Transcript
Page 1: CHE Dr. Griffith CLINICAL ROLE OF PHARMACIST TO IMPROVE …pharmacy.famu.edu/wp-content/uploads/2017/02/CHE-Dr... · 2017-02-23 · 2/23/17 1 CLINICAL ROLE OF PHARMACIST TO IMPROVE

2/23/17

1

CLINICALROLEOFPHARMACISTTOIMPROVEMENTALHEALTHOUTCOMESAMONGVETERANS

JUNEA.GRIFFITH,PharmD,CGP,BCPPTuscaloosaVeteransAffairMedicalCenter

PGY2ResidencyDirectorPsychiatricpharmacypracticeFebruary24,2017

DisclosureStatement

Idonothaveavestedinterestoraffiliationwithanycorporateorganizationofferingfinancialsupportorgrantmoneyforthiscontinuingeducationprogramoranyaffiliationwithanorganizationwhosephilosophycouldpotentiallybiasanypresentation.

ORIdonothaveavestedinterestinoraffiliationwithanycorporateorganizationofferingfinancialsupportorgrantmoneyforthiscontinuingeducationprogram,oranyaffiliationwithanorganizationwhosephilosophycouldpotentiallybiasmypresentation.

OJECTIVES

• UponcompletionofthisCEactivity,pharmacists,nurses,andotherhealthcareprofessionalsshouldbeableto:• Understandthevarioustypesofmentalillnessthatmightgountreated:• AbuseofdrugsandAlcoholtotreatmentalhealthproblems:• NeedofpharmaciststoeducateveteransaboutthecorrectTXofmentalhealthconditions:• TypesofOTCtreatmentsformentalhealth• InteractionswithOTCandconventionalmedications.• Waystoreducethestigmaofmentalhealthdisorders• Identifythevarioustypesofmentalhealthdisordersandknowwhentoreferfortreatment.

OBJECTIVES

• UponcompletionofthisCEactivity,Techniciansandstudentsshouldbeableto:• Understandthevarioustypesofmentalillnessthatmightgountreated;• AbuseofdrugsandAlcoholtotreatmentalhealthproblems;• Needofpharmacists,techniciansandstudentstoeducateeachotherandfamilymembersaboutthecorrectTXofmentalhealthconditions;• TypesofOTCtreatmentformentalhealth;• InteractionsbetweenOTCagentsandconventionalmedications,• Waystoreducethestigmaofmentalhealthdisorders• Identifythevarioustypesofmentalhealthdisordersandknowwhentoreferfortreatment.

Page 2: CHE Dr. Griffith CLINICAL ROLE OF PHARMACIST TO IMPROVE …pharmacy.famu.edu/wp-content/uploads/2017/02/CHE-Dr... · 2017-02-23 · 2/23/17 1 CLINICAL ROLE OF PHARMACIST TO IMPROVE

2/23/17

2

ANXIETYVSDEPRESSION

ANXIETY

SAD

PANIC

GAD

SEPARATION

OCD

PTSD

ANXIETYVSDEPRESSION

• TypesofAnxietydisorders:• SAD– socialanxietydisorder– fearofbeinginpublicplaceswiththepossibilityofbeingembarrassed• GAD– Generalizedanxietydisorder– excessiveanxietyorworryaboutalmosteverythingandconstantworrying• PD– panicdisordercharacterizedbyintensefearthatlastfor5– 10secondsandthensubsides.Notsurewhenitwilloccuragain.• OCD– obsessivecompulsivedisorderswhichischaracterizedbyfearandcontinuousritualstocalmfearsthatmainlyincreasesthefearmore.• Separationanxiety– afraidtobeseparatedfromloveones,orfamilymembersduetofearofsomethingbadhappeningtoloveones.• PTSD– removedfromanxietydisorderinDSMVcriteria,butisstillactuallyananxietytypeofdisorder.

ANXIETYVSDEPRESSION

• TreatmentforanxietyisusuallytheuseofSSRI– SelectiveSerotoninreceptoruptakeinhibitors.• Itinhibitsthereuptakeofserotoninforthereceptorstorepackageitanduseitagain.Insteadthereisaconstantsupplyofserotonininthereceptorsynapticcleft,leadingtoincreasebindingtotheserotoninreceptor.• AnothertypeoftreatmentistheSNRI– Serotoninnorepinephrinereceptoruptakeinhibitors-• Itallowsforserotoninandnorepinephrinetobeavailabletothereceptorsalotlongerandthereforeleadstoincreaseactions.• Thenorepinephrine– dopaminereceptorreuptakeinhibitors–Wellbutrinorbupropion- allowsfornorephinphrineanddopaminetobeavailablealotlongerinthereceptorsynapticcleft.

ANXIETYVSDEPRESSION

• THESAMEAGENTSUSEDTOTREATANXIETYISALSOUSEDTOTREATDEPRESSION.

• WHY?????

• DEPRESSIONischaracterizedbyhaving5ormoreofthefollowingsymptomseverydayforatleast2weeks– depressedmood,irritability,anxiety,tearfulnessandsomaticcomplaints.• AnacronymusedisSIGECAPS

Page 3: CHE Dr. Griffith CLINICAL ROLE OF PHARMACIST TO IMPROVE …pharmacy.famu.edu/wp-content/uploads/2017/02/CHE-Dr... · 2017-02-23 · 2/23/17 1 CLINICAL ROLE OF PHARMACIST TO IMPROVE

2/23/17

3

ANXIETYVSDEPRESSION

• S- sleepdisturbance(insomniaorhypersomnia)• I– Interest(lossof)• G- Guilt(excessive)• Energy(Changesin)• Concentration(impaired)• AppetiteChanges(increasedordecreased)• Psychomotoragitationorretardation• Suicidalideationsoractions• Somaticcomplaints– (GIdisturbances,headaches,musclepain)

CPNPPyschiatricPharmacotherapyreviewpg188 9

ANXIETYVSDEPRESSION

• Ifanxietygoesuntreatedforalongperiodoftime,dependingontheseverityitcanproducedepressionsymptomsnext.• Thatiswhyitisimportanttorecognizedandgettherapyassoonaspossible.• Pillsarenottheonlywaytotreatdepressionandanxiety.• Psychotherapy–• CBT– Cognitivebehaviortherapy– patientaretaughttorecognizedbadthoughtsandlearnhowtochangethoughtprocesses.• ECT– electroconductivetherapy– forseveredepression.

EVALUATIONCASESTUDY

• Awomanis24yearsoldfemale,complainsofchestpain,shortnessofbreathandimpendingdomewhileinacrowdedshoppingcenter,thishasoccurredonmorethanoneoccasionandaftertravellingtotheER.AttheERifwasdeterminedthattheywasnocardiacinvolvement.• 1)Whattypeofanxietydisorderisthiscondition?• a)SocialAnxiety• b)panicdisorder• c)generalizedanxietydisorder• d)separationanxiety

EVALUATIONCASESTUDY

• Aftermanymonthsofthisdisorderthepatienthasstopsocializingwithherfriends,andhasstopleavingthehouseeventobutgroceries.Whattypeofsymptomisthispatientexperiencing?• a)Guilt• b)lossofinterest• c)isolation• d)changesinenergy

• Howwouldthisconditionbetreatedwithwhatagent?• a)SSRIb)Busparc)lorazepamd)St.John’swort

Page 4: CHE Dr. Griffith CLINICAL ROLE OF PHARMACIST TO IMPROVE …pharmacy.famu.edu/wp-content/uploads/2017/02/CHE-Dr... · 2017-02-23 · 2/23/17 1 CLINICAL ROLE OF PHARMACIST TO IMPROVE

2/23/17

4

BIPOLARDISORDER DIAGNOSTICCRITERIA

HYPOMANIC HYPOMANICCRITERIA

Page 5: CHE Dr. Griffith CLINICAL ROLE OF PHARMACIST TO IMPROVE …pharmacy.famu.edu/wp-content/uploads/2017/02/CHE-Dr... · 2017-02-23 · 2/23/17 1 CLINICAL ROLE OF PHARMACIST TO IMPROVE

2/23/17

5

SPECTRUMOFMOODS DIAGNOSTICCRITERIA

BIPOLARDISORDER1OR11

• BIPOLARTERMSusedtobecalledmanicdepressivedisorders.

• Bipolar1– apersonwhohavehadatleastonemanicepisodeinhis/herlifetime.• Bipolar11– mainlycharacterizedbydepressiveepisodeandhypomanicepisode.• Manicischaracterizedbyperiodofloudexpansivemood,withrequirementoflittlesleepandthoughtsofonlyselfpleasurableactivities,thatusuallyrequireeitherhospitalizationorincarceration.• Hypomanicisusuallyperiodofhighexpansivemoodbutnotattheseverityofmanicandrequiringlessneedforsleep.Usuallylasting4-7days,beforecrashingintodepression.

BIPOLAR1OR11

• Mostpatientswithbipolartype11usuallygoestotheirdoctorwhentheyareinadepressiveepisode.• Wheninahypomanicepisode,theyfeelgood,extraenergyandabletodoalotoftasks,butmightnotfinishanyofthemcompletely.• Inthemanicphasic,havelotofracingthoughtsandwanttodoalotofdifferentthings,butmightnevercompleteanything.• Inmanicphasemoreinterestedwiththepleasurableactivities,thanworkorproduction.• Whichusuallyleadtooverspending,extramartialaffairswithmanypartners,gamblinganddoingdrugsandoftenquestionableactivitiesthatmayendupinjailorhospital.• Treatmentisoftencomplex,andusuallyendsupwithalotofnon-compliance.

Page 6: CHE Dr. Griffith CLINICAL ROLE OF PHARMACIST TO IMPROVE …pharmacy.famu.edu/wp-content/uploads/2017/02/CHE-Dr... · 2017-02-23 · 2/23/17 1 CLINICAL ROLE OF PHARMACIST TO IMPROVE

2/23/17

6

TREATMENTOFBIPOLAR1AND11

• DRUGOFCHOICEISLITHIUM.• MOODSTABILIZER– DEPAKOTE,CARBAMAZEPINE,LAMICTAL,• SSRI,SNRI– BUTMUSTBEACCOMPANIEDBYAMOODSTABILIZERONBOARDOTHERWISEITMAYCAUSESWITCHINGTOMANIA• BUPROPIONISTHEONLYANTIDEPRESSANTTHATISLESSLIKELYTOCAUSESWITCHINGTOMANIA.• WHYDOESANTI-EPILEPTICAGENTHELPWITHMOODSTABILIZATION• ITACTUALLYSLOWSDONETHEFASTRACINGTHOUGHTSANDGIVETHEBRAINTIMETOMAKERATIONALDECISIONINSTEADOFBEINGIMPULSIVE.• BIOLARPATIENTSDON’TLIKETHEFEELINGANDISTHEREFORENON-COMPLIANT.

DRUGOFCHOICEFORMANIA

OTHERAGENTSUSEDINTHETREATMENTOFBIPOLARDISORDER

• DEPAKOTE– VALPROICACID• TEGRETOL– CARBAMAZEPINE• TRILEPTAL– OXCARBAZEPINE• LAMICTAL– LAMOTRIGINE– MAINLYFORBIPOLAR11• SECONDGENERATIONANTIPSYCHOTICAGENTS• ABILIFY–ARIPIPRAZOLE• OLANZAPINE-ZYPREXA• RISPERIDONE-RISPERDAL• QUETIAPINE-SEROQUEL

EXPLANATIONSOFMOAOFANTIEPILEPTIC

Page 7: CHE Dr. Griffith CLINICAL ROLE OF PHARMACIST TO IMPROVE …pharmacy.famu.edu/wp-content/uploads/2017/02/CHE-Dr... · 2017-02-23 · 2/23/17 1 CLINICAL ROLE OF PHARMACIST TO IMPROVE

2/23/17

7

EVALUATIONCASESTUDY

• RODNEYISA24YEAROLDMAN,THATWASDIAGNOSEDWITHDEPRESSIVESYMPTOMS,ANDWENTTOHISPCPCOMPLAININGOFNOTBEINGABLETOSLEEPFORAFEWDAYSANDLOWENERGYANDTEARFULMOSTDAYS.HECAN’TEXPLAINWHYHEISSOTEARFUL.HISPCPPRESCRIBEDSERTRALINEFORHIMWITHASLOWGRADUALINCREASEDINDOSE.TWOWEEKSLATER,HEISOUTONTHENEIGHBOURSLAWNSWIMMINGINTHENUDEWITHOUTANYPOOL.THEPOLICEISCALLEDANDHEWASBAKERACTEDTOAPSYCHIATRICWARDFOR3DAYSOBSERVATION.WHATISPROBABBLYRODNEY’SDIAGNOSIS?• A)BIPOLAR1DISORDER• B)BIPOLARCPSYCHOTICFEATURES• C)BIPOLAR11DISORDER• D)DEPESSION

EVALUATIONCASESTUDY

• FROMHISDIFFERENTIALDIAGNOSISWHATMEDICATIONSSHOULDRODNEYBETREATEDWITHATTHISTIME.• A)LAMICTAL• B)PROPRANOLOL• C)LITHIUM• D)ARIPIPRAZOLE• IFRODNEYISTREATEDWITHLITHIUMWHATMONITORINGISNECESSARYFORNEEDEDFORTHISMEDICATION?• A)LITHIUMLEVELIN5DAYS• B)LITHIUMLEVELIN2DAYS• C)LITHIUMLEVELIN2WEEKS• D)LITHIUMLEVELIN6MONTHS

SCHIZOPHRENIA

• COMEONINTHELATETEENTOEARLYTWENTIES• ITCANOCCURREDINMALE:FEMALEEQUALLY,• CANBEDUETOHERIDITARY• AFFECTS1%OFTHEPOPULATION,• ITCANBEDUETOEXPOSUREFROMCANNABISANDMETHAMPHETMINES

CPNP2016-2017PG586

SCHIZOPHRENIA

• TYPESOFSYMPTOMS• POSITIVE• HALLUCINATIONS• DELUSION• MOVEMENTDISORDER• NEGATIVE• LOSSOFINTEREST• LACKOFEMOTIONS• SOCIALWITHDRAWAL• COGNITIVE• PROBLEMSMAKINGDESIONS• MEMORYPROBLEMS

Page 8: CHE Dr. Griffith CLINICAL ROLE OF PHARMACIST TO IMPROVE …pharmacy.famu.edu/wp-content/uploads/2017/02/CHE-Dr... · 2017-02-23 · 2/23/17 1 CLINICAL ROLE OF PHARMACIST TO IMPROVE

2/23/17

8

TREATMENTOFSCHIZOPHRENIA

• USEOFEITHERFIRSTGENERATIONANTIPSYCHOTICAGENTS• Haloperidol• Chlorpromazine• Fluphenazine• Perphenazine• Thorazine• OR• USEOFSECONDGENERATIONANTIPSYCHOTICAGENTS• RISPERIDONE

• ARIPIPRAZOLE

• OLANZAPINE

• CLOZAPINE

TREATMENTOFSCHIZOPHRENIA

• THECHOICETOTREATSCHIZOPHRENIA,NEEDSTOLOOKATTHEENTIREINDIVIDUAL,BEFORECHOOSINGANANTIPSYCHOTICAGENT.• NEEDTOLOOKAT:• MEDICALHX• HEIGHT,WEIGHT,BMI• ALLERGIES• RACE• PREVIOUSUSEOFANTIPSYCHOTICANDWHATWORKED• FAMILYHXANDWHATMEDICATIONWORKEDINTHEPASTINOTHERFAMILYMEMBERS• AGEOFTHEPATIENT.

POSSIBLEADVERSEEFFECTSOFATYPICALANTIPSYCHOTICDRUGS EVALUATIONCASESTUDY

• ASTUDENTISFOUNDWALKINGTHEROADINNEWYORKINTHEDEADOFWINTERINABATHINGSHORTS,WHENASKEDWHATHEISDOINGHESAYSHEISWALKINGTOTHEBEACH.HEWASPICKUPBYTHEPOLICEANDCARRIEDINFOREVALUATION.ITWASDISCOVEREDTHATHEWASINHISJUNIORYEAROFCOLLEGEANDALLOFASUDDENOVERTHELASTSIXMONTHSHEBEGANBEHAVINGWEIRDTOHISCLASSMATES.WHATISONEOFTHEFIRSTBLOODTESTTHATHEHASTOBEDONE?• A)EKG• B)UDS• C)CHEM8• D)CBC

Page 9: CHE Dr. Griffith CLINICAL ROLE OF PHARMACIST TO IMPROVE …pharmacy.famu.edu/wp-content/uploads/2017/02/CHE-Dr... · 2017-02-23 · 2/23/17 1 CLINICAL ROLE OF PHARMACIST TO IMPROVE

2/23/17

9

EVALUATIONSCASESTUDY:

• ISTHEREATESTFORSCHIZOPHRENIA• A)TRUE• B)FALSE

• SAMHASJUSTBEENDIAGNOSEDWITHSCHIZOPHRENIAAFTERAYEAROFCONTINUOUSSYMPTOMS.HEISOVERWEIGHT,ANDISATYPE1DIABETIC.WHICHAGENTWOULDBEAGOODCHOICETOSTARTSAMONANDTOCONTINUEFORCONTINUOUSTHERAPY?• A)OLANZAPINE B)HALDOL• C)ARIPIPRAZOLE D)QUETIAPINE

PERSONALITYDISORDERS

• COMESINTHREEMAINGROUPSANDJUSTADDSTOTHEFURTHERCOMPLICATIONOFDIAGNOSISWITHMENTALHEALTHILLNESS.• CLUSTERA– ODD• CLUSTERB- DRAMATIC• CLUSTERC– ANXIOUSORFEARFUL

PERSONALITYDISORDER• JUSTAFURTHERDEMONSTRATIONOFTHEDIFFERENTTYPESOFPERSONALITIES.

ABUSEOFDRUGSANDALCOHOL

• WHYALCOHOLISTHEMOSTABUSEDRUGALONGWITHNICOTINE• MOSTPEOPLEWITHANXIETYORDEPRESSIVESYMPTOMSDON’TWANTTOADMITTHATSOMETHINGISWRONG• SOINSTEADTHEYBEGINWITHAGLASSOFWINETOLOOSENUP,THENMAYBE2-3ANDBEFOREYOUKNOWIT,THEENTIREBOTTLE.BUTASFARASTHEYARECONCERN,THEYARESTILLINCONTROL.• NICOTINETENDSTOHELPWITHANXIETESANDATTHESAMETIMEADDTOANXIETYIFYOUTRYTOREDUCETHEAMOUNTYOUTAKE.• ITISVERYADDICTIVEANDQUICKLYBECOMEADDICTIVETOTHEPRODUCT.

Page 10: CHE Dr. Griffith CLINICAL ROLE OF PHARMACIST TO IMPROVE …pharmacy.famu.edu/wp-content/uploads/2017/02/CHE-Dr... · 2017-02-23 · 2/23/17 1 CLINICAL ROLE OF PHARMACIST TO IMPROVE

2/23/17

10

ABUSEOFDRUGSANDALCOHOL DURGSOFABUSE

• COCAINECAUSECARDIACPROBLEMS• STROKES• SEIZURES• HEADACHES• DEATH• EXTREMEWEIGHTLOSS• EFFECTSONTHEMENTALCAPACITY

ABUSEOFDRUGSANDALCOHOL

Page 11: CHE Dr. Griffith CLINICAL ROLE OF PHARMACIST TO IMPROVE …pharmacy.famu.edu/wp-content/uploads/2017/02/CHE-Dr... · 2017-02-23 · 2/23/17 1 CLINICAL ROLE OF PHARMACIST TO IMPROVE

2/23/17

11

DRUGSOFABUSE

• DIFFCULTYPAYINGATTENTION• AMOTIVATION• LOSSOFSHORTTERMMEMORY• INCREASEDHEARTRATE• SADNESSORFEARFULNESS• ANXIETYANDPANIC

METHAMPHETAMINEEFFECTSONTHEBODY.

WHATDOESEDUCATIONDOFORVETERANS

• FIRSTWEDOEDUCATIOONALCLASSESON• OPIODSAFETY• CIGARETTECESSATION• SUBSTANCEABUSE• POSTTRAUMATICDISORDER

• THEFOURWEEKSCLASSESSTARTWITH:• ONEWEEKINTRODUCTIONTOSUBSTANCEABUSEORPTSD• 2ND WEEK– SYMPTOMSANDEFFECTSONTHEBODYSYSTEMS• 3RD WEEK- TREATMENTOFEITHERSAORPTSD• 4TH WEEK– LIVINGWITHANDCOPINGWITHADIAGNOSISOFSAORPTSD.

WHATDOEDUCATIONDOFORVETERANS

• MOSTVETERANSLIKETHEFACTTHATTHEYARELEARNINGABOUTTHEMEDICATIONSTHATAREBEINGUSEDANDHOWTHEYWORKTOHELPWITHTHECONDITION.• THESAMEWAYTHATTHEPHARMACISTHASBEENINSTRUMENTALINEDUCATINGTHEPUBLICABOUTDIABETESANDHYPERTENSION.• VETERANSNEEDEDUCATIONABOUTTHEIRSYSMPTOMSANDWHATEFFECTSTHEDRUGSOFABUSEANDTHEDRUGSTHATARECONVENTIONALAGENTSHAVEONTHEIRBODIES.• ONEQUESTIONSARETHEYSUBSTITUTINGONEDRUGOFABUSEFORANOTHERDRUGOFABUSEANDWEDEFINITELYEXPLAINSTHEMECHANISMOFACTIONS• THEYALSOWANTTOKNOWIFTHEYWILLBEABLETOSTOPTHEMEDICATIONANDWHEN.

Page 12: CHE Dr. Griffith CLINICAL ROLE OF PHARMACIST TO IMPROVE …pharmacy.famu.edu/wp-content/uploads/2017/02/CHE-Dr... · 2017-02-23 · 2/23/17 1 CLINICAL ROLE OF PHARMACIST TO IMPROVE

2/23/17

12

WHATDOESEDUCATIONDOFORTHEPUBLIC

• EDUCATIONMAKESTHEVETERANMOREINFORMABOUTBOTHTHECONDITIONANDTHETREATMENTOFTHECONDITIONS• ITMAKESTHEMAWAREOFPOSSIBLESIDEEFFECTSANDWHYTHEIROCCURANDWHATAGENTSMIGHTBEANALTERNATIVEFORTREATMENTOFTHESIDEEFFECTS.• FORSSRIINDUCEDSEXUALSIDEEFFECTS,WECOULDRECOMMENDTALKINGTOTHEYDOCTORSABOUTCHANGINGTHEAGENTTOANOTHERANTIDEPRESSANTSUCHASBUPROPION• ORTAKINGASEROTONERGISTAGONIST– CYPROHEPTADINEABOUT2HRBEFORESEXUALSIDEEFFECT.• THEUSEOFDRUGOFABUSETOTREATPTSDISUSUALLYAOTCEFFECTTOTREATTHEPROBLEM,BUTPRODUCESAWORSEREACTION.

EVALUATION

• VETERANCAMEINTOEMERGENCYROOMCOMPLAININGOFSUICIDALIDEATIONS,WITHAPLANTOJUMPINFRONTOFACAR.COMPLAINSOFHOMELESSNESS,COCAINEANDALCOHOLABUSEANDHEHASNOPLACETOGO,COMPLAINSOFDEPRESSION,LONLINESSANDTEARFULFORPASTMONTH,AFTERWIFEHASLEFTHIM.HISUDSWASPOSITIVEFORCOCAINE,ALCOHOLANDBENZOS.• WHATISTHEMAINCAUSEOFHISDEPRESSION.• A)HOMELESSNESS• B)WIFELEFTHIM• C)DRUGSANDALCOHOL• D)ALLOFTHEABOVE.

EVALUATION

• WHATDIAGNOSISSHOULDHEBETREATEDFORFIRST?• A)ALCOHOLWITHDRAWAL• B)COCAINEWITHDRAWAL• C)DEPRESSION• D)AANDB

WHATISTHEFIRSTAGENTSWILLBEUSEDTOTREATALCOHOLWITHDRAWAL?A) LORAZEPAMB) CLONIDINEC) NAPROXEND) ALLOFTHEABOVE

TYPESOFOTCAGENTSUSEDFORMENTALILLNESS• ST.JOHN’SWORT• CHAMOMILE• LEMONBALM• ROSEMARY• VALERIAN• SAMe• FOLATEANDL-METHYLFOLATE• OMEGA-3FATTYACIDS

Page 13: CHE Dr. Griffith CLINICAL ROLE OF PHARMACIST TO IMPROVE …pharmacy.famu.edu/wp-content/uploads/2017/02/CHE-Dr... · 2017-02-23 · 2/23/17 1 CLINICAL ROLE OF PHARMACIST TO IMPROVE

2/23/17

13

TYPESOFOTCMEDICATIONSFORMENTALILLNESS

• ST.JOHN’SWORT-• Inhibits5-HT,NEandDAtransporter• Alsoweaknon-selectiveinhibitionofMAO• Dose300mgdaily• CaninteractwithotherSSRIorSNRItoproduceSerotoninsyndrome.• Shouldnotbeusedwithotherconventionalagents

• SAMe–• MethyldonorinthesynthesisofdopamineandSerotonin.• Dose– 800-1600mgperdayorIM400mg.• NotregulatedbyFDA• Usedfordepression,veryexpensive.

TYPESOFOTCAGENTSUSEDFORMENTALILLNESS

• OMEGA-3FATTYACIDS–• Containseicosapentaenoicacid(EPA)docosahexaenoicacid(DHA)-• Doserangefrom1– 9gramsperday.• Adverseeffects– GIupset,diarrhea,constipation.• Useformoodstabilizerandasaantidepressant

Magnesiumhydroxide-Helpsregulatecalcium,copper,zinc,potassium,vitamindlevelsUsedforanxiety,insomnia,headache,irritability,HTN,headachesActivatesco-enzymes

OTCAGENTS

• AGENTSTHATCANBEUSEDFORGAD• PASSIONFRUITFLOWER• KAVA• CHAMOMILE• VALERIAN• GINGER• LICORICE

HERBSANDOTCAGENTS

• KAVAROOT–• ADRINKPREPAREDFORUSEINANXIETY,INSOMNIA,• ENHANCEDLIGANDBINDINGTOGABAARECEPTORS• ACTSTOELEVATEMOOD,WELLBEING• KRATOMFOUNDINSPICEANDVARIOUSOTCDRUGS.

Page 14: CHE Dr. Griffith CLINICAL ROLE OF PHARMACIST TO IMPROVE …pharmacy.famu.edu/wp-content/uploads/2017/02/CHE-Dr... · 2017-02-23 · 2/23/17 1 CLINICAL ROLE OF PHARMACIST TO IMPROVE

2/23/17

14

HERBSANDOTCAGENTS

• PASSIONFRUIT– MADEINTOADRINK• SEDATIVEEFFECT• CALMING• CANBEUSEDFORGAD

INTERACTIONBETWEENOTCANDCONVENTIONALMEDICATIONS

• KAVA– CANCAUSELIVEDAMAGEANDLIVERTOXICITY• ST.JOHN’SWORTANDSSRI– MAYLEADTOSEROTONINSYNDROME• SIGNIFICANTINTERACTIONSWITHOTHERANTIDEPRESSANTS• SHOULDNOTUSEST.JOHN’SWORTWITHSSRI’S,TCA,ORMAOI’S• OMEGAFATTYACIDSMAYINTERACTWITHSSRIANDANTICOAGULANTTOINCREASEDTHERISKOFBLEEDING.• PASSIONFLOWERWITHOTHERSEDATIVES,ANTICONVULSANT,TCA,ANDANTICONVULSANT.• CHAMOMILEINTERACTIONWITHWARFARINANDCYCLOSPORINE–• DERMATITIS

INTERACTIONSWITHOTCANDCONVENTIONALMEDICATIONS

• BEWAREOFTHETYPEOFALDULTERANTSINPRODUCTS.• WHETHERITWASTHELEAF,BARK,ORROOTCOULDMAKETHEDIFFERENCEINPOTENCY.• INTERACTIONSWITHCONVENTIONALAGENTS• PLEASEUSEONETYPEOFAGENTSEITHERHERBALORCONVENTIONALTHERAPY• BEWAREOFHERBALAGENTSTHATCUREEVERYTHING,KNOWINGTHATEVERYHERBANDMEDICATIONALWAYSHAVESOMEADVERSEEFFECTS.• BEWAREOFHERBALMEDICATIONSTHATSTATENOADVERSEEFFECTS,MAYBENOTDOINGANYTHINGEITHER.

EVALUATION- CASESTUDY

• APATIENTCOMESTOTHEDRUGSTORECOMPLAININGOFSEVEREANXIETYSINCEBEGINNINGTOTAKEST.JOHN’SWORTABOUTTWOWEEKSAGO.SHEISTAKING3TABLETSADAY,ANDISNOTSLEEPINGASGOODWORSETHANWHENSHEBEGANTAKINGTHEST.JOHN’SWORT.• WHATDOYOUTELLTHISPATIENTTODO?• A)STOPTAKINGTHETABLETS• B)REDUCETHEDOSETO2TABLETSADAY• C)REDUCETHEDOSETO1TABLETADAY• D)STOPTAKINGMEDICATIONFORAWEEKANDTHENRESTARTAGAIN.

Page 15: CHE Dr. Griffith CLINICAL ROLE OF PHARMACIST TO IMPROVE …pharmacy.famu.edu/wp-content/uploads/2017/02/CHE-Dr... · 2017-02-23 · 2/23/17 1 CLINICAL ROLE OF PHARMACIST TO IMPROVE

2/23/17

15

EVALUATION– CASESTUDY

• AVETERANCOMESINTOTHEDRUGSTOREWANTINGSOMETHINGFORSLEEP.HECAN’TSLEEPVERYWELLANDISVERYIRRITABLEINTHEMORNING.WHATDORECOMMENDTOTHISVETERAN?• A)DIPHENHYDRAMNE25MGPOATBEDTIME• B)DOXYLAMINE25MGPOATBEDTIME• C)VALERIANTEAATBEDTIME• D)REFERTOMENTALHEALTHCOUNSELLOR

• TWOWEEKSLATERHECOMESBACKANDCOMPLAINSTHATHEISWAKINGUPWITHNIGHTMARESANDCAN’TGETBACKTOSLEEP,HISIRRITABILITYISWORSE,ANDHISWIFEWANTSTOLEAVEHIM.• A)INCREASEDOSEOFSLEEPAID• B)REFERTOPCPDOCTOR• C)REFERTOMENTALHEALTHDOCTOR• D)RECOMMENDKAVATEA

EVALUATIONCASESTUDY

• VETERANGOESTOHISMENTALHEALTHPHYSCIAN,WHATWOULDYOUEXPECTTHATHISPSYCHIATRISTWOULDGIVETOTHISVETERANFORHISNIGHTMARES?• A)PRAZOSIN• B)ARIPIPRAZOLE• C)SERTRALINE• D)PROPRANOL.• WHATWOULDYOUEXPECTHISPSYCHIATRISTTOGIVEHIMFORHISANXIETY?• A)PRAZOSIN• B)ARIPIPRAZOLE• C)SERTRALINE• D)PROPRANOLOL

EVALUATIONCASESTUDY

• THEVETERANCOMESBACKTOTHEPHARMACYCOMPLAININGOFSTILLHAVINGSUICIDALIDEATIONSAFTER2WEEKSOFTHERAPY.WhatSHOULDTHEPHARMACISTADVICETHEVETERAN?• A)STOPTAKINGMEDICATION• B)CONTACTMENTALHEALTHPHYSICIAN• C)INCREASETHEDOSEOFSERTRALINE• D)CONTINUETAKINGMEDICATIONSASTHEMEDICATIONMAYTAKE6WEEKSTOHAVEANEFFECT.

STIGMA

Page 16: CHE Dr. Griffith CLINICAL ROLE OF PHARMACIST TO IMPROVE …pharmacy.famu.edu/wp-content/uploads/2017/02/CHE-Dr... · 2017-02-23 · 2/23/17 1 CLINICAL ROLE OF PHARMACIST TO IMPROVE

2/23/17

16

QUESTIONSANDANSWERSECTION REFERENCES

• 1)CPNP2016-2017Anxietyandanxietyrelateddisorderspg.1-79.• 2)CPNP2016-2017Bipolardisorderpg.127-181.• 3)CPNP2016-2017;Depression,pg.181-243• 4)CPNP2016-2017;Schizophreniaspectrumandotherpsychoticdisorders,pg.579– 645• www.SAMHSA.gov.Treatmentofmentaldisorders,lastupdated10/27/2015• Collingwood.J.(2016).NaturalandherbalSupplementsforcommonMentalDisorders.Psych.Central.Retrievedfromhttps://psychcentral.com/lib/natural-and-herbal-supplements-for-common-mental-disorders/• Eversole.g.(2017)HerbsforTreatmentofEmotionalandMentalstates,retrievedfromwww.alternativementalhealth.com• FreemanMP,LakeJ,ComplimentaryandAlternativeMedicineinMajorDepressivedisorder:TheAmericanPsychiatricAssociationsTaskForceReport.J.Clinpsychiatry,2010june71(6)669-680.


Top Related