Download - Catabolism final 27.09.13
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CATABOLISM
Presented by : Julies Sagare
Rahul Pawar
Vandana Dubey
Asma Mazgaonkar
Priti Tawde
Shadab Khan
Submitted to : Dr. Darinka Dsouza
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INTRODUCTION
The metabolic breakdown of complex molecules into simpler ones, often resulting in a release of energy.
A series of degradative chemical reactions that break down complex molecules into smaller units, and in most cases releasing energy in the process.
The catabolic chemical reactions in the living cell break down polymers into their constituent monomers.
For example:
• Polysaccharides are broken down into monosaccharide.
• Proteins are broken down into amino acids.
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IMPORTANCE OF CATABOLISM The human body needs nutrients (both micro and macro) to rebuild and
grow muscle. If the body is deprived of nutrition, then it will target essential fatty acids and muscle for energy – making it impossible to build muscle.
The Anabolic state occurs during rest, when provided with proper nutrition. If you are finding it difficult to gain muscle, most likely you are not getting enough rest or nutrition. We do not grow in the gym; in fact, the gym promotes a Catabolic state – the breaking down of muscle. It's the rest and nutrition we get after the gym that promotes Anabolic growth.
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CARBOHYDRATE CATABOLISM Glycolysis is the initial pathway in the catabolism of carbohydrates, by which
a molecule of glucose is broken down to two molecules of pyruvate, with a net production of ATP molecules and the reduction of two NAD+ molecules to NADH.
Under aerobic conditions, these NADH molecules are reoxidized by the electron transport chain.
Under anaerobic conditions, a different electron acceptor is used.
The terminal products of glycolysis are carbon dioxide and water.
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APPLICATION OF CARBOHYDRATE
CATABOLISM
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USED IN TREATMENT OF
DISEASE CONDITIONGlycerol:-
Glycerol can cause a rapid, temporary decrease in the
internal pressure of the eye. This can be a useful as
emergency treatment of severely elevated eye
pressure(Glaucoma).
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Phosphofructokinase-2 (PFK-2) Inhibitor:-
Phosphofructokinase-2 is a bifunctional enzyme and regulator
of Glycolysis cycle.
Fructose-6-Phosphate
PFK-2
(PFKFBs isoforms)
Fructose-1,6-bisphosphate
Thus used to treat breast cancer, ovarian cancer, lung cancer
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USED TO DETECT CONGENITAL
DEFECTS Pyruvate Dehydrogenase Antibody:-
Pyruvate Dehydrogenase Antibody is used to detects
congenital defects that are usually associated with lactic
acidosis.
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USED FOR THE DESIGN OF
NEW DRUGS ANTI-TRYPANOSOME DRUG:-
Glycolysis cycle is a target for the design of new
anti-trypanosome drug used against parasitic trypanosomatid
protozoa.
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Protein Catabolism
MEANING :
Breakdown of the proteins into the amino acids by the various
proteases.
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What happens during protein
catabolism?
During protein catabolism, the proteins are first broken down into amino
acids by the various proteases. The amino acids are then absorbed by
the small intestine, from which they are sent to the liver via the hepatic
portal vein. In the liver, the amino acids are deaminated.
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When does protein catabolism
usually occur?
Due to illness
Prolonged starvation
when the body does not get adequate energy, this excess of amino acid in
the form of fats or sugar get breakdown and provides energy.
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Protein Catabolic Reactions In Body
Catabolism of body protein to amino acids:
Our body proteins are converted to amino acids via a series
of catabolic reactions.
Transamination and Deamination
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Deamination
amino groups are removed from excess proteins.
liver, kidneys
convert excess amino acids into usable resources such as
hydrogen and carbon.
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Deamination
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Transamination
Transamination is the process of transferring an amino acid (R-NH2)
from a molecule with an amino acid to a molecule that has a keto(=0)
group.
Main Site : Liver
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Essential Nonessential
Alanine
Isoleucine Arginine
Leucine Aspartic acid
Lysine Cysteine
Methionine Glutamic acid
Phenylalanine Glutamine
Threonine Glycine
Tryptophan Proline
Valine Serine
Tyrosine
Asparagine
Selenocystein
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L-dopa therapy for treating
Parkinson’s disease
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Tryptophan is an essential amino acid
Acts as a biochemical precursor for the following compounds
Serotonin a (neurotransmitter) synthesized via tryptophan hydroxylase.
melatonin (a neurohormone), via N-acetyltransferase and 5-
hydroxyindole-O-methyltransferase activities.
Niacin is synthesized from tryptophan via kynurenine and quinolinic
acids as key biosynthetic intermediates.
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Tryptophan
Sleep Disorders
Depression
Smoking Ceasation
5-hydroxytryptophan(5-HTP) for treatment for Epilepsy
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Melatonin
Therapy for Alzheimer’s Disease
this neurohormone prevents neuronal death caused by exposure to
the amyloid beta protein, a neurotoxic substance that accumulates in
the brains of patients with the Alzheimer’s disease.
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Enteral Formulas Containing Glutamine
JUVEN
Is a therapeutic nutritional that contains Arginine,Glutamine and
HMB(betahydroxy beta methylbutyrate)
JUVEN has been clinically shown
to help build lean body mass
Enhance immune response
Collagen synthesis
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