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Cord Blood“ The Hidden Treasure of Life ”
Presented By
Asma I. Al-Asad
Laboratory Manager
Damascus, 2009
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Dubai Cord Blood & Research Centre (DCRC)
Established in 2006 as a turnkey project
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Dubai Cord Blood & Research Centre (DCRC)
Total Cost 17.5 million AED• 5.5 m Equipment.
• 12 m construction.
Total Built area 1303 m2• Ground Floor area 777 m2
• First Floor area 526 m2
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Mission
To provide high quality HLA-typed units for transplantation to patients in need.
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Goals of DCRC
To build a Cord-Blood Bank that captures the rich ethnic diversity of the Arab population & the Middle East.
To develop a programme which results in the highest quality units exceeding National and International standards.
Engage with the International Registries to include DCRC units.
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DCRC Services
Collect, Process, Test and Store Umbilical Cord Blood stem cell to be used for future therapy.
Perform the Molecular HLA Typing test for patients in need.
Perform a search for possible match for the patients worldwide.
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Organization Structure
DCRC
Administrative Service Unit
Laboratory Unit
Stem Cell Lab HLA LabFlocytometry
LabCord Blood
Registry Collection
Subunit
Donor Counseling
office
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Total No. of stuff (18)
Medical Director : 1 Lab Manager : 1 Registration : 2 Collection & Counseling : 3 Stem Cell Lab : 4 Specialized Lab : 3 Lab Attendance : 2 Cleaner : 2
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DCRC international Recognition & agreements
Nov 2006 : Member of International Cord Blood Society (ICBS).
Jan 2007: signed a contract with KSA (Dallah Group) to collect CBU from GCC countries.
June 2008: Registered in Netcord Virtual Office. January 2009: Associate member of FACT-NetCord
Foundation. March 2009: Opened a collection center that is Orient
Stem Cell Center to Collect CBU.
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Mixed Cord Blood Bank
Collection Method“In-Utero ”
the placenta is still in Uterus
•Directed Cord Blood Donation= 1365 CBU
•Volunteer Cord Blood Donation= 199 CBU
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Statistics(2006-2008)
343
709512
0
100
200
300
400
500
600
700
800
Year 2006 Year 2007 Year 2008
Cord Blood Collections 2006-2008
Year 2006
Year 2007
Year 2008
217126
509
200
424
880
100
200
300
400
500
600
Year 2006 Year 2007 Year 2008
Accepted & Rejected CBUs 2006-2008
Accepted
Rejected
Related & Volunteer Percentage
358
454
141665578
0
100
200
300
400
500
Year 2006 Year 2007 Year 2008
Related
Volunteer
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Total CBU stored 1564UAE
BahrainOman
EygptLebanon
CyprusItaly
0
200
400
600
800
1000
1200
1400
1600
Series1 1500 35 15 4 3 2 1
UAE Bahrain Oman Eygpt Lebanon Cyprus Italy
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3 Units → Transplants
_ University of Minnesota Cancer Centre/USA.
_ King Hussein Cancer Centre/ Jordan.
_ Royal Marsden Hospital/ UK.
47 Units → Allocated for patients.
Used & Allocated Units
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Cord-Blood Processing2006- 2009: Manually
April 2009: Automated By Sepax System
Method: Volume reduction by depletion. Clean room Temp=14-19˚Celcius Pressure = 25 Pascals Humidity = 45%
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Processing Criteria Volume of accepted cord blood ≥ 40 ml. Nucleated cell count ≥ 6.0 x 106 cells ml-1. Viability of cells ≥ 90%. Pre-CD34 ≥ 106 cells ml-1. Recovery rate ≥ 60%.
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CryopreservationThe Final Volume stored= 25ml
The CBU is stored in monitored liquid Nitrogen tanks in -196˚C, for ~ 15-20 years.
Extremely low temperatures inhibit the cellular activities when a cryo-preservative is used.
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Cord blood has been successfully used to treat over 70 different diseases to date.
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Don’t Throw it Away…
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Cord Blood“ The Hidden Treasure of Life ”
Presented By
Asma I. Al-Asad
Laboratory Manager
Damascus, 2009