BIOPHARMACEUTICS & DRUG DISPOSITION
Biopharm. Drug Dispos
Contents Volume 25, Numbers 1-9
ISSUE 1 JANUARY 2004
ORIGINAL PAPERS
Comparative Pharmacokinetics of Acetyl Salicylic Acid and its Metabolites in Children Suffering
from Autoimmune Diseases
H. Juarez Olguin, J. Flores Pérez, I. Lares Asseff, A. Loredo Abdala and L. Carbajal Rodriguez
Transdermal Delivery System for Zidovudine: in vitro, ex vivo and in vivo Evaluation
S. T. K. Narishetty and R. Panchagnula
Comparative Evaluation of Digoxin Concentrations Determined by Three Assay Systems: TDx,
IMx and OPUS
Y. Kagawa, T. Iwamoto, H. Matsuda, R. Mukohara, J.-I. Sawada and M. Kojima
Disposition of WR-1065 in the Liver of Tumor-bearing Rats Following Regional vs Systemic
Administration of Amifostine
M. Levi, S. J. DeRemer, C. Dou, W. D. Ensminger and D. E. Smith
In vitro Investigation on the Impact of the Surface-active Excipients Cremophor EL, Tween 80
and Solutol HS 15 on the Metabolism of Midazolam
R. C. Bravo Gonzalez, J. Huwyler, F. Boess, I. Walter and B. Bittner
ISSUE 2 MARCH 2004
ORIGINAL PAPERS
Steady-State Pharmacokinetics of Fluvastatin in Healthy Subjects Following a New Extended
Release Fluvastatin Tablet, Lescol XL D. Barilla, P. Prasad, M. Hubert and K. Gumbhir-Shah
Rapid Determination Method of Caffeine and Application to Monitoring of Caffeine-Assisted
Chemotherapy
M. Kawahara, H. Kagiyama, Y. Kanazawa, H. Tsuchiya, K. Tomita, K. Yokogawa and K.-I. Miyamoto
Evaluation of Pharmacokinetics, Brain Levels and Protein Binding of Centpropazine in Rats
V. A. Bhattaram, J. K. Paliwal and R. C. Gupta
Pharmacokinetics of Nifedipine in Taiwanese
S.-C. Chien, Y.-S. Uang, H.-Y. Lin and K.-Y. Hsu
Pharmacokinetics of HEPP, a New Anticonvulsant, in Healthy Subjects and Rabbits After Multiple
Doses
D. F. Gonzalez-Esquivel, R. M. Pérez and H. J. Cook
In vitro Dissolution and In vivo Oral Absorption of Methylphenidate from a Bimodal Release
Formulation in Healthy Volunteers
Y. Wang, L. Lee, R. Somma, G. Thompson, R. Bakhtiar, J. Lee, G. S. Rekhi, H. Lau, G. Sedek and M. Hossain
SHORT COMMUNICATION
Mathematical Comparison Between Volume of Distribution (V) and Volume of Distribution at
Steady-State (V,,) Utilizing Model-Independent Approach
E. Sobol and M. Bialer
VOLUME CONTENTS
ISSUE APRIL 2004
ORIGINAL PAPERS
Bioequivalence Evaluation of Two Brands of Aceclofenac 100 mg Tablets (Aceclofar and
Bristaflam) in Healthy Human Volunteers
ajib, N. Idkaidek, M. Beshtawi, M. Bade: Admour, S. Mahmood Alam, Q. Zaman and R. Dham
The Bioavailability and Pharmacokinetics of Glucosamine Hydrochloride and Chondroitin Sulfate
after Oral and Intravenous Single Dose Administration in the Horse
J. Du, N. White and N. D. Eddington
Identification of Rat Faecal, Urinary and Biliary Metabolites of Thionorphine, a Novel Mixed
Agonist-Antagonist Analgesic, Using Liquid Chromatography/Electrospray lonization Tandem
Mass Spectrometry
Wang and J.-F. Guo
Pharmacokinetics, Blood Partition and Protein Binding of DA-7867, a New Oxazolidinone
Kwon, W. B. Kim and M. G. Lee
SHORT COMMUNICATIONS
Pharmacokinetic Changes of DA-8159, a New Erectogenic, After Intravenous and Oral
Administration to Rats with Acute Renal Failure Induced by Uranyl Nitrate
H. J. Shim, Y. C. Kim, E. J. Kim, D. G. Kim, J. W. Kwon, W. B. Kim and M. G. | s. Lee
Dose-dependent Pharmacokinetics of KR-31378, a New Neuroprotective Agent for
Ischaemia-reperfusion Damage in Dogs
S.-O. Kim, S.-H. Kwak, B. H. Lee, D.-H. Lee, H. Lim, S.-E N Yoo, H. J. Chung and M G. Lee
ORIGINAL PAPERS
Pharmacokinetic Tracer Kinetics Analysis of Changes in Erythropoietin Receptor Population in
Phlebotomy-Induced Anemia and Bone Marrow Ablation D 1
Veng-Pedersen hapel, N. H. Al-Huniti, R. L. Schmidt, E. M. Sedars, R. J. Hohl and J. A. Widness
The Relationships Between Half-Life (t,,;,) and Mean Residence Time (MRT) in the
Two-Compartment Open Body Model
E. Sobol and M. Bialer
Interaction of Dexloxiglumide, a Cholecystokinin Type-1 Receptor Antagonist, with Human
Cytochromes P450
Cheung, A. Matthews, Z. R. Cybulski, J. D. Holding, R. Kapil, M. D'Amato, F. Makovec and L. C. Rovati
Interspecies Scaling of the Monoclonal Anti-EGF Receptor ior EGF/r3 Antibody Disposition
Using Allometric Paradigm: is it Really Suitable? iT ne } j ge, E. Fernandez-Sanchez and D. Alvarez
Pharmacokinetics of Mebudipine, a New Calcium Antagonist, Following Single Intravenous and
Oral Administrations in Rats
S. Bohlooli, F. Keyhanfar and M. Mahmoudian
Dose-dependent Pharmacokinetics of KR-31378, a New Neuroprotective Agent for
Ischaemia-reperfusion Damage in Dogs
S.-O. Kim, S.-H. Kwak, B. H. Lee, D.-H. Lee, H. Lim, S.-E. Yoo, H. J. Chung and M. G. Lee
VOLUME CONTENTS
ISSUE 5 JULY 2004
ORIGINAL PAPERS
Topical Disposition of Two Strengths of a ‘?°I-rhEGF Jelly in Rat Skin Wounds
Duconge, P. A. Prats, C. Valenzuela, A. Aguilera, I. Rojas, M. A. Becquer, D. Alvarez, L. Estrada, S. Alfonso-Ortiz
E. Hardy-Rando, O. Garcia-Pulpeiro and E. Fernandez-Sanchez
Bioequivalence Evaluation of Two Brands of Ketoconazole Tablets (Onofin-K “ and Nizoral") in a
Healthy Female Mexican Population
G. Marcelin-Jiménez, J. Hernandez, A. P. Angeles, L. Contreras, M. Hinojosa, L. Rivera, L. Martinez-Rossier, O. Amancio and
A. Fernandez
Effect of Intravenous Infusion Time on the Pharmacokinetics and Pharmacodynamics of the Same
Total Dose of Torasemide in Rabbits
Y. C. Kim, M. G. Lee, S.-H. Ko and S. H. Kim
Pharmacodynamics of Controlled Release Verapamil in Patients with Hypertension: An Analysis
using Spline Functions
L. Aarons, C. Baxter and S. Gupta
DM27, an Enaminone, Modifies the In Vitro Transport of Antiviral Therapeutic Agents
N. N. Salama, K. R. Scott and N. D. Eddington
ISSUE 6 SEPTEMBER 2004
ORIGINAL PAPERS
Acetylation Phenotype Status in a Bangladeshi Population and its Comparison with that of Other
Asian Population Data
R. B. Zaid, M. Nargis, S. Neelotpol, J. M. A. Hannan, S. Islam, R. Akhter, L. Ali and A. K. Azad Khan
Identification of Human UDP-Glucuronosyltransferase Enzyme(s) Responsible for the
Glucuronidation of 3-Hydroxydesloratadine
A. Ghosal, Y. Yuan, N. Hapangama, A. Duen (Iris) Su, N. Alvarez, S. K. Chowdhury, K. B. Alton, J. E. Patrick and S. Zbaida
Absorption, Distribution, Metabolism and Excretion of YM466, a Novel Factor Xa Inhibitor, in Rats
Y. Mano, T. Sonoda, E. Nakamura, T. Usui and H. Kamimura
Pharmacokinetics and Dose Proportionality of Extended-Release Metformin following
Administration of 1000, 1500, 2000 and 2500 mg in Healthy Volunteers
E. Cullen, J. Liao, P. Lukacsko, R. Niecestro and L. Friedhoft
The Plasma Pharmacokinetics and Cerebral Spinal Fluid Penetration of Intravenous Topiramate in
Newborn Pigs
J. L. Galinkin, C. D. Kurth, H. Shi, M. A. Priestley, A. W. Loepke and P. C. Adamson
Pharmacokinetics of Clarithromycin in Rats with Acute Renal Failure Induced by Uranyl Nitrate
A. K. Lee, J. H. Lee, J. W. Kwon, W. B. Kim, S. G. Kim, S. H. Kim and M. G. Lee
ISSUE 7 OCTOBER 2004
ORIGINAL PAPERS
Interactions of Tamoxifen, N-Desmethyltamoxifen and 4-Hydroxytamoxifen with P-Glycoprotein
and CYP3A
D. J. Greenblatt, L. L. von Moltke, J. L. Weemhoff, M. D. Perloff and T. S. Bekaii-Saab
A Multiple-Dose, Safety, Tolerability, Pharmacokinetics and Pharmacodynamic Study of Oral
Recombinant Human Interleukin-11 (Oprelvekin)
M. M. Cotreau, L. Stonis, A. Strahs and U. S. Schwertschlag
VOLUME CONTENTS
Characterisation of Early Plasma Concentrations of Midazolam in Pigs after Administration by an
Autoinjector
A. Levy, M. Kushnir, S. Chapman, R. Brandeis, Z. Teitelbaum and E. Gilat
Pharmacokinetics and Safety of Oral Almotriptan in Healthy Male Volunteers
|. McEwen, M. Salva, J. M. Jansat and X. Cabarrocas
Pharmacokinetics and Splenic Accumulation of N-Acetylamino-3-Chloro-N-(2-Diethylamino-Ethy])
Benzamide after a Single Administration to Rats
J. Hua, Y. Sheng, M. Olin, R. Pero and K. Edvardsen
Intravenous Pharmacokinetics, Oral Bioavailability and Dose Proportionality of Ragaglitazar, a
Novel PPAR-dual Activator in Rats
N. R. Srinivas, N. V. S. Rao Mamidi, R. Mullangi, M. Rao Chaluvadi and K. Jagannath
ISSUE 8 NOVEMBER 2004
ORIGINAL PAPERS
Pharmacokinetics, Metabolism and Excretion of Intravenous ['*C]-Palonosetron in Healthy Human
Volunteers
+ t? Par A yah nd A \N ) Stoitz, S. Parisi Shah and A. Macciocchi
Effects of B-estradiol and Propofol on the 4-Methylumbelliferone Glucuronidation in Recombinant
Human UGT Isozymes 1A1, 1A8 and 1A9
Mano and H. Kamimura
Bioavailability of Divalproex Extended-Release Formulation Relative to the Divalproex
Delayed-Release Formulation
S. Dutta and Y. Zhang
SHORT COMMUNICATION
Comparison of the Bioavailability of 250 and 500 mg Divalproex Sodium Extended-Release
Tablets in Healthy Volunteers
S. Dutta, Y. Zhang, L. L. Lee and R. O'Dea
ORIGINAL PAPER
Cetirizine from Topical Phosphatidylcholine Liposomes: Evaluation of Peripheral Antihistaminic
Activity and Systemic Absorption in a Rabbit Model
4. A.W. I X. Gu, F. E. R. Simons and K. J. Simon 1K ions
SSUE < DECEMBER 2004
ORIGINAL PAPERS
Bioequivalence Evaluation of Two Brands of Amoxicillin/Clavulanic Acid 250/125 mg
Combination Tablets in Healthy Human Volunteers: Use of Replicate Design Approach 4 A |} 4 cies J NIai; A \ l Idkaidek, Ahmad Al-Ghazawi and Naji M. Najib
The Utility of Mixed-Effects Covariate Analysis in Rapid Selection of Doses in Pediatric Subjects:
A Case Study with Fexofenadine Hydrochloride
h Krishna, Sriram Krishnaswami, Barbara Kittner, Abdul J. Sankoh and Bradford K. Jensen
Erythropoietin Production Rate in Phlebotomy-Induced Acute Anemia
t 1. Al-Hunit ‘ Vidness, R. L. Schmidt and P. Veng-Pedersen
Author Index
Keyword Index .
Volume Contents