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INDUSTRIAL MICROBIOLOGY - BIOL 4433 0
Componentes Conceptual Profesor Jesus Santiago, RM 2509
Department of Science and Technology Universidad InterAmericana –Recinto Metro
Cupey, PR [email protected]
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"5 W's + 1 How"
1. What
2. When
3. Where
4. Who
5. Why
6. HOW
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WHAT
1. Bio-Transformación de Materia (Orgánica e Inorgánica) mediado por Metabolismo Microbiano para la obtención de un producto conValor comercial deseado
2. Materia Prima para el Microorganismo. a. Azucares (Simples y Complejas) b. Lipidos (Simples y Complejos) c. Proteinas (Estructurales y Funcionales) d. Acidos Nucléicos (Simples y Complejos)
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What…
4. Algunos Productos: 1. Industriales (solventes –alcohole-acetonas; acidos) 2. Farmaceúticos (Esteroides, Vitaminas, Vacunas,
Antibióticos, ect) 3. Alimentos (Lácteos, No Lácteos) 4. Pesticidas 5. Metabolitos (Vitaminas, Antibióticos, preservativos)
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WHERE
� EN TODO AMBIENTE � AEROBICO � ANAEROBICO � AIRE, SUPERFICIE, AGUA
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WHEN
� NATURALMENTE
� CONTROLADO POR HUMANOS
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WHO
� TODOS LOS PHYLUM
� UNICELULARES PROCARIOTAS
� UNICELULARES EUCARIOTAS
� HONGOS, LEVADURAS, PROTISTAS
� MULTICELULARES
� FOTOSINTETICOS
� ALGAS AZUL-VERDOSAS (CIANOBACTER)
� OTRAS
� NO FOTOSINTETICOS
� SETAS,
� SIMBIONTES (PLANTAS , ANIMALES, HONGOS , BACTERIAS, VIRUS)
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WHY
� COMO PARTE DE SU CICLO VITAL
� COMO RESPUESTA A PRESION/STRESS AMBIENTAL � SUPERVIVENCIA � EFICIENCIA � ADAPTABILIDAD � INTERES COMERCIAL (SALUD, ALIMENTO,
AMBIENTAL, ENERGETICO, ECT)
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HOW
� ATRAVES DE METABOLISMO ESPECIAL NATURAL
� ATRAVES DE INGENIERIA GENETICA-MOLECULAR
� INDUCCION, MANIPULACION, CONTROL Y REGULACION DE RUTAS METABOLICAS
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How…
� Mediante uso Estrategias para la Manipulación de microorganismos: 1. Selección por Medios de Cultivo
2. Factores Limitantes Nutricionales 3. Bloqueos Bioquímicos
4. Control enzimáticos de Rutas Metabólicas
5. Recombinantes Genéticos (genetic engeneering Mab) ( IPC Isolation, Culture & Purification-Cloning)
a. Cloning b. Uso Vector de Expression (Bacteria o Célula mamíferas)
a. Producto Intra cell, o Producto Extra-cell
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SECTORES
1. ALIMENTOS, AGUA Y DROGAS (FARMACOS) � MANUFACTURA
� REGULACION, LEYES, AGENCIAS (FDA, USDA, EPA) � DOCUMENTACION COMO PRUEBA DE
CUMPLIMIENTO � CONTROLESY GARANTIA DE CALIDAD (QA/(QC)
� MONITOREO DE: � MATERIALES, FACILIDADES, EQUIPOS,
INSTRUMENTOS, PERSONAL, PROCESOS (IN-COMING, IN-PROCESS, FINISHED PRODUCTS)
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SECTORES…
2. AGRICULTURA � BIOCONTROL DE PLAGAS
� MANIPULACION GENETICA (GMO) � MAXIMIZAR PRODUCCION/REDUCIR PERDIDA
� CICLO PROD-CONTINUO "ALL SEASON SPECIES ”
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SECTORES…
3. AMBIENTAL a. BIO-DEGRADACION b. BIO-CONTROLES c. RECICLAJE d. MINERALIZACION (BIOLEACHING),
Recuperación y acondicionamiento de suelos.
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SECTORES…
4. BIOTECNOLOGICAS: a. BIOREACTORES
1. BIOFERMENTORS a. Batch Culture
1. Bacterial
2. Mammalian Tissue Culture
2. Recombinación Genética (Genetic engineered)
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INDUSTRIAL MICROBIOLOGY “THE ANALYST"
� MICROBIAL TEST (ROUTINARY)
1. Bioburden (BB)- (Packaging components, Raw Matter, Product, Medical device). ISO11737 or USP 61
1a. Microbial Limits (la parte cuantitativa de BB TAC, yeast,