Download - Chemistry of Lipids Prostaglandins
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CHEMISTRY OF LIPIDSPROSTAGLANDINS
Dr Vijay Marakala
Dr. Vijay Marakala, MBBS, MD. Assistant professor
BIOCHEMISTRY SIMS RC
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EICOSANOIDS
Eicosanoids ar
!or"d!ro" #$car%onP&FA
arac'idoni
Eicosa
Pros(anoids
Pros(a)landins
PG
Pros(acyclins
PGI
-'a( is Eicosanoids. Classi/ca
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PROSTAGLANDINS
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PROSTAGLANDINS
-'yPG.
S(r,c(,r
Loca(ion
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Pros(a)landins Classi/ca(io
A010C
2I
PG S,%classi/ca(ion
30#04 PGF3 5PGF#α β
PROSTAGLANDINS6PG
No"ncla(,r
Classi/ca(io
n
S,%scri8(
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No"ncla(,r
Classi/ca(ion
S,%scri8(
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No"ncla(,r
Classi/ca(ion
S,%scri8(
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PROSTAGLANDINS
Hor"ons.
Pri"ary PG
O('r PG
PG
Ac( lik local'or"ons
39 na(,rally occ,r
PG
: ar !o,nd('ro,)'o,( (' %o
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PROSTAGLANDINS ; F&NC
E
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PROSTAGLANDINS ; F&NC
PGI#
Vasodila(a(ion
In'i%i(s 8la(l( a))r)a(ionPGA and PGE class 8ros(a)landins
lo>r %lood 8rss,r?
E
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PROSTAGLANDINS ; F&NC
PGF#
Ind,cin) la%o
E
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PROSTAGLANDINS ; F&NC
PGF;1ronc'ocons(ric(ion
PGE;1ronc'odila(or
E
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PROSTAGLANDINS ; F&NC
PGE#
In@ol@d in in=a""a(oryrs8ons
E
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PROSTAGLANDINS ; F&NC
PGE#
s,88rss
)as(ric acidscr(ion
E
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Firs( isola(d !ro" %lood 8la(l(s0 ('ro"
T!AT!A
S,%scri8( n,"%r dno(s n,"%r o! do,%
Ca8i(al l((rs dsi)na( class
Mos(co""o
n
T'ro"%o*ans 6T+7
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Incras 8la(l( a))r)a(
Vasocons(ric(ion
Mo%iliB in(racll,lar calc
S"oo(' ",scl con(rac(
1ronc'ocons(ric(ion
T'ro"%o*ans ; F&NCTI
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#E$%OTRI&ES 'ERE SO &AMED BECA$
'ERE I&ITIA##Y DESCRIBED I& #E$COCY
Gro,8d in(o classs 6A (o E7
s*ript n(+)er enotes n(+)er of
LTC
L,ko(rins 6LT7
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Incras c'"o(a*is
Facili(a( in=a""a(ion 5 allrac(ions
Con(rac(ion o! s"oo(' ",sc
1ronc'ocons(ric(ion
Vasocons(ric(ion
L,ko(rins ; F,nc(ion
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a sort )reak
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HYDROLYSISSAPONIFICATIO
NRANC
O+IDATIONHYDROGENATI
ON
CHEMICAL PROPERTITES O
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SAPONIFICATION T' 'ydrolysis o! !a(s %y alkali is calld sa8oni/c
rac(ion rs,l(sin (' !or"a(ion o! )lycrol and sal(s o! !a((y acidscalld soa8s
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HYDROLYTIC RANCIDIT -'n %,((r or o('r !a(s ar s(ord0
o!(n %co" rancid and 'nc ,n8ala( Rancidi(y is ca,sd %y (' )ro>(
"icroor)anis"s >'ic' scr( nBy"li8ass?
T's s8li( (' !a(s in(o )lycrol and!a((y acids?
T' !a((y acids i"8ar( ,n8lasan( odo,=a@o,r (o (' !a(?
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O+IDATIVE RANCIDITY Oils con(ainin) 'i)'ly ,nsa(,ra(d !a((y
ar s8on(ano,sly o*idiBd %y a("oso*y)n a( ordinary ("8ra(,rs? T' o*ida(ion (aks 8lac slo>ly and r
in (' !or"a(ion o! s'or( c'ain !a((y C(o C3$ and ald'yds >'ic' )
rancid (as( and odo,r (o (' !a(s? O*ida(i@ rancidi(y is o%sr@d
!r,n(ly in ani"al !a(s ('an in @)!a(s?
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HYDROGENATION
I( con@r(s ,nsa(,ra(d !a((y acid(ri)lycrids in(o sa(,ra(d !a((y acids?
Co""rcially 'ydro)na(ion is ,scon@r( li,id !a(s o! 8lan( ori)in (o
cookin) !a(s? Vanas8a(i dalda is o%(aind !ro" @)
oils ('ro,)' ('is 8rocss?
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FATS FACTS AND FANTA Irrs8c(i@ o! (' so,rc0 !a( is (' "os( conc
!or" o! di(ary nr)y? T'r is no s,c' ('in) as lo>;calori !a(? For >i)'( rd,c(ion0 (' only r,l is (o a( l
*rcis "or? N,(ri(ionally0 8oly,nsa(,ra(d !a((y acids P&F
considrd s,8rior? Fa(s o! ani"al ori)in ar sa(,ra(d >'ras @oils ar ,nsa(,ra(d?
Fis' oils (oo ar ,nsa(,ra(d and 'a@ lon)ln)(' !a((y acids?
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D CHEMISTRY