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Chapter 16 Mutation, Repair and Recombination
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Lysine and arginine are two amino acids with similar sized “R” (side-) groups and similar biochemical behavior (for example, both are basic residues). A mutation results in substitution of lysine for arginine and has no detectable effect on the function of that protein. Which statement best applies to this situation?
•The mutation is a silent mutation.
•The mutation is a frameshift mutation.
•The amino acid change is conservative.
•The amino acid change is silent.
•This organism displays no codon bias.
Question
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Which of the following represents a correct or acceptable phrase in genetics?
•Mutant protein
•Protein mutation
•DNA mutation
•A and C
•All of the above
Question
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Which of the following statements is correct about the bases in DNA under normal circumstances:
•Adenine should pair with thymine.
•The bonds holding guanine and cytosine together are stronger than the bonds holding adenine and thymine together.
•A purine always binds to a pyrimidine.
•A substitution of adenine for guanine is a transition mutation.
•All of the above
Question
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Carcinogens and the Ames Test
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Repair mechanisms
Photo reactivation repair Base excision repair Nucleotide excision repair Transcription coupled repair Mismatch repair
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Undamaged DNA
UV light (mutagenic agent)
EMS, NG (mutagenic agent)
Pyrimidine dimers Methylated base
Original Base
Photolyase
Visible lightAlkyl Transferase
Inactivated after action
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Replication dependent repair
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Which of the following repair pathways do not involve the use of a homology-dependent repair system?
a. Base excision repairb. Photo reactivation repairc. Transcription coupled repaird. Nucleotide excision repaire. Mismatch repair
Question
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•Which of the following DNA duplexes is most stable?
5’ AATTAATTAATTAATTAATT 3’ 3’ TTAATTAATTAATTAATTAA 5’
5’ GGCCGGCCGGCCGGCCGGCC 3’3’ CCGGCCGGCCGGCCGGCCGG 5’
• Both are equally stable.• B is more stable than A.
Question
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Which of the following repair pathways do not involve the use of a homology-dependent repair system?
a. Base excision repairb. Photo reactivation repairc. Transcription coupled repaird. Nucleotide excision repaire. Mismatch repair
Question