveratrol induces apoptotic death of
human U251 glioma cells. Society for Neuroscience Abstracts, New Orleans, LA, November,
2003.
5. Rodriguez AI, Pocock J, and Levine RA. Reduction of chronic pain using complementary and
alternative medicine modalities, Society for Neuroscience, San Diego, CA, November 2004.
6. Rodriguez AI, Mandel SS, Nunez R, Pocock JR, Ball RM, and Levine RA. Novel treatment of
chronic low back pain (LBP): complementary and alternative medicine (CAM) therapies reduce
or eliminate pain in a controlled randomized trial. Society for Neuroscience, Washington, D.C.,
November, 2005.
7. Levine RA, Mandel SS, Nunez R, Pocock JR, Ball RM, Seidman MD & Rodriguez AI.
Randomized Controlled Clinical Trial Testing Complementary and Alternative Medicine
Therapies to Alleviate Chronic Low Back Pain. North American Research Conference on
Complementary & Integrative Medicine, Edmonton, Alberta, Canada, 2006.
8. Rodriguez AI, Pocock JR, Ball RM & Levine RA. Tracking Health Outcomes of Complementary
and Alternative Medicine Treatments in an Integrative Medicine Center. North American
Research Conference on Complementary & Integrative Medicine, Edmonton, Alberta, Canada,
2006.
Robert A. Levine, Ph.D., C.Ht.
31
CIM Activities Summary (continued):
9. Walker EM, Rodriguez AI & Levine RA. Acupuncture for the Treatment of Vasomotor
Symptoms in Breast Cancer Patients Receiving Hormonal Therapy: A Preliminary Report. North
American Research Conference on Complementary & Integrative Medicine, Edmonton, Alberta,
Canada, 2006.
10. Levine RA, St. John P, Eckert E, Rau BJA, Lang DR, Tashman S, Peterson EL, Conrad KA,
Mitsias P & Rodriguez AI. St. John Neuromuscular Therapy is Effective in Reducing Symptoms
of Intractable Headache: A Complementary and Integrative Medicine Pilot Study. North
American Research Conference on Complementary & Integrative Medicine, Edmonton, Alberta,
Canada, 2006.
11. Levine RA, Jiang H, Kuo Kelly, Kuo J, Jackson-Hunter T, Gautam SC, Corcoran GB, Seidman
MD & Rodriguez AI. Resveratrol-induced apoptotic death in human U251 glioma cells. North
American Research Conference on Complementary & Integrative Medicine, Edmonton, Alberta,
Canada, 2006.
12. Rodriguez AI, Walker EM, Kohn B, Ball RM, Pegg J, & Levine RA. Acupuncture is Superior to
Pharmacotherapy Management of Hot flashes and Other Side Effects of Conventional Breast
Cancer Care: A Preliminary Report. Integrative Medicine for Healthcare Organizations
Conference, San Diego, CA, 2007.
13. Levine RA, Nunez R, Mandel SS, Ball RM, & Rodriguez AI. Direct Comparison of
Conventional Physical Therapy vs. Two Different CAM Approaches for Chronic Back Pain: a
Randomized Clinical Trial (RCT). Integrative Medicine for Healthcare Organizations
Conference, San Diego, CA, 2007.
14. Levine RA, Nunez R, Ball RM, & Rodriguez AI. Pioneering a Hands-off Group Intervention for
Chronic Back Pain: A Paradigm Shift to Reduce Cost and Practitioner Contact Time by Over
Ninety Percent. Integrative Medicine for Healthcare Organizations Conference, San Diego, CA,
2007.
15. Levine RA, Rodriguez AI, Ball R, Asbell DA, Walsh M. Pain Elimination in the Chrysler and
HFHS Workforce. Poster: HFHS Quality Exposition Abstracts, Detroit, MI, 2008.
16. Walker EM, Rodriguez AI, Kohn B, Pegg J, Ball RM and Levine RA. Acupuncture for the
treatment of vasomotor symptoms in breast cancer patients receiving hormone suppression
treatment. International Journal of Radiation Oncology Biology Physics, 72(1): S103-S03, 2008.
17. Levine, RA: Hypnotherapy for the Treatment of Gastroesophageal Reflux Disease, Alternative
and Complementary Therapies. 15(1): 37, 2009.
Robert A. Levine, Ph.D., C.Ht.
32
CIM Activities Summary (continued):
18. Levine RA, Rodriguez AI, Nunez R, Ball R, Thayer B, Salter R, Asbell DA, Walsh M, Wisdom
K. Stress & Pain Elimination in the Chrysler and Henry Ford Health System (HFHS) Workforce.
HFHS Quality Exposition Abstracts, Detroit, MI 2009.
19. Walker EM, Rodriguez AI, Kohn B, Ball RM, Pegg J, Pocock JR, Nunez R, Peterson E, Jakary S,
& Levine RA. Acupuncture versus Venlafaxine for the Management of Vasomotor Symptoms in
Hormone Positive Breast Cancer Patients: A Randomized Controlled Trial, Journal of Clinical
Oncology, 28: 634-640, 2010.
20. Levine RA, Nunez R, Ball RM, & Rodriguez AI. An Integrative Group Wellness Program
Reduces/Eliminates Chronic Back Pain. Academy Health Annual Research Meeting, Boston,
MA, Jun 2010.
21. Rodriguez AI, Nunez R, Ball RM, Nowicki J, & Levine RA. An Integrative Group Wellness
Program Concurrently Reduces Pain and Stress, and Improves Stress-Related Chronic Illnesses.
Panelist: Academy Health Annual Research Meeting, Boston, MA, Jun 2010.
22. Levine RA, Nunez R, Ball RM, & Rodriguez AI. An Integrative Group Wellness Program
Concurrently Reduces Pain, Stress, and Improves Stress-Related Chronic Illnesses. Corporate
Wellness Conference, Los Angeles, CA, Sep 2010.
23. Nunez R, Rodriguez AI, Ball RM, & Levine RA. An Interactive Demonstration of Somatic
Functional Therapy: Implications for Enhancing the Effectiveness of Health and Wellness
Programs. National Wellness Conference. Corporate Wellness Conference, Los Angeles, CA,
Sept 2010.
24. Rodriguez AI, Nunez R, Ball RM, Wisdom K, & Levine RA. Group Wellness Program
Reduces/Eliminates Pain and Stress in the Corporate Workforce and Local Faith-Based
Community. 2010 Conference on Pain, Plymouth, MI, Oct 2010.
25. Levine RA & Rodriguez AI. Growing Wellness: Using Clinical Trials to Prove Corporate and
Faith-based Community Wellness Programs Improve Health, Reduce Healthcare Costs, and
Optimize Return on Investment. National Wellness Conference, Stevens Point, WI, July 2011
Speaker: National Wellness Conference, Stevens Point, WI, Jul 2011.
26. Levine RA, St. John P, Mitsias P, Eckert E, Rau BJA, Conrad K, Ball, RM, Peterson EL, and
Rodriguez, AI. Integrative Neurosomatic Therapy Reduces Symptoms of Intractable Chronic
Headaches, Headache, to be submitted.
27. Rodriguez AI, Ball RM, Peterson E, Cogan CM, Ball RM, and Levine RA. Tracking Health
Outcomes of Complementary and Alternative Medicine Treatments in an Integrative Medicine
Center, BMC Complementary and Alternative Medicine Journal, to be submitted.
Robert A. Levine, Ph.D., C.Ht.
33
CIM Activities Summary (continued):
28. Levine RA, Rodriguez AI, Nunez R, Anderson K, Collon DJ, Rapp J, and Seidman MD. Hypnosis
and Acupuncture as the Primary Modes of Anesthesia during Anterior Cruciate Ligament
Reconstruction Surgery (in preparation).
29. Levine RA, Rodriguez AI, Nunez R, Ball RM, Mandel SS, Jackson-Schulte O, Peterson EL, and
Seidman MD. A Multimodal Complementary and Alternative Medicine Approach is More
Effective than Conventional Physical Therapy for Eliminating Chronic Back Pain: A Randomized
Controlled Trial (in preparation).
30. Levine RA, Nunez R, Ball RM, Peterson EL, and Rodriguez AI. Reducing and Eliminating
Chronic Back Pain using a Hands-Off Group Intervention with Complementary and Alternative
Medicine Therapies: A Randomized Controlled Trial in the Corporate Workplace (in preparation).
MEDIA COVERAGE OF DR. LEVINE’S CIM ACTIVITIES (selected events):
Jul 2004 - Present Co-host of live weekly radio talk show, “Wellness Action Report”
WNZK, 690 AM band, covering wide-ranging health topics from alternative to
conventional and integrative medicine.
Dec 2002 National TV and radio coverage of HFHS press release
Anterior cruciate ligament reconstruction knee surgery using hypnosis and
acupuncture successfully to replace general and spinal anesthesia
Nov 2002 Minds of Medicine
WXYZ (ABC) TV covering HFHS Center for Integrative Medicine; topics
included treatments of failed back surgery syndrome and ACL reconstruction
knee surgery using hypnosis and acupuncture to replace general and anesthesia
July 2002 The Detroit News
The Use of Mind-Body Connection Techniques to Support Birthing
Feb 18, 2002 Henry Ford Health System Monitor
“Acupuncturist offers another healing path”
Nov 14, 2001 Detroit News
“Neuromuscular therapy brings the body back into alignment and eases pain”
Oct 3, 2001 Detroit News
“Holistic healing: Ancient ideas are new again”
Apr 23, 2001 Henry Ford Health System Monitor
“Yoga is the connection between mind, body”
Robert A. Levine, Ph.D., C.Ht.
34
CIM Activities Summary (continued):
MEDIA COVERAGE OF DR. LEVINE’S CIM ACTIVITIES (selected events):
Sep 11, 2000 Henry Ford Health System Monitor
“Planned center integrates styles of medicine”
INVITED PRESENTATIONS (selected from a larger sample):
Sept 2010 Corporate Wellness Conference
“An Integrative Group Wellness Program Concurrently Reduces Pain, Stress,
and Improves Stress-Related Chronic Illnesses Panel presentation.”
Los Angeles, CA
May 2010 Hypno-Expo 2010 (combined conference of the Association of Counselors and
Therapists and the International Medical and Dental Hypnotherapy
Association)
“Pain and Stress Elimination Techniques Used in Large Group Clinical
Research and Practice”
Daytona Beach, FL
April 2009 Invited Guest Lecture
“Group Hands-off Complementary and Alternative Medicine Treatment
Approach on site at Chrysler with Employees Having Chronic Back Pain”
Lyon, France
May 2008 Integrative Medicine for Healthcare Organizations
“A Cost-Effective and Efficient, Hands-off Group Intervention with
Employees at Chrysler LLC, Michigan, Reduces and Eliminates Chronic Back
Pain”
Phoenix, AZ
May 2008 Integrative Medicine for Healthcare Organizations
“Multimodal Complementary and Alternative Medicine (CAM) Approaches
Are Superior to Conventional Physical Therapy (PT) for Reducing and
Eliminating Chronic Back Pain: A Randomized Clinical Trial (RCT)”
Phoenix, AZ
April 2008 Institute for Health and Productivity Management
“Group Hands-off CAM Treatment Approach on site at Chrysler with
Employees Having Chronic Back Pain”
Orlando, FL
Robert A. Levine, Ph.D., C.Ht.
35
CIM Activities Summary (continued):
INVITED PRESENTATIONS (continued):
April 2007 Integrative Medicine for Healthcare Organizations
“Group Treatment of Chronic Back Pain Using CAM for DaimlerChrysler
Employees is as Effective and Much Less Costly Than 1-on-1 Treatment with
Physical Therapy”
San Diego, CA
May 2006 The North American Research Conference on Complementary & Integrative
Medicine
“Tracking Health Outcomes of Complementary and Alternative Medicine
Treatments in an Integrative Medicine Center”
Edmonton, Alberta, Canada
May 2006 The North American Research Conference on Complementary & Integrative
Medicine
“Randomized controlled clinical trial testing complementary and alternative
medicine therapies to alleviate chronic low back pain”
Edmonton, Alberta, Canada
May 2006 The North American Research Conference on Complementary & Integrative
Medicine
“Resveratrol-induced apoptotic death in human U251 glioma cells”
Edmonton, Alberta, Canada
May 2006 The North American Research Conference on Complementary & Integrative
Medicine
“Acupuncture for the Treatment of Vasomotor Symptoms in Breast Cancer
Patients Receiving Hormonal Therapy: A Preliminary Report”
Edmonton, Alberta, Canada
May 2006 The North American Research Conference on Complementary & Integrative
Medicine
“St. John Neuromuscular Therapy is Effective in Reducing Symptoms of
Intractable Headache: A Complementary and Integrative Medicine Pilot
Study”
Edmonton, Alberta, Canada
May 2006 Conference on Complementary and Alternative Medicine (CAM) and End-of-
Life Care
“The Critical Role of Research in Integrating CAM into End-of-Life Care"
Conference organizer and keynote speaker in Livonia, MI
Robert A. Levine, Ph.D., C.Ht.
36
CIM Activities Summary (continued):
INVITED PRESENTATIONS (continued):
June 2005 Fourth Stromboli Conference on Neuroimmunology, Aging, and Cancer: The
Reversal of Aging, Myth and Reality
“The Mind-body Connection as a Key Component of a Multimodal Strategy to
Alleviate Stress, and Achieve Longevity and Optimal Health”
Stromboli, Italy
October 2004 International Medical and Dental Hypnotherapy Association
“Hypnotherapy as a Key Intervention in Multimodal Therapeutic Approaches
to Improving and Resolving Chronic Illness”
Keynote speaker at the international symposium in Troy, MI
January 2004 Integrative Medicine for Healthcare Organizations
“Evidence of Efficacy: Tracking Health Outcomes of CAM Treatments in an
Integrative Medicine Center”
San Diego, CA
October 2003 International Medical and Dental Hypnotherapy Association
“Practical Applications of Hypnotherapy in an Integrative Medicine Clinic”
Royal Oak, MI
September 2003 Michigan Tremor Support Group Annual Conference
“Can Integrative Medicine Work for You?”
Berkley, MI
July 2003 Crittenton Hospital
“CAM Treatments for Cancer and Optimizing Health: A New Paradigm”
Rochester, MI
June 2003 Breast and Cervical Cancer Control Program
“Integrative Medicine for Cancer Treatment and Optimizing Health”
Bellaire, MI
May 2003 North American Womens Business Association (NAWBO)
“Complementary & Alternative Medicine (CAM): Why it’s Important You
Know About it!”
Roseville, MI
March 2003 City of Livonia Government
“Complementary and Integrative Medicine: How Can You Use it to Manage
Your Stress?”
Livonia, MI
Robert A. Levine, Ph.D., C.Ht.
37
CIM Activities Summary (continued):
INVITED PRESENTATIONS (continued):
March 2003 Wayne State University Physicians Assistant Program
“The Integration of Complementary Therapies into Conventional Medicine:
The Future Key to Optimal Healing, Health, and Longevity”
Detroit, MI
March 2003 Integrative Medicine Symposium
“The Science and Philosophy of Integrative Medicine”
Windsor, Canada
February 2003 Automobile Alliance International
“The Integration of Complementary Therapies into Conventional Medicine:
The Future Key to Optimal Healing, Health, and Longevity”
Southgate, MI
November 2002 Providence Hospital
“Research on Complementary and Integrative Medicine: Expanding the
Possibilities of Healthcare”
Southfield, MI
October 2002 International Medical and Dental Hypnotherapy Association
“Hypnotherapy: Key Modality in Multimodal Complementary and Integrative
Medicine Therapy”
Royal Oak, MI
October 2002 Michigan Tremor Support Group
“Optimizing Health Through Complementary and Integrative Medicine: You
Do Have a Choice”
West Bloomfield, MI
October 2002 Wayne County Community College
“Incorporating Integrative Medicine into Medical Practice: Critical Roles for
Research and Education”
Detroit, MI
October 2002 Renaissance Unity Church
“Rational Use of Pharmaceuticals and Complementary Medicine Therapies”
Warren, MI
Robert A. Levine, Ph.D., C.Ht.
38
CIM Activities Summary (continued):
INVITED PRESENTATIONS (continued):
September 2002 National Center for Complementary and Alternative Medicine (NCCAM)
“Incorporating Integrative Medicine into Medical Practice: Critical Roles for
Research and Education”
Bethesda, MD
May 2002 Church of Today
"Holistic Healing in Western Medicine"
Warren, MI
April 2002 Mind-Body-Spirit Festival
“New Avenues for Holistic Healing in Western Medicine”
Rochester, MI
April 2002 West Bloomfield Breast Cancer Support Group
“Cancer Treatment Using Complementary and Integrative Medicine: Creating
Balance in the Human Host”
West Bloomfield, MI
March 2002 Birmingham Rotary Club
“The Integration of Alternative and Conventional Therapies: A New Approach
to Providing Healthcare”
Birmingham, MI
March 2002 Henry Ford Health Sciences Center Research Seminar
“Research and Clinical Care in Henry Ford Health System’s Center for
Complementary and Integrative Medicine: Expanding the Possibilities of
Healthcare”
Detroit, MI
February 2002 Good Company Cable TV Show
“Complementary and Integrative Medicine”
Dearborn, MI
January 2002 Dearborn Rotary Club
“The Integration of Alternative and Conventional Therapies: A New Paradigm
for Medical Care in the United States”
Dearborn, MI
Robert A. Levine, Ph.D., C.Ht.
39
CIM Activities Summary (continued):
INVITED PRESENTATIONS (continued):
November 2001 Cancer Care Symposium, Mercy Hospital
“Market Presence, Research, and Ethics of Complementary and Integrative
Medicine: Emphasis on Cancer Treatment”
Port Huron, MI
September 2001 American College of Physicians, American Society of Internal Medicine
“Complimentary and Integrative Medicine (CIM): Market Presence, Ethics,
and Research”
Traverse City, MI
May 2001 Christus Health System
“Complimentary and Integrative Medicine (CIM): Market Presence, Ethics,
and Research”
San Antonio, TX
February 2001 Department of Neurology Grand Rounds, Henry Ford Health System
“Complementary and Alternative Medicine (CAM) in the Department of
Neurology, HFHS”
Detroit, MI
January 2001 Department of Pharmaceutical Sciences, Wayne State University
“The Arrival of Complementary and Alternative Medicine (CAM): Impact on
Conventional Western Medicine”
Detroit, MI
December 1999 Ethics Advisory Council, Henry Ford Health System
“Ethics and Complementary/Alternative Medicine (CAM)”
Detroit, MI
September 1999 Board of Governors, Henry Ford Health System
“Complementary/Alternative Medicine Activities in the Henry Ford Health
System”
Detroit, MI
End of Integrative Medicine Activity Summary
Robert A. Levine, Ph.D., C.Ht.
40
BIBLIOGRAPHY
PUBLICATIONS IN SCIENTIFIC JOURNALS:
1. Robinson, D.S., Levine, R.A., Williams, A. and Statham, N.: Hydroxylase cofactor in human
CSF- An index of central aminergic activity. Psychopharm. Bull. 14: 49-51, 1978.
2. Van Kammen, D.P., Levine, R.A., Sternberg, D., Ballenger, J., Marder, S., Post, R. and Bunney,
W. Jr.: Preliminary evaluation of hydroxylase cofactor in human spinal fluid: Potential
biochemical and clinical relevance in the study of psychiatric disease. Psychopharm. Bull.
14: 51-52, 1978.
3. Levine, R.A., Kuhn, D.M. and Lovenberg, W.: Regional distribution of hydroxylase cofactor in
rat brain. J. Neurochem. 32: 1575-1578, 1979.
4. Lovenberg, W., Levine, R.A., Robinson, D.S., Ebert, M., Williams, A.C. and Calne, D.B.:
Hydroxylase cofactor activity in cerebrospinal fluid of normal subjects and patients with
Parkinson's Disease. Science 204: 624-626, 1979.
5. Levine, R.A., Williams, A.C., Robinson, D.S., Calne, D.B. and Lovenberg, W.: Analysis of
hydroxylase cofactor activity in human cerebrospinal fluid of patients with Parkinson's disease.
Advances in Neurology, 24: 303-307, 1979.
6. Williams, A.C., Eldridge, R., Levine, R.A., Lovenberg, W. and Paulson, G.: Low CSF
hydroxylase cofactor (tetrahydrobiopterin) levels in inherited dystonia. Lancet 2 8139: 410-411,
1979.
7. Williams, A., Ballenger, J., Levine, R.A., Lovenberg, W. and Calne, D.B.: The effect of aging
on CSF hydroxylase cofactor levels. Neurology 30: 1244-1246, 1980.
8. Williams, A.C., Levine, R.A., Calne, D.B., Chase, T.N. and Lovenberg, W.: CSF hydroxylase
cofactor levels in some neurological diseases. J. Neurosurgery and Psychiatry 43: 735-738, 1980.
9. Hanson, G. R., Alphs, L., Wolf, W., Levine, R.A. and Lovenberg, W.: Haloperidol-induced
reduction of nigral substance P-like immunoreactivity: A probe for the interaction between
dopamine and substance P neuronal systems. J. Pharmacol. Exp. Ther. 218: 568-574, 1981.
10. Levine, R.A., Miller, L. and Lovenberg, W.: Tetrahydrobiopterin in the striatum: Localization in
dopamine nerve terminals and its role in catecholamine synthesis. Science 214: 919-921, 1981.
11. Garbutt, J.C., van Kammen, D.P., Levine, R.A., Sternberg, D.E., Murphy, D.L., Ballenger, J.,
Bunney, W.E., Jr. and Lovenberg, W.: Cerebrospinal fluid hydroxylase cofactor in
schizophrenia. Psychiatry Res. 6: 145-151, 1982.
Robert A. Levine, Ph.D., C.Ht.
41
PUBLICATIONS IN SCIENTIFIC JOURNALS (continued):
12. Curtius, H.-Ch., Niederwieser, A., Levine, R.A. and Muldner, H.: Effectiveness of
tetrahydrobiopterin in the treatment of Parkinson's disease. Adv. Neurol. 33: 1983.
13. LeWitt, P., Miller, L., Insel, T., Calne, D., Lovenberg, W., Levine, R.A. and Chase, T.: Tyrosine
hydroxylase cofactor (tetrahydrobiopterin) in Parkinsonism. Adv. Neurol. 40: 459-462, 1983.
14. Curtius, H.-Ch., Niederwieser, A., Levine, R.A., Lovenberg, W., Woggon, B., and Angst, J.:
Successful treatment of depression with tetrahydrobiopterin. Lancet l: 657-658, 1983.
15. Heintel, D., Ghisla, S., Curtius, H.-Ch., Niederwieser, A., and Levine, R.A.: Biosynthesis of
tetrahydrobiopterin: Possible involvement of tetrahydropterin intermediates. Neurochem. Int. 6:
141-155, 1984.
16. Levine, R.A. and Lovenberg, W.: CSF tetrahydrobiopterin levels in patients with affective
disorders. Lancet l: 284, 1984.
17. Culvenor, A.J., Miller, L.P., Levine, R.A., and Lovenberg, W.: Effect of methotrexate on
biopterin levels and synthesis in rat cultured pineal glands. J. Neurochem. 42: 1707-1714, 1984.
18. Levine, R.A., Pollard, H.B., and Kuhn, D.M.: A rapid and simplified assay method for tyrosine
hydroxylase. Anal. Biochem. 143: 205-208, 1984.
19. Kelner, K.L., Levine, R.A., Morita, K., and Pollard, H.B.: A comparison of trihydroxyindole and
HPLC/electrochemical methods for catecholamine measurement in adrenal chromaffin cells.
Neurochem. Int. 7: 373-378, 1985.
20. LeWitt, P.A., Levine, R.A., Lovenberg, W., Pomara, N., Stanley, M., Schlick, P., Roberts, R.,
and Gurevich, D.: Biopterin, neopterin, and monoamine neurotransmitter metabolites in
Alzheimer-type dementia. Neurology, 35: 265, 1985.
21. LeWitt, P., Miller, L., Levine, R.A., Lovenberg, W., Newman,R., Papavasiliou, A., Rayes, A.,
Eldridge, R., and Burns, R. Tetrahydrobiopterin in dystonia: Identification of abnormal
metabolism and therapeutic trials. Neurology 36: 760-764, 1986.
22. LeWitt, P., Miller, L., Levine, R.A., Lovenberg, Newman, R., Papavasiliou, A., Rayes, A.,
Eldridge, R., and Burns, R. Pterin Abnormalities in Dystonia: A Metabolic Marker with
Therapeutic Implications. Adv. Neurol. 50: 193-201, 1988.
23. Levine, R.A., Zoephel, G.P., Niederwieser, A., and Curtius, H.C.: Entrance of tetrahydropterin
derivatives in brain after peripheral administration: Effect on biogenic amine metabolism. J.
Pharmacol. Exp. Ther. 242: 514-522, 1987.
Robert A. Levine, Ph.D., C.Ht.
42
PUBLICATIONS IN SCIENTIFIC JOURNALS (continued):
24. Fink, J.K., Ravin, P., Argoff, C., Levine, R.A., Brady, R., Hallett, M., and Barton, N.:
Tetrahydrobiopterin administration in biopterin-deficient progressive dystonia with diurnal
variation. Neurology, 39: 1393-1395, 1989.
25. Levine, R.A., Kapatos, G., Kaufman, S., and Milstien, S.: Immunological evidence for the
requirement of sepiapterin reductase for tetrahydrobiopterin biosynthesis in brain. J. Neurochem.,
54: 1218-1224, 1990.
26. Wolf, W.W., Anastasiadis, P.A., Kuhn, D.M., and Levine, R.A.: Influence of
Tetrahydrobiopterin on Serotonin Synthesis, Metabolism, and Release in Synaptosomes.
Neurochem. Int., 16: 335-340, 1990.
27. Citron, B.A., Milstien, S., Gutierrez, J.C., Levine, R.A., Yanak, B.L., and Kaufman, S.: Isolation
and Expression of Rat Liver Sepiapterin Reductase cDNA. Proc. Nat. Acad. Sci. 87: 6436-6440,
1990.
28. Park, Y.S., Heizmann, C.W., Wermuth, B., Levine, R.A., Steinerstauch, P., Guzman, J., and
Blau, N. Human carbonyl and aldose reductases: New catalytic functions in tetrahydrobiopterin
biosynthesis. Biochem. Biophys. Res. Comm., 175: 738-744, 1991.
29. Wolf, W.A., Zaija. E., Arthur, R.A. Jr., Anastasiadis, P.Z., Levine, R.A., and Kuhn, D.M. Effect
of tetrahydrobiopterin on serotonin synthesis, release, and metabolism in superfused hippocampal
slices. J. Neurochem., 57: 1191-1197, 1991.
30. Fleischhacker, W.W., Levine, R.A., Lieberman, J.A., Pollack, S., Johns, C.A., and Richardson,
M.A. Neopterin and biopterin CSF levels in tardive dyskinesia after clozapine treatment. Biol.
Psychiatry, 34:741-745, 1993.
31. Takahashi, H., Levine, R.A., Galloway, M.P., Snow, B.J., Calne, D.B., and Nygaard, T.G.
Biochemical and fluorodopa positron emission tomographic findings in an asymptomatic carrier
of the gene for DOPA-responsive dystonia. Ann. Neurol., 35: 354-6, 1994.
32. Nygaard, T.G., Waran, S.P., Levine, R.A., Naini, A.B., and Churtorian, A.M.: Dopa-responsive
dystonia simulating cerebral palsy. Pediatr. Neurol., 11: 236-40, 1994.
33. Anastasiadis, P.Z., Kuhn, D.M., and Levine, R.A.: Tetrahydrobiopterin uptake in rat brain
synapatosomes, cultured PC12 cells, and rat striatum. Brain Res., 665: 77-84, 1994.
34. Anastasiadis P.Z., Imerman B., Kuhn D.M., and Levine R.A.: Nitric oxide and catecholamine
synthesis: Involvement in tetrahydrobiopterin-mediated PC12 cell proliferation. Pteridines, 6 (3):
132-134, 1995.
Robert A. Levine, Ph.D., C.Ht.
43
PUBLICATIONS IN SCIENTIFIC JOURNALS (continued):
35. Anastasiadis P.Z., Kuhn D.M., Blitz, J., Imerman, B.A., Louie, M.C., and Levine R.A.: Regulation
of tyrosine hydroxylase and tetrahydrobiopterin biosynthetic enzymes in PC12 cells by NGF, EGF
and IFN-. Brain Res., 713: 125-133, 1996.
36. Anastasiadis, P.Z., States, J.C., Imerman, B.A., Louie, M.C., Kuhn, D.M., and Levine, R.A.:
Mitogenic effects of tetrahydrobiopterin in PC12 cells. Mol. Pharmacol., 49: 149-155, 1996.
37. Anastasiadis P.Z., Imerman B., Louie M.C., States J.C., Kuhn D.M., and Levine R.A.:
Tetrahydrobiopterin as a mediator of PC12 cell proliferation induced by EGF and NGF. European J. Neuosci. 9: 1831-1837, 1997.
38. Bezin, L., Nygaard, T.G., Neville, J.D., Shen, H., and Levine, R.A.: Reduced lymphoblast
neopterin detects GTP cyclohydrolase dysfunction in dopa-responsive dystonia. Neurology 50(4):
1021-1027, 1998.
39. Anastasiadis, P.Z., Imerman, B., Blitz, J., Flam, M., Kuhn, D.M., and Levine, R.A.: Vasoactive
intestinal peptide induces both tyrosine hydroxylase and BH4 biosynthesis in PC12 cells.
Neuroscience 86: 179-189, 1998.
40. Groc, L., Levine, R.A., Foster, J.A., Normile, H.J., Weissmann, D., and Bezin, L.: Evidence of
deprenyl-insensitive apoptosis of nigral dopamine neurons during development. Brain Res. Dev.
Brain Res. 120: 95-98, 1999.
41. Anastasiadis, P.Z., Bezin, L., Imerman, B., Blitz, J., Kuhn, D.M., and Levine, R.A.:
Tetrahydrobiopterin enhances apoptotic PC12 cell death following withdrawal of trophic support.
J. Biol. Chem. 276: 9050-9058, 2001.
42. Groc, L., Bezin, L., Foster, J.A., Jiang, H., Jackson, T.S., Weissmann, D., and Levine, R.A.:
Lipid peroxidation-mediated oxidative stress and dopamine neuronal apoptosis in the substantia
nigra during development. Neurochem. Int. 39(2): 127-133, 2001.
43. Groc, L., Bezin, L., Jiang, H., Hunter, T.S., Weissmann, D., Levine, R.A.: Bax, bcl-2, cyclin
expression, and apoptosis in rat substantia nigra during development. Neurosci. Let. 306(3): 198-
202, 2001.
44. Groc L., Jackson T., Jiang H., Bezin L., Koubi D., Corcoran G., and Levine R.A. Nitric oxide
synthase inhibition during development: effect on apoptotic death of dopamine neurons. Dev.
Brain Res. 138: 147-153, 2002.
45. Foster, J.A., P.L. Christopherson, and R.A. Levine. GTP cyclohydrolase I induction in striatal
astrocytes following intrastriatal kainic acid lesion. J. Chem. Neuroanat., 24: 173-179, 2002.
Robert A. Levine, Ph.D., C.Ht.
44
PUBLICATIONS IN SCIENTIFIC JOURNALS (continued):
46. Foster, J.A., Bezin, L., Groc, L., Christopherson, P.L., and Levine, R.A.: Kainic acid lesion-
induced nigral neuronal death. J. Chem. Neuroanat., 26: 65-73, 2003.
47. Groc L, Hunter T, Jiang H, Bezin L, Levine RA: Developmental cell death and oxidative stress:
lessons from nigral dopamine neurons, Annals of New York Academy of Science 991: 307-310,
2003.
48. Tabakman, R., Jiang, H., Levine, R.A. , Kohen, R., and Lazarovici, P.: Apoptotic characteristics
of cell death and the neuroprotective effect of homocarnosine on pheochromocytoma PC12 cells
exposed to ischemia. J. Neurosci. Res. 75: 499-507, 2004
49. Tabakman, R., Jiang, H, Schaefer, E., Levine, R.A., and Lazarovici, P.: Nerve growth factor
(NGF) pretreatment attenuetes oxygen-glucose-deprivation induced c-Jun NH2-terminal kinase 1
and stress activated kinases p-38 alpha and p-38 beta activation and confers neuroprotection in
the pheochromocytoma PC12 model. J. Mol. Neurosci. 22: 237-250, 2004.
50. Koubi D, Jiang H, Zhang LJ, Tang W, Kuo J, Rodriguez AI, Hunter T, Seidman MD, Corcoran
GB, Levine RA (2004) Role of the Bcl-2 family of proteins in mediating apoptotic death of PC12
cells exposed to oxygen and glucose deprivation, Neurochem. Int. 46:73-81, 2005.
51. Jiang, H, Koubi, D, Zhang, L, Kuo, J, Rodriguez, AI, Jackson Hunter, T, Gautam, SC, and
Levine, RA: Inhibitors of iNOS protects PC12 cells against the apoptosis induced by oxygen and
glucose deprivation. Neurosci. Let. 375: 59-63, 2005.
52. Jiang, H, Zhang, L, Koubi, D, Kuo, J, Groc, L, Rodriguez, AI, Jackson-Hunter, T, Tang, S,
Lazarovici, P, Gautam, SC, and Levine, RA. Roles of Ras-Erk in apoptosis of PC12 cells induced
by trophic factor withdrawal or oxidative stress, J. Mol. Neurosci. 25:133-40, 2005.
53. Jiang H, Zhang LJ, Kuo J, Kuo K, Groc L, Rodriguez AI, Koubi D, Hunter T, Corcoran GB,
Seidman MD, Gautam SC, Levine RA. Resvetratrol-induced apoptotic cell death in human U251
glioma cells. Mol. Cancer Therapeutics 4:554-61, 2005.
54. Angoa-Pérez M, Jiang H, Rodríguez AI, Lemini-Guzmán C, Levine RA, and Rivas-Arancibia S.
Estrogen treatment counteracts the oxidative stress and loss of dopamine neurons in rat substantia
nigra produced by chronic ozone inhalation. NeuroReport, 17: 629-633, 2006.
55. Levine, RA: Hypnotherapy for the Treatment of Gastroesophageal Reflux Disease, Alternative and
Complementary Therapies. 15(1): 37, 2009.
56. Levine RA, St. John P, Mitsias P, Eckert E, Rau BJA, Conrad K, Ball, RM, Peterson EL, and
Rodriguez, AI. Integrative Neurosomatic Therapy Reduces Symptoms of Intractable Chronic
Headaches, Headache, to be submitted.
Robert A. Levine, Ph.D., C.Ht.
45
PUBLICATIONS IN SCIENTIFIC JOURNALS (continued):
57. Rodriguez AI, Ball RM, Peterson E, Cogan CM, Ball RM, and Levine RA. Tracking Health
Outcomes of Complementary and Alternative Medicine Treatments in an Integrative Medicine
Center, BMC Complementary and Alternative Medicine Journal, to be submitted.
58. Levine RA, Rodriguez AI, Nunez R, Anderson K, Collon DJ, Rapp J, and Seidman MD. Hypnosis
and Acupuncture as the Primary Modes of Anesthesia during Anterior Cruciate Ligament
Reconstruction Surgery (in preparation).
59. Levine RA, Rodriguez AI, Nunez R, Ball RM, Mandel SS, Jackson-Schulte O, Peterson EL, and
Seidman MD. A Multimodal Complementary and Alternative Medicine Approach is More
Effective than Conventional Physical Therapy for Eliminating Chronic Back Pain: A Randomized
Controlled Trial (in preparation).
60. Levine RA, Nunez R, Ball RM, Peterson EL, and Rodriguez AI. Reducing and Eliminating
Chronic Back Pain using a Hands-Off Group Intervention with Complementary and Alternative
Medicine Therapies: A Randomized Controlled Trial in the Corporate Workplace (in preparation).
61. Walker EM, Rodriguez AI, Kohn B, Ball RM, Pegg J, Pocock JR, Nunez R, Peterson E, Jakary S,
& Levine RA. Acupuncture versus Venlafaxine for the Management of Vasomotor Symptoms in
Hormone Positive Breast Cancer Patients: A Randomized Controlled Trial, Journal of Clinical
Oncology, 28: 634-640, 2010.
Robert A. Levine, Ph.D., C.Ht.
46
BOOK CHAPTERS:
1. Eisler, T., Calne, D.B., Ebert, M.H., Kopin, I.J., Ziegler, M.G. and Levine, R.A.: Biochemical
measurements during (-)deprenyl treatment of Parkinsonism. In: MAO Structure, Function, and
Altered Function, Murphy, D., Singer, T., and Vonkoff, R. (Eds.), New York, Academic Press,
1979, pp. 497-506.
2. Lovenberg, W., Alphs, L., Pradhan, S., Bruckwick, E. and Levine, R.A.: Long-term haloperidol
and factors affecting the activity of striatal tyrosine hydroxylase. In: Advances in Biochemistry
and Psychopharmacology, Racagni, G., Spano, O. and Catabeni, F. (Eds.), Raven Press, New
York, pp. 9-15, 1980.
3. Levine, R.A., Kuhn, D.M., Williams, A.C. and Lovenberg, W.: The influence of aging on
biogenic amine synthesis: The role of the hydroxylase cofactor. In: Influence of Age on the
Pharmacology of Psychoactive Drugs, Raskin, A., Robinson, D.S. and Levine, J. (Eds.), Elsevier,
New York, pp. 37-46, 1981.
4. Levine, R.A., Lovenberg, W., Niederwieser, A., Leimbacher, W., Redwick, U., Staudenmann,
W., and Curtius, H.-Ch.: Penetration of reduced pterins into rat brain: Effect on biogenic amine
synthesis. In: Chemistry and Biology of Pteridines, Blair, J.A. (Ed.), Walter de Gruyter, Berlin,
New York, pp. 176-182, 1983.
5. Levine, R.A., Lovenberg, W., Curtius, H-Ch., and Niederwieser, A.: Speculation on the
mechanism of therapeutic action of tetrahydrobiopterin in human disease. In: Chemistry and
Biology of Pteridines, Blair, J.A. (Ed.), Walter de Gruyter, Berlin, New York, pp. 833-837, 1983.
6. Curtius, H.-Ch., Hausermann, M., Heintel, D., Niederwieser, A., and Levine, R.A.: Perspectives
on tetrahydrobiopterin biosynthesis in mammals. In: Chemistry and Biology of Pteridines, Blair,
J.A. (Ed.), Walter de Gruyter, Berlin, New York, 1983.
7. Lovenberg, W., Levine, R.A., Aiken, M.A., Miller, L.P. and LeWitt, P.: Regulation of biogenic
amine synthesis by the hydroxylase cofactor and its relation to aging and parkinsonism. In:
Intervention in the Aging Process, Part A, Regelson, W. and Sinex, F.M. (Eds.), Alan R. Liss,
Inc., New York, pp. 215-224, 1983.
8. Levine, R.A., Heintel, D., Leimbacher, W., Niederwieser, A., Curtius, H.-Ch., and Ghisla, S.:
Recent advances in tetrahydrobiopterin biosynthesis and the treatment of human disease. In:
Biochemical and Clinical Aspects of Pteridines, Vol. 2, Wachter, H., Curtius, H.-Ch., and
Pfleiderer, W. (Eds.), Walter de Gruyter, Berlin and New York, pp. 325-337, 1983.
9. Levine, R.A., Zoephel, G.P., Niederwieser, A. and Curtius, H.-Ch.: Tetrahydrobiopterin
analogues and their ability to enter the rat striatum after peripheral administration. In:
Biochemical and Clinical Aspects of Pteridines, Vol. 4, Wachter, H., Curtius, H.-Ch., and
Pfleiderer, W. (Eds,), Walter de Gruyter, Berlin and New York, pp. 267-276, 1985.
Robert A. Levine, Ph.D., C.Ht.
47
BOOK CHAPTERS (continued):
10. Levine, R.A. and Kelner, K.L.: Tetrahydrobiopterin and the regulation of catecholamine
synthesis in bovine adrenal medullary chromaffin cells. In: Chemistry and Biology of Pteridines,
B.A. Cooper and V.W. Whitehead (Eds.), Walter de Gruyter, Berlin, New York, pp. 373-76,
1986.
11. Galloway, M.P. and Levine, R.A.: Modulation of dopamine synthesis by nerve terminal
autoreceptors: A role for tetrahydrobiopterin? In: Chemistry and Biology of Pteridines, B.A.
Cooper and V.W. Whitehead (Eds.), Walter de Gruyter, Berlin, New York, pp. 347-50, 1986.
12. Levine, R.A. and Galloway, M.P.: The regulation of biogenic amine synthesis and role of
tetrahydrobiopterin. In: Unconjugated Pterins in Neurobiology: Basic and Clinical Aspects, W.
Lovenberg and R.A. Levine (eds.), Taylor and Francis, London, New York, pp. 119-130, 1987.
13. Levine, R.A.: Tetrahydrobiopterin and biogenic amine metabolism in neuropsychiatry,
immunology, and aging. In: Neuroimmunomodulation: Interventions in aging and cancer - First
Stromboli Conference on Aging and Cancer. W. Pierpoali, N.H. Specter, and B. Jankovic.
Annals of New York Academy of Sciences, pp. 129-139, 1987.
14. Levine, R.A., Wolf, W.A., Anastasiadis, P.Z., and Kuhn, D.M.: Effects of tetrahydrobiopterin on
the synthesis of serotonin in brain slices and synaptosomes: Implications for the use of BH4 as a
therapeutic agent. In: Chemistry and Biology of Pteridines, H.-Ch. Curtius and N. Blau (Eds.),
Walter de Gruyter, Berlin, New York, pp. 497-504, 1989.
15. Anastasiadis, P.Z., Wolf, W.A., Levine, R.A., and Kuhn, D.M.: Studies of tetrahydrobiopterin
uptake in rat brain synaptosomes. In: Chemistry and Biology of Pteridines, H.-Ch. Curtius and N.
Blau (Eds.), Walter de Gruyter, Berlin, New York, pp. 648-651, 1989.
16. Levine, R.A., Solus, J.F., Goustin, A.S., Tait, S., Demetriou, S., Citron, B., and Kaufman, S.:
Isolation of a putative cDNA encoding human brain sepiapterin reductase. In: Pterins and
Biogenic Amines in Neurology, Pediatrics, and Immunology, N.Blau, H.-Ch. Curtius, R.A.
Levine, and R.G.H. Cotton (Eds.), Lakeshore Publishing, pp. 81-88, 1991.
17. Anastasiadis, P.Z., Wolf, W.A., Kuhn, D.M., and Levine, R.A.: Sudies on the mechanism of
cellular tetrahydrobiopterin uptake. In: Pteridines and Related Biogenic Amines and Folates-
1992, N. Blau, H.-Ch. Curtius, R.A. Levine, and J. Yim (Eds.), Hanrim Publishing, Korea, pp.
116-122, 1992.
18. Levine, R.A., States, J.C., Anastasiadis, P.Z., and Kuhn, D.M.: Cloning and characterization of
genes encoding tetrahydrobiopterin biosynthetic enzymes. In: Chemistry and Biology of
Pteridines and Folates, J.E. Ayling, M.G. Nair, and C.M. Baugh (Eds.), Plenum Press, New York,
pp. 139-145, 1993
Robert A. Levine, Ph.D., C.Ht.
48
BOOK CHAPTERS (continued):
19. Anastasiadis, P.Z., States, J.C., Kuhn, D.M., and Levine, R.A.: Co-induction of
tetrahydrobiopterin (BH4) levels and tyrosine hydroxylase activity in cultured PC12 cells. In:
Chemistry and Biology of Pteridines and Folates, J.E. Ayling, M.G. Nair, and C.M. Baugh (Eds.),
Plenum Press, New York, pp. 227-230, 1993.
20. Bezin, L., Anastasiadis, P.Z., Corcoran, G.B., Nygaard, T.G., and Levine, R.A.:
Tetrahydrobiopterin Metabolism in Cell Death by Apoptosis. In: Chemistry and Biology of
Pteridines and Folates, H. Rokos and W. Pfleiderer (Eds.), Blackwell Publishers, Berlin, pp 747-
754, 1997.
21. Bezin, L., Nygaard, T.G., Anastasiadis, P.Z., and Levine, R.A.: Tetrahydrobiopterin metabolism
and GTP cyclohydrolase I mutations in L-dopa-responsive dystonia. In: Proceedings of the Third
International Dystonia Symposium, S. Fahn and C.D. Marsden (Eds.), (in press).
22. Groc L, Bezin L, Jiang H, Hunter
T, Foster JA, Levine RA: Inhibition of oxidative stress during
developmental cell death: Cellular and behavioral effects. In: Chemistry and Biology of
Pteridines and Folates, S. Milstien, G. Kapatos, R.A. Levine and B. Shane (Eds), Kluwer
Academic Publishers, Boston/Dordrecht/London, pp399-404, 2002.
23. Jiang H, Koubi D, Groc L, Hunter T, Anastasisdis PZ, Rodriguez AI, Corcoran GB, Levine RA:
The role of tetrahydrobiopterin (BH4) in apoptosis of catecholamine (PC12) cells induced by
trophic factor withdrawal. In: Chemistry and Biology of Pteridines and Folates, S. Milstien, G.
Kapatos, R.A. Levine and B. Shane (Eds), Kluwer Academic Publishers,
Boston/Dordrecht/London, pp405-408, 2002.
24. Koubi D, Jiang H, Hunter T, Anastasisdis PZ, Rodriguez AI, Corcoran GB, Levine RA (2002)
The involvement of tetrahydrobiopterin in ischemia-induced apoptosis. In: Chemistry and
Biology of Pteridines and Folates, S. Milstien, G. Kapatos, R.A. Levine and B. Shane (Eds),
Kluwer Academic Publishers, Boston/Dordrecht/London, pp409-413, 2002.
25. Foster JA, Levine RA: Tetrahyrdobiopterin (BH4)-medidated neuronal death following
intrastriatal kainic acid: implications for Parkinson's disease. In: Chemistry and Biology of
Pteridines and Folates, S. Milstien, G. Kapatos, R.A. Levine and B. Shane (Eds), Kluwer
Academic Publishers, Boston/Dordrecht/London, pp393-397, 2002.
26. Koubi D, Jiang H, Hunter T, Rodriguez AI, Corcoran GB, Levine RA: Tetrahydrobiopterin
(BH4) mediates necrotic death of PC12 cells exposed to ischemia-like conditions. In: Pterins,
Folates, and Neurotransmitters in Molecular Medicine, SPS Verlagsgesellscraft mbH, Heilbronn,
Germany, pp. 35-40, 2003.
27. Levine, RA: Dr. Bob Levine on Health and Wellness. In: You Make a Difference, Babypie
Publishing, Waitsfield, VT, USA, pp. 79-87, 2012. (Amazon Best Seller)
ABSTRACTS: (full list provided on request)